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Atrophy of the cholinergic regions advances from early to late mild cognitive impairment

Neuroradiology 2024年第4期66卷 543-556页

作者： Lai, Ying-Liang Larry Hsu, Fei-Ting Yeh, Shu-Yi Kuo, Yu-Tzu Lin, Hui-Hsien Lin, Yi-Chun Kuo, Li-Wei Chen, Cheng-Yu Liu, Hua-Shan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei Taiwan Department of Biological Science and Technology China Medical University Taichung Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan CT/MR Division Rotary Trading CO. LTD Taipei Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli Taiwan Institute of Medical Device and Imaging National Taiwan University College of Medicine Taipei Taiwan Department of Radiology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Medical Imaging Taipei Medical University Hospital Medical University Taipei Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan

Purpose: We investigated the volumetric changes in the components of the cholinergic pathway for patients with early mild cognitive impairment (EMCI) and those with late mild cognitive impairment (LMCI). The effect of patients’ apolipoprotein 4 (APOE-ε4) allele status on the structural changes were analyzed. Methods: Structural magnetic resonance imaging data were collected. Patients’ demographic information, plasma data, and validated global cognitive composite scores were included. Relevant features were extracted for constructing machine learning models to differentiate between EMCI (n = 312) and LMCI (n = 541) and predict patients’ neurocognitive function. The data were analyzed primarily through one-way analysis of variance and two-way analysis of covariance. Results: Considerable differences were observed in cholinergic structural changes between patients with EMCI and LMCI. Cholinergic atrophy was more prominent in the LMCI cohort than in the EMCI cohort (P < 0.05 family-wise error corrected). APOE-ε4 differentially affected cholinergic atrophy in the LMCI and EMCI cohorts. For LMCI cohort, APOE-ε4 carriers exhibited increased brain atrophy (left amygdala: P = 0.001;right amygdala: P = 0.006, and right Ch123, P = 0.032). EMCI and LCMI patients showed distinctive associations of gray matter volumes in cholinergic regions with executive (R² = 0.063 and 0.030 for EMCI and LMCI, respectively) and language (R² = 0.095 and 0.042 for EMCI and LMCI, respectively) function. Conclusions: Our data confirmed significant cholinergic atrophy differences between early and late stages of mild cognitive impairment. The impact of the APOE-ε4 allele on cholinergic atrophy varied between the LMCI and EMCI groups. © 2024, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： APOE-ε4 allele cholinergic pathway Early mild cognitive impairment (EMCI) mild cognitive impairment (MCI) nucleus basalis of Meynert

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deep Learning-Based Positioning Error Fault diagnosis of Wire Bonding Equipment and an Empirical Study for IC Packaging

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IEEE Transactions on Semiconductor Manufacturing 2023年第4期36卷 619-628页

作者： Kao, Sheng-Xiang Chien, Chen-Fu International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan Intelligent Manufacturing and Circular Economy Research Center National Tsing Hua University Artificial Intelligence for Intelligent Manufacturing Systems Research Center National Science and Technology Council Department of Industrial Engineering and Engineering Management Hsinchu300044 Taiwan

Little research has been done for artificial intelligence applications of semiconductor backend. This study aims to develop a deep learning based fault diagnosis framework as prognostics and health management (phM) solutions with a comprehensive analytics process. A linear encoder sensor is employed to measure position, while data preparation is conducted to convert position information into a signal. Then, signal processing is used to extract the features, in which high pass filter is applied to normalize the signal and emphasize the features. High-dimensional features including time domain statistical features, time-frequency domain features obtained by continuous wavelet transform (CWT), and frequency domain features converted by fast Fourier transform (FFT) are extracted to prepare the dataset. An ensemble neural network model that integrates deep neural network (dNN) and convolutional neural network (CNN) is employed to recognize the pattern and diagnose the positioning errors. The accuracy and false alarm rate are considered to support maintenance decisions. An empirical study was conducted in a world leading IC assembly and testing company for validation. The results have shown that the proposed approach can effectively detect inappropriate installation of the bond head in wire bonding equipment for predictive maintenance and cost reduction. © 1988-2012 IEEE.

