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Organic and Hybrid Sensors and Bioelectronics XIII 2020

作者： debesay, Thomas H. Sun, Sam-Shajing Bahoura, Messaoud Center for Materials Research Norfolk State University 700 Park Avenue NorfolkVA23504 United States Ph.D. Program in Materials Science and Engineering Norfolk State University 700 Park Avenue NorfolkVA23504 United States Department of Chemistry Norfolk State University 700 Park Avenue NorfolkVA23504 United States Engineering Department Norfolk State University 700 Park Avenue NorfolkVA23504 United States

ISBN: (数字)9781510637573

ISBN: (纸本)9781510637566

Field-Effect Transistors (FETs) are the key building blocks in a wide range of electronic applications such as sensors and electrical switches. The emergence of Organic Field-Effect Transistors (OFETs) unveiled special features, which have taken the application of FETs into uncharted territories. These unique features include but are not limited to, low- cost processing, lightweight, mechanical flexibility, biocompatibility, broad material availability, etc. Similar to their inorganic counterparts, doping organic semiconductors (OSC) can significantly alter or improve their electrical and optoelectronic properties, resulting in doping induced OFET multi-functionalities. In this study, the impact of multi-doping on the OFET device performance and functionalities has been systematically investigated and evaluated under varying conditions of light, heat, and gate voltages. The experimental results appear to support the proposed hypothesis behind the multi-functionality of the system under study. The present work will provide valuable scientific insights for the advancement of OFET based sensors, switches, and modulators. © COPYRIGHT SPIE. downloading of the abstract is permitted for personal use only.

关键词： Organic field effect transistors

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The numbers of fungi:are the most speciose genera truly diverse?

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Fungal diversity 2022年第3期114卷 387-462页

作者： Chitrabhanu S.Bhunjun Tuula Niskanen Nakarin Suwannarach Nopparat Wannathes Yi-Jyun Chen Eric H.C.McKenzie Sajeewa S.N.Maharachchikumbura Bart Buyck Chang-Lin Zhao Yu-Guang Fan Jing-Yi Zhang Asha J.dissanayake diana S.Marasinghe Ruvishika S.Jayawardena Jaturong Kumla Mahajabeen Padamsee Ya-Ya Chen Kare Liimatainen Joseph F.Ammirati Chayanard phukhamsakda Jian-Kui Liu Wiphawanee phonrob Émile Randrianjohany Sinang Hongsanan Ratchadawan Cheewangkoon digvijayini Bundhun Surapong Khuna Wen-Jie Yu Lun-Sha deng Yong-Zhong Lu Kevin d.Hyde Saisamorn Lumyong Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Jodrell Laboratory Royal Botanic GardensKewSurrey TW93ABUK Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Research Center of Microbial Diversity and Sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand Microbiology Program Faculty of Science and TechnologyPibulsongkram Rajabhat UniversityPhitsanulok 65000Thailand Manaaki Whenua-Landcare Research Private Mail Bag 92170AucklandNew Zealand School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Institut de Systématique EvolutionBiodiversité(ISYEB)Muséum National d’Histoire naturelleCNRSSorbonne UniversitéEPHEUniversitédes Antilles57 rue CuvierCP 3975231 Paris cedex 05France College of Biodiversity Conservation Southwest Forestry UniversityKunming 650224People’s Republic of China Key Laboratory of Tropical Translational Medicine of Ministry of Education Tropical Environment and Health LaboratoryCollege of PharmacyHainan Medical UniversityHaikou 571199People’s Republic of China Institute of Crop Germplasm Resources Guizhou Academy of Agricultural SciencesGuiyang 550006People’s Republic of China Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006People’s Republic of China School of Food and Pharmaceutical Engineering Guizhou Institute of TechnologyGuiyang 550003People’s Republic of China Centre National de Recherche sur l’Environnement(CNRE) BP 1739Laboratoire de Microbiologie de l’Environnement(LME)AntananarivoMadagascar Department of Biology University of WashingtonBox 351800SeattleWA 98195-1800USA College of Plant Protection Jilin Agricultural UniversityChangchun 130118JilinPeople’s Republic of China Engineering Research Center of Chinese Ministry of Education for Edible and

