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Anticancer polypyrrole-polyethylenimine drug-free nanozyme for precise B-cell lymphoma therapy

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023年 160卷 114397页

作者： Thi Thuy Nguyen Er-Yuan Chuang Ya-Ping Chen Po-Chun Tseng Ming-Kai Jhan Chun-Yi Lai Yung-Ting Wang Yu-Ping Hung Chun Austin Changou Chi-Ming Lee Chia-Ling Chen Chiou-Feng Lin International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei 110 Taiwan Department of Oncology Hue University of Medicine and Pharmacy Hue University Hue Viet Nam. Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei 11696 Taiwan. Division of Hematology Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 704 Taiwan. Department of Microbiology and Immunology School of Medicine College of Medicine Taipei Medical University Taipei 110 Taiwan Core Laboratory of Immune Monitoring Office of Research & Development Taipei Medical University Taipei 110 Taiwan. Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei 110 Taiwan. Core Laboratory of Immune Monitoring Office of Research & Development Taipei Medical University Taipei 110 Taiwan Core Facility Center Office of Research and Development Taipei Medical University Taipei 11031 Taiwan. School of Respiratory Therapy College of Medicine Taipei Medical University Taipei 110 Taiwan. Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei 110 Taiwan. Electronic address: cflin2014@tmu.edu.tw.

As an alternative strategy for cancer treatment, the combination of cancer nanomedicine and immunotherapy is promising with regard to efficacy and safety; however, precise modulation of the activation of antitumor immunity remains challenging. Therefore, the aim of the present study was to describe an intelligent nanocomposite polymer immunomodulator, drug-free polypyrrole-polyethyleneimine nanozyme (PPY-PEI NZ), which responds to the B-cell lymphoma tumor microenvironment, for precision cancer immunotherapy. Earlier engulfment of PPY-PEI NZs in an endocytosis-dependent manner resulted in rapid binding in four different types of B-cell lymphoma cells. The PPY-PEI NZ effectively suppressed B cell colony-like growth in vitro accompanied by cytotoxicity via apoptosis induction. during PPY-PEI NZ-induced cell death, mitochondrial swelling, loss of mitochondrial transmembrane potential (MTP), downregulation of antiapoptotic proteins, and caspase-dependent apoptosis were observed. deregulated AKT and ERK signaling contributed to glycogen synthase kinase-3-regulated cell apoptosis following deregulation of Mcl-1 and MTP loss. Additionally, PPY-PEI NZs induced lysosomal membrane permeabilization while inhibiting endosomal acidification, partly protecting cells from lysosomal apoptosis. PPY-PEI NZs selectively bound and eliminated exogenous malignant B cells in a mixed culture system with healthy leukocytes ex vivo. While PPY-PEI NZs showed no cytotoxicity in wild-type mice, they provided long-term and efficient inhibition of the growth of B-cell lymphoma-driven nodules in a subcutaneous xenograft model. This study explores a potential PPY-PEI NZ-based anticancer agent against B-cell lymphoma.

关键词： Anticancer Apoptosis B-cell lymphoma Nanozyme Polyethyleneimine Polypyrrole

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deePMd-kit v2: A software package for deep Potential models

