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Automated Eight-Arm Maze Trajectory Tracking System for Feature Extraction of TBI Animals

Automated Eight-Arm Maze Trajectory Tracking System for Feat...

ACIS International Conference on Software engineering, Artificial Intelligence, Networking, and Parallel/distributed Computing (SNPd)

作者： Shu-Cing Wu Chi-Yuan Lin Liang-Jyun Hong Chi-Chun Chen Ph.D. Program Prospective Technology of Electrical Engineering and Computer Science National Chin-Yi University of Technology Taichung Taiwan National Chin-Yi University of Technology Taichung Taiwan

ISBN: (纸本)9781665447324

Traumatic Brain Injury (TBI) is most commonly accident injury in modern society. The deterioration of cognition and memory is a common phenomenon caused by TBI. Most of the basic experiments used rats for pathological research. Moreover, an eight-arm maze was often used to test the spatial learning behavior of brain diseases, such as Alzheimer’s disease and TBI. However, most of maze experimental data were collected in manual records. This process would take a lot of manpower and time. Therefore, the research built an automatic tracking trajectory system of the eight-arm maze to collect experiment data. Furthermore, the path trajectory of the rat can be recorded in time. Finally, these path trajectory data were used to analysis behavior feature of TBI animals. The results showed that TBI rats have a 40%~80% chance of having a trajectory to the right.

关键词： Pathology Trajectory tracking Manuals Rats Feature extraction Cognition Trajectory

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Advances in surgical treatment for atlantoaxial instability focusing on rheumatoid arthritis: Analysis of a series of 67 patients

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International Journal of Rheumatic diseases 2023年第10期26卷 1996-2006页

作者： Lin, Mao-Shih Huang, Chih-Wei Tsou, Hsi-Kai Tzeng, Chung-Yuh Kao, Ting-Hsien Lin, Ruei-Hong Chen, Tse-Yu Li, Chi-Ruei Lee, Cheng-Ying Department of Neurosurgery Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Functional Neurosurgery Division Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Department of Rehabilitation Jen-Teh Junior College of Medicine Nursing and Management Houlong Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan College of Health National Taichung University of Science and Technology Taichung Taiwan Department of Orthopedics Taichung Veterans General Hospital Taichung Taiwan Department of Medicinal Botanicals and Foods on Health Applications Da-Yeh University Changhua Taiwan Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan

Aim: An estimated 88% of rheumatoid arthritis (RA) patients experience various degrees of cervical spine involvement. The excessive movement of the atlantoaxial joint, which connects the occiput to the upper cervical spine, results in atlantoaxial instability (AAI). AAI stabilization is usually achieved by C1 lateral mass-to-C2 pedicle screw-rod fixation (LC1–PC2 fixation), which is technically challenging in RA patients who often show destructive changes in anatomical structures. This study aimed to analyze the clinical results and operative experiences of C1–C2 surgery, with emphasis on the advancement of image-guided surgery and augmented reality (AR) assisted navigation. Methods: We presented our two decades of experience in the surgical management of AAI from April 2004 to November 2022. Results: We have performed surgery on 67 patients with AAI, including 21 traumatic odontoid fractures, 20 degenerative osteoarthritis, 11 inflammatory diseases of RA, 5 congenital anomalies of the os odontoideum, 2 unknown etiologies, 2 movement disorders, 2 previous implant failures, 2 osteomyelitis, 1 ankylosing spondylitis, and 1 tumor. Beginning in 2007, we performed LC1–PC2 fixation under C-arm fluoroscopy. As part of the progress in spinal surgery, since 2011 we used surgical navigation from presurgical planning to intraoperative navigation, using the preoperative computed tomography (CT) -based image-guided BrainLab navigation system. In 2021, we began using intraoperative CT scan and microscope-based AR navigation. Conclusion: The technical complexities of C1–C2 surgery can be mitigated by CT-based image-guided surgery and microscope-based AR navigation, to improve accuracy in screw placement and overall clinical outcomes, particularly in RA patients with AAI. © 2023 The Authors. International Journal of Rheumatic diseases published by Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.

