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Correction to: Assessment of Geotechnical Properties and determination of Shear Strength Parameters

Geotechnical and Geological engineering 2020年第1期39卷 479-479页

作者： Ghoreishi, Benyamin Esfahani, Mohammad Khaleghi Lushabi, Nargess Alizadeh Amini, Omid Aghamolaie, Iman Hashim, Nik Alif Amri Nik Alizadeh, Seyed Mehdi Seyed School of Railway Engineering Iran University of Science and Technology Tehran Iran M.Sc. Graduate of Engineering Geology University of Isfahan Isfahan Iran M.Sc. Graduate of Structural Geology Shahrood University of Technology Shahrood Iran Faculty of Civil and Surveying Engineering Graduate University of Advanced Technology Kerman Iran Ph.D. Department of Geology Faculty of Science Shahid Bahonar University Kerman Iran Faculty of Hospitality Tourism and Wellness University Malaysia Kelantan Kelantan Malaysia Petroleum Engineering Department Australian College of Kuwait West Mishref Kuwait

In the original publication of the article, the first author name was incorrectly published as “Benyamin Ghoreishii”. However, the correct name is “Benyamin Ghoreishi”. The original article has been corrected.

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Correction: Excess glucose alone depress young mesenchymal stromal/stem cell osteogenesis and mitochondria activity within hours/days via NAd+/ SIRT1 axis

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Journal of biomedical science 2024年第1期31卷 61页

作者： B Linju Yen Li-Tzu Wang Hsiu-Huang Wang Chin-Pao Hung Pei-Ju Hsu Chia-Chi Chang Chien-Yu Liao Huey-Kang Sytwu Men-Luh Yen Regenerative Medicine Research Group Institute of Cellular & System Medicine National Health Research Institutes (NHRI) No.35 Keyan Road Zhunan 35053 Taiwan. blyen@nhri.edu.tw. Department of Obstetrics & Gynecology National Taiwan University (NTU) Hospital & College of Medicine NTU No.1 Section 1 Jen‑Ai Road Taipei 10051 Taiwan. School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University No. 250 Wuxing Street Taipei 11042 Taiwan. Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University No.250 Wuxing Street Taipei 11042 Taiwan. Regenerative Medicine Research Group Institute of Cellular & System Medicine National Health Research Institutes (NHRI) No.35 Keyan Road Zhunan 35053 Taiwan. Graduate Institute of Life Sciences National Defense Medical Center (NDMC) No.161 Section Minquan East Road Taipei 11490 Taiwan. National Institute of Infectious Diseases & Vaccinology NHRI No.35 Keyan Road Zhunan 35053 Taiwan. Graduate Institute of Microbiology & Immunology NDMC No.161 Section 6 Minquan East Road Taipei 11490 Taiwan. Department of Obstetrics & Gynecology National Taiwan University (NTU) Hospital & College of Medicine NTU No.1 Section 1 Jen‑Ai Road Taipei 10051 Taiwan. mlyen@ntu.edu.tw.

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The Application of Last Observation Carried Forward Method for Missing data Estimation in the Context of Industrial Wireless Sensor Networks

The Application of Last Observation Carried Forward Method f...

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IEEE Asia-Pacific Conference on Antennas and Propagation (APCAP)

作者： Hong Zhou Kun-Ming Yu Ming-Gong Lee Chin-Chuan Han Ph.D. Program in Engineering Science College of Engineering Chung Hua University Hsinchu Taiwan Department of Computer Science and Information Engineering Chung Hua University Hsinchu Taiwan Leisure and Recreation Management Chung Hua University Hsinchu Taiwan Department of Computer Science and Information Engineering National United University Miaoli Taiwan

Thanks to advances in wireless communication technologies, the wireless sensor network (WSNs) have been attracting a lot of attention from academic communities and successfully applied to various domains. Along with developments of the Industry 4.0, the WSNs start to play a vital role in the construction of smart factories and realization of intelligent manufacturing. Although, the industrial WSNs (IWSNs) presents great quantity of advantages, there still have some drawbacks to overcome such as challenges of the quality of data for IWSNs. In order to resolve the data missing problems in the context of IWSNs, the Last Observation Carried Forward method is adopted to estimate the missing value and reconstruct the sensing dataset which takes into account the temporal characteristics of sensing data in IWSNs. Through experiments, this method is proved to be an easy and effective measurement for missing value imputation of the large multi-dimensional sensing data achieved by the IWSNs.

