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arXiv 2023年

作者： Pauw, Brian R. Smales, Glen J. Anker, Andy S. Balazs, daniel M. Beyer, Frederick L. Bienert, Ralf Bouwman, Wim G. Breßler, Ingo Breternitz, Joachim Brok, Erik S. Bryant, Gary Clulow, Andrew J. Crater, Erin R. de Geuser, Frédéric Giudice, Alessandra del deumer, Jérôme disch, Sabrina dutt, Shankar Frank, Kilian Fratini, Emiliano Gilbert, Elliot P. Hahn, Marc Benjamin Hallett, James Hohenschutz, Max Hollamby, Martin Huband, Steven Ilavsky, Jan Jochum, Johanna K. Juelsholt, Mikkel Mansel, Bradley W. Penttilä, Paavo Pittkowski, Rebecca K. Portale, Giuseppe Pozzo, Lilo d. de Abreu Furtado Garcia, Paulo Ricardo Rochels, Leonhard Rosalie, Julian M. Saloga, Patrick E.J. Seibt, Susanne Smith, Andrew J. Smith, Gregory N. Annadurai, Venkatasamy Spiering, Glenn A. Stawski, Tomasz M. Taché, Olivier Thünemann, Andreas F. Toth, Kristof Whitten, Andrew E. Wuttke, Joachim BAM Federal Institute for Materials Research and Testing Berlin12205 Germany Department of Chemistry University of Copenhagen Copenhagen2100 Denmark Am Campus 1 Klosterneuburg3400 Austria U.S. Army Research Laboratory 6300 Rodman Road Aberdeen Proving Ground MD21005 United States BAM Federal Institute for Materials Research and Testing Richard-Willstätter-Str. 11 Berlin12489 Germany Delft University of Technology Netherlands Helmholtz-Zentrum Berlin für Materialien und Energie GmbH Germany FORCE Technology Park Alle 345 Brøndby2605 Denmark Physics School of Science RMIT University Melbourne Australia ANSTO - Australian Synchrotron 800 Blackburn Road ClaytonVIC3168 Australia Virginia Polytechnic Institute State University BlacksburgVA24060 United States Univ. Grenoble Alpes CNRS Grenoble INP SIMAP GrenobleF-38000 France Department of Chemistry Sapienza Università di Roma P.le A. Moro 5 RomeI-00185 Italy Physikalisch-Technische Bundesanstalt Abbestr. 2 Berlin10587 Germany Department für Chemie Universität zu Köln Greinstraße 4-6 Köln50939 Germany Department of Materials Physics Australian National University ACT Australia Faculty of Physics and CeNS Ludwig-Maximilians-Universität München Geschwister-Scholl-Platz 1 Munich80539 Germany Department of Chemistry "Ugo Schiff" & CSGI University of Florence Via della Lastruccia 3 Sesto Fiorentino50019 Italy Australian Centre for Neutron Scattering Australian Nuclear Science and Technology Organisation New Illawarra Road Lucas HeightsNSW2234 Australia Department of Chemistry School of Chemistry Food and Pharmacy University of Reading Whiteknights PO Box 224 ReadingRG6 6AD United Kingdom Institute of Physical Chemistry RWTH Aachen University Landoltweg 2 AachenD-52056 Germany School of Chemical and Physical Sciences Keele University United Kingdom Department of Physics University of Warwick CV4 7AL United Kingdom APS ANL 9700S Cass ave LemontIL United States Heinz Maier-L

A Round Robin study has been carried out to estimate the impact of the human element in small-angle scattering data analysis. Four corrected datasets were provided to participants ready for analysis. All datasets were measured on samples containing spherical scatterers, with two datasets in dilute dispersions, and two from powders. Most of the 46 participants correctly identified the number of populations in the dilute dispersions, with half of the population mean entries within 1.5 % and half of the population width entries within 40 %, respectively. due to the added complexity of the structure factor, much fewer people submitted answers on the powder datasets. For those that did, half of the entries for the means and widths were within 44 % and 86 % respectively. This Round Robin experiment highlights several causes for the discrepancies, for which solutions are proposed. © 2023, CC BY.

