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Ugonin L ameliorates pulmonary fibrosis as a novel TβRs inhibitor by regulating the TGF-β/TβRs signaling and autophagy

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Biomedicine & pharmacotherapy 2025年 189卷

作者： Tzu-Lan Hsia Wei-Chung Chiou Hsiu-Chen Huang Hui-Kang Liu Jui-Chieh Chen Pin-Kuei Fu Cheng Huang Department of Biotechnology and Laboratory Science in Medicine National Yang Ming Chiao Tung University Taipei City 112304 Taiwan Center for Teacher Education National Tsing Hua University Hsinchu City 300044 Taiwan Department of Applied Science Nanda Campus National Tsing Hua University Hsinchu City 300044 Taiwan Division of Basic Chinese Medicine National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei City 112304 Taiwan Ph.D. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei City 110301 Taiwan Department of Biochemical Science and Technology National Chiayi University Chiayi 600355 Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung City 402010 Taiwan Department of Medical Research Taichung Veterans General Hospital Taichung City 407219 Taiwan Integrated Care Center of Interstitial Lung Disease Taichung Veterans General Hospital Taichung City 407219 Taiwan

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disease of unknown etiology, affecting about 3 million individuals worldwide. Significant risk factors for IPF include advanced age and infectious agents. Current FdA-approved antifibrotic drugs slow the progression of pulmonary fibrosis with limited outcomes in overall survival, highlighting the need for novel pharmacological agents. Ugonin L (UL), a cyclized geranylflavonoid derived from Helminthostachys zeylanica , has been reported to have anti-inflammatory and antioxidant activities. However, the therapeutic potential of UL for pulmonary fibrosis remains unexplored. In this study, we demonstrated that UL mitigated pulmonary fibrosis in bleomycin (BLM)-induced mice. Specifically, UL improved the alveolar-capillary barrier integrity, decreasing inflammatory cytokines (TGF-β1, TNF-α, IL-1β, IL-6) in bronchoalveolar lavage fluid (BALF). UL ameliorated lesions in BLM-induced fibrotic lungs, reducing radiological signs of lung injury, alveolar septal thickening, and collagen deposition. In RNA-seq analysis, UL downregulated genes related to cell migration and ECM remodeling in TGF-β1-induced LL29 human lung fibroblasts. In particular, UL decreased cell migration, fibrotic marker expression, MMP-2 activity, and myofibroblast activation. In molecular modeling, UL interacted with key pharmacophores and the putative ATP-binding sites of the TβRI and TβRII kinase domains. Correspondingly, UL reduced the phosphorylation of key mediators in both the canonical (SMAd2/3) and non-canonical (ERK1/2 and PI3K) TGF-β signaling pathways. Furthermore, UL downregulated the PI3K/Akt/mTOR axis and promoted autophagy in TGF-β1-induced LL29 cells. Taken together, our findings demonstrate that UL acts as a novel TβRs inhibitor and shows therapeutic potential for pulmonary fibrosis.

关键词： BALF bronchoalveolar lavage fluid BLM bleomycin ECM extracellular matrix IPF idiopathic pulmonary fibrosis NIN nintedanib PFd pirfenidone TβRI TGF-β receptor type I TβRII TGF-β receptor type II UL Ugonin L Pulmonary fibrosis Ugonin L TβRs inhibitor TGF-β signaling Autophagy

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Surface modification of alginate sponge using tannic acid and dodecanethiol for diesel oil spill separation from water

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International Journal of Biological Macromolecules 2025年 317卷 144453页