Fungi play vital roles in ecosystems as endophytes,pathogens and *** current estimate of fungal diversity is highly uncertain,ranging from 1.5 to 12 million,but only around 150,000 species have been named and classified to *** the introduction of dNA based methods for species identification,the number of newly described taxa has increased from approximately 1000 to around 2000 *** demonstrates the importance of dNA based methods to identify and distin-guish species,especially cryptic *** novel species from recent studies have been found in historically understudied regions and habitats,but these still represent only a small percentage of the estimated *** this paper,we examine 16 genera from the top 40 most speciose genera as listed in Species Fungorum as case studies to examine the diversity of taxa in each *** genera treated herein are Cercospora,diaporthe,Meliola,Passalora,phyllachora,phyllosticta,Pseudocer-cospora,Ramularia(ascomycetes)and Cortinarius,Entoloma,Inocybe,Marasmius,Psathyrella,Puccinia,Russula,Uromyces(basidiomycetes).We critically evaluate the number of species in these genera and correlate these numbers with the number of entries in *** introduce 18 new species Apiospora multiloculata,Candolleomyces thailandensis,Cortinarius acutoproximus,Cortinarius melleoalbus,Cortinarius pacificus,Cortinarius parvoacetosus,diaporthe guizhouensis,Entoloma pseudosubcorvinum,Inocybe meirensongia,Marasmius albulus,Marasmius obscuroaurantiacus,Meliola camporesii,phyl-lachora siamensis,phyllosticta doitungensis,Picipes yuxiensis,Pseudocercospora vignae,Puccinia maureanui and Russula *** also introduce a new record of Candolleomyces cladii-marisci and Inocybe *** discuss the genera Colletotrichum and Pleurotus that are speciose,but do not occur in the top *** hypothesize whether there might be more species in these genera and discuss why these genera have some of the largest number of specie

关键词： 18 new taxa Ascomycota Basidiomycota Fungal diversity Host-specificity Taxonomy

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design of an ultrasensitive electrochemical sensor using a carbon black/zinc-organic framework nanocomposite for quantifying quercetin in fruits

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Food Chemistry 2025年

作者： Arunkumar Selvam Meenakumari Gopakumar Gopika Chih-Yu Kuo Kareem Yusuf Beena Saraswathyamma Mani Govindasamy Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Department of Chemistry Amrita Vishwa Vidyapeetham Amritapuri Campus Clappana P O Kollam Kerala 690525 India High-Value Biomaterials Research and Commercialization Center National Taipei University of Technology Taipei 106 Taiwan Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan

Quercetin, a potent flavonoid recognized for its antioxidant and anti-inflammatory attributes, is abundantly found in fruits and vegetables, considerably enhancing their health benefits. Monitoring quercetin concentrations in food matrices is crucial for quality assurance, nutritional assessment, and substantiating health claims. We report a unique zinc-based metal–organic framework (Zn-MOF) incorporated with carbon black (CB) to create a highly sensitive electrochemical sensor specifically designed for quercetin detection. The distinctive porous architecture of the Zn-MOF, together with the superior conductivity of carbon black, have a synergistic effect that improves electron transfer. The sensor reports a wide linear range of 0.05–350.9 μM and a lowest detection limit of 3.7 nM. Furthermore, Zn-MOF@CB/GCE demonstrates excellent current retention (95.64 %) over a period of one month, together with commendable repeatability and reproducibility. The real-sample study of the proposed sensor demonstrates an effective recovery range for fruits: apple (95.0–99.0 %), grapes (96.0–98.0 %), and guava (97.0–101.0 %).

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Correction to: A mini‑review on plasticrusts: occurrence, current trends, potential threats, and recommendations for coastal sustainability

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Environmental monitoring and assessment 2024年第7期196卷 629页

作者： Minh-Ky Nguyen Md Refat Jahan Rakib Hoang-Lam Nguyen Chitsan Lin Guilherme Malafaia Abubakr M Idris Faculty of Environment and Natural Resources Nong Lam University of Ho Chi Minh City Hamlet 6 Linh Trung Ward Thu Duc City Ho Chi Minh City 700000 Vietnam. Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan. Department of Fisheries and Marine Science Faculty of Science Noakhali Science and Technology University Sonapur Noakhali 3814 Bangladesh. Department of Civil Engineering McGill University Montreal Canada. Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan. ctlin@nkust.edu.tw. Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan. ctlin@nkust.edu.tw. Post‑Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlandia Uberlandia MG Brazil. guilhermeifgoiano@***. Post‑Graduation Program in Biotechnology and Biodiversity Federal University of Goias Goiania GO Brazil. guilhermeifgoiano@***. Post‑Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutai GO Brazil. guilhermeifgoiano@***. Department of Chemistry College of Science King Khalid University 62529 Abha Saudi Arabia. Research Center for Advanced Materials Science (RCAMS) King Khalid University 62529 Abha Saudi Arabia.