关键词： atlantoaxial instability augmented reality C1–C2 surgery CT-based image-guided intraoperative CT scan navigation os odontoideum rheumatoid arthritis

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Electrochemical biosensor based on an atomic layered composite of graphene oxide/graphene as an electrode material towards selective and sensitive detection of miRNA-21

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Microchemical Journal 2024年 199卷

作者： Huang, Min-Shin Govindasamy, Mani Chinnapaiyan, Sathishkumar Lin, Yi-Ting Lu, Shao-Yang Samukawa, Seiji Huang, Chi-Hsien Department of Materials Engineering Ming Chi University of Technology New Taipei City 243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 24303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai-602105 Tamil Nadu India Institute of Fluid Science Tohoku University Sendai 980-8577 Japan College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan Division of Rheumatology Allergy and Immunology Chang Gung Memorial Hospital Taoyuan City 33305 Taiwan College of Engineering Chang Gung University Taoyuan City 33302 Taiwan

development of an efficient technique towards the detection of miRNAs is highly significant for the timely diagnosis and prognosis of cancers. In this study, we utilized the chemical vapor deposition (CVd) technique to grow bilayer graphene (BLG) on copper foil and subsequently transferred the BLG to fluorine doped tin oxide (FTO) substrate via a facile wet transfer technique. The upper layer of the BLG was modified to graphene oxide (GO) with a low damage plasma treatment (LdPT) process to serve as a biomolecule receiving layer and the lower graphene layer (G) serves as an electron transport layer. The developed GO/G/FTO platform offers superior sensing ability towards the miRNA-21. The results demonstrated that the proposed GO/G/FTO substrate detect the miRNA-21 with a wide linear range (10 fM ∼ 1 nM), low limit of detection (3.18 fM), high sensitivity (0.6 mApM⁻¹cm⁻²), selectivity and stability via the differential pulse voltammetry method. Additionally, the sensors can efficiently discriminate the target miRNA-21 from its complementary base mismatched counterparts. The proposed approach serves as an excellent tool for the early diagnosis of diseases. © 2024 Elsevier B.V.

关键词： Atomic layer oxidation Biosensor Cancer biomarkers Electrochemical Graphene oxide Plasma treatment

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ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota

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Molecular Medicine 2025年第1期31卷 1-13页

作者： Liu, Yi-Hsuan Lee, Yueh-Lun Han, Chia-Li Lo, Yu-Chun Liao, Zih-An Shih, Yu-Syuan Lin, Yi-Wen Peng, Syue-Wei Lee, Kang-Yun Ho, Shu-Chuan Wu, Sheng-Ming Lin, Cheng-Wei Chung, Kian Fan Chang, Jer-Hwa Chuang, Hsiao-Chi School of Respiratory Therapy College of Medicine Taipei Medical University 250 Wuxing Street Taipei 11031 Taiwan Department of Microbiology and Immunology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Master Program in Clinical Genomics and Proteomics College of Pharmacy Taipei Medical University Taipei Taiwan The Ph.D. Program for Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Division of Pulmonary Medicine Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Division of Pulmonary Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan Department of Biochemistry and Molecular Cell Biology Taipei Medical University Taipei Taiwan National Heart and Lung Institute Imperial College London London United Kingdom Division of Pulmonary Medicine Department of Internal Medicine Wan Fang Hospital Taipei Medical University Taipei Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei Taiwan

