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Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance

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Journal of experimental & clinical cancer research : CR 2023年第1期42卷 171页

作者： Ting-Wan Kao Geng-Hao Bai Tian-Li Wang Ie-Ming Shih Chi-Mu Chuang Chun-Liang Lo Meng-Chen Tsai Li-Yun Chiu Chu-Chien Lin Yao-An Shen Department of Pathology School of Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. Department of Internal Medicine National Taiwan University Hospital College of Medicine National Taiwan University Taipei City 100225 Taiwan. Departments of Pathology Oncology and Gynecology and Obstetrics Johns Hopkins Medical Institutions 1550 Orleans StreetRoom 306 Baltimore MD CRB221231 USA. Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore MD USA. Faculty of Medicine School of Medicine National Yang-Ming Chiao Tung University Taipei 112304 Taiwan. Department of Obstetrics and Gynecology Taipei Veterans General Hospital Taipei 112201 Taiwan. Department of Midwifery and Women Health Care National Taipei University of Nursing and Health Sciences Taipei 112303 Taiwan. Department of Biomedical Engineering National Yang-Ming Chiao Tung University Taipei 112304 Taiwan. Medical Device Innovation and Translation Center National Yang Ming Chiao Tung University Taipei 112304 Taiwan. Department of General Medicine Taipei Medical University Hospital Taipei 110301 Taiwan. Department of General Medicine Mackay Memorial Hospital Taipei 104217 Taiwan. School of Medicine College of Medicine Taipei Medical University Taipei City 110301 Taiwan. Department of Pathology School of Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. shen1202@tmu.edu.tw. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. shen1202@tmu.edu.tw. International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. shen1202@tmu.edu.tw.

Chemotherapy, radiotherapy, targeted therapy, and immunotherapy are established cancer treatment modalities that are widely used due to their demonstrated efficacy against tumors and favorable safety profiles or tolerability. Nevertheless, treatment resistance continues to be one of the most pressing unsolved conundrums in cancer treatment. Hypoxia-inducible factors (HIFs) are a family of transcription factors that regulate cellular responses to hypoxia by activating genes involved in various adaptations, including erythropoiesis, glucose metabolism, angiogenesis, cell proliferation, and apoptosis. despite this critical function, overexpression of HIFs has been observed in numerous cancers, leading to resistance to therapy and disease progression. In recent years, much effort has been poured into developing innovative cancer treatments that target the HIF pathway. Combining HIF inhibitors with current cancer therapies to increase anti-tumor activity and diminish treatment resistance is one strategy for combating therapeutic resistance. This review focuses on how HIF inhibitors could be applied in conjunction with current cancer treatments, including those now being evaluated in clinical trials, to usher in a new era of cancer therapy.

关键词： Chemotherapy Combination therapy HIF-1 HIF-2 Hypoxia Immunotherapy Metabolic therapy Radiotherapy Target therapy Therapeutic resistance

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Global tracking of marine megafauna space use reveals how to achieve conservation targets

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science (New York, N.Y.) 2025年第6751期388卷 1086-1097页