关键词： Failure analysis

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An Anti-Plasma Etching Film of Y2O3 Film 10

An Anti-Plasma Etching Film of Y2O3 Film

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10th International Conference on Applied System Innovation, ICASI 2024

作者： Wei, Chia-Chih Chen, Hsuan-Jung Lee, Yi-Mu Chang, Shao-Fu Chen, Chien-Chon College of Engineering and Science Ph.D. Program in Materials and Chemical Engineering National United University Miaoli Taiwan Michigan State University Department of Chemistry MI48824 United States National United University Department of Electronic Miaoli Taiwan National United University Department of Energy Engineering Miaoli Taiwan

ISBN: (纸本)9798350394924

In this paper, we have presented our experiment results including (a) use a slowly thermal spray process deposition an yttrium oxide (Y2O3) film with thickness of $200\ \mu\mathrm{m}$ on the aluminum alloy (AA6061). The image analysis showed that the porosity of Y2O3 film can be reduced to less than 2%. The further aerosol deposition can be used filling the pores and can reduce the porosity of the film to less than 0.5%. This low-porosity Y2O3 film will be able to meet the increasingly stringent requirements for surface coating protection of semiconductor vacuum chamber. (b) Compared the corrosion characterization in 3.5 wt. % NaCl solution between naked AA6061 and AA6061 with Y2O3 coating, a high corrosion reactivity ($\mathrm{I}_{\text{corr}}=10^{-3.3}\mathrm{A}/\text{cm}^{2}$) of naked AA6061 then AA6061 with Y2O3 coating ($\mathrm{I}_{\text{corr}}=10^{-5.8}\mathrm{A}/\text{cm}^{2}$). The corrosion reactivity of AA6061 with Y2O3 is reduced by 316 times to a naked AA6061. © 2024 IEEE.

关键词： Porosity

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Properties of the mixing layer height retrieved from ceilometer measurements in Slovakia and its relationship to the air pollutant concentrations

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Environmental science and Pollution Research 2023年第54期30卷 115666-115682页

作者： Nguyen, duy-Hieu Štefánik, dušan Šedivá, Tereza Lin, Chitsan Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung811213 Taiwan Slovak Hydrometeorological Institute Jeséniova 17 Bratislava833 15 Slovakia Faculty of Mathematics Physics and Informatics Comenius University in Bratislava Mlynská Dolina F1 Bratislava842 48 Slovakia Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung811213 Taiwan

Mixing layer height (MLH) is an important meteorological parameter for air quality since it significantly affects ground-level pollution in the atmosphere. This study examined the properties of the MLH on diurnal and seasonal timescales over a 3-year period (2020–2022) using high temporal resolution measurements from eight Vaisala CL31 ceilometers situated around Slovakia. Hourly averaged MLH data was retrieved from the BL-View software using merged method. The highest daily maxima for the MLH occurred mostly in summer and spring, while the lowest values occurred predominantly during winter and autumn. The average MLH daily maximum in summer was 2229 m, and just 859 m in winter. during summer, the spatial distribution of the MLH daily maxima was more uniform compared to winter, when the air masses within the individual valleys did not mix well. Correlations between ground-level pollutant concentrations and hourly mean/daily mean MLH were analyzed. The highest correlation, R≈0.6, was found for O3. For PM10, PM2.5, and NOx, the anticorrelations with MLH were found with maximum in winter (R ≈ − 0.3 for hourly data and R ≈ − 0.5 for daily mean data) but no relation in summer. Lastly, the ceilometer MLH was compared to the radiosonde retrieved MLH for various cloud covers. Our analysis is based on an extensive set of empirical data, which can improve the accuracy and effectiveness of meteorological and atmospheric chemistry models. The findings can support air pollution forecasting and warning systems, providing valuable insights for policymakers and researchers. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： Air quality

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Meal Image Recognition and Healthy Meal Combination Recommendation System Integrated with Generative Artificial Intelligence 6

Meal Image Recognition and Healthy Meal Combination Recommen...

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6th IEEE Eurasia Conference on Biomedical engineering, Healthcare and Sustainability, ECBIOS 2024

作者： Chang, Chin-Chih Wei, Chi-Hung Hsiao, Sean Yang, Chyuan-Huei Thomas Chung Hua University Department of Computer Science and Information Engineering Hsinchu Taiwan Chung Hua University Ph.D. Program in Engineering Science Hsinchu Taiwan Chung Hua University Program in Applied Foreign Language and Smart Commerce Hsinchu Taiwan School of Information Engineering Shandong Vocational and Technical University of International Studies Shandong China

ISBN: (纸本)9798350396133

People increasingly prioritize a balanced diet to enhance well-being, yet making informed dietary choices remains challenging amidst the abundance of options. To address this, we developed a meal image recognition and healthy meal combination recommender system, integrating generative artificial intelligence (AI). Convolutional neural networks were used for precise meal image recognition to identify diverse food items. The generative AI-augmented recommendation engine offers personalized meal suggestions aligned with nutritional goals and dietary preferences, utilizing a nutrition knowledge base to ensure overall well-being. The system's feasibility was validated, illustrating its excellence in meal recognition accuracy, recommendation diversity, and user engagement. By integrating generative AI, the system shows its potential to enhance dietary recommendations and public health. © 2024 IEEE.