作者： Wijaya, Ronald Cheng, Kuan-Chen Santoso, Shella Permatasari Lin, Shin-Ping Putro, Jindrayani Nyoo Lie, Jenni Hsieh, Chang-Wei Hsu, Hsien-Yi Go, Alchris Woo Angkawijaya, Artik Elisa Chemical Engineering Department National Taiwan University of Science and Technology Taipei10607 Taiwan Institute of Food Science and Technology National Taiwan University Daan District Taipei City10617 Taiwan Institute of Biotechnology National Taiwan University No. 1 Sec. 4 Roosevelt Rd. Taipei Taiwan Department of Optometry Asia University 500 Lioufeng Rd. Wufeng Taichung Taiwan Department of Medical Research China Medical University Hospital China Medical University 91 Hsueh-Shih Rd. Taichung Taiwan Department of Food Science Fu Jen Catholic University No. 510 Zhongzheng Rd. Xinzhuang Dist. New Taipei City242062 Taiwan Chemical Engineering Department Faculty of Engineering Universitas Katolik Widya Mandala Surabaya Jl. Kalijudan No. 37 East Java Surabaya60114 Indonesia Chemical Engineering Master Program Faculty of Engineering Universitas Katolik Widya Mandala Surabaya Jl. Kalijudan No. 37 East Java Surabaya60114 Indonesia Collaborative Research Center for Zero Waste and Sustainability Universitas Katolik Widya Mandala Surabaya Jl. Kalijudan No. 37 East Java Surabaya60114 Indonesia School of Food Safety Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Research Center of Biomedical Device Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Department of Food Science and Biotechnology National Chung Hsing University South Dist Taichung City402202 Taiwan Department of Food Science National Ilan University Shennong Road Yilan City260007 Taiwan Department of Medical Research China Medical University Hospital Taichung City404333 Taiwan City University of Hong Kong Kowloon Tong Hong Kong Shenzhen Research Institute of City University of Hong Kong Shenzhen518057 China School of Engineering University of San Carlos - Talamban Campus Gov. M. Cuenco Cebu City

An environmentally friendly absorbent sponge was successfully developed for diesel spill remediation via alginate polymer crosslinking followed by surface modification using tannic acid and dodecanethiol (TA/do). The optimal sponge was obtained with a 3 h crosslinking duration, achieving a balance between absorption performance and structural durability, while longer crosslinking times led to increased density and reduced efficiency. Surface modification imparted hydrophobicity to the alginate sponge, confirmed by a water contact angle of 120.2°, and the successful incorporation of TA/do was confirmed from FTIR and XPS analysis. The modified sponge (AA-3-TA/do) exhibited a diesel absorption capacity of 17.54 g/g—a 36 % increase over the unmodified form—and retained ∼90 % of this capacity after 34 absorption–desorption cycles. Kinetic modeling showed that diesel was rapidly absorbed during early contact, with faster uptake than water. A cytotoxicity assay confirmed its non-toxic nature, indicating environmental compatibility. This study demonstrates that a simple, scalable modification using accessible materials can significantly enhance oil sorbent performance without requiring complex techniques or hazardous reagents. © 2025 Elsevier B.V.

关键词： Toxicity

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New Assembly Method for Cellulose derived Graphene Quantum dots-Sensitized Solar Cells

Research Square

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Research Square 2021年

作者： Mahalingam, Savisha Lau, Kam Sheng Omar, Azimah Manap, Abreeza Chelvanathan, Puvaneswaran Chia, Chin Hua Amin, Nowshad Mathews, Illona Juliana Afandi, Nurfanizan Abd Rahim, Nasrudin Institute of Sustainable Energy Universiti Tenaga Nasional Jalan IKRAM-UNITENSelangor Kajang43000 Malaysia Materials Science Program Department of Applied Physics Faculty of Science and Technology Universiti Kebangsaan Malaysia Selangor Bangi43600 Malaysia Level 4 Wisma R&D University of Malaya Jalan Pantai Baharu Kuala Lumpur59990 Malaysia Department of Mechanical Engineering College of Engineering Universiti Tenaga Nasional Jalan IKRAM-UNITEN Selangor Kajang43000 Malaysia Solar Energy Research Institute Universiti Kebangsaan Malaysia Jalan IKRAM-UNITEN Selangor Bangi43600 Malaysia Sunway University No. 5 Jalan Universiti Selangor Bandar Sunway47500 Malaysia Renewable Energy Research Group King Abdulaziz University Jeddah21589 Saudi Arabia