关键词： Wireless sensor networks Estimation Industries Temperature sensors Smart manufacturing

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Big data and Machine Learning Based Secure Healthcare Framework

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Procedia Computer science 2018年 132卷 1049-1059页

作者： Prableen Kaur Manik Sharma Mamta Mittal Ph.D. Research Scholar Department of Computer Science and Applications DAV University Jalandhar India Department of Computer Science and Applications DAV University Jalandhar India Department of Computer Science and Engineering G.B. Pant Govt. Engineering College New Delhi India

The paper presents a brief introduction to big data and its role in healthcare applications. It is observed that the use of big data architecture and techniques are continuously assisting in managing the expeditious data growth in healthcare industry. Here, initially an empirical study is performed to analyze the role of big data in healthcare industry. It has been observed that significant work has been done using big data in healthcare sector. Nowadays, it is intricate to envision the way the machine learning and big data can influence the healthcare industries. It has been observed that most of the authors who implemented the use of machine learning and big data analytics in disease diagnosis have not given significant weightage to the privacy and security of the data. Here, a novel design of smart and secure healthcare information system using machine learning and advanced security mechanism has been proposed to handle big data of medical industry. The innovation lies in the incorporation of optimal storage and data security layer used to maintain security and privacy. different techniques like masking encryption, activity monitoring, granular access control, dynamic data encryption and end point validation have been incorporated. The proposed hybrid four layer healthcare model seems to be more effective disease diagnostic big data system.

关键词： Big data Healthcare Big data analytics disease diagnosis predictive analysis security privacy

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Correction: Utilizing TP53 hotspot mutations as effective predictors of gemcitabine treatment outcome in non-small-cell lung cancer

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Cell death discovery 2025年第1期11卷 1-2页

作者： Yen-Han Tseng Yuh-Min Chen Tzu-Yi Huang Peter Mu-Hsin Chang Trieu Thi My Tran Yu-Tang Huang Anh Thuc Nguyen Chi-Ying F. Huang Jinghua Tsai Chang Ian Yi-Feng Chang Yi-Tung Chen Hsuan Liu Hao-Wen Hsieh Yue-Li Juang Ying-Chih Chang Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan Program in Molecular Medicine College of Life Sciences National Yang Ming Chiao Tung University Taipei Taiwan School of Medicine College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Institute of Biopharmaceutical Sciences College of Pharmaceutical Sciences National Yang Ming Chiao Tung University Taipei Taiwan Department of Oncology Taipei Veterans General Hospital Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei 11529 Taiwan Biomedical Industry Ph.D. Program College of Life Sciences National Yang Ming Chiao Tung University Taipei 112304 Taiwan Program in Molecular Medicine Taiwan International Graduate Program in Molecular Medicine National Yang Ming Chiao Tung University and Academia Sinica Taipei Taiwan Department of Biochemistry School of Medicine Kaohsiung Medical University Kaohsiung Taiwan Chong Hin Loon Memorial Cancer and Biotherapy Research Center National Yang Ming Chiao Tung University Taipei Taiwan Institute of Medicine Chung Shan Medical University 110 Sec.1 Chien-Kuo N. Road Taichung City 402306 Taiwan Molecular Medicine Research Center Chang Gung University Taoyuan Taiwan Department of Neurosurgery Lin-Kou Medical Center Chang Gung Memorial Hospital Taoyuan Taiwan Department of Cell and Molecular Biology College of Medicine Chang Gung University Taoyuan Taiwan Graduate Institute of Biomedical Sciences College of Medicine Chang Gung University Taoyuan Taiwan Division of Hematology-Oncology Department of Internal Medicine Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan Institute of Clinical Medicine School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Institute of Biomedical Sciences Mackay Medical College New Taipei City Taiwan Genomics Research Center Academia Sinica Taipei 115 Taiwan Department of Chemical Engineering Stanford University Stanford CA 94305 USA

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CXCR7 activation evokes the anti-Pd-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity

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Cell death & disease 2024年第6期15卷 434页