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Ultrasensitive and selective electrochemical detection of hydroquinone using electropolymerized 7-amino cephalosporanic acid modified GCE

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Surface and Coatings technology 2025年 512卷

作者： Sathya, H. Varatharajan, Pandiaraja Ashkar, M.A. Chandhru, M. Govindasamy, Mani Rani, S. Kutti Vasimalai, N. Department of Chemistry B.S. Abdur Rahman Crescent Institute of Science and Technology Chennai Vandalur600 048 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Physics B.S. Abdur Rahman Crescent Institute of Science and Technology Chennai Vandalur600 048 India Tamil Nadu Chennai602105 India Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

Industrial wastewater pollution harms ecosystems and hinders sustainable development growth. Particularly, hydroquinone (HQ) has transitioned from a commercial chemical to an environmental hazard because of its extensive use in beauty products, pharmaceuticals, chemicals, and food industries. Therefore, developing electrochemical sensors for the detection of HQ is very important for environmental safety. Herein, the 7-ACA monomer was electropolymerized on the glassy carbon electrode (GCE) surface to examine the electrochemical oxidation of HQ utilizing CV (cyclic voltammetry) and dPV (differential pulse voltammetry) techniques. Scanning electron microscopy (SEM) characterization verified the deposition of the p-7-ACA on the glassy carbon electrode (GCE) surface. The designed p-7-ACA@GCE sensor exhibited better electrocatalytic properties. The acquired dPV observations for the p-7-ACA@GCE demonstrated excellent limit of detection (LOd) 8.86 nmol L−1 and broad linear range (0.33 μM to 955 μM) for the detection of HQ. The developed sensor exhibits excellent repeatability, reproducibility, selectivity and better cyclic stability. In addition, the fabricated p-7-ACA@GCE was used to determine the HQ in a different environmental water sample. © 2025

关键词： Cyclic voltammetry

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Plasma-derived Nanoclusters for Site-Specific Multimodality photo/Magnetic Thrombus Theranostics

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Advanced Healthcare Materials 2023年第28期12卷 2301504-2301504页

作者： Liu, Chia-Hung Liu, Ming-Che Jheng, Pei-Ru Yu, Jiashing Fan, Yu-Jui Liang, Jia-Wei Hsiao, Yu-Cheng Chiang, Chih-Wei Bolouki, Nima Lee, Jyh-Wei Hsieh, Jang-Hsing Mansel, Bradley W Chen, Yan-Ting Nguyen, Hieu Trung Chuang, Er-Yuan Department of Urology School of Medicine College of Medicine Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan TMU Research Center of Urology and Kidney Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Department of Urology Shuang Ho Hospital Taipei Medical University 291 Zhongzheng Road Zhonghe District New Taipei City23561 Taiwan Clinical Research Center Taipei Medical University Hospital Taipei11031 Taiwan School of Dental Technology College of Oral Medicine Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering International Ph.D. Program in Biomedical Engineering Graduate Institute of Biomedical Optomechatronics School of Biomedical Engineering Research Center of Biomedical Device Innovation Entrepreneurship Education Center College of Interdisciplinary Studies Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering College of Engineering National Taiwan University Taipei106 Taiwan Department of Orthopedics Taipei Medical University Taipei11031 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei11031 Taiwan Department of Physical Electronics Faculty of Science Masaryk University Brno60177 Czech Republic Department of Materials Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei City24301 Taiwan National Synchrotron Radiation Research Center Hsinchu Science Park Hsinchu30076 Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City700000 Viet Nam Cell Physiology and Molecular Image Research Center Taipei Medical University Wan Fang Hospital Taipei11696 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei11031 Taiwan

Traditional thrombolytic therapeutics for vascular blockage are affected by their limited penetration into thrombi, associated off-target side effects, and low bioavailability, leading to insufficient thrombolytic efficacy. It is hypothesized that these limitations can be overcome by the precisely controlled and targeted delivery of thrombolytic therapeutics. A theranostic platform is developed that is biocompatible, fluorescent, magnetic, and well-characterized, with multiple targeting modes. This multimodal theranostic system can be remotely visualized and magnetically guided toward thrombi, noninvasively irradiated by near-infrared (NIR) phototherapies, and remotely activated by actuated magnets for additional mechanical therapy. Magnetic guidance can also improve the penetration of nanomedicines into thrombi. In a mouse model of thrombosis, the thrombosis residues are reduced by ≈80% and with no risk of side effects or of secondary embolization. This strategy not only enables the progression of thrombolysis but also accelerates the lysis rate, thereby facilitating its prospective use in time-critical thrombolytic treatment. © 2023 Wiley-VCH GmbH.