作者： Ana M M Sequeira Jorge P Rodríguez Sarah A Marley Hannah J Calich Mirjam van der Mheen Michelle VanCompernolle Lucy M Arrowsmith Lauren R Peel Nuno Queiroz Marisa Vedor Ivo da Costa Gonzalo Mucientes Ana Couto Nicolas E Humphries Sara Abalo-Morla Francisco J Abascal debra L Abercrombie Katya Abrantes F Alberto Abreu-Grobois André S Afonso Pedro Afonso Heidi Ahonen Susanne Åkesson Joanna Alfaro-Shigueto Russel d Andrews Frédéric Angelier Marina Antonopoulou Javier A Arata Gonzalo Araujo Randall Arauz José Manuel Arcos Igor Arregui Haritz Arrizabalaga Marie Auger-Méthé Steffen Bach Fred Bailleul Robin W Baird George H Balazs Susan G Barco Adam Barnett Warren Baverstock Alastair M M Baylis Annalea Beard Juan Bécares Eduardo J Belda Ian Bell Ashley Bennison Scott R Benson diego Bernal Michael L Berumen Sandra Bessudo Natalia P A Bezerra Antonin V Blaison Gabriela S Blanco Barbara A Block Mark Bolton Mark E Bond Ramón Bonfil Camrin d Braun Annette C Broderick Michael de L Brooke Annabelle M L Brooks Edward J Brooks Ignacio M Bruno Jennifer M Burns Michael E Byrne Steven E Campana Hamish A Campbell Richard A Campbell Aaron Carlisle Ruth H Carmichael Gemma Carroll Paolo Casale Filipe R Ceia demian d Chapman Taylor K Chapple Jean-Benoit Charrassin Andre Chiaradia John Chisholm Christopher R Clarke Thomas A Clay Christophe Cleguer Elizabeth Clingham Eric E G Clua Jesse E M Cochran Rochelle Constantine Robert W Cooper Estelle Crochelet Michelle Cronin Eduardo Cuevas Kayla P daCosta Laurent dagorn Ryan daly Randall W davis P J Nico de Bruyn Carlos delgado-Trejo Thomas dellinger Solène derville Stella diamant Andrew diMatteo Kara L dodge philip d doherty Michael C double Alistair d M dove Thomas K doyle Michael J drew Lindsay L dubbs Clinton A J duffy Peter H dutton Ewan W J Edwards Luke d Einoder Mark V Erdmann Eduardo Espinoza Nicole Esteban Ana Isabel Fagundes Chris Feare Steven H Ferguson Luciana C Ferreira Francesco Ferretti John Filmalter Brittany Finucci G Chris Fischer Richard J Fitzpatrick Jorge Fontes Angela Formia Division of Ecology and Evolution Research School of Biology The Australian National University Canberra (Australian Capital Territory) Australia. UWA Oceans Institute and the School of Biological Sciences The University of Western Australia Perth (Western Australia) Australia. Instituto de Física Interdisciplinar y Sistemas Complejos (IFISC) CSIC-UIB Palma de Mallorca Spain. Instituto Mediterráneo de Estudios Avanzados (IMEDEA) CSIC-UIB Esporles Illes Balears Spain. C.A. Illes Balears Universidad Nacional de Educación a Distancia (UNED) Palma Spain. Delegación Territorial en Illes Balears Agencia Estatal de Meteorología (AEMET) Muelle de Poniente s/n Palma Spain. Scotland's Rural College (SRUC) Craibstone Estate Bucksburn Aberdeen UK. Oceans Graduate School and the UWA Oceans Institute The University of Western Australia Perth (Western Australia) Australia. School of Engineering and the UWA Oceans Institute The University of Western Australia Perth (Western Australia) Australia. Department of Biodiversity Conservation and Attractions Biodiversity and Conservation Science Kensington (Western Australia) Australia. Save Our Seas Foundation Geneva Switzerland. The Manta Trust Catemwood House Norwood Lane Corscombe Dorset UK. Centro de Investigação em Biodiversidade e Recursos Genéticos (CIBIO) InBIO Laboratório Associado Campus de Vairão Universidade do Porto Vairão Portugal. BIOPOLIS Program in Genomics Biodiversity and Land Planning Campus de Vairao Vairão Portugal. Instituto de Investigaciones Marinas Consejo Superior de Investigaciones Científicas (IIM-CSIC) Vigo Pontevedra Spain. School of Biological Sciences University of Aberdeen Aberdeen UK. Biomathematics and statistics Scotland The kings building Edinburgh Scotland. Marine Biological Association (MBA) The Laboratory Citadel Hill Plymouth UK. Instituto de Investigación para la Gestión Integrada de Zonas Costeras Universitat Politècnica de València Gandia València Spain. Instituto Español de O

The recent Kunming-Montreal Global Biodiversity Framework (GBF) sets ambitious goals but no clear pathway for how zero loss of important biodiversity areas and halting human-induced extinction of threatened species will be achieved. We assembled a multi-taxa tracking dataset (11 million geopositions from 15,845 tracked individuals across 121 species) to provide a global assessment of space use of highly mobile marine megafauna, showing that 63% of the area that they cover is used 80% of the time as important migratory corridors or residence areas. The GBF 30% threshold (Target 3) will be insufficient for marine megafauna's effective conservation, leaving important areas exposed to major anthropogenic threats. Coupling area protection with mitigation strategies (e.g., fishing regulation, wildlife-traffic separation) will be essential to reach international goals and conserve biodiversity.

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Long-term study of the intermittent extreme behaviour of 1ES 2344+514 38