关键词： Generative adversarial networks

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Reusable Hydrogen Storage Tank with Flange design 10

Reusable Hydrogen Storage Tank with Flange Design

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10th International Conference on Applied System Innovation, ICASI 2024

作者： Li, Yun-Qi Chen, Hsuan-Jung Yang, Hsi-Wen Chen, Chih-Yuan Chang, Shao-Fu Chen, Ssu-Ying Chen, Chien-Chon College of Engineering and Science Ph.D. Program in Materials and Chemical Engineering National United University Miaoli Taiwan Michigan State University Department of Chemistry MI48824 United States National United University Department of Materials Engineering Miaoli Taiwan Graduate Institute of Intellectual Property National Taipei University of Technology Taiwan National United University Department of Energy Engineering Miaoli Taiwan

ISBN: (纸本)9798350394924

For how to store and transport hydrogen, the first thought is to store hydrogen directly in the cylinder. However, this method is not desirable, because generally at least 700 atm high pressure, the hydrogen contained in the cylinder to be useful. Therefore it is very unsafe at such high pressures. In This paper, we design and production of a new generation of solid-state hydrogen storage and discharge container. The goal of 'development of solid-state hydrogen storage technology' is to break through the bottlenecks of hydrogen storage technology safety, hydrogen storage density, high-efficiency hydrogen absorption and release, transportation safety, and engineering practice. © 2024 IEEE.

关键词： Aluminum

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Microwave dielectric and structural characteristics in Li2O-B2O3-SiO2 glass ceramics

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Ceramics International 2025年第16期51卷 22925-22931页

作者： Qiu, Jun-Yan Tu, Chi-Shun Huang, Szu-Ting Li, Yongxiang Chen, Pin-Yi Chen, Cheng-Sao Montecillo, Rhys Feng, Kuei-Chih International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan Department of Physics Fu Jen Catholic University New Taipei City Taiwan Department of Mechanical Engineering Ming Chi University of Technology New Taipei City Taiwan School of Engineering RMIT University MelbourneVIC3000 Australia Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City Taiwan Department of Mechanical Engineering Hwa Hsia University of Technology New Taipei City Taiwan

Advancements in high-frequency communication devices have emphasized miniaturization and low energy consumption. This work focuses on developing microwave dielectric materials characterized by an ultra-low dielectric constant and low dielectric loss coefficient. In this study, B2O3 and Li2O were added into the SiO2 matrix to form the LBS glass-ceramics. The B2O3-added SiO2 shows a formation of α-cristobalite phase, and the Li2O additive in the B2O3-SiO2 glass-ceramics sintered at 900 °C reveal a primary quartz phase with a secondary phase Li2Si2O5, that partially transformed into Li2SiO3 in the specimen sintered at 950 °C. The LBS12 (x = 12 wt%) show stronger Raman peaks of Li2Si2O5 and Li2SiO3, indicating increase of highly-crystallized Si-O network. As the quartz phase diminishes, Li2Si2O5 and Li2SiO3 begin to develop in the glass-ceramic matrix. dense microstructures and well-formed crystalline grains were observed in the LBS glass-ceramics. The quality factors were primarily affected by grain size and density. The Li2Si2O5 additive in the LBS glass-ceramics can reduce dielectric permittivity (Εr) and increase Q × f, particularly at higher frequencies. A low Εr of 4.7–5, a high Q × f of 2600 GHz, and a hardness of 249 MHV were achieved in the LBS12 sintered at 900 °C. These LBS glass-ceramics exhibit potential for use in low-temperature co-fired ceramic (LTCC) applications in high-frequency communication devices. © 2025

关键词： Sintering

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Integration of a Microfluidics System With a U-Shaped Optical Fiber Sensor for Sensing Various Concentrations of Glucose

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IEEE Sensors Journal 2024年第13期24卷 20617-20628页

作者： Hsiang-Cheng Hsu Tien-Bao Tran Thi Thuy-Vy Nguyen Hoang-dang Le Chia-Chin Chiang Department of Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung Taiwan Department of Mechanical Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan College of Engineering Can Tho University Ninh Kieu Can Tho Vietnam

This study introduces a successfully manufactured U-shaped optical fiber sensor integrated with a microfluidics system to detect varying glucose concentrations. It outlines the fabrication process of the microfluidics system, accomplished using a CO2 laser on polymethyl methacrylate (PMMA) material. Through three cycles of experiments involving different glucose concentrations, the results indicate a consistent trend in both resonance wavelength and transmission loss, showing an increase as glucose concentration rises from 5% to 50%. The system demonstrates a high wavelength sensitivity coefficient of 0.114 nm/% with ${R}^{{2}} =0.95$ and a notable transmission loss sensitivity of 0.09 dB/% and ${R}^{{2}} =0.94$ . This advanced system proves to be effective in achieving rapid, sensitive, and cost-efficient glucose monitoring. Consequently, the microfluidics system is deemed suitable for its intended purpose.