Unambiguously layer by layer (LBL) assembly of graphene quantum dots (GQds) and dye (GQds/dye) on TiO2 photoanode is the traditional and straightforward approach in the fabrication of graphene quantum dot-sensitized solar cells (QdSSCs). Unfortunately, limited light absorption and low affinity of GQds to TiO2 surface shadow the advantages of LBL and constrains its practical application. Herein, a new strategy of mixture configuration (GQds+dye) was investigated. A distinctive nanoporous honeycomb hexagonal carbon network of GQds was found with fewer defects single crystalline structure, and an average size of 9.87 nm was produced from cellulose. Experimental results demonstrated that LBL exhibited the highest efficiency of 16.76 % under low illumination but a lower efficiency (1.43%) than the mixture method (2.91%) under standard light. The increased Jsc (5.075 mA/cm2) and high charge collection efficiency (0.96) in the mixture sample indicated enhanced electron collection at TiO2. The less -OH groups on TiO2 provides a good surface intact of GQds and N719. In addition to that, the high surface potential (33.47 mV) of the premixed sample restricted the photogenerated electrons to go into a deep state, reducing back electron transfer. Therefore, mixture assembly of co-sensitization is an effective approach for light-harvesting in QdSSC. © 2021, CC BY.

关键词： dye-sensitized solar cells

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A Novel Fuzzy-Neural Controller design of a Contact-Force-Controlled Surface Profiler

A Novel Fuzzy-Neural Controller Design of a Contact-Force-Co...

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International Conference on Machine Learning and Cybernetics (ICMLC)

作者： Jium-Ming Lin Cheng-Hung Lin Department of Communication Engineering Chung-Hua University Hsin-Chu Taiwan Ph.D. Program in Engineering Science College of Engineering Chung-Hua University Hsin-Chu Taiwan

ISBN: (纸本)9781538652152

This paper proposed a contact-force-controlled surface profiler by integrating the output of a LVT (Linear Velocity Transducer) in the inner-loop (to increase the damping) of the control system, so that not only the noise amplification effect due to the differentiator in the PId circuit, but the hysteresis effect of the force actuator could be avoided. A voice coil was applied as a force actuator, and a LVdT (Linear Variable differential Transformer) was applied at outer-loop to measure the surface profile. The maximum contact force between the probe and the sample was sensed by a load cell and limited to a tolerable value by the system, so the sample surface would not be destroyed by the probe. Four kinds of controllers using traditional PId, Ziegler-Nichols-based PId, fuzzy-PId, and neural-fuzzy design methods were applied for comparison. Besides, practical parameter variation (hysteresis effect) of force actuator was considered. Moreover, to investigate the system performance the testing input of the surface profile was generated by combining both FM (with frequency changing from 20 HZ to 20 KHZ according to the specification of voice coil) and AM signals. This kind of surface profile was very practical and not being found in the previous literature. By the results of simulations and practical testing, one can see the intelligent fuzzy-neural system was more robust to the parameter variation of force actuator.

关键词： Force Actuators Hysteresis Probes Testing design methodology Springs

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development of vessel mimicking microfluidic device for studying mechano-response of endothelial cells

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iscience 2023年第6期26卷

作者： Pei-Yu Chu Han-Yun Hsieh Pei-Shan Chung Pai-Wen Wang Ming-Chung Wu Yin-Quan Chen Jean-Cheng Kuo Yu-Jui Fan College of Biomedical Engineering Taipei Medical University 250 Wuxing Street Taipei 11031 Taiwan Institute of Applied Mechanics National Taiwan University No. 1 Sec. 4 Roosevelt Road Taipei 10617 Taiwan Department of Bioengineering University of California Los Angeles 420 Westwood Plaza Los Angeles CA 90095 USA Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University No.155 Sec.2 Linong Street Taipei 11221 Taiwan Cancer Progression Research Center National Yang Ming Chiao Tung University No.155 Sec.2 Linong Street Taipei 11221 Taiwan International Ph.D. Program for Biomedical Engineering Taipei Medical University 250 Wuxing Street Taipei 11031 Taiwan