arXiv

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arXiv 2023年

作者： Zeng, Jinzhe Zhang, duo Lu, denghui Mo, Pinghui Li, Zeyu Chen, Yixiao Rynik, Marián Huang, Li'ang Li, Ziyao Shi, Shaochen Wang, Yingze Ye, Haotian Tuo, Ping Yang, Jiabin ding, Ye Li, Yifan Tisi, davide Zeng, Qiyu Bao, Han Xia, Yu Huang, Jiameng Muraoka, Koki Wang, Yibo Chang, Junhan Yuan, Fengbo Bore, Sigbjørn Løland Cai, Chun Lin, Yinnian Wang, Bo Xu, Jiayan Zhu, Jia-Xin Luo, Chenxing Zhang, Yuzhi Goodall, Rhys E.A. Liang, Wenshuo Singh, Anurag Kumar Yao, Sikai Zhang, Jingchao Wentzcovitch, Renata Han, Jiequn Liu, Jie Jia, Weile York, darrin M. Weinan, E. Car, Roberto Zhang, Linfeng Wang, Han Laboratory for Biomolecular Simulation Research Institute for Quantitative Biomedicine Department of Chemistry and Chemical Biology Rutgers University PiscatawayNJ08854 United States AI for Science Institute Beijing100080 China DP Technology Beijing100080 China Academy for Advanced Interdisciplinary Studies Peking University Beijing100871 China HEDPS CAPT College of Engineering Peking University Beijing100871 China College of Electrical and Information Engineering Hunan University Changsha China Yuanpei College Peking University Beijing100871 China Program in Applied and Computational Mathematics Princeton University PrincetonNJ08540 United States Department of Experimental Physics Comenius University Mlynská Dolina F2 Bratislava842 48 Slovakia Center for Quantum Information Institute for Interdisciplinary Information Sciences Tsinghua University Beijing100084 China Center for Data Science Peking University Beijing100871 China ByteDance Research Zhonghang Plaza No. 43 North 3rd Ring West Road Haidian District Beijing China College of Chemistry and Molecular Engineering Peking University Beijing100871 China Baidu Inc. Beijing China Key Laboratory of Structural Biology of Zhejiang Province School of Life Sciences Westlake University Zhejiang Hangzhou China Westlake AI Therapeutics Lab Westlake Laboratory of Life Sciences and Biomedicine Zhejiang Hangzhou China Department of Chemistry Princeton University PrincetonNJ08544 United States SISSA Scuola Internazionale Superiore di Studi Avanzati Trieste34136 Italy Laboratory of Computational Science and Modeling Institute of Materials École Polytechnique Fédérale de Lausanne Lausanne1015 Switzerland Department of Physics National University of Defense Technology Hunan Changsha410073 China State Key Lab of Processors Institute of Computing Technology Chinese Academy of Sciences Beijing China University of Chinese Academy of Sciences Beijing China School of Electronics Engineerin

deePMd-kit is a powerful open-source software package that facilitates molecular dynamics simulations using machine learning potentials (MLP) known as deep Potential (dP) models. This package, which was released in 2017, has been widely used in the fields of physics, chemistry, biology, and material science for studying atomistic systems. The current version of deePMd-kit offers numerous advanced features such as deepPot-SE, attention-based and hybrid descriptors, the ability to fit tensile properties, type embedding, model deviation, deep Potential - Range Correction (dPRc), deep Potential Long Range (dPLR), GPU support for customized operators, model compression, non-von Neumann molecular dynamics (NVNMd), and improved usability, including documentation, compiled binary packages, graphical user interfaces (GUI), and application programming interfaces (API). This article presents an overview of the current major version of the deePMd-kit package, highlighting its features and technical details. Additionally, the article benchmarks the accuracy and efficiency of different models and discusses ongoing developments. © 2023, CC BY-NC-Nd.

关键词： Molecular dynamics

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Human platelet lysate-cultured adipose-derived stem cell sheets promote angiogenesis and accelerate wound healing via CCL5 modulation

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Stem cell research & therapy 2024年第1期15卷 163页

作者： Yueh-Chen Chen Er-Yuan Chuang Yuan-Kun Tu Chia-Lang Hsu Nai-Chen Cheng Department of Surgery National Taiwan University Hospital and College of Medicine 7 Chung-Shan S. Rd Taipei 100 Taiwan. International Ph.D. Program in Biomedical Engineering Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University Taipei Taiwan. Department of Orthopedics E-Da Hospital/I-Shou University Kaohsiung Taiwan. Department of Medical Research National Taiwan University Hospital Taipei Taiwan. Department of Surgery National Taiwan University Hospital and College of Medicine 7 Chung-Shan S. Rd Taipei 100 Taiwan. nccheng@ntu.edu.tw. Research Center for Developmental Biology and Regenerative Medicine National Taiwan University Taipei Taiwan. nccheng@ntu.edu.tw.