关键词： Microfluidics Glucose Optical fiber sensors Sensors Sensitivity Claddings Viscosity

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Cuisine Image Recognition and Recommender System using Convolutional Neural Network 5

Cuisine Image Recognition and Recommender System using Convo...

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5th IEEE Eurasia Conference on IOT, Communication and engineering, ECICE 2023

作者： Chang, Chin-Chih Wei, Chi-Hung Wu, Kuan-Yun Kao, Hao-Xiang Hsiao, Sean Chung Hua University Department of Computer Science and Information Engineering Hsinchu Taiwan Chung Hua University Ph.D. Program in Engineering Science Hsinchu Taiwan National Kaohsiung University of Science and Technology Department of Computer Science and Information Engineering Kaohsiung Taiwan Chung Hua University Program of Applied Foreign Language and Smart Commerce Hsinchu Taiwan

ISBN: (纸本)9798350314694

The fusion of technology and culinary exploration has allowed for the emergence of advanced online customer service systems. We developed a novel approach to enhance the dining experience. We used a Cuisine Image Recognition and Recommender System (CIRRS) powered by Convolutional Neural Network (CNN) to identify and suggest diverse cuisines based on visual inputs. CIRRS swiftly identified diverse cuisines from user-captured images, offering information on origin, ingredients, and variations by crawling websites. The system enhanced dining experiences by suggesting personalized menus based on individual preferences and past selections. Extensively tested across various culinary genres, CIRRS consistently demonstrated accuracy and adaptability. User feedback validated its potential to simplify dining choices and elevate satisfaction. This innovative system enriched dining experiences as a valuable tool for culinary enthusiasts, chefs, and restaurateurs, bridging the gap between technology and gastronomy, It also offers a unique way to explore Taiwanese cuisines. © 2023 IEEE.

关键词： convolutional neural network (CNN) deep learning image recognition recommender system web crawler

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TiO2 Hole Transport Layer Incorporated in a Thermally Evaporated Sb2Se3 photoelectrode Exhibiting Low Onset Potential for photoelectrochemical Applications

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Energy and Fuels 2024年第17期38卷 16936-16948页

作者： Xavier, Thatheyus Peter Piraviperumal, Malar Kuo, Chih-Yu Govindasamy, Mani Thinfilm Photovoltaics Laboratory Department of Physics and Nanotechnology SRM Institute of Science and Technology Tamil Nadu Kattankulathur603203 India Department of Chemical Engineering & Biotechnology National Taipei University of Technology Taipei City10608 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Research and Innovation Saveetha School of Engineering SIMATS Chennai602105 India Taipei10608 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

developing cost-effective photoelectrodes with a low band gap in the NIR-visible regions remains a challenge to achieve effective hydrogen production. We report the details of superstrate-configured photocathodes, consisting of antimony selenide (Sb2Se3) light absorbing layers with titanium dioxide (TiO2) as a hole transport layer, exhibiting the capability for hydrogen evolution with broad range light absorption enabled by the low band gap value of ∼1.2 eV of Sb2Se3. Strong anisotropy is a significant characteristic property of Sb2Se3, allowing superior electrical transportation along the [hkl] crystallographic orientation, which is obtained via close space evaporation of presynthesized bulk material at a growth temperature of 250 °C, over the solution-processed TiO2 film on a fluorine-doped tin oxide (FTO) substrate. The superstrate-configured FTO/TiO2/Sb2Se3 photocathode exhibited a photocurrent density of 100 μA cm-2 at −0.3 V vs RHE in 0.5 M H2SO4 under 1 sun illumination. To further improve photocurrent density, Pt as a cocatalyst was deposited over Sb2Se3 that led to enhanced photocurrent to 3 mA cm-2 at −0.3 V vs RHE in 0.5 M H2SO4 under 1 sun illumination. despite the relatively lower photocurrent observed, which resulted due to a large conduction band offset (ΔECB = 0.99 eV) of the TiO2/Sb2Se3 interface in a superstrate configuration, a significantly lower onset potential of −0.1 V vs RHE was observed. The results are encouraging due to the low band gap of Sb2Se3, photocorrosion stability, and straightforward fabrication, which is expected to assist for significant outcomes. © 2024 American Chemical Society.

关键词： Titanium dioxide

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