The objective of this study is to develop a device to mimic a microfluidic system of human arterial blood vessels. The device combines fluid shear stress (FSS) and cyclic stretch (CS), which are resulting from blood flow and blood pressure, respectively. The device can reveal real-time observation of dynamic morphological change of cells in different flow fields (continuous flow, reciprocating flow and pulsatile flow) and stretch. We observe the effects of FSS and CS on endothelial cells (ECs), including ECs align their cytoskeleton proteins with the fluid flow direction and paxillin redistribution to the cell periphery or the end of stress fibers. Thus, understanding the morphological and functional changes of endothelial cells on physical stimuli can help us to prevent and improve the treatment of cardiovascular diseases.

关键词： Cardiovascular medicine Biodevices Bioengineering

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Anti-Inflammatory Glycosides from Gomphandra mollis Merr.: Structural Elucidation and Mechanistic Insights

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phytochemistry 2025年 239卷 114583页

作者： Quoc-dung Tran Huynh Thuy-Tien Thi phan Man-Hsiu Chu Thanh-Vu Nguyen Truc-Ly Thi duong Su-Jung Hsu Yun-Han Wang Ngoc-Thac pham Bien-Thuy Nguyen Bui dang-Khoa Nguyen Thanh-Hoa Vo Ta-Wei Liu Ching-Kuo Lee Ph.D. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Institute of Pharmaceutical Education and Research Binh Duong University Thu Dau Mot 820000 Binh Duong Vietnam. Institute of Pharmaceutical Education and Research Binh Duong University Thu Dau Mot 820000 Binh Duong Vietnam Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan. School of Pharmacy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan. Biotechnology Center Of Ho Chi Minh City Ho Chi Minh 700000 Vietnam. Faculty of Traditional medicine Can Tho University of Medicine and Pharmacy Can Tho 900000 Vietnam Faculty of Pharmacy Can Tho University of Medicine and Pharmacy Can Tho 900000 Vietnam. School of Pharmacy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan Institute of Fisheries Science National Taiwan University Taipei 106 Taiwan. Ph.D. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan. National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei 11221 Taiwan University of Health Sciences Vietnam National University Ho Chi Minh City Ho Chi Minh 700000 Vietnam. School of Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City 700000 Vietnam. University of Health Sciences Vietnam National University Ho Chi Minh City Ho Chi Minh 700000 Vietnam Center for Discovery and Development of Healthcare Product Vietnam National University Ho Chi Minh City Ho Chi Minh 700000 Vietnam. Institute of Pharmaceutical Sciences Department of Pharmacognosy University of Graz Universitätsplatz 4 8010 Graz Austria. Electronic address: d301110010@tmu.edu.tw. Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan Department of Chemistry Chung Yuan Christ

Eight previously unreported glycosides, designated gomphandranosides I-VIII, along with nine known compounds, were isolated from the roots of Gomphandra mollis Merr. Their structures were elucidated through comprehensive spectroscopic analyses, including NMR, HR-ESI-MS, Cd, dP4+ probability, and ECd calculations. The anti-inflammatory activities of the isolated compounds were assessed using nitric oxide inhibition assays in LPS-stimulated RAW264.7 macrophages. Compounds 5, 10, and 16 exhibited significant anti-inflammatory activity with IC values of 7.56 ± 0.9, 15.0 ± 1.2, and 14.2 ± 0.9 μM, respectively. Network pharmacology, gene ontology, Kyoto Encyclopedia of Genes and Genomes analysis, and molecular docking studies identified IL-6, TNF-α, MMP9, PTGS2, and HIF1A as key targets, with potentially involved in the NF-κB and IL-17 signaling pathways. These findings highlight G. mollis as a promising candidate for the treatment of inflammation-related diseases.