BACKGROUNd:A rising population faces challenges with healing-impaired cutaneous wounds, often leading to physical disabilities. Adipose-derived stem cells (ASCs), specifically in the cell sheet format, have emerged as a promising remedy for impaired wound healing. Human platelet lysate (HPL) provides an attractive alternative to fetal bovine serum (FBS) for culturing clinical-grade ASCs. However, the potential of HPL sheets in promoting wound healing has not been fully investigated. This study aimed to explore the anti-fibrotic and pro-angiogenic capabilities of HPL-cultured ASC sheets and delve into the molecular mechanism. METHOdS:A rat burn model was utilized to evaluate the efficacy of HPL-cultured ASC sheets in promoting wound healing. ASC sheets were fabricated with HPL, and those with FBS were included for comparison. Various analyses were conducted to assess the impact of HPL sheets on wound healing. Histological examination of wound tissues provided insights into aspects such as wound closure, collagen deposition, and overall tissue regeneration. Immunofluorescence was employed to assess the presence and distribution of transplanted ASCs after treatment. Further in vitro studies were conducted to decipher the specific factors in HPL sheets contributing to angiogenesis. RESULTS:HPL-cultured ASC sheets significantly accelerated wound closure, fostering ample and organized collagen deposition in the neo-dermis. Significantly more retained ASCs were observed in wound tissues treated with HPL sheets compared to the FBS counterparts. Moreover, HPL sheets mitigated macrophage recruitment and decreased subsequent wound tissue fibrosis in vivo. Immunohistochemistry also indicated enhanced angiogenesis in the HPL sheet group. The in vitro analyses showed upregulation of C-C motif chemokine ligand 5 (CCL5) and angiogenin in HPL sheets, including both gene expression and protein secretion. Culturing endothelial cells in the conditioned media compared to media supplemen

关键词： Adipose-derived stem cells Angiogenesis CCL5 Cell sheet Wound healing

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Association between parental well-being and preschooler stress measured as hair cortisol concentration: A prospective cohort study

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Stress and health : journal of the International Society for the Investigation of Stress 2024年第5期40卷 e3462页

作者： Yun-Shiang Kang Ling-Chu Chien Jian-Pei Huang Yen-Tzu Fan Wen-Yi Lin Pairote Chakranon Heng-Kien Au Yi-Yung Chen Hsing Jasmine Chao Pilyoung Kim Yi-Hua Chen School of Public Health College of Public Health Taipei Medical University Taipei Taiwan. Neuroscience Research Center Taipei Medical University Taipei Taiwan. Nutrition Research Center Taipei Medical University Hospital Taipei Taiwan. Department of Obstetrics and Gynecology Mackay Memorial Hospital Taipei Taiwan. Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan. Ph.D. Program for Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Obstetrics and Gynecology Taipei Medical University Hospital Taipei Taiwan. Department of Obstetrics and Gynecology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Psychology College of Arts Humanities and Social Sciences University of Denver Denver Colorado USA. Department of Psychology Ewha Womans University Seoul South Korea. Research Center of Health Equity College of Public Health Taipei Medical University Taipei Taiwan.

Hair cortisol concentration (HCC) is a valuable biomarker for evaluating chronic stress in preschoolers. However, few studies have explored early life HCC and its associated factors. This prospective cohort study analysed the HCC in children aged 6-48 months and its associations with parental HCC as well as positive and negative parental mental health outcomes. We used data from the ongoing Longitudinal Examination Across Prenatal and Postpartum Health in Taiwan (LEAPP-HIT) project, conducted in Taipei between 2020 and 2024. Hair samples were collected from both parents and children in 177 families (91 samples obtained during pregnancy and 86 during the postpartum period). The parents also completed self-reported questionnaires. Multiple linear regression was conducted to analyse the data. We observed a significant positive correlation between parents' and preschoolers' HCC. Furthermore, maternal depression (adjusted beta coefficient [aβ] = 0.09, 95% confidence interval [CI] = 0.02, 0.16) and perceived stress (aβ = 0.15, 95% CI = 0.02, 0.26) were positively associated with preschoolers' HCC. By contrast, higher maternal eudaimonia was associated with lower HCC in preschoolers (aβ = -0.11, 95% CI = -0.20, -0.01). For parents, maternal depression, anxiety, and perceived stress were independently associated with an increased HCC during the postnatal period, whereas maternal eudaimonia was negatively associated with HCC. Our results indicate that both mothers and fathers affect children's responses to stress. Assessment of cortisol stress hormone concentrations through hair samples can be a key means of detecting preschoolers' stress levels and enabling early intervention.

关键词： anxiety eudaimonia fathers hair cortisol concentration perceived stress preschoolers

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Tannic Acid Impedes the Proliferation of Bladder Cancer Cells by Elevating Mitochondrial Pathways of Apoptosis

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Cell biochemistry and biophysics 2024年第2期82卷 1325-1333页