关键词： diseases

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Ser235 phosphorylation of hepatitis C virus NS5A is required for NS5A dimerization and drug resistance

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Life sciences 2024年 337卷 122338页

作者： Lee, Wei-Ping Tsai, Keng-Chang Liao, Shi-Xian Huang, Yi-Hsiang Hou, Ming-Chih Lan, Keng-Hsin Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan Institute of Biochemistry and Molecular Biology School of Life Sciences National Yang Ming Chiao Tung University Taipei Taiwan National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei Taiwan The Ph.D. Program for Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan School of Medicine College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Institute of Clinical Medicine School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Institute of Pharmacology College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan

Hepatitis C virus (HCV) infection is recognized as a major causative agent of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HCV non-structural protein 5A (NS5A) is a dimeric phosphoprotein with a hyperphosphorylated form to act as a switch that regulates HCV replication and assembly. NS5A inhibitors have been utilized as the scaffold for combination therapy of direct-acting antiviral agents (dAA). However, the mode of action of NS5A inhibitors is still unclear due to the lack of mechanistic detail regarding NS5A phosphorylation and dimerization in the HCV life cycle. It has been demonstrated that phosphorylation of NS5A at Ser235 is essential for RNA replication of the JFH1 strain. In this report, we found that NS5A phosphomimetic Ser235 substitution (Ser-to-Asp mutation) formed a dimer that was resistant to disruption by NS5A inhibitors as was the NS5A resistance-associated substitution Y93H. phosphorylation of NS5A at Ser235 residue was required for the interaction of two NS5A-WT molecules in JFH1-based cell culture system but not absolutely required for dimerization of the NS5A-Y93H mutant. Interestingly, HCV nonstructural proteins from the subgenomic replicon NS3-5A was required for NS5A-WT dimerization but not required for NS5A-Y93H dimerization. Our data suggest that spontaneous Ser235 phosphorylation of NS5A and ensuing dimerization account for resistance of the JFH1/NS5A-Y93H mutant to NS5A inhibitors. © 2023 Elsevier Inc.

关键词： drug resistance Hepatitis C virus NS5A dimerization Ser235 phosphorylation

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Sulfur-inspired layered g-C 3 N 4 -incorporated NiFe 2 S 4 nanocomposite for electrochemical and real-time detection of vanillin in food samples

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Journal of the Taiwan Institute of Chemical Engineers 2025年 174卷

作者： Arun Tamilselvan Meenakumari Gopakumar Gopika Aravinth Karuppanan Beena Saraswathyamma Norah A. Albassami Mani Govindasamy Department of Physics SSN Research centre Sri Sivasubramaniya Nadar College of Engineering Kalavakkam Tamilnadu 603110 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Department of chemistry Amrita Vishwa Vidyapeetham Amritapuri Campus Clappana Kollam Kerala 690525 India Department of Chemistry Faculty of Science King Khalid University P.O.Box 9004 Abha 61413 Saudi Arabia Research Centre for Intelligent Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan

Background Vanillin is a widely used flavoring agent and plays a crucial role in food safety, making its accurate detection essential. developing sensitive and cost-effective methods for vanillin detection is vital for ensuring food quality and consumer protection. Methods This study introduces a novel sulfur-engineered g-C 3 N 4 /NiFe 2 S 4 nanocomposite synthesized via a simple and scalable method. The composite was employed to modify a glassy carbon electrode (GCE), significantly improving its electrochemical properties. Structural and morphological characterizations confirmed the successful integration of g-C 3 N 4 with NiFe 2 S 4 . differential pulse voltammetry (dPV) was conducted under optimized conditions (ph 7). Significant Findings The modified GCE exhibited a substantially enhanced oxidation peak current for vanillin, indicating superior electrocatalytic activity. The sensor achieved a wide linear detection range (0.01 - 360 µmol l -1 ), a low detection limit (0.00031 µmol l -1 ), and excellent selectivity, stability, repeatability, and reproducibility. Uniquely, the synergy between g-C 3 N 4 and NiFe 2 S 4 provided enhanced charge transfer and surface activity. Application of the sensor to real food samples including ice cream, wafers, and coffee demonstrated accurate recovery and practical feasibility, underscoring its potential as a reliable tool for food safety monitoring in real-world scenarios.