作者： Chan-Chuan Liu Wen-Bin Yang Chia-Hung Chien Cheng-Lin Wu Jian-Ying Chuang Pin-Yuan Chen Jui-Mei Chu Siao Muk Cheng Li-Ying Qiu Yung-Chieh Chang daw-Yang Hwang Chih-Yuan Huang Jung-Shun Lee Kwang-Yu Chang National Institute of Cancer Research National Health Research Institutes Tainan Taiwan. Research Center for Neuroscience Taipei Medical University Taipei Taiwan. Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan. School of Medicine I-Shou University Kaohsiung Taiwan. Department of Pathology National Cheng Kung University Hospital College of Medicine National Cheng-Kung University Tainan Taiwan. International Master Program in Medical Neuroscience Taipei Medical University Taipei Taiwan. Department of Biomedical Science and Environmental Biology Kaohsiung Medical University Kaohsiung Taiwan. School of Medicine Chang Gung University Taoyuan Taiwan. Department of Neurosurgery Keelung Chang Gung Memorial Hospital Keelung Taiwan. TMU Research Center of Cancer Translational Medicine Taipei Cancer Center Taipei Medical University Hospital College of Medicine Taipei Medical University Taipei Taiwan. Division of Neurosurgery Department of Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan. National Institute of Cancer Research National Health Research Institutes Tainan Taiwan. kwang2@nhri.edu.tw. Department of Oncology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan. kwang2@nhri.edu.tw. Center of Cell Therapy National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan. kwang2@nhri.edu.tw.

The interaction between glioblastoma cells and glioblastoma-associated macrophages (GAMs) influences the immunosuppressive tumor microenvironment, leading to ineffective immunotherapies. We hypothesized that disrupting the communication between tumors and macrophages would enhance the efficacy of immunotherapies. Transcriptomic analysis of recurrent glioblastoma specimens indicated an enhanced neuroinflammatory pathway, with CXCL12 emerging as the top-ranked gene in secretory molecules. Single-cell transcriptome profiling of naïve glioblastoma specimens revealed CXCL12 expression in tumor and myeloid clusters. An analysis of public glioblastoma datasets has confirmed the association of CXCL12 with disease and Pd-L1 expression. In vitro studies have demonstrated that exogenous CXCL12 induces pro-tumorigenic characteristics in macrophage-like cells and upregulated Pd-L1 expression through NF-κB signaling. We identified CXCR7, an atypical receptor for CXCL12 predominantly present in tumor cells, as a negative regulator of CXCL12 expression by interfering with extracellular signal-regulated kinase activation. CXCR7 knockdown in a glioblastoma mouse model resulted in worse survival outcomes, increased Pd-L1 expression in GAMs, and reduced Cd8 T-cell infiltration compared with the control group. Ex vivo T-cell experiments demonstrated enhanced cytotoxicity against tumor cells with a selective CXCR7 agonist, VUF11207, reversing GAM-induced immunosuppression in a glioblastoma cell-macrophage-T-cell co-culture system. Notably, VUF11207 prolonged survival and potentiated the anti-tumor effect of the anti-Pd-L1 antibody in glioblastoma-bearing mice. This effect was mitigated by an anti-Cd8β antibody, indicating the synergistic effect of VUF11207. In conclusion, CXCL12 conferred immunosuppression mediated by pro-tumorigenic and Pd-L1-expressing GAMs in glioblastoma. Targeted activation of glioblastoma-derived CXCR7 inhibits CXCL12, thereby eliciting anti-tumor immunity and enha

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How Jupiter’s Unusual Magnetospheric Topology Structures Its Aurora

arXiv

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arXiv 2020年

作者： Zhang, Binzheng delamere, Peter A. Yao, Zhonghua Bonfond, Bertrand Lin, d. Sorathia, Kareem A. Brambles, Oliver J. Lotko, William Garretson, Jeff S. Merkin, Viacheslav G. Grodent, denis dunn, William R. Lyon, John G. Department of Earth Sciences University of Hong Kong Hong Kong Hong Kong High Altitude Observatory National Center for Atmospheric Research BoulderCO United States Geophysical Institute University of Alaska Fairbanks Fairbanks AK United States Key Laboratory of Earth and Planetary Physics Institute of Geology and Geophysics Chinese Academy of Sciences Beijing China Belgium Applied Physics Laboratory Johns Hopkins University LauralMD United States Oliver J. Brambles Ph.D. Preston United Kingdom Thayer School of Engineering Dartmouth College HanoverNH United States Mullard Space Science Laboratory University College London Dorking United Kingdom Gamera Consulting HanoverNH United States

Jupiter’s bright persistent polar aurora and Earth’s dark polar region indicate that the planets’ magnetospheric topologies are very different. High-resolution global simulations show that the reconnection rate at the interface between the interplanetary and jovian magnetic fields is too slow to generate a magnetically open, Earth-like polar cap on the timescale of planetary rotation, resulting in only a small crescent-shaped region of magnetic flux interconnected with the interplanetary magnetic field. Most of the jovian polar cap is threaded by helical magnetic flux that closes within the planetary interior, extends into the outer magnetosphere and piles-up near its dawnside flank where fast differential plasma rotation pulls the field lines sunward. This unusual magnetic topology provides new insights into Jupiter’s distinctive auroral morphology. Copyright © 2020, The Authors. All rights reserved.