关键词： data handling

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OPTIMAdE, an API for exchanging materials data

arXiv

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arXiv 2021年

作者： Andersen, Casper W. Armiento, Rickard Blokhin, Evgeny Conduit, Gareth J. dwaraknath, Shyam Evans, Matthew L. Fekete, Ádám Gopakumar, Abhijith Gražulis, Saulius Merkys, Andrius Mohamed, Fawzi Oses, Corey Pizzi, Giovanni Rignanese, Gian-Marco Scheidgen, Markus Talirz, Leopold Toher, Cormac Winston, donald Aversa, Rossella Choudhary, Kamal Colinet, Pauline Curtarolo, Stefano di Stefano, davide draxl, Claudia Er, Suleyman Esters, Marco Fornari, Marco Giantomassi, Matteo Govoni, Marco Hautier, Geoffroy Hegde, Vinay Horton, Matthew K. Huck, Patrick Huhs, Georg Hummelshøj, Jens Kariryaa, Ankit Kozinsky, Boris Kumbhar, Snehal Liu, Mohan Marzari, Nicola Morris, Andrew J. Mostofi, Arash A. Persson, Kristin A. Petretto, Guido Purcell, Thomas Ricci, Francesco Rose, Frisco Scheffler, Matthias Speckhard, daniel Uhrin, Martin Vaitkus, Antanas Villars, Pierre Waroquiers, david Wolverton, Chris Wu, Michael Yang, Xiaoyu École Polytechnique Fédérale de Lausanne Lausanne1015 Switzerland Materials Design and Informatics Unit Department of Physics Chemistry and Biology Linköping University Sweden Tilde Materials Informatics Straßmannstraße 25 Berlin10249 Germany Materials Platform for Data Science Sepapaja 6 Tallinn15551 Estonia Theory of Condensed Matter Group Cavendish Laboratory 19 J.J. Thomson Avenue CambridgeCB3 0HE United Kingdom Lawrence Berkeley Labs BerkeleyCA United States Chemin des Étoiles 8 Louvain-la-Neuve1348 Belgium Department of Physics King's College London London United Kingdom Department of Materials Science and Engineering Northwestern University EvanstonIL60208 United States Institute of Biotechnology Life Science Center Vilnius University Saulétekio av. 7 VilniusLT-10257 Lithuania Institute of Computer Science Faculty of Mathematics and Informatics Vilnius University Naugarduko g. 24 VilniusLT-03225 Lithuania Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4-6 Berlin14195 Germany Center for Autonomous Materials Design Duke University DurhamNC27708 United States Department of Mechanical Engineering and Materials Science Duke University DurhamNC27708 United States Humboldt-Universität zu Berlin Institut für Physik and IRIS Adlershof Berlin12489 Germany École Polytechnique Fédérale de Lausanne Sion1951 Switzerland Trieste34136 Italy Hermann-von-Helmholtz-Platz 1 Eggenstein-Leopoldshafen76344 Germany Materials Measurement Laboratory National Institute of Standards and Technology GaithersburgMD20899 United States Ansys 300 Rustat House 62 Clifton Rd CambridgeCB1 7EG United Kingdom De Zaale 20 Eindhoven5612 AJ Netherlands Department of Physics and Science of Advanced Materials Program Central Michigan University Mount PleasantMI48859 United States Argonne National Laboratory LemontIL60439 United States Thayer School of Engineering Dartmouth College HanoverNH03755 United States Los AltosCA940

The Open databases Integration for Materials design (OPTIMAdE) consortium has designed a universal application programming interface (API) to make materials databases accessible and interoperable. We outline the first stable release of the specification, v1.0, which is already supported by many leading databases and several software packages. We illustrate the advantages of the OPTIMAdE API through worked examples on each of the public materials databases that support the full API specification. © 2021, CC BY.