Long-term study of the intermittent extreme behaviour of 1ES...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Arbet-Engels, A. Mondal, H.A. Fukami, S. d’Ammando, F. dorner, d. Chatterjee, R. Majumdar, P. Manganaro, M. Hovatta, T. das, S. Raiteri, C.M. Villata, M. Perri, M. Verrechia, F. Leto, C. Filippenko, A. Zheng, W. Abe, H. Abe, S. Abhir, J. Acciari, V.A. Agudo, I. Aniello, T. Ansoldi, S. Antonelli, L.A. Arbet Engels, A. Arcaro, C. Artero, M. Asano, K. Baack, d. Babić, A. Baquero, A. Barres de Almeida, U. Barrio, J.A. Batković, I. Baxter, J. Becerra González, J. Bednarek, W. Bernardini, E. Bernardos, M. Bernete, J. Berti, A. Besenrieder, J. Bigongiari, C. Biland, A. Blanch, O. Bonnoli, G. Bošnjak, Ž. Burelli, I. Busetto, G. Campoy-Ordaz, A. Carosi, A. Carosi, R. Carretero-Castrillo, M. Castro-Tirado, A.J. Ceribella, G. Chai, Y. Chatterjee, R. Chilingarian, A. Cifuentes, A. Cikota, S. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. d’Ammando, F. d’Amico, G. d’Elia, V. da Vela, P. dazzi, F. de Angelis, A. de Lotto, B. del Popolo, A. delfino, M. delgado, J. delgado Mendez, C. depaoli, d. di Pierro, F. di Venere, L. dominis Prester, d. donini, A. doro, M. Elsaesser, d. Emery, G. Escudero, J. Fariña, L. Fattorini, A. Foffano, L. Font, L. Fröse, S. Fukazawa, Y. García López, R.J. Garczarczyk, M. Gasparyan, S. Gaug, M. Giesbrecht Paiva, J.G. Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Grau, R. Green, d. Green, J.G. Hadasch, d. Hahn, A. Hassan, T. Heckmann, L. Herrera, J. Hrupec, d. Hütten, M. Imazawa, R. Inada, T. Iotov, R. Ishio, K. Jiménez Martínez, I. Jormanainen, J. Kerszberg, d. Kluge, G.W. Kobayashi, Y. Kouch, P.M. Kubo, H. Kushida, J. Láinez Lezáun, M. Lamastra, A. Lelas, d. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Lorini, A. Lyard, E. Machado de Oliveira Fraga, B. Majumdar, P. Makariev, M. Maneva, G. Mang, N. Manganaro, M. Mangano, S. Mannheim, K. Mariotti, M. Martínez, M. Martínez-Chicharro, M. Mas-Aguilar, A. Mazin, d. Menchiari, S. Saha Inst. of Nuclear Physics A CI of Homi Bhabha National Inst. West Bengal Kolkata700064 India INAF - Istituto di Radioastronomia Via Gobetti 101 BolognaI-40129 Italy School of Astrophysics Presidency University 86/1 College Street Kolkata700073 India University of Rijeka Faculty of Physics Rijeka51000 Croatia - ASI via del Politecnico s.n.c. RomaI-00133 Italy INAF Osservatorio Astrofisico di Torino Pino TorineseI-10025 Italy University of Turku TurkuFI-20014 Finland Aalto University Metsähovi Radio Observatory Metsähovintie 114 Kylmälä02540 Finland Italian Space Agency ASI via del Politecnico snc Roma00133 Italy INAF - Osservatorio Astronomico di Roma via di Frascati 33 MonteporzioI-00040 Italy Department of Astronomy University of California BerkeleyCA94720-3411 United States Miller Institute for Basic Research in Science University of California BerkeleyCA94720 United States The University of Tokyo Chiba Kashiwa277-8582 Japan ETH Zürich ZürichCH-8093 Switzerland Instituto de Astrofísica de Canarias Dpto. de Astrofísica Universidad de La Laguna Tenerife La LagunaE-38200 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain RomeI-00136 Italy Università di Udine INFN Trieste UdineI-33100 Italy Max-Planck-Institut für Physik MünchenD-80805 Germany Università di Padova INFN PadovaI-35131 Italy Bellaterra BarcelonaE-08193 Spain Technische Universität Dortmund DortmundD-44221 Germany Zagreb10000 Croatia IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain URCA RJ Rio de Janeiro22290-180 Brazil University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain Departament de Física CERES-IEEC Universitat Autònoma de Barcelona BellaterraE-08193 Spain Università di Pisa INFN Pisa Pisa

Extreme high-frequency-peaked BL Lac objects (EHBLs) are the most energetic persistent sources in the Universe. They are characterized by a spectral energy distribution (SEd) featuring a synchrotron peak energy above 1 keV. 1ES 2344+514 is a blazar known to behave as an EHBL intermittently. Until now, its EHBL nature was only reported during flares, but a coherent picture is missing as unbiased monitoring campaigns are lacking. This work presents the longest observing campaign from radio to very-high-energy (VHE) frequencies performed so far on 1ES2344+514. Using observations during 2019-2021, we carry out a systematic investigation of the intermittent EHBL phases. Together with MAGIC, the dataset also includes X-ray observations from NuSTAR, XMM-Newton, and AstroSAT, providing an unprecedented determination of the two SEd components. For the first time we report a clear EHBL behaviour during a low flux activity in 1ES 2344+514. It implies a significant hardening of the electron distribution inside the jet independent of flux. We also detect a bright X-ray state characterized by an unusually soft spectra, thus violating the harder-when-brighter relation typically found in blazars. The SEd study further reveals an excess in the ultraviolet data with respect to the extrapolation of the X-ray spectrum, suggesting at least two regions contributing to the synchrotron flux. Finally we investigate a gamma-ray flare not accompanied by an X-ray counterpart. This peculiar outburst is interpreted using a time-dependent model involving two emitting components. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Synchrotrons