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The need for precise and accurate imaging navigation in cervical spine surgery for rheumatoid arthritis

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International Journal of Rheumatic diseases 2024年第2期27卷 e15084-e15084页

作者： Huang, Chih-Wei Lin, Mao-Shih Tzeng, Chung-Yuh Chen, Tse-Yu Tsou, Hsi-Kai Department of Neurosurgery Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Department of Rehabilitation Jen-Teh Junior College of Medicine Nursing and Management Houlong Miaoli County Taiwan Department of Orthopedics Taichung Veterans General Hospital Taichung Taiwan Department of Medicinal Botanicals and Foods on Health Applications Da-Yeh University Changhua County Taiwan Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan Functional Neurosurgery Division Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan College of Health National Taichung University of Science and Technology Taichung Taiwan

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Computer-aided drug discovery of a dual-target inhibitor for ovarian cancer: therapeutic intervention targeting CdK1/TTK signaling pathway and structural insights in the NCI-60

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Computers in Biology and Medicine 2025年 193卷 110445页

作者： Tang, Sung-Ling Sumitra, Maryam Rachmawati Kuo, Yu-Cheng Hsu, Han-Lin Ansar, Muhamad Huang, Sheng-Liang Lee, Shih-Yu Wang, Hong-Jaan Lawal, Bashir Wu, Alexander T.H. Chen, Lung-Ching Huang, Hsu-Shan School of Pharmacy National Defense Medical Center Taipei11490 Taiwan PhD Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei11031 Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei11031 Taiwan Department of Pharmacology School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan School of Post-Baccalaureate Chinese Medicine College of Chinese Medicine China Medical University Taichung40604 Taiwan Graduate Institute of Clinical Medicine Taipei Medical University Taipei11031 Taiwan Division of Pulmonary Medicine Department of Internal Medicine Wanfang Hospital Taipei Medical University Taipei11031 Taiwan Ph.D. Program in the Clinical Drug Development of Herbal Medicine Taipei Medical University Taipei110301 Taiwan Graduate Institute of Aerospace and Undersea Medicine National Defense Medical Center Taipei11490 Taiwan UPMC Hillman Cancer Center University of Pittsburgh PittsburghPA United States Ph.D. Program of Translational Medicine College of Science and Technology Taipei Medical University Taipei11031 Taiwan Division of Cardiology Department of Internal Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei11101 Taiwan Ph.D. Program in Biotechnology Research and Development College of Pharmacy Taipei Medical University Taipei11031 Taiwan

Ovarian cancer remains the third most prevalent and deadliest gynecologic malignancy worldwide, with most patients eventually developing resistance to platinum-based chemotherapy. This highlights a critical unmet need for innovative multitargeted therapies to address current treatment challenges. In this study, we identified 35 differentially expressed genes (dEGs) through integrated analysis of four GEO ovarian cancer datasets, with validation using TCGA data. Gene Ontology (GO) and KEGG enrichment analyses highlighted key tumor-associated pathways, and protein–protein interaction (PPI) network modeling prioritized CdK1 and TTK as high-value therapeutic targets. We evaluated the association between molecular genomic features and drug responses across the NCI-60 ovarian cancer cell line panel (IGROV1, OVCAR-3, OVCAR-4, OVCAR-5, OVCAR-8, NCI/AdR-RES, and SK-OV-3), using a series of salicylanilide-derived compounds and four FdA-approved drugs (cabozantinib, paclitaxel, rapamycin, and niclosamide) from the NCI developmental Therapeutics program (dTP). Among these, NSC765690 (MCC22) emerged as the most promising candidate. It demonstrated potent antiproliferative activity, high target selectivity, and strong binding affinity to both CdK1 and TTK. Multi-omics integration, combined with AI-driven network modeling, further elucidated NSC765690's mechanism of action and its relevance to ovarian cancer pathogenesis. Additionally, AdMET and pharmacokinetic profiling confirmed its favorable drug-like properties and low predicted toxicity. Collectively, these findings establish NSC765690 as a potent dual-target inhibitor and exemplify a rational, data-driven drug discovery pipeline for overcoming chemotherapy resistance in ovarian cancer. © 2025 The Authors

关键词： Chemotherapy

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