关键词： Specifications

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Ovatodiolide and antrocin synergistically inhibit the stemness and metastatic potential of hepatocellular carcinoma via impairing ribosome biogenesis and modulating ERK/Akt-mTOR signaling axis

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phytomedicine : international journal of phytotherapy and phytopharmacology 2023年 108卷 154478页

作者： Ming-Yao Chen Chia-Hung Hsu Syahru Agung Setiawan david T W Tzeng Hon-Ping Ma Jiann Ruey Ong Yi Cheng Chu Ming-Shou Hsieh Alexander T H Wu Yew-Min Tzeng Chi-Tai Yeh Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine Taipei Medical University-Shuang Ho Hospital New Taipei City 235 Taiwan. Department of Emergency Medicine Taipei Medical University-Shuang Ho Hospital New Taipei City 235 Taiwan Graduate Institute of Injury Prevention and Control College of Public Health Taipei Medical University Taipei City 110 Taiwan Department of Emergency Medicine School of Medicine Taipei Medical University Taipei City 110 Taiwan. International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan Department of Medical Research & Education Taipei Medical University - Shuang-Ho Hospital New Taipei City 235 Taiwan. School of Life Sciences The Chinese University of Hong Kong Hong Kong SAR 999077 China Lifebit Mindspace Shoreditch London England EC2A 2AP UK. Department of Medicine St. George's University School of Medicine St. George Grenada. Department of Applied Science National Taitung University Taitung 95092 Taiwan. Electronic address: ymtzeng@nttu.edu.tw. Department of Medical Research & Education Taipei Medical University - Shuang-Ho Hospital New Taipei City 235 Taiwan Continuing Education Program of Food Biotechnology Applications College of Science and Engineering National Taitung University Taitung 95092 Taiwan. Electronic address: ctyeh@s.tmu.edu.tw.

Activation of mitogen-activated protein kinase (MAPK) and PI3K signaling confers resistance against sorafenib, a mainstay treatment for advanced hepatocellular carcinoma (HCC). Antrocin and ovatodiolide constitute as the most potent secondary metabolites isolated from Antrodia camphorata and Anisomeles indica, respectively. Both natural compounds have recently gained a lot of attention due to their putative inhibition of MAPK and PI3K signaling in various solid cancers. However, whether their combination is effective in HCC remains unknown. Here, we investigated their effect, alone or in various combinations, on MAPK and PI3K signaling pathways in HCC cells. An array of in vitro study were used to investigate anticancer and stemness effects to treat HCC, such as cytotoxicity, drug combination index, migration, invasion, colony formation, and tumor sphere formation. drug effect in vivo was evaluated using mouse xenograft models. In this study, antrocin and ovatodiolide synergistically inhibited the SNU387, Hep3B, Mahlavu, and Huh7 cell lines. Sequential combination treatment of Huh7 and Mahlavu with ovatodiolide followed by antrocin resulted stronger cytotoxic effect than did treatment with antrocin followed by ovatodiolide, their simultaneous administration, antrocin alone, or ovatodiolide alone. In the Huh7 and Mahlavu cell lines, ovatodiolide→antrocin significantly suppressed colony formation and proliferation as well as markedly downregulated ERK1/2, Akt, and mTOR expression. Inhibition of ERK1/2 and Akt/mTOR signaling by ovatodiolide→antrocin suppressed ribosomal biogenesis, autophagy, and cancer stem cell-like phenotypes and promoted apoptosis in Huh7 and Mahlavu cells. The sorafenib-resistant clone of Huh7 was effectively inhibited by synergistic combination of both compound in vitro. Eventually, the ovatodiolide→antrocin combination synergistically suppressed the growth of HCC xenografts. Taken together, our findings suggested that ovatodiolide→antrocin combi

关键词： Advanced HCC Antrocin (ANC) MAPK Ovatodiolide (OVA) PI3K

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Arrival time estimation and reminders on public bus system 7

Arrival time estimation and reminders on public bus system

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2017 7th International Workshop on Computer science and engineering, WCSE 2017

作者： Lin, Bo-Wei Huang, ding-Ray Yang, Yun-Chung Huang, Yi-Chin Kiong, Ye Chin Lin, Jim-Min Tsai, Ming-Fong Department of Information Engineering and Computer Science Feng Chia University Taichung Taiwan Industrial Ph.D. Program of Internet of Things Feng Chia University Taichung Taiwan