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Author Correction: Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis

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Nature Astronomy 2023年 633页

作者： Marine Paquet Frederic Moynier Wei dai Yan Hu Martin Bizzarro Marc Chaussidon Tetsuya Yokoyama Ikshu Gautam Makiko K. Haba Akira Ishikawa Yuki Masuda Yoshinari Abe Jérôme Aléon Conel M. O’d. Alexander Richard W. Carlson Larry Nittler Sachiko Amari Yuri Amelin Ken-ichi Bajo Noriyuki Kawasaki Sohei Wada Hisayoshi Yurimoto Audrey Bouvier Byeon-Gak Choi Nicolas dauphas Andrew M. davis Tommaso di Rocco Andreas Pack Wataru Fujiya Ryota Fukai Tomohiro Usui Kanako Sakamoto Masanao Abe Akiko Miyazaki Aiko Nakato Masahiro Nishimura Tatsuaki Okada Toru Yada Kasumi Yogata Satoru Nakazawa Takanao Saiki Satoshi Tanaka Yuichi Tsuda Makoto Yoshikawa Yuki Hibiya Hiroshi Hidaka Sei-ichiro Watanabe Hisashi Homma Peter Hoppe Gary R. Huss Alexander N. Krot Kazuhide Nagashima Kiyohiro Ichida Shintaro Komatani Mayu Morita Morihiko Onose Tsuyoshi Iizuka Trevor R. Ireland Motoo Ito Takaaki Noguchi Shoichi Itoh Noriko T. Kita Kouki Kitajima Thorsten Kleine Ming-Chang Liu Kevin d. McKeegan Lauren Tafla Haolan Tang Edward d. Young Kazuko Motomura Izumi Nakai david Nesvorný Ann N. Nguyen Changkun Park Laurette Piani Liping Qin Sara S. Russell Naoya Sakamoto Maria Schönbächler Kentaro Terada Yasuko Terada Meenakshi Wadhwa Richard J. Walker Katsuyuki Yamashita Qing-Zhu Yin Shigekazu Yoneda Hiroharu Yui Ai-Cheng Zhang Tomoki Nakamura Hiroshi Naraoka Ryuji Okazaki Hikaru Yabuta Fuyuto Terui Shogo Tachibana Université Paris Cité Institut de Physique du Globe de Paris CNRS Paris France Centre for Star and Planet Formation GLOBE Institute University of Copenhagen Copenhagen Denmark Department of Earth and Planetary Sciences Tokyo Institute of Technology Tokyo Japan Graduate School of Engineering Materials Science and Engineering Tokyo Denki University Tokyo Japan Institut de Minéralogie de Physique des Matériaux et de Cosmochimie Sorbonne Université Muséum National d’Histoire Naturelle CNRS UMR 7590 IRD Paris France Earth and Planets Laboratory Carnegie Institution for Science Washington DC USA McDonnell Center for the Space Sciences and Physics Department Washington University St. Louis MO USA Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou China Natural History Sciences IIL Hokkaido University Sapporo Japan Bayerisches Geoinstitut Universität Bayreuth Bayreuth Germany Department of Earth Science Education Seoul National University Seoul Republic of Korea Department of the Geophysical Sciences and Enrico Fermi Institute The University of Chicago Chicago IL USA Faculty of Geosciences and Geography University of Göttingen Göttingen Germany Faculty of Science Ibaraki University Mito Japan ISAS/JSEC JAXA Sagamihara Japan General Systems Studies The University of Tokyo Tokyo Japan Earth and Planetary Sciences Nagoya University Nagoya Japan Osaka Application Laboratory SBUWDX Rigaku Corporation Osaka Japan Max Planck Institute for Chemistry Mainz Germany Hawai’i Institute of Geophysics and Planetology University of Hawai’i at Mānoa Honolulu HI USA Analytical Technology Horiba Techno Service Co. Ltd Kyoto Japan Earth and Planetary Science The University of Tokyo Tokyo Japan School of Earth and Environmental Sciences The University of Queensland St Lucia Queensland Australia Kochi Institute for Core Sample Research JAMSTEC Kochi Japan Earth and Planetary Sciences Kyoto University Kyoto Japan Geoscience Universit

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Simulation of a 3d Turbulent Wavy Channel based on the High-order WENO Scheme

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IOP Conference Series: Materials science and engineering 2018年第1期307卷

作者： Bor-Jang Tsai Chung-Chyi Chou Yeong-Pei Tsai Ying Hung Chuang Ph.D. Program in Engineering Science Chung Hua University Department of Fire and Safety Da-Yeh University

Passive interest turbulent drag reduction, effective means to improve air vehicle fuel consumption costs. Most turbulent problems happening to the nature and engineering applications were exactly the turbulence problem frequently caused by one or more turbulent shear flows. This study was operated with incompressible 3-d channels with cyclic wavy boundary to explore the physical properties of turbulence flow. This research measures the distribution of average velocity, instant flowing field shapes, turbulence and pressure distribution, etc. Furthermore, the systematic computation and analysis for the 3-d flow field was also implemented. It was aimed to clearly understand the turbulence fields formed by wavy boundary of tube flow. The purpose of this research is to obtain systematic structural information about the turbulent flow field and features of the turbulence structure are discussed.