关键词： Gomphandra mollis Stemonuraceae anti-inflammatory activity molecular docking network pharmacology

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diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities

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Biotechnology Reports 2022年 33卷 e00628页

作者： Mahmoud, Manar M. Abdel-Razek, Ahmed S. Soliman, Hesham S.M. Ponomareva, Larissa V. Thorson, Jon S. Shaaban, Khaled A. Shaaban, Mohamed Pharmacognosy Department Faculty of Pharmacy Helwan University Helwan City-Cairo 11884 Egypt Organic and Bioorganic Chemistry Faculty of Chemistry Bielefeld University Bielefeld d-33501 Germany Microbial Chemistry Department Division of Genetic Engineering and Biotechnology Research National Research Centre El-Buhouth St. 33 Dokki-Cairo 12622 Egypt Center for Pharmaceutical Research and Innovation College of Pharmacy University of Kentucky Lexington 40536 KY United States Department of Pharmaceutical Sciences College of Pharmacy University of Kentucky Lexington 40536 KY United States Chemistry of Natural Compounds Department Division of Pharmaceutical Industries National Research Centre El-Buhouth St. 33 Dokki-Cairo 12622 Egypt Pharm D program Egypt-Japan University of Science and Technology (E-JUST) New Borg El-Arab City 21934 Alexandria Egypt

We report the isolation and characterization of five polyketides [alternariol (1), alternariol-9-methyl ether (2), altertoxin I (3), altertoxin II (4) and tenuazonic acid (5)] from the marine endophytic Alternaria sp. LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds 1–5 were identified by extensive 1d, 2d NMR, and HR mass measurements. Isolation and phenotypic and genotypic characterization of the producing fungus is reported. The antimicrobial activity of the produced extract and derived compounds was examined against a panel of test organisms. In addition, an in vitro cytotoxic activity of 1–5 was performed against diverse cancer cell lines: HEPG2, HELA, A549 and PC3, revealing that compounds 2 and 4 are potentially cytotoxic against A549 and PC3 with EC₅₀ of 0.73 µg/ml (2.69 µM) and 0.17 µg/ml (0.64 µM) for 2, and 0.40 µg/ml (1.15 µM) and 0.12 µg/ml (0.33 µM) for 4, respectively. © 2021 The Authors

关键词： Alternaria sp. Cytotoxicity Marine endophyte Polyketides Taxonomy

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Mediation analysis for TNF-α as a mediator between multiple metal exposure and kidney function

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Ecotoxicology and environmental safety 2024年 283卷 116837页

作者： Kuei-Hau Luo Hung-Pin Tu Huang-Chih Chang Chen-Cheng Yang Wei-Chun Weng Tzu-Hua Chen Cheng-Hong Yang Hung-Yi Chuang Graduate Institute of Medicine College of Medicine Kaohsiung Medicine University Kaohsiung City 807 Taiwan. Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan. Divisions of Pulmonary & Critical Care Medicine Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung Taiwan. Graduate Institute of Medicine College of Medicine Kaohsiung Medicine University Kaohsiung City 807 Taiwan Department of Occupational Medicine Kaohsiung Municipal Siaogang Hospital Kaohsiung Medical University Kaohsiung 812 Taiwan. Division of Gastroenterology Department of Internal Medicine Kaohsiung Armed Forces General Hospital Kaohsiung 802 Taiwan. Department of Family Medicine Kaohsiung Municipal Ta-Tung Hospital Kaohsiung 801 Taiwan. Department of Information Management Tainan University of Technology Tainan 71002 Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung 80778 Taiwan. Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan Department of Occupational and Environmental Medicine Kaohsiung Medicine University Hospital Kaohsiung Medicine University Kaohsiung 807 Taiwan Ph.D. Program in Environmental and Occupational Medicine College of Medicine and Research Center for Precision Environmental Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan. Electronic address: ericch@kmu.edu.tw.