ISBN: (纸本)9789811136719

The public bus service, which is one of the most frequently used public transportation methods, is an indispensable part of public lifestyle. Hence, government and companies have integrated the public bus service with smart device applications, enabling the public to check information such as bus schedules and instant information at any time. Their aim is to improve the efficiency of the public bus service. Unfortunately, their efforts have faced a variety of problems, such as the distrust of the public regarding the provided information, traffic situation, and unexpected incidents which disturb the bus schedule. In order to overcome the mentioned problems, a smart bus stop signboard system will be designed. The smart signboard will show the current position of the bus and provides a reservation service, which the public may access using smart devices. The proposed system allows bus drivers to obtain information about a particular bus stop to determine whether they should drive to that bus stop. Because the traffic situation and the embarkment and disembarkment of passengers affects the arrival time of the bus, the proposed system will take the change in the number of bus passengers and travel time into account in order to predict the arrival time of the bus.

关键词： Travel time

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Multi-objective design of synthetic biological circuits

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IFAC-PapersOnLine 2017年第1期50卷 9871-9876页

作者： Lormeau C. Rybiński M. Stelling J. Department of Biosystems Science and Engineering ETH Zurich SIB Swiss Institute of Bioinformatics Life Science Zurich Ph.D. program ”Systems Biology” Basel 4058 Switzerland Department of Biosystems Science and Engineering ETH Zurich SIB Swiss Institute of Bioinformatics Basel 4058 Switzerland

Computational methods enable the design of synthetic biological circuits demonstrating a specific dynamic behavior. Current methods are based on the assembly of parts characterized in different contexts, which often fail to operate as predicted when combined. Here we introduce a circuit design method that compensates for parts uncertainty by identifying circuit topologies whose behavior is robust to variations in parameters. Our heuristic topological filtering approach efficiently yields robust circuit designs in a Bayesian framework, and enables to reliably assess trade-offs between performance, robustness, and experimental feasibility, thus increasing the probability of success of circuit implementation. © 2017

关键词： Biocybernetics Computer-aided circuit design Multiobjective optimisations Robustness Synthetic biology

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ANTARCTICA ANd THE SOUTHERN OCEAN

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BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY 2023年第9期104卷 S322-S365页

作者： Clem, Kyle R. Raphael, Marilyn N. School of Geography Environment and Earth Sciences Victoria University of Wellington Wellington New Zealand Scripps Institution of Oceanography University of California San Diego La Jolla California Department of Atmospheric and Oceanic Sciences University of Colorado Boulder Boulder Colorado Earth Science Observation Center Cooperative Institute for Research in Environmental Sciences (ESOC/CIRES) University of Colorado Boulder Boulder Colorado Argentine Naval Hydrographic Service Buenos Aires Argentina Department of Earth and Environmental Science Temple University Philadelphia Pennsylvania Department of Meteorology University of Valparaíso Valparaíso Chile Center for Climate and Resilience Research (CR)2 Santiago Chile British Antarctic Survey Cambridge United Kingdom Science Systems and Applications Inc. Lanham Maryland NASA Goddard Space Flight Center Greenbelt Maryland Royal Netherlands Meteorological Institute (KNMI) DeBilt The Netherlands Department of Marine Sciences University of Gothenburg Gothenburg Sweden Department of Geography Ohio University Athens Ohio NASA Jet Propulsion Laboratory Pasadena California NOAA/OAR Earth System Research Laboratory Global Monitoring Division Boulder Colorado University of Colorado Boulder Boulder Colorado National Oceanography Centre Southampton United Kingdom. Antarctic Meteorological Research and Data Center Space Science and Engineering Center University of Wisconsin-Madison Madison Wisconsin Department of Physical Sciences School of Arts and Sciences Madison Area Technical College Madison Wisconsin Australian Bureau of Meteorology and Institute for Marine and Antarctic Studies (IMAS) University of Tasmania Hobart Australia Earth Science and Observation Center CIRES University of Colorado Boulder Colorado University of St. Andrews St Andrews United Kingdom Princeton University Princeton New Jersey Australian Antarctic Division Australian Antarctic Program Partnership (AAPP) and Australian Centre fo