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Corrigendum to "Multiband rabi antenna using nest microstrip add-drop filter (NMAdF) for relativistic sensing applications" [Heliyon 9(2) (February 2023) e13611]

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Heliyon 2023年第7期9卷 e16846页

作者： Somchat Sonasang M Jamsai M A Jalil N T pham K Ray Niwat Angkawisittpan Preecha Yupapin Sarawoot Boonkirdram Martha Alicia Palomino-Ovando Miller Toledo-Solano Khashayar Misaghian J E Lugo Electronic Technology Faculty of Industrial Technology Nakon Phanom University Nakon Phanom 48000 Thailand. Department of Electrical Engineering Faculty of Industry and Technology Rajamagala University of Technology Isan Sakon Nakhon Campus Sakon Nakhon 47160 Thailand. Department of Physics Universiti Teknologi Malaysia 81310 Skuda Johor Malaysia. Institute for Computational Science Ton Duc Thang University Ho Chi Minh City Viet Nam. Amity School of Applied Sciences Amity University Rajasthan Jaipur India. Facultad de CienciasFisico-Matematicas Benemérita Universidad Autónoma de Puebla Av. San Claudio y AV. 18 sur Col. San Manuel Ciudad Universitaria Pueble Pue 72570 Mexico. Faubert Lab Ecole d'optométrie Université de Montréal Montréal QC H3T1P1 Canada. Research Unit for Computational Electromagnetics and Optical Systems Faculty of Engineering Mahasarakham University Maha Sarakham 44150 Thailand. Department of Electrical Technology School of Industrial Technology Sakonnakhon Technical College Institute of Vocational Education Northeastern 2 Sakonnakhon 47000 Thailand. Program of Electrical and Electronics Faculty of Industrial Technology Sakon Nakhon Rajabhat University 680 Nittayo Mueang Sakon Nakhon 47000 Thailand. CONACYT-Facultad de CienciasFisico-Matematicas Benemérita Universidad Autónoma de Pueble Av. San Claudio y Av. 18 sur Col. San Manuel Ciudad Universitaria Puebla Pue 72570 Mexico. Faubert Lab School of Optometry Université de Montréal Montréal QC H3T1P1 Canada. Sage-Sentinel Smart Solutions 1919-1 Tancha Onna-son Kunigamigun Okinawa 904-0495 Japan.

[This corrects the article dOI: 10.1016/***.2023.e13611.].

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Women for Quantum - Manifesto of Values