Background: Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), a Type 2 acute phase protein, is critical for resolving inflammation and promoting tissue repair. While its role in chronic respiratory diseases is recognized, its effects on asthma remain unclear. This study investigated the effects of ITIH4 on the modulation of lung and gut microbiota, the attenuation of allergic inflammation, and the improvement of respiratory outcomes in an asthma mouse model. Methods: Six-week-old male Balb/c mice were divided into five groups: control, ITIH4, ovalbumin (OVA), and two OVA + ITIH4 treatment groups at different doses. Lung function and oxygen saturation were measured, and bronchoalveolar lavage fluid (BALF) was analyzed for white blood cell counts and cytokines. Lung and gut microbiota were profiled using 16 S rRNA gene sequencing, and short-chain fatty acids (SCFAs) were measured using gas chromatography-mass spectrometry (GC-MS). Proteomic profiling of intestinal tissues was conducted to identify ITIH4-associated signaling pathways. Results: ITIH4 administration significantly mitigated OVA-induced asthma symptoms by reducing weight loss, airway resistance, and tissue damping (p < 0.05). Histological analysis showed decreased airway wall thickening and lung injury scores (p < 0.05). ITIH4 also lowered BALF eosinophils and lymphocytes, IgE, and Th2 cytokines (IL-4, IL-5, and IL-13) (p < 0.05). ITIH4 treatment modulated microbiome composition, enriching Gram-positive taxa (Nocardioidaceae and Acholeplasmataceae) and depleting Gram-negative Helicobacteraceae (p < 0.05). SCFAs correlated with microbiome alterations, notably reduced 4-methylpentanoic acid levels (p < 0.05). Proteomic analysis revealed a dose-dependent activation of granzyme A signaling and suppression of metabolic and solute transport pathways. Conclusions: ITIH4 ameliorates asthma symptoms by modulating lung and gut microbiota, dampening Th2-driven inflammation, and restoring mucosal immune balance. Th

关键词： Airway hyperresponsiveness Inflammation Microbiome Short-chain fatty acid Th2

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Boron carbide decorated tungsten disulfide nanosheet composite for determination of chloramphenicol in food and pharmaceutical samples

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Microchemical Journal 2024年 203卷

作者： Senthilkumar, dhayanithi Kuo, Chih-Yu Aldossari, Samar A. Govindasamy, Mani Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Department of Chemistry P. O. Box 2455 College of Science King Saud University Riyadh 11451 Saudi Arabia Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan

Making the nanocomposites of metal oxides or metal sulfides with carbon source materials has a huge impact on the electrochemical determination of toxic chemicals. To determine the adverse side effects of the antibiotics, electrochemical sensors have been used as they can peek into the sensitivity of the drug sample. This work has done the sensitive amperometric evaluation of a chloramphenicol antibiotic by modifying the electrode of tungsten disulfide decorated boron carbide. Here, tungsten disulfide (WS₂) nanosheets and boron carbide (B₄C) materials were synthesized by conventional methods which give a good amount of yield. The composite was prepared by the green and cost-effective sonochemical approach with good morphology. The conductivity of the nanocomposite and the response to chloramphenicol were determined by cyclic voltammetry. The sensitivity, limit of detection (LOd), and the linear range were observed by the highly sensitive amperometric technique. From the amperometric analysis, the prepared nanocomposite shows nominal LOd as a 17.4 nM, a broad linear range (0.025–1134.6 µM), and good sensitivity of 1.52 µA µM⁻¹ cm⁻². Practicability of the modified sensor was studied in food and pharmaceutical samples with adequate recovery performances. Moreover, the modified electrode shows good stability, repeatability, reproducibility, and anti-interfering properties against the array of food and biological interferences. © 2024 Elsevier B.V.

关键词： Amperometric technique Antibiotic detection Boron carbide Food quality test Health analysis Tungsten disulfide

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Snake-Scale Stimulated Robust Biomimetic Composite Triboelectric Layer for Energy Harvesting and Smart Health Monitoring

SSRN

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SSRN 2023年

作者： Lin, Zong-Hong Huang, Ming-Zheng Parashar, Parag Chen, An-Rong Shi, Shih-Chen Tseng, Yao-Hsuan Lim, Kee Chin Yeh, Hsuan-Yu Pal, Arnab Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Mechanical Engineering National Cheng Kung University Tainan70101 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan