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Corrigendum to "N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HdAC and HSP90, downregulating IFN-γ induced Pd-L1 expression"[Eur. J. Med. Chem. 2020 Jan 1;185:111725]

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European journal of medicinal chemistry 2020年 199卷 112406页

作者： Samir Mehndiratta Mei-Hsiang Lin Yi-Wen Wu Chun-Han Chen Tung-Yun Wu Kuo-Hsiang Chuang Min-Wu Chao Yi-Ying Chen Shiow-Lin Pan Mei-Chuan Chen Jing-Ping Liou School of Pharmacy College of Pharmacy Taipei Medical University Taiwan. PhD Program for Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taiwan. Department of Pharmacology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs College of Pharmacy University Taipei Taiwan. Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei Taiwan Graduate Institute of Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs College of Pharmacy University Taipei Taiwan. Electronic address: mcchen1250@tmu.edu.tw. School of Pharmacy College of Pharmacy Taipei Medical University Taiwan School of Pharmacy National Defense Medical Center Taipei Taiwan TMU Biomedical Commercialization Center Taipei Medical University Taiwan. Electronic address: jpl@tmu.edu.tw.

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Population of Merging Compact Binaries Inferred Using Gravitational Waves through GWTC-3

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physical Review X 2023年第1期13卷 011048-011048页

作者： R. Abbott T. d. Abbott F. Acernese K. Ackley C. Adams N. Adhikari R. X. Adhikari V. B. Adya C. Affeldt d. Agarwal M. Agathos K. Agatsuma N. Aggarwal O. d. Aguiar L. Aiello A. Ain P. Ajith T. Akutsu P. F. de Alarcón S. Akcay S. Albanesi A. Allocca P. A. Altin A. Amato C. Anand S. Anand A. Ananyeva S. B. Anderson W. G. Anderson M. Ando T. Andrade N. Andres T. Andrić S. V. Angelova S. Ansoldi J. M. Antelis S. Antier F. Antonini S. Appert Koji Arai Koya Arai Y. Arai S. Araki A. Araya M. C. Araya J. S. Areeda M. Arène N. Aritomi N. Arnaud M. Arogeti S. M. Aronson K. G. Arun H. Asada Y. Asali G. Ashton Y. Aso M. Assiduo S. M. Aston P. Astone F. Aubin C. Austin S. Babak F. Badaracco M. K. M. Bader C. Badger S. Bae Y. Bae A. M. Baer S. Bagnasco Y. Bai L. Baiotti J. Baird R. Bajpai M. Ball G. Ballardin S. W. Ballmer A. Balsamo G. Baltus S. Banagiri d. Bankar J. C. Barayoga C. Barbieri B. C. Barish d. Barker P. Barneo F. Barone B. Barr L. Barsotti M. Barsuglia d. Barta J. Bartlett M. A. Barton I. Bartos R. Bassiri A. Basti M. Bawaj J. C. Bayley A. C. Baylor M. Bazzan B. Bécsy V. M. Bedakihale M. Bejger I. Belahcene V. Benedetto d. Beniwal T. F. Bennett J. d. Bentley M. BenYaala F. Bergamin B. K. Berger S. Bernuzzi C. P. L. Berry d. Bersanetti A. Bertolini J. Betzwieser d. Beveridge R. Bhandare U. Bhardwaj d. Bhattacharjee S. Bhaumik I. A. Bilenko G. Billingsley S. Bini R. Birney O. Birnholtz S. Biscans M. Bischi S. Biscoveanu A. Bisht B. Biswas M. Bitossi M.-A. Bizouard J. K. Blackburn C. d. Blair d. G. Blair R. M. Blair F. Bobba N. Bode M. Boer G. Bogaert M. Boldrini L. d. Bonavena F. Bondu E. Bonilla R. Bonnand P. Booker B. A. Boom R. Bork V. Boschi N. Bose S. Bose V. Bossilkov V. Boudart Y. Bouffanais A. Bozzi C. Bradaschia P. R. Brady A. Bramley A. Branch M. Branchesi J. Brandt J. E. Brau M. Breschi T. Briant J. H. Briggs A. Brillet M. Brinkmann P. Brockill A. F. Brooks J. Brooks d. d. Brown S. Brunett G. Bruno R. Bruntz J. Bryant T. Bulik H. J. Bulten A. Buonanno R. Buscicchio d. Buskulic C. Buy R. L. Byer L. Cadonati LIGO Laboratory California Institute of Technology Pasadena California 91125 USA Louisiana State University Baton Rouge Louisiana 70803 USA Dipartimento di Farmacia Università di Salerno I-84084 Fisciano Salerno Italy INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy OzGrav School of Physics & Astronomy Monash University Clayton 3800 Victoria Australia LIGO Livingston Observatory Livingston Louisiana 70754 USA University of Wisconsin-Milwaukee Milwaukee Wisconsin 53201 USA OzGrav Australian National University Canberra Australian Capital Territory 0200 Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-30167 Hannover Germany Leibniz Universität Hannover D-30167 Hannover Germany Inter-University Centre for Astronomy and Astrophysics Pune 411007 India University of Cambridge Cambridge CB2 1TN United Kingdom Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena D-07743 Jena Germany University of Birmingham Birmingham B15 2TT United Kingdom Center for Interdisciplinary Exploration & Research in Astrophysics (CIERA) Northwestern University Evanston Illinois 60208 USA Instituto Nacional de Pesquisas Espaciais 12227-010 São José dos Campos São Paulo Brazil Gravity Exploration Institute Cardiff University Cardiff CF24 3AA United Kingdom INFN Sezione di Pisa I-56127 Pisa Italy International Centre for Theoretical Sciences Tata Institute of Fundamental Research Bengaluru 560089 India Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Universitat de les Illes Balears IAC3–IEEC E-07122 Palma de Mallorca Spain University College Dublin Dublin 4 Ireland INFN Sezione di Torino I-10125 Torino Italy Università di Napoli “Federico II” Complesso Universitario di Monte S. Angelo I-80126 Napoli