arXiv

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arXiv 2024年

作者： Beige, Almut Predojević, Ana Metelmann, Anja Sanpera, Anna Macchiavello, Chiara Koch, Christiane P. Silberhorn, Christine Toninelli, Costanza Bruß, dagmar Ercolessi, Elisa Paladino, Elisabetta Ferlaino, Francesca Ferrini, Giulia Platero, Gloria Fuentes, Ivette Nemoto, Kae Tarruell, Leticia Bondani, Maria Chiofalo, Marilu Pons, Marisa d'Angelo, Milena Murao, Mio Fabbri, Nicole Verrucchi, Paola Senellart-Mardon, Pascale Citro, Roberta Zambrini, Roberta González-Férez, Rosario Maniscalco, Sabrina Huelga, Susana Mehlstäubler, Tanja Parigi, Valentina Ahufinger, Verónica Aharonov, dorit Allevi, Alessia Amini, Nina Anders, Janet Millán, Marta Anguiano Contera, Sonia Antoranz Arapinis, Myrto Ares, Natalia Auffèves, Alexia Ban, Ticijana Bañuls, Mari Carmen Barz, Stefanie Bascones, Leni Bausá, Luisa Beauchard, Karine Bergamini, Silvia Biel, Blanca Borras, Kerstin Bouchoule, Isabelle Bouloufa, Nadia Broadbent, Anne Bruno, Natalia Caglayan, Humeyra Calderón, María José Calegari, Francesca del Carmen Carrión Pérez, María Caspani, Lucia Cerdeira, Hilda Cetto, Ana María Champenois, Caroline Clementi, Cecilia Colautti, Maja Cottet, Audray Croke, Sarah d'Huys, Otti d'Amico, Irene d'Auria, Virginia datta, Nilanjana de Jesus Raimundo, Sandra de Lacerda Paiva, Thereza Cristina de Morais Smith, Cristiane de Morisson Faria, Carla de Vega, Inés de Zawadzki, Krissia diamanti, Eleni doosti, Mina draxl, Claudia dréau, Anaïs ducci, Sara dultzin, deborah Eberlein, Claudia Esposito, Martina Estarellas, Marta P. Everschor-Sitte, Karin Facao, Margarida Roudsari, Anita Fadavi Fermanian, Clotilde Marmol, Veronica Fernandez Florido, Estrella França, Vivian F. Franke-Arnold, Sonja Gagnon, Pauline Gallo, Elisabetta Alonso, Gemma García Pietro, Ana García Recio, Carmen García García-Álvarez, Laura García-Martínez, Pascuala Garutti, Erika Ghose, Shohini Giacobino, Elisabeth Gianani, Ilaria Goddard, Noel Goldfarb, Fabienne González, Gabriela Gordillo, María Carmen Gorfinkiel, Jimena d. Grange, Rachel Guellati-Khélifa, Saïda Guha, Suchi Guilleumas, Mon The School of Physics and Astronomy University of Leeds United Kingdom Department of Physics Stockholm University Sweden Institute for Theory of Condensed Matter Karlsruhe Institute of Technology Germany Institute for Quantum Materials and Technology Karlsruhe Institute of Technology Germany ISIS Université de Strasbourg France Informació i Fenòmens Quàntics Departament de Física Universitat Autònoma de Barcelona Spain ICREA Institució Catalana de Recerca i Estudis Avançats Spain Dipartimento di Fisica Università degli Studi di Pavia Italy INFN Sezione di Pavia Italy Dahlem Center for Complex Quantum Systems and Fachbereich Physik Freie Universität Berlin Germany Paderborn University Germany -INO Sesto Fiorentino Italy Sesto Fiorentino Italy Institut für Theoretische Physik III Heinrich-Heine-Universität Düsseldorf Germany Dipartimento di Fisica e Astronomia University of Bologna Italy INFN Sezione di Bologna Italy Dipartimento di Fisica e Astronomia "Ettore Majorana" Università di Catania Italy INFN Sezione di Catania Italy CNR-IMM UoS Università Catania Italy Institut für Quantenoptik und Quanteninformation Österreichische Akademie der Wissenschaften Innsbruck Austria Universität Innsbruck Institut für Experimentalphysik Austria Wallenberg Centre for Quantum Technology Department of Microtechnology and Nanoscience Chalmers University of Technology Göteborg Sweden Spain School of Physics and Astronomy University of Southampton United Kingdom Okinawa Institute of Science and Technology Graduate University Japan National Institute of Informatics Tokyo Japan ICFO Institut de Ciències Fotòniques The Barcelona Institute of Science and Technology Castelldefels Barcelona Spain CNR-Institute for Photonics and Nanotechnologies Como Italy Department of Physics "Enrico Fermi" University of Pisa INFN-Sezione di Pisa Italy EHU Quantum Center Universidad del País Vasco UPV EHU Leioa Spain Departamento de Física Aplicada Universidad del País Vasco UPV EH

data show that the presence of women in quantum science is affected by a number of detriments and their percentage decreases even further for higher positions. Beyond data, from our shared personal experiences as female tenured quantum physics professors, we believe that the current model of scientific leadership, funding, and authority fails to represent many of us. It is time for a real change that calls for a different kind of force and for the participation of everyone. Women for quantum calls for a joint effort and aims with this initiative to contribute to such a transformation. © 2024, CC BY-NC-SA.

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Unsupervised extraction of phenotypes from cancer clinical notes for association studies

arXiv

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arXiv 2019年

作者： Stark, Stefan G. Hyland, Stephanie L. Pradier, Melanie F. Lehmann, Kjong-Van Wicki, Andreas Perez-Cruz, Fernando Vogt, Julia E. Rätsch, Gunnar Computational Biology Program Memorial Sloan Kettering Cancer Center New York United States Tri-Institutional Ph.D. Program in Computational Biology and Medicine Weill Cornell Medicine New York United States Department of Computer Science ETH Zürich Zürich Switzerland Medical Informatics Group University Hospital Zürich Zürich Switzerland Swiss Institute for Bioinformatics Zurich Switzerland Department of Biology ETH Zürich Zürich Switzerland Department of Signal Processing and Information Theory University Carlos III in Madrid Leganés Spain School of Engineering and Applied Sciences Harvard University CambridgeMA United States Department of Biomedicine University of Basel Basel Switzerland Tumorzentrum University Hospital Basel Basel Switzerland Swiss Data Science Center ETH Zürich and EPFL Lausanne Switzerland Department of Mathematics and Computer Science University of Basel Basel Switzerland