关键词： Magnetosphere

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Camera Calibration of the CTA-LST prototype 37

Camera Calibration of the CTA-LST prototype

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37th International Cosmic Ray Conference, ICRC 2021

作者： Kobayashi, Yukiho Okumura, Akira Cassol, Franca Katagiri, Hideaki Sitarek, Julian Gliwny, Pawel Nozaki, Seiya Nogami, Yuto Abe, H. Aguasca, A. Agudo, I. Antonelli, L.A. Aramo, C. Armstrong, T. Artero, M. Asano, K. Ashkar, H. Aubert, P. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Becerra Gonzalez, J. Bernardos, M.I. Berti, A. Biederbeck, N. Bigongiari, C. Blanch, O. Bonnoli, G. Bordas, P. Bose, d. Bulgarelli, A. Burelli, I. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Cerruti, M. Chai, Y. Cheng, K. Chikawa, M. Chytka, L. Contreras, J.L. Cortina, J. Costantini, H. dalchenko, M. de Angelis, A. de Bony de Lavergne, M. deleglise, G. delgado, C. delgado Mengual, J. della Volpe, d. depaoli, d. di Pierro, F. di Venere, L. daaz, C. dominik, R.M. dominis Prester, d. donini, A. dorner, d. doro, M. Elsaasser, d. Emery, G. Escudero, J. Fiasson, A. Foffano, L. Fonseca, M.V. Freixas Coromina, L. Fukami, S. Fukazawa, Y. Garcia, E. Garcia Lapez, R. Giglietto, N. Giordano, F. Godinovic, N. Green, d. Grespan, P. Gunji, S. Hackfeld, J. Hadasch, d. Hahn, A. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Herrera Llorente, J. Hirotani, K. Hoffmann, d. Horns, d. Houles, J. Hrabovsky, M. Hrupec, d. Hui, d. HÃŒtten, M. Inada, T. Inome, Y. Iori, M. Ishio, K. Iwamura, Y. Jacquemont, M. Jimenez Martinez, I. Jouvin, L. Jurysek, J. Kagaya, M. Karas, V. Kataoka, J. Kerszberg, d. Kong, A. Kubo, H. Kushida, J. Lamanna, G. Lamastra, A. Le Flour, T. Longo, F. Lapez-Coto, R. Lapez-Moya, M. Lapez-Oramas, A. Luque-Escamilla, P.L. Majumdar, P. Makariev, M. Mandat, d. Manganaro, M. Mannheim, K. Mariotti, M. Marquez, P. Marsella, G. Marta, J. Martinez, O. MartÃnez, G. MartÃnez, M. Marusevec, P. Mas, A. Maurin, G. Mazin, d. Mestre Guillen, E. Micanovic, S. Miceli, d. Miener, T. Miranda, J.M. Miranda, L.d.M. Mirzoyan, R. Mizuno, T. Molina, E. Montaruli, T. Monteiro, I. Moralejo, A. Morcuende, d. Moretti, E. Morselli, A. Mrakovcic, K. Institute for Cosmic Ray Research The University of Tokyo Chiba Japan Institute for Space-Earth Environmental Research Kobayashi-Maskawa Institute for the Origin of Particles and the Universe Nagoya University Nagoya Japan Aix Marseille Univ CNRS IN2P3 CPPM Marseille France College of Science Ibaraki University Ibaraki Japan Faculty of Physics and Applied Informatics University of Lodz ul. Pomorska 149/153 Lódz90-236 Poland Department of Physics Kyoto University Kyoto606-8502 Japan Institute for Cosmic Ray Research University of Tokyo Japan Departament de Fasica Quantica i Astrofasica Institut de Ciancies del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofasica de Andalucaa-CSIC Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy Aix Marseille Univ CNRS IN2P3 CPPM France The Barcelona Institute of Science and Technology Spain IRFU CEA Universita© Paris-Saclay France LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Universitaat Hamburg Institut faer Experimentalphysik Germany Graduate School of Science University of Tokyo Japan EMFTEL Department IPARCOS Universidad Complutense de Madrid Spain INAF - Osservatorio di Astrofisica e Scienza dello Spazio di Bologna Italy Centro Brasileiro de Pesquisas Fasicas Brazil INFN Sezione di Padova Universita degli Studi di Padova Italy Instituto de Astrofasica de Canarias Departamento de Astrofasica Universidad de La Laguna Spain Max-Planck-Institut faer Physik Germany Department of Physics TU Dortmund University Germany Saha Institute of Nuclear Physics India INFN Sezione di Trieste Universita degli Studi di Udine Italy INFN Sezione di Catania Italy Italy University of Geneva Da©partement de Physique Nucla©aire et Corpusculaire Switzerland Palacky University Olomouc Faculty of Science Czech Republic CIEMAT Spain Port d'Informacia Cientafica Spain INFN Sezione di Torino Italy Dipartimento di Fisica Universita degli Studi di Tori