We report on the population properties of compact binary mergers inferred from gravitational-wave observations of these systems during the first three LIGO-Virgo observing runs. The Gravitational-Wave Transient Catalog 3 (GWTC-3) contains signals consistent with three classes of binary mergers: binary black hole, binary neutron star, and neutron star–black hole mergers. We infer the binary neutron star merger rate to be between 10 and 1700 Gpc−3 yr−1 and the neutron star–black hole merger rate to be between 7.8 and 140 Gpc−3 yr−1, assuming a constant rate density in the comoving frame and taking the union of 90% credible intervals for methods used in this work. We infer the binary black hole merger rate, allowing for evolution with redshift, to be between 17.9 and 44 Gpc−3 yr−1 at a fiducial redshift (z=0.2). The rate of binary black hole mergers is observed to increase with redshift at a rate proportional to (1+z)κ with κ=2.9−1.8+1.7 for z≲1. Using both binary neutron star and neutron star–black hole binaries, we obtain a broad, relatively flat neutron star mass distribution extending from 1.2−0.2+0.1 to 2.0−0.3+0.3M⊙. We confidently determine that the merger rate as a function of mass sharply declines after the expected maximum neutron star mass, but cannot yet confirm or rule out the existence of a lower mass gap between neutron stars and black holes. We also find the binary black hole mass distribution has localized over- and underdensities relative to a power-law distribution, with peaks emerging at chirp masses of 8.3−0.5+0.3 and 27.9−1.8+1.9M⊙. While we continue to find that the mass distribution of a binary’s more massive component strongly decreases as a function of primary mass, we observe no evidence of a strongly suppressed merger rate above approximately 60M⊙, which would indicate the presence of a upper mass gap. Observed black hole spins are small, with half of spin magnitudes below χi≈0.25. While the majority of spins are preferentially aligned wi