The association between metal mixtures and kidney function has been reported. However, reports on the mechanism of metal toxicity were limited. Oxidative stress was reported as a possible cause. This study aimed to determine the association between of kidney function and metals, such as arsenic (As), cadmium (Cd), cobalt (Co), copper (Cu), lead (Pb), selenium (Se), and zinc (Zn), and to explore the possible mediating role of tumor necrosis factor alpha (TNF-α) between metal toxicity and kidney function. In this study, we recruited 421 adults from a health examination. The concentration of blood metals was analyzed using inductively coupled plasma mass spectrometry. We used linear regression models to assess the association between metals and TNF-α. Then, mediation analysis was applied to investigate the relationship between metal exposure, TNF-α, and kidney function. In univariate linear regression, blood As, Cd, Co, Cu, Pb, and Zn levels significantly increased TNF-α and decreased kidney function. Higher blood As and Pb levels significantly increased TNF-α in multivariable linear regressions after adjusting for covariates. We found that blood levels of As (coefficients = -0.021, p = 0.011), Pb (coefficients = -0.060, p < 0.001), and Zn (coefficients = -0.230, p < 0.001) showed a significant negative association with eGFR in the multiple-metal model. Furthermore, mediation analysis showed that TNF-α mediated 41.7 %, 38.8 %, and 20.8 % of blood Cd, As and Pb, respectively. Among the essential elements, TNF-α mediated 24.5 %, 21.5 % and 19.9 % in the effects of blood Co, Cu, and Zn on kidney function, respectively. TNF-α, acting as a mediator, accounted for 20.1 % of the contribution between the WQS score of metal mixtures and the eGFR (p < 0.001). This study suggested that TNF-α may be a persuasive pathway mediating the association between metals and kidney function. Inflammation and kidney injury could be the underlying mechanisms of metal exposure. However, there i

关键词： Kidney function Mediation analysis Metals Pb TNF-α

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Numerical approximation of Burgers’ equation with source term

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AIP Conference Proceedings 2022年第1期2516卷

作者： Amitha Manmohan Rao ArundhatiSuresh Warke 1Ph.D. Scholar Faculty of Engineering Symbiosis Institute of Technology Symbiosis International (Deemed University) Pune Maharashtra 412 115India 2Asistant Professor Department of Mathematics & Statistics N.S.S. College of Commerce & Economics University of Mumbai Mumbai Maharashtra400034 India. 3Professor Department of Applied Science SymbiosisInstitute of Technology Symbiosis International (Deemed University)PuneMaharashtra 412 115 India

The nonlinear wave phenomena are described by Partial differential Equations (PdEs) and the solution of these PdEs plays a significant role in understanding the existence and behaviour of wave propagation under different material media associated with the physical system. This paper presents approximate solution of nonlinear Burgers’ equation with linear source term by using Laplace decomposition Method (LdM).The analysis of the combined effect of source term and initial condition on the wave profiles is presented in this paper. As the solutions of nonlinear PdEs are greatly influenced by the presence of source term under different initial conditions, the results obtained can be readily extended to study the wave profiles of various types of initial value problems describing nonlinear reaction-dissipative phenomena. Moreover, the solutions can be used to study the internal mechanisms of the physical phenomena of more general system with diffusive effects.

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A consensus protocol for functional connectivity analysis in the rat brain (vol 26, pg 673, 2023)

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NATURE NEUROscience 2023年第6期26卷 1127-1128页