作者： Chi-Cheng Li Bruce Chi-Kang Tsai Selvaraj Annseles Rajula Chiung-Hung Hsu Ming-Cheng Chen Chia-Hua Kuo Chung-Min Yeh dennis Jine-Yuan Hsieh Wei-Wen Kuo Chih-Yang Huang Center of Stem Cell and Precision Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan. School of Medicine Tzu Chi University Hualien Taiwan. Department of Hematology and Oncology Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan. Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan. Division of Colorectal Surgery Department of Surgery Taichung Veterans General Hospital Taichung Taiwan. Faculty of Medicine National Yang Ming Chiao Tung University Taipei Taiwan. Department of Sports Sciences University of Taipei Taipei Taiwan. Laboratory of Exercise Biochemistry University of Taipei Tianmu Campus Taipei Taiwan. Department of Kinesiology and Health Science College of William and Mary Williamsburg VA USA. School of Physical Education and Sports Science Soochow University Suzhou China. Department of Pathology Changhua Christian Hospital Changhua Taiwan. Department of Medical Technology Jen-Teh Junior College of Medicine Nursing and Management Miaoli Taiwan. Department of Surgical Pathology Changhua Christian Hospital Changhua Taiwan. Department of Medical Laboratory and Biotechnology Chung Shan Medical University Taichung Taiwan. Clinical Laboratory Chung Shan Medical University Hospital Taichung Taiwan. Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan. wwkuo@mail.cmu.edu.tw. Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan. wwkuo@mail.cmu.edu.tw. School of Pharmacy China Medical University Taichung Taiwan. wwkuo@mail.cmu.edu.tw. Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan. cyhuang@mail.cmu.edu.tw. Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan. cyhuang@mail.cmu.edu.tw. Departmen

Bladder cancer stands as a prevailing neoplasm among men globally, distinguished for its pronounced malignancy attributed to invasiveness and metastatic proclivity. Tannic acid (TA), an organic compound in many plants, has garnered recent attention for its discernible anti-mutagenic attributes. This investigation endeavored to scrutinize the repercussions of TA on grade II bladder cancer, with a concerted focus on unraveling its anti-cancer mechanisms. The cytotoxic effects of TA on grade II bladder cancer cells were investigated using multiple techniques, including MTT assay, flow cytometry, TUNEL assay, and western blot. Our findings revealed that elevated concentrations of TA induced cytotoxic effects in grade II bladder cancer cells. Both flow cytometry and the TUNEL assay substantiated the dose-dependent capacity of TA to prompt apoptosis. Western blot analysis corroborated that TA treatment in bladder cancer cells resulted in the upregulation of cleaved caspase-3 expression and PARP. Furthermore, heightened TA dosage elicited an augmentation in the expression of pro-apoptotic proteins, namely Bax and Bak, alongside a reduction in the expression of the anti-apoptotic protein Bcl-2 within bladder cancer cells. This study confirms TA as a potential anticancer agent, demonstrably diminishing the viability of bladder cancer cells. TA exerts cytotoxicity through the activation of mitochondrial apoptotic pathways. Specifically, TA initiates the cleavage of PARP and caspase-3, concurrently augmenting the expression of pro-apoptotic proteins to facilitate apoptosis. Collectively, the present study indicates that TA effectively impedes the proliferation of bladder cancer cells by instigating apoptosis through the intrinsic mitochondrial pathway.

关键词： Bax Bladder cancer Caspase Mitochondria Tannic acid

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Nano-orchestrated magnetotactic-like navigation for electromagnetic theranostics and immune enhancement via photoautotrophic oxygenation, mild hyperthermia, and ferroptosis

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Journal of nanobiotechnology 2025年第1期23卷 442页

作者： Chi-Hung Hsiao Yung-Wei Lin Chia-Hung Liu Yan-Ting Chen Hieu Trung Nguyen Andrew E-Y Chuang Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City 235603 Taiwan. Department of Urology Wan Fang Hospital Taipei Medical University 111 Hsing Long Road Section 3 Taipei 11696 Taiwan. TMU Research Center of Urology and Kidney Taipei Medical University Taipei 11031 Taiwan. Department of Urology School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Department of Urology Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan. Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City 700000 Viet Nam. Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City 235603 Taiwan. eychuang@tmu.edu.tw. International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City 235603 Taiwan. eychuang@tmu.edu.tw. Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei 11696 Taiwan. eychuang@tmu.edu.tw. Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei 11031 Taiwan. eychuang@tmu.edu.tw.