The Cherenkov Telescope Array (CTA) is the next-generation gamma-ray observatory that is expected to reach one order of magnitude better sensitivity than that of current telescope arrays. The Large-Sized Telescopes (LSTs) have an essential role in extending the energy range down to 20 GeV. The prototype LST (LST-1) proposed for CTA was built in La Palma, the northern site of CTA, in 2018. LST-1 is currently in its commissioning phase and moving towards scientific observations. The LST-1 camera consists of 1855 photomultiplier tubes (PMTs) which are sensitive to Cherenkov light. PMT signals are recorded as waveforms sampled at 1 GHz rate with domino Ring Sampler version 4 (dRS4) chips. Fast sampling is essential to achieve a low energy threshold by minimizing the integration of background light from the night sky. Absolute charge calibration can be performed by the so-called F-factor method, which allows calibration constants to be monitored even during observations. A calibration pipeline of the camera readout has been developed as part of the LST analysis chain. The pipeline performs dRS4 pedestal and timing corrections, as well as the extraction and calibration of charge and time of pulses for subsequent higher-level analysis. The performance of each calibration step is examined, and especially charge and time resolution of the camera readout are evaluated and compared to CTA requirements. We report on the current status of the calibration pipeline, including the performance of each step through to signal reconstruction, and the consistency with Monte Carlo simulations. © 2022 Sissa Medialab Srl. All rights reserved.

关键词： Calibration

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Corrigendum to "1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma" [Eur. J. Med. Chem. 140 (2017) 84-91]

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European journal of medicinal chemistry 2020年 202卷 112633页

作者： Yi-Min Liu Wei-Chun HuangFu Han-Li Huang Wei-Cheng Wu Yi-Lin Chen Yun Yen Hsiang-Ling Huang Chih-Ying Nien Mei-Jung Lai Shiow-Lin Pan Jing-Ping Liou School of Pharmacy College of Pharmacy Taipei Medical University 250 Wuxing Street Taipei 11031 Taiwan. The Ph.D. Program for Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Center for Translational Medicine Taipei Medical University Taiwan. The Ph.D. Program for Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Pharmacology College of Medicine Taipei Medical University Taipei Taiwan. Electronic address: slpan@tmu.edu.tw. School of Pharmacy College of Pharmacy Taipei Medical University 250 Wuxing Street Taipei 11031 Taiwan School of Pharmacy National Defense Medical Center Taipei Taiwan. Electronic address: jpl@tmu.edu.tw.

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Continuous and pulsed experiments with numerical simulation to dissect pituitary gland tumour by using liquid jet

arXiv

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arXiv 2019年

作者： Alamoud, Ahmed H. Baillot, Emmanuel Belabbas, Camila Samimi Ardestani, Hadi S. Bahai, Hamid Baldit, Adrien Chizari, Mahmoud Mechanical Aerospace and Civil Engineering Department College of Engineering Design and Physical Sciences Brunel University London Uxbridge UB8 3PH United Kingdom Metz France Tehran University of Medical Science Research Centre of Otolaryngology Head and Neck Surgery Amiralam Hospital Tehran Iran Mechanical Aerospace and Civil Engineering Department College of Engineering Design and Physical Sciences Brunel University London United Kingdom Department of Mechanics Physics Mathematics 1 route d'Ars Laquenexy Metz Cedex 3 57078 France School of Mechanical Engineering Sharif University of Technology Tehran Iran

Endoscopic endonasal surgery is a minimal invasive surgery that has been used to dissect pituitary gland tumour via curettes with the help of endoscope. However, this type of surgery has a high risk of failure because curettes may cause damages to blood vessels and optical nerves that lead to more complication for the patient. The aim of this study is to develop a new technique to dissect the tumour by using liquid jet. A series of experimental tests have been performed on animal tissue to study the effect of liquid pressure and nozzle diameter on dissecting and cutting the tissue. Continuous / pulsed liquid jet used with variable nozzle diameters, distances, pressures and angles. The study concluded with promising results on liquid jet to dissect hypophysis tumour and preserving fine blood vessels and optical nerve located near the pituitary gland. Copyright © 2019, The Authors. All rights reserved.

关键词： Tumors

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