关键词： Gravitational wave sources Gravitational waves Gravitational wave detection

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direct Imaging discovery and dynamical Mass of a Substellar Companion Orbiting an Accelerating Hyades Sun-like Star with SCExAO/CHARIS

arXiv

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arXiv 2022年

作者： Kuzuhara, Masayuki Currie, Thayne Takarada, Takuya Brandt, Timothy d. Sato, Bun'ei Uyama, Taichi Janson, Markus Chilcote, Jeffrey Tobin, Taylor Lawson, Kellen Hori, Yasunori Guyon, Olivier Groff, Tyler d. Lozi, Julien Vievard, Sebastien Sahoo, Ananya deo, Vincent Jovanovic, Nemanja Ahn, Kyohoon Martinache, Frantz Skaf, Nour Akiyama, Eiji Norris, Barnaby R. Bonnefoy, Mickaël Helminiak, Krzysztof G. Kudo, Tomoyuki McElwain, Michael W. Samland, Matthias Wagner, Kevin Wisniewski, John Knapp, Gillian R. Kwon, Jungmi Nishikawa, Jun Serabyn, Eugene Hayashi, Masahiko Tamura, Motohide Astrobiology Center of NINS 2-21-1 Osawa Mitaka Tokyo181-8588 Japan National Astronomical Observatory of Japan 2-21-2 Osawa Mitaka Tokyo181-8588 Japan Subaru Telescope National Astronomical Observatory of Japan 650 North A'ohōkū Place HiloHI96720 United States NASA-Ames Research Center Moffett Blvd. Moffett Field CA United States Eureka Scientific 2452 Delmer Street Suite 100 OaklandCA United States Department of Physics University of California Santa Barbara Santa BarbaraCA United States Department of Earth and Planetary Sciences School of Science Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo152-8551 Japan Infrared Processing and Analysis Center California Institute of Technology PasadenaCA91125 United States Department of Astronomy Stockholm University Stockholm Sweden Department of Physics University of Notre Dame Notre DameIN United States Homer S Dodge Department of Physics and Astronomy University of Oklahoma NormanOK United States Department of Astronomical Science The Graduate University for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Steward Observatory The University of Arizona TucsonAZ85721 United States College of Optical Sciences University of Arizona TucsonAZ85721 United States NASA-Goddard Space Flight Center GreenbeltMD United States Department of Astronomy California Institute of Technology 1200 E. California Blvd. PasadenaCA91125 United States Université Côte d'Azur Observatoire de la Côte d'Azur CNRS Laboratoire Lagrange France LESIA Observatoire de Paris Univ. PSL CNRS Sorbonne Univ. Univ. de Paris 5 pl. Jules Janssen Meudon92195 France Division of Fundamental Education and Liberal Arts Department of Engineering Niigata Institute of Technology 1719 Fujihashi Niigata Kashiwazaki945-1195 Japan Sydney Institute for Astronomy School of Physics University of Sydney SydneyNSW Australia Institut de Planétologie et d'Astrophysique de Grenoble CNRS IPAG Franc

We present the direct-imaging discovery of a substellar companion in orbit around a Sun-like star member of the Hyades open cluster. So far, no other substellar companions have been unambiguously confirmed via direct imaging around main-sequence stars in Hyades. The star HIP 21152 is an accelerating star as identified by the astrometry from the Gaia and Hipparcos satellites. We have detected the companion, HIP 21152 B, in multi-epoch using the high-contrast imaging from SCExAO/CHARIS and Keck/NIRC2. We have also obtained the stellar radial-velocity data from the Okayama 188cm telescope. The CHARIS spectroscopy reveals that HIP 21152 B's spectrum is consistent with the L/T transition, best fit by an early T dwarf. Our orbit modeling determines the semi-major axis and the dynamical mass of HIP 21152 B to be (Equation presented) au and (Equation presented) MJup, respectively. The mass ratio of HIP 21152 B relative to its host is ≈2%, near the planet/brown dwarf boundary suggested from recent surveys. Mass estimates inferred from luminosity evolution models are slightly higher (33-42 MJup). With a dynamical mass and a well-constrained age due to the system's Hyades membership, HIP 21152 B will become a critical benchmark in understanding the formation, evolution, and atmosphere of a substellar object as a function of mass and age. Our discovery is yet another key proof-of-concept for using precision astrometry to select direct imaging targets. Copyright © 2022, The Authors. All rights reserved.