Overcoming the hypoxic tumor microenvironment (TME) and immune suppression remains a significant challenge in solid bladder tumor therapies. This study introduces a translational system of nano-orchestrated magnetotactic-like system, integrating photosynthetic oxygenation, remote hyperthermia, and ferroptosis to achieve comprehensive tumor eradication and immune activation. The developed system, composed of electromagnetic-responsive iron oxide nanoparticles (IO NPs) encapsulated within a glycol chitosan (GCS) matrix and coated onto Chlorella (CHL; CHL-GCS-IO NPs), exhibited versatility for precise magnetic targeting, photothermal-hypertehrmia and photosynthesis-driven oxygen generation under light irradiation. The CHL enhanced oxygen production by continuously alleviating hypoxia, boosting both electromagnetic therapeutic efficacies and ferroptosis-induced tumor cell death. Moreover, the multimodal CHL-GCS-IO NPs reprogrammed the TME, facilitating immune activation by promoting macrophage polarization towards the proinflammatory M1 phenotype, engaging cytotoxic T cells and natural killer cells, programmed death ligand 1 (Pd-L1) downregulation, and driving dendritic cell reprogramming towards improved antigen presentation. In vivo, this approachsuggested significant tumor growth inhibition and prevented recurrence in bladder cancer models, highlighting its potential for robust and durable anticancer immunity. This magnetotactic-like CHL platform presents a highly promising theranostic strategy, merging multimodal therapies with immune modulation to tackle both direct and systemic challenges of solid bladder tumors.

关键词： Electromagnetic theranostic Immune augmentation Magnetotactic-like system photoautotrophic oxygenation

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Clinical Features and Outcomes of Primary Breast diffuse Large B-Cell Lymphoma: A Matched-Pair Study

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Clinical Medicine Insights: Oncology 2023年 17卷

作者： Teng, Ling-Chiao Liao, Yu-Min Gau, Jyh-Pyng Hsiao, Tzu-Hung Chen, Tsung-Chih Chen, Mei-Hui Yeh, Su-Peng Teng, Chieh-Lin Jerry Division of Hematology/Medical Oncology Department of Medicine Taichung Veterans General Hospital Taichung Taiwan Department of Hematology and Oncology China Medical University Hospital Taichung Taiwan Division of Hematology and Oncology Department of Medicine Taipei Medical University Hospital Taipei City Taiwan Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan Department of Chemical Engineering National Tsing Hua University Hsinchu Taiwan Department of Public Health Fu Jen Catholic University New Taipei City Taiwan Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan Department of Nursing Taichung Veterans General Hospital Taichung Taiwan College of Nursing Hung Kuang University Taichung Taiwan School of Medicine China Medical University Taichung Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Department of Life Science Tunghai University Taichung Taiwan School of Medicine Chung Shan Medical University Taichung Taiwan Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan

Background: The influence of the breast as the primary site on the outcome of diffuse large B-cell lymphoma (dLBCL) and further changes in therapeutic strategies remain unclear. We aimed to compare the outcomes between primary breast and non-breast dLBCL and analyze the genetic profiles of some of the study cohorts using next-generation sequencing. Methods: This matched-pair study reviewed the medical records of 19 patients with stage I and II primary breast dLBCL diagnosed between January 2005 and december 2021 on the basis of the Wiseman and Liao criteria, and we used 1:4 propensity score matching to identify patients with non-breast dLBCL as the control group. The overall response rate, progression-free survival (PFS), and overall survival (OS) were the outcome measures. Results: Patients with primary breast and non-breast dLBCL had a 5-year PFS of 72.6% and 86.9%, respectively (P =.206). These 2 groups also had comparable 5-year OS (86.9% vs 87.8%;P =.772). The breast as the primary site was not associated with inferior PFS (hazard ratio [HR]: 2.14;95% CI: 0.66-6.96;P =.206) and OS (HR: 1.26;95% CI: 0.27-5.93;P =.772). Conclusion: Patients with primary breast dLBCL and those with non-breast dLBCL had comparable PFS and OS under rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) or R-CHOP-like regimens. Further investigations of the mutation profile, its clinical impact, potential central nervous system relapse, and prognosis of primary breast dLBCL are required. © The Author(s) 2023.