Extreme frictional wear of triboelectric layers severely hinders long-term sustainability of triboelectric nanogenerators (TENGs) for efficient ambient energy harvesting. The state-of-the-art solutions necessitate sophisticated structural designs and complex packaging constraints, impeding the feasibility of TENGs for practical applications. Herein, inspired by the structures and compositions of snake scales, a biomimetic composite (BC) film is fabricated as a wear-resistant triboelectric contact layer. The successful formation of disulfide bond-facilitated cross-linkage of cysteine proteins in the keratin-based BC film promotes excellent mechanical resilience and durability, thereby solving the material abrasion challenges associated with solid-solid triboelectric layers. The BC film, with toothed microstructure, exhibits improved charge transfer, low friction, and consistent long-term stable outputs compared to commercial films. Furthermore, a self-powered BC film-based TENG is integrated into a bicycle for biomechanical energy harvesting, lightening warning signals for safer night ride with stable 300 V electrical output for at least 6 hours. Moreover, a smart health monitoring system is further proposed by embedding TENG-based sensors into the bicycle saddle, accurately capturing the rider’s pelvic-saddle interactions on varying terrain slopes. By leveraging the unique biomechanical information, machine learning-assisted user identification and terrain slope data classifications are achieved with high accuracies, laying a foundation for futuristic smart healthcare applications. This work provides a strategy to reduce material abrasion by exploiting the unique characteristics of a biomimetic material, facilitating a basis for efficient environmental energy harvesting and smart sensing. © 2023, The Authors. All rights reserved.

关键词： Nanogenerators

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Battery testing methods in fuel cell research

arXiv

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arXiv 2022年

作者： Ahmad, Shahbaz Egilmez, Mehmet Department of Physics American University of Sharjah PO Box: Sharjah26666 United Arab Emirates Material Science and Engineering Ph.D. Program American University of Sharjah PO Box: Sharjah26666 United Arab Emirates

This report presents some of the key laboratory electrochemical battery testing methods that are used in fuel cell research. Methods such as voltammetry, chronoamperometry, chronopotentiometry, and electrochemical impedance spectroscopy are of major importance. All the electrochemical corrosion tests are performed through a tri-electrode polarization cell setup containing a reference electrode, a counter electrode, and the working electrode (metal sample of interest) in an electrolyte solution. All three electrodes are connected to a potentiostat. Corrosion of metal occurs through an oxidation-reduction (redox) reaction. All the above testing methods can be performed by manipulating the current and voltage responses from the cell. Potentiostatic experiments (voltammetry and chronoamperometry) are performed using constant potential at the working electrode and recording the current response while galvanostatic experiments (chronopotentiometry) and vice versa. The measured data through all these experiments can provide very useful information regarding reaction reversibility, diffusion coefficient, reduction potential, rate of chemical reaction, durability, adsorption, voltage losses, and effective resistance to the mass and charge transport offered by electrode material. Copyright © 2022, The Authors. All rights reserved.

关键词： Electrochemical impedance spectroscopy

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deep learning-based photodamage reduction on harmonic generation microscope at low-level optical power

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Journal of Biophotonics 2024年第1期17卷 e202300285-e202300285页

作者： Shen, Yi-Jiun Liao, En-Yu Tai, Tsung-Ming Liao, Yi-Hua Sun, Chi-Kuang Lee, Cheng-Kuang See, Simon Chen, Hung-Wen International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics National Taiwan University Taipei Taiwan NVIDIA AI Technology Center NVIDIA Taipei Taiwan Department of Dermatology National Taiwan University Hospital and College of Medicine National Taiwan University Taipei Taiwan Institute of Photonics Technologies National Tsing Hua University Hsinchu Taiwan

The trade-off between high-quality images and cellular health in optical bioimaging is a crucial problem. We demonstrated a deep-learning-based power-enhancement (PE) model in a harmonic generation microscope (HGM), including second harmonic generation (SHG) and third harmonic generation (THG). Our model can predict high-power HGM images from low-power images, greatly reducing the risk of phototoxicity and photodamage. Furthermore, the PE model trained only on normal skin data can also be used to predict abnormal skin data, enabling the dermatopathologist to successfully identify and label cancer cells. The PE model shows potential for in-vivo and ex-vivo HGM imaging. © 2023 Wiley-VCH GmbH.