关键词： Stars

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Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

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science (New York, N.Y.) 2025年第6732期387卷 eadn7277页

作者： Harvey, Lloyd d. Alotaibi, Mona Tai, Yi-Yin Tang, Ying Kim, Hee-Jung J Kelly, Neil J. Sun, Wei Woodcock, Chen-Shan C Arshad, Sanya Culley, Miranda K. El Khoury, Wadih Xie, Rong Al Aaraj, Yassmin Zhao, Jingsi Hafeez, Neha Rao, Rashmi J. Jiang, Siyi Negi, Vinny Kirillova, Anna Perk, dror Watson, Annie M. St Croix, Claudette M. Stolz, donna B. Lee, Ji Young Cheng, Mary Hongying Zhang, Manling detmer, Samuel Guzman, Edward Manan, Rajith S. Saggar, Rajan Haley, Kathleen J. Waxman, Aaron B. Okawa, Satoshi Schwantes-An, Tae-Hwi Pauciulo, Michael W. Wang, Bing Webb, Amy Chauvet, Caroline Anderson, daniel G. Nichols, William C. desai, Ankit A. Lafyatis, Robert Nouraie, S Mehdi Wu, Haodi Mcdonald, Jeffrey G. Cheng, Susan Bahar, Ivet Bertero, Thomas Benza, Raymond L. Jain, Mohit Chan, Stephen Y. Medical Scientist Training Program University of Pittsburgh Pittsburgh PA United States Center for Pulmonary Vascular Biology and Medicine Heart Lung Blood Vascular Medicine Institute University of Pittsburgh Pittsburgh PA United States Division of Cardiology University of Pittsburgh School of Medicine Pittsburgh PA United States Division of Pulmonary and Critical Care Medicine University of California San Diego La Jolla CA United States Department of Medicine University of California La Jolla San Diego CA United States Department of Pharmacology University of California La Jolla San Diego CA United States Division of Cardiology Veterans Affairs Pittsburgh Healthcare System Pittsburgh PA United States Center for Biologic Imaging University of Pittsburgh Pittsburgh PA United States Laufer Center for Physical and Quantitative Biology Stony Brook University Stony Brook NY United States Department of Biochemistry and Cell Biology Stony Brook University Stony Brook NY United States Department of Chemistry Massachusetts Institute of Technology Boston MA United States Institute of Medical Engineering and Science Massachusetts Institute of Technology Boston MA United States School of Engineering and Applied Sciences Harvard University Cambridge MA United States Department of Chemical Engineering Massachusetts Institute of Technology Boston MA United States Department of Medicine David Geffen School of Medicine University of California Los Angeles (UCLA) Los Angeles CA USA Department of Pathology David Geffen School of Medicine UCLA Los Angeles CA United States Division of Pulmonary and Critical Care Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA United States Department of Computational and Systems Biology University of Pittsburgh Pittsburgh PA United States McGowan Institute for Regenerative Medicine University of Pittsburgh Pittsburgh PA United States Department of Medical and Molecular G

Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. Nuclear receptor coactivator 7 (NCOA7) deficiency in endothelium produced an oxysterol and bile acid signature through lysosomal dysregulation, promoting endothelial pathophenotypes. This oxysterol signature overlapped with a plasma metabolite signature associated with human PAH mortality. Mice deficient for endothelial Ncoa7 or exposed to an inflammatory bile acid developed worsened PAH. Genetic predisposition to NCOA7 deficiency was driven by single-nucleotide polymorphism rs11154337, which alters endothelial immunoactivation and is associated with human PAH mortality. An NCOA7-activating agent reversed endothelial immunoactivation and rodent PAH. Thus, we established a genetic and metabolic paradigm that links lysosomal biology and oxysterol processes to endothelial inflammation and PAH.

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