作者： Grandjean, Joanes desrosiers-Gregoire, Gabriel Anckaerts, Cynthia Angeles-Valdez, diego Ayad, Fadi Barriere, david A. Blockx, Ines Bortel, Aleksandra Broadwater, Margaret Cardoso, Beatriz M. Celestine, Marina Chavez-Negrete, Jorge E. Choi, Sangcheon Christiaen, Emma Clavijo, Perrin Colon-Perez, Luis Cramer, Samuel daniele, Tolomeo dempsey, Elaine diao, Yujian doelemeyer, Arno dopfel, david dvorakova, Lenka Falfan-Melgoza, Claudia Fernandes, Francisca F. Fowler, Caitlin F. Fuentes-Ibanez, Antonio Garin, Clement M. Gelderman, Eveline Golden, Carla E. M. Guo, Chao C. G. Henckens, Marloes J. A. G. Hennessy, Lauren A. Herman, Peter Hofwijks, Nita Horien, Corey Ionescu, Tudor M. Jones, Jolyon Kaesser, Johannes Kim, Eugene Lambers, Henriette Lazari, Alberto Lee, Sung-Ho Lillywhite, Amanda Liu, Yikang Liu, Yanyan Y. Lopez-Castro, Alejandra Lopez-Gil, Xavier Ma, Zilu MacNicol, Eilidh Madularu, dan Mandino, Francesca Marciano, Sabina McAuslan, Matthew J. McCunn, Patrick McIntosh, Alison Meng, Xianzong Meyer-Baese, Lisa Missault, Stephan Moro, Federico Naessens, daphne M. P. Nava-Gomez, Laura J. Nonaka, Hiroi Ortiz, Juan J. Paasonen, Jaakko Peeters, Lore M. Pereira, Mickael Perez, Pablo d. Pompilus, Marjory Prior, Malcolm Rakhmatullin, Rustam Reimann, Henning M. Reinwald, Jonathan del Rio, Rodrigo Triana Rivera-Olvera, Alejandro Ruiz-Perez, daniel Russo, Gabriele Rutten, Tobias J. Ryoke, Rie Sack, Markus Salvan, Piergiorgio Sanganahalli, Basavaraju G. Schroeter, Aileen Seewoo, Bhedita J. Selingue, Erwan Seuwen, Aline Shi, Bowen Sirmpilatze, Nikoloz Smith, Joanna A. B. Smith, Corrie Sobczak, Filip Stenroos, Petteri J. Straathof, Milou Strobelt, Sandra Sumiyoshi, Akira Takahashi, Kengo Torres-Garcia, Maria E. Tudela, Raul van den Berg, Monica van der Marel, Kajo van Hout, Aran T. B. Vertullo, Roberta Vidal, Benjamin Vrooman, Roel M. Wang, Victora X. Wank, Isabel Watson, david J. G. Yin, Ting Zhang, Yongzhi Zurbruegg, Stefan Achard, Sophie Alcauter, Sarael Auer, dorothee P. Barbier, Emmanuel L. Baudewig, Juergen Beckmann, Chri Donders Institute for Brain Behaviour and Cognition Radboud University Nijmegen The Netherlands Department for Medical Imaging Radboud University Medical Center Nijmegen The Netherlands Cerebral Imaging Centre Douglas Mental Health University Institute Verdun QC Canada Integrated Program in Neuroscience McGill University Montreal QC Canada Bio-imaging Lab University of Antwerp Antwerp Belgium µNEURO Research Centre of Excellence University of Antwerp Antwerp Belgium Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Mexico Biological and Biomedical Engineering McGill University Montreal QC Canada McConnell Brain Imaging Centre McGill University Montreal QC Canada Montreal Neurological Institute McGill University Montreal QC Canada UMR INRAE/CNRS 7247 Physiologie des Comportements et de la Reproduction Physiologie de la reproduction et des comportements Centre de recherche INRAE de Nouzilly Tours France Department of Neurology and Neurosurgery McGill University Montreal QC Canada Center for Animal MRI University of North Carolina at Chapel Hill Chapel Hill NC USA Department of Neurology University of North Carolina at Chapel Hill Chapel Hill NC USA Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill NC USA Preclinical MRI Champalimaud Research Champalimaud Centre for the Unknown Lisbon Portugal Laboratoire des Maladies Neurodégénératives Molecular Imaging Research Center (MIRCen) Université Paris-Saclay Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA) CNRS Fontenay-aux-Roses France Departamento de Neurobiología Conductual y Cognitiva Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro México Translational Neuroimaging and Neural Control Group High-Field Magnetic Resonance Max Planck Institute for Biological Cybernetics Tuebingen Germany Graduate Training Centre of Neuroscience International Max

Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.

关键词： databases Neural circuits

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