关键词： Harmonic generation

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Bismuth Sulfide doped in Graphitic Carbon Nitride degrades Nitric Oxide Under Solar Irradiation

SSRN

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SSRN 2022年

作者： Lin, Chitsan Hussain, Adnan Cheruiyot, Nicholas Kiprotich Huang, Wen-Yen Ahsan, Wazir Aitizaz Lee, Yen-Yi Ph.D. Program of Aquatic Science and Technology National Kaohsiung University of Science and Technology Kaohsiung 811213 Taiwan Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan Super Micro Mass Research and Technology Center Cheng Shiu University Kaohsiung City 833301 Taiwan Institute of Environmental Toxin and Emerging-Contaminant Cheng Shiu University Kaohsiung 833301 Taiwan Department of Food and Beverage Management Cheng Shiu University Kaohsiung 833301 Taiwan Center for Environmental Toxin and Emerging-Contaminant Research Cheng Shiu University Kaohsiung City 833301 Taiwan

This study developed and evaluated the application of bismuth sulfide doped on graphitic carbon nitride (Bi 2 S 3 @g-C 3 N 4 ) in the degradation of NO under solar irradiation. Bi 2 S 3 @g-C 3 N 4 was prepared through the grinding method. The morphological structure and chemical properties of the synthesized photocatalyst were analyzed before the degradation tests. After doping with Bi 2 S 3 , the bandgap was reduced to 2.85 eV, which increased the absorption of solar light. As a result, Bi 2 S 3 @g-C 3 N 4 achieved higher NO degradation (55%) compared to pure Bi 2 S 3 (35%) and g-C 3 N 4 (45%). The trapping test revealed that electrons were the primary species responsible for most of the NO degradation. The photocatalyst was stable under repeated solar irradiation, maintaining degradation efficiencies of 50% after five consecutive recycling tests. The present work offers strong evidence that Bi 2 S 3 @g-C 3 N 4 is stable and efficient catalyst for photocatalytic oxidation of NO over solar irradiation. © 2022, The Authors. All rights reserved.

关键词： Heterojunctions

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Electrochemical detection of antimalarial drug (Amodiaquine) using dy-MOF@MWCNTs composites to prevent erythrocytic stages of plasmodium species in human bodies

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Microchemical Journal 2024年 202卷

作者： Peter, X. Thatheyus Kuo, Chih-Yu Malar, P. Govindasamy, Mani Rajaji, Umamaheswari Yusuf, Kareem Thinfilm Photovoltaics Laboratory Department of Physics and Nanotechnology SRM Institute of Science and Technology Tamil Nadu Kattankulathur 603203 India Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia

Herein, we report on fabrication of dysprosium-based metal–organic framework (dy-MOF)@multiwalled carbon nanotubes (MWCNT) composites modified with glassy carbon electrode (dy-MOF@MWCNT/GC) as a working electrode for Antimalarial drug detection. dy-MOF@MWCNT composites was prepared by sonochemical process along with ultrasonication. The composite structure, phase purity, morphology and composition of the composites were confirmed by X-ray diffraction, Scanning electron microscope, and X-ray photoelectron spectroscopy. Further, dy@MWCNT composites were deposited on a glassy carbon electrode by drop casting method, and used as an electrode material to efficiently detect Amodiaquine (Add) by electrochemical techniques such as CV and dPV. The as-prepared dy@MWCNT composite material showed the oxidation peak current of Add to be ∼ 60 % higher than other unmodified GC electrodes and showed a low charge transfer resistance (R_ct) of 24 Ω. The dy@MWCNT provided a broad linear range of 0.4 to 20 µM with a limit of detection of 0.377 μM and sensitivity of 1.817 μA.μM⁻¹ for the detection of Add. According to the ph study, the amount of electrons and protons involved in the electrochemical processes of Add was calculated and a plausible mechanism for Add electro-oxidation was proposed. Thus, the prepared sensor exhibited practical usefulness by determining the Add drug in human urine samples. Hence, the results shows that the dy@MWCNT- modified sensor has good electrocatalytic activity for the redox of Add. © 2024 Elsevier B.V.

关键词： Amodiaquine Antimalarial drug Carbon nanomaterials Electrochemical sensor Metal organic framework

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