The recent adoption of Electronic Health Records (EHRs) by healthcare providers has introduced an important source of data that provides detailed and highly specific insights into patient phenotypes over large cohorts. These datasets, in combination with machine learning and statistical approaches, generate new opportunities for research and clinical care. However, many methods require the patient representations to be in structured formats, while the information in the EHR is often locked in unstructured text designed for human readability. In this work, we develop the methodology to automatically extract clinical features from clinical narratives from large EHR corpora without the need for prior knowledge. We consider medical terms and sentences appearing in clinical narratives as atomic information units. We propose an efficient clustering strategy suitable for the analysis of large text corpora and utilize the clusters to represent information about the patient compactly. Additionally, we define the sentences on ontologic and natural language vocabularies to automatically detect pertinent combinations of concepts present in the corpus, even when an ontology is not available. To demonstrate the utility of our approach, we perform an association study of clinical features with somatic mutation profiles from 4,007 cancer patients and their tumors. We apply the proposed algorithm to a dataset consisting of .65 thousand documents with a total of .3.2 million sentences. After correcting for cancer type and other confounding factors, we identify a total of 340 significant statistical associations between the presence of somatic mutations and clinical features. We annotated these associations according to their novelty and we report several known associations. We also propose 37 plausible, testable hypothesis for associations where the underlying biological mechanism does not appear to be known. These results illustrate that the automated discovery of clinical features

关键词： diseases

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Search for continuous gravitational waves from 20 accreting millisecond x-ray pulsars in O3 LIGO data

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physical Review d 2022年第2期105卷 022002-022002页

作者： R. Abbott T. d. Abbott F. Acernese K. Ackley C. Adams N. Adhikari R. X. Adhikari V. B. Adya C. Affeldt d. Agarwal M. Agathos K. Agatsuma N. Aggarwal O. d. Aguiar L. Aiello A. Ain T. Akutsu S. Albanesi A. Allocca P. A. Altin A. Amato C. Anand S. Anand A. Ananyeva S. B. Anderson W. G. Anderson M. Ando T. Andrade N. Andres T. Andrić S. V. Angelova S. Ansoldi J. M. Antelis S. Antier S. Appert Koji Arai Koya Arai Y. Arai S. Araki A. Araya M. C. Araya J. S. Areeda M. Arène N. Aritomi N. Arnaud S. M. Aronson K. G. Arun H. Asada Y. Asali G. Ashton Y. Aso M. Assiduo S. M. Aston P. Astone F. Aubin C. Austin S. Babak F. Badaracco M. K. M. Bader C. Badger S. Bae Y. Bae A. M. Baer S. Bagnasco Y. Bai L. Baiotti J. Baird R. Bajpai M. Ball G. Ballardin S. W. Ballmer A. Balsamo G. Baltus S. Banagiri d. Bankar J. C. Barayoga C. Barbieri B. C. Barish d. Barker P. Barneo F. Barone B. Barr L. Barsotti M. Barsuglia d. Barta J. Bartlett M. A. Barton I. Bartos R. Bassiri A. Basti M. Bawaj J. C. Bayley A. C. Baylor M. Bazzan B. Bécsy V. M. Bedakihale M. Bejger I. Belahcene V. Benedetto d. Beniwal T. F. Bennett J. d. Bentley M. BenYaala F. Bergamin B. K. Berger S. Bernuzzi d. Bersanetti A. Bertolini J. Betzwieser d. Beveridge R. Bhandare U. Bhardwaj d. Bhattacharjee S. Bhaumik I. A. Bilenko G. Billingsley S. Bini R. Birney O. Birnholtz S. Biscans M. Bischi S. Biscoveanu A. Bisht B. Biswas M. Bitossi M.-A. Bizouard J. K. Blackburn C. d. Blair d. G. Blair R. M. Blair F. Bobba N. Bode M. Boer G. Bogaert M. Boldrini L. d. Bonavena F. Bondu E. Bonilla R. Bonnand P. Booker B. A. Boom R. Bork V. Boschi N. Bose S. Bose V. Bossilkov V. Boudart Y. Bouffanais A. Bozzi C. Bradaschia P. R. Brady A. Bramley A. Branch M. Branchesi J. E. Brau M. Breschi T. Briant J. H. Briggs A. Brillet M. Brinkmann P. Brockill A. F. Brooks J. Brooks d. d. Brown S. Brunett G. Bruno R. Bruntz J. Bryant T. Bulik H. J. Bulten A. Buonanno R. Buscicchio d. Buskulic C. Buy R. L. Byer L. Cadonati G. Cagnoli C. Cahillane J. Calderón Bustillo J. d. Callaghan T. A. Callister E. Ca LIGO Laboratory California Institute of Technology Pasadena California 91125 USA Louisiana State University Baton Rouge Louisiana 70803 USA Dipartimento di Farmacia Università di Salerno I-84084 Fisciano Salerno Italy INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy OzGrav School of Physics & Astronomy Monash University Clayton 3800 Victoria Australia LIGO Livingston Observatory Livingston Louisiana 70754 USA University of Wisconsin-Milwaukee Milwaukee Wisconsin 53201 USA OzGrav Australian National University Canberra Australian Capital Territory 0200 Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-30167 Hannover Germany Leibniz Universität Hannover D-30167 Hannover Germany Inter-University Centre for Astronomy and Astrophysics Pune 411007 India University of Cambridge Cambridge CB2 1TN United Kingdom Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena D-07743 Jena Germany University of Birmingham Birmingham B15 2TT United Kingdom Center for Interdisciplinary Exploration & Research in Astrophysics (CIERA) Northwestern University Evanston Illinois 60208 USA Instituto Nacional de Pesquisas Espaciais 12227-010 São José dos Campos São Paulo Brazil Gravity Exploration Institute Cardiff University Cardiff CF24 3AA United Kingdom INFN Sezione di Pisa I-56127 Pisa Italy Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan INFN Sezione di Torino I-10125 Torino Italy Università di Napoli “Federico II” Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy Université de Lyon Université Claude Bernard Lyon 1 CNRS Institut Lumière Matière F-69622 Villeurbanne France Department of Physics The University of Tokyo Bunkyo-ku Tokyo 113-0033 Japan Research Center for the Early Un