关键词： breast dLBCL NGS OS PFS

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photo-responsive platelet vesicles-iron oxide nanoparticles-bioglass composite for orthopedic bioengineering

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Composite Structures 2024年 344卷

作者： Andrew E.-Y. Chuang Pei-Wei Weng Chia-Hung Liu Pei-Ru Jheng Lekshmi Rethi Hieu Trung Nguyen Hsien-Tsung Lu Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan ROC International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan ROC Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei 11696 Taiwan ROC Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan ROC Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan ROC Department of Urology School of Medicine College of Medicine Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan ROC TMU Research Center of Urology and Kidney Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan ROC Department of Urology Shuang Ho Hospital Taipei Medical University 291 Zhongzheng Road Zhonghe District New Taipei City 23561 Taiwan ROC Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City 700000 Viet Nam School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan ROC Department of Orthopedics Taipei Medical University Hospital Taipei 11031 Taiwan ROC

In our study, we present an innovative approach to precisely modulate cellular activity and facilitate bone regeneration through non-invasive, remote stimuli application. Our methodology involves the creation of a composite material, namely platelet vesicles, iron oxide nanoparticles, and 45 s5 Bioglass (PLTV-IO NPs/BG), designed to establish a photoelectric and photothermal (PET/PTT) environment around an implant. Under near-infrared (NIR) light, the PLTV-IO NPs/BG composite demonstrates mild-hyperthermic and photoelectric responsive effects. Notably, this application enhances the mechanical strength of the hydrogel F127 and encourages sequential cell management. These observed effects collectively indicate the material’s potential in tissue engineering, specifically for bone regeneration. Our research introduces a biological therapeutic strategy that achieves remote and non-invasive regulation of cellular progression behaviors within phototherapeutic microenvironments, effectively harnessing the power of NIR light. This multidimensional approach holds promise for advancing the field of biomedical research and therapeutic applications.

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Anosmia caused by brain tumor

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The American journal of the medical sciences 2023年第1期365卷 e12页

作者： Lok-Yee Joyce Li Lin Chien-Yi Cheng-Yu Tsai Cheng-Jung Wu Department of Anatomical Pathology Far Eastern Memorial Hospital New Taipei Taiwan Department of Medicine Shin Kong Wu-Ho-Su Memorial Hospital Taipei Taiwan Department of Otolaryngology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Otolaryngology Shuang Ho Hospital Taipei Medical University Taipei Taiwan. Department of Pediatrics Shin Kong Wu-Ho-Su Memorial Hospital Taipei Taiwan. Department of Civil and Environmental Engineering Imperial College London London England. Department of Otolaryngology Shuang Ho Hospital Taipei Medical University Taipei Taiwan Ph.D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan. Electronic address: b101090126@tmu.edu.tw.

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SWEET: a single-sample network inference method for deciphering individual features in disease

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Briefings in bioinformatics 2023年第2期24卷 bbad032页

作者： Hsin-Hua Chen Chun-Wei Hsueh Chia-Hwa Lee Ting-Yi Hao Tzu-Ying Tu Lan-Yun Chang Jih-Chin Lee Chun-Yu Lin Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu 300 Taiwan. School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei 110 Taiwan. Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Otolaryngology-Head and Neck Surgery Tri-Service General Hospital National Defense Medical Center Taipei 110 Taiwan. Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu 300 Taiwan. Institute of Data Science and Engineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan. Center for Intelligent Drug Systems and Smart Bio-devices National Yang Ming Chiao Tung University Hsinchu 300 Taiwan. School of Dentistry Kaohsiung Medical University Kaohsiung 807 Taiwan.

Recently, extracting inherent biological system information (e.g. cellular networks) from genome-wide expression profiles for developing personalized diagnostic and therapeutic strategies has become increasingly important. However, accurately constructing single-sample networks (SINs) to capture individual characteristics and heterogeneity in disease remains challenging. Here, we propose a sample-specific-weighted correlation network (SWEET) method to model SINs by integrating the genome-wide sample-to-sample correlation (i.e. sample weights) with the differential network between perturbed and aggregate networks. For a group of samples, the genome-wide sample weights can be assessed without prior knowledge of intrinsic subpopulations to address the network edge number bias caused by sample size differences. Compared with the state-of-the-art SIN inference methods, the SWEET SINs in 16 cancers more likely fit the scale-free property, display higher overlap with the human interactomes and perform better in identifying three types of cancer-related genes. Moreover, integrating SWEET SINs with a network proximity measure facilitates characterizing individual features and therapy in diseases, such as somatic mutation, mut-driver and essential genes. Biological experiments further validated two candidate repurposable drugs, albendazole for head and neck squamous cell carcinoma (HNSCC) and lung adenocarcinoma (LUAd) and encorafenib for HNSCC. By applying SWEET, we also identified two possible LUAd subtypes that exhibit distinct clinical features and molecular mechanisms. Overall, the SWEET method complements current SIN inference and analysis methods and presents a view of biological systems at the network level to offer numerous clues for further investigation and clinical translation in network medicine and precision medicine.

关键词： drug repurposing gene expression network inference network medicine precision medicine single-sample network

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