Results are presented of searches for continuous gravitational waves from 20 accreting millisecond x-ray pulsars with accurately measured spin frequencies and orbital parameters, using data from the third observing run of the Advanced LIGO and Advanced Virgo detectors. The search algorithm uses a hidden Markov model, where the transition probabilities allow the frequency to wander according to an unbiased random walk, while the J-statistic maximum-likelihood matched filter tracks the binary orbital phase. Three narrow subbands are searched for each target, centered on harmonics of the measured spin frequency. The search yields 16 candidates, consistent with a false alarm probability of 30% per subband and target searched. These candidates, along with one candidate from an additional target-of-opportunity search done for SAX J1808.4−3658, which was in outburst during one month of the observing run, cannot be confidently associated with a known noise source. Additional follow-up does not provide convincing evidence that any are a true astrophysical signal. When all candidates are assumed nonastrophysical, upper limits are set on the maximum wave strain detectable at 95% confidence, h095%. The strictest constraint is h095%=4.7×10−26 from IGR J17062−6143. Constraints on the detectable wave strain from each target lead to constraints on neutron star ellipticity and r-mode amplitude, the strictest of which are ε95%=3.1×10−7 and α95%=1.8×10−5 respectively. This analysis is the most comprehensive and sensitive search of continuous gravitational waves from accreting millisecond x-ray pulsars to date.

关键词： Gravitational waves Binary stars Neutron stars & pulsars

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STATE OF THE CLIMATE IN 2021

引用

BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY 2022年第8期103卷 S1-S1页

作者： Blunden, Jessica NOAA/NESDIS National Centers for Environmental Information Asheville NC United States NOAA NESDIS National Centers for Environmental Information Silver Spring MD United States Met Office Hadley Centre Exeter United Kingdom Cooperative Institute for Satellite Earth System Studies North Carolina State University Asheville NC United States Communications and Outreach NOAA/NESDIS National Centers for Environmental Information Asheville NC United States Innovative Consulting and Management Services LLC NOAA/NESDIS National Centers for Environmental Information Asheville NC United States European Centre for Medium-Range Weather Forecasts Reading United Kingdom CMNS-Earth System Science Interdisciplinary Center University of Maryland College Park MD United States Department of Meteorology National Centre for Earth Observation University of Reading Reading United Kingdom Department of Atmospheric and Planetary Science Hampton University Hampton VA United States National Research Institute for Agriculture Food and Environment (INRAE) CARRTEL Université Savoie Mont Blanc Thonon les Bains France Graduate School of Life and Environmental Sciences Osaka Prefecture University Osaka Sakai Japan University of Bremen Bremen Germany NOAA Global Monitoring Laboratory Boulder CO United States Centro de Investigaciones sobre Desertificación Spanish National Research Council (CIDE CSIC-UV-Generalitat Valenciana) Climate Atmosphere and Ocean Laboratory (Climatoc-Lab) Moncada Valencia Spain Instituto de Geografía Pontificia Universidad Católica de Valparaíso Valparaíso Chile Climatic Research Unit School of Environmental Sciences University of East Anglia Norwich United Kingdom Joint Research Centre of the European Commission Ispra Italy GloH2O Almere Netherlands University of Reading Reading United Kingdom School of Engineering Newcastle University Newcastle-upon-Tyne United Kingdom Université de Paris Cité Institut de physique du globe de Paris CNRS IGN Paris

Editors note: For easy download the posted pdf of the State of the Climate in 2021 is a low-resolution file. A high-resolution copy of the report is available by clickinghere. Please be patient as it may take a few mi... 详细信息

关键词： Greenhouse gases

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