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Impact of transient liquid phase bonding on CuFeNiMnTi high entropy alloy: A microstructural and mechanical perspective

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physica B: Condensed Matter 2025年 712卷

作者： Hosseini, S.H. Adabavazeh, Z. Karimzadeh, F. Abbasi, M.H. Department of Materials Engineering Isfahan University of Technology Isfahan*** Iran Ph.D. Program Graduate Institute of Precision Manufacturing National Chin-Yi University of Technology Taichung411030 Taiwan

High-entropy alloys exhibit unique properties but face challenges in permanent joining, particularly in maintaining mechanical integrity. Transient liquid phase bonding offers an efficient solution using a controlled solidifying interlayer. This study investigates the effect of bonding temperature on the microstructure and mechanical properties of CuFeNiMnTi HEA joints using AWS BNi-2 and pure copper interlayers. Bonding was conducted at 980 °C, 1030 °C, and 1080 °C for 30 min. The HEA was cast using vacuum induction melting and heat-treated at 940 °C for 5 h. Samples underwent polishing, cleaning, and bonding in a furnace. Mechanical performance was assessed through microhardness and shear strength tests, while SEM and XRd characterized the diffusion-affected and isothermally solidified zones. AWS BNi-2 improved microstructural uniformity and increased joint strength from 200 MPa to over 350 MPa, achieving 91 % of the base metal's shear strength. These results confirm its effectiveness in optimizing HEA bonding for high-strength applications. © 2025

关键词： Microhardness

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Cytocompatible and antibacterial Fe-, Cu- and Zn-substituted calcium hydroxyapatite materials for skin applications

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Ceramics International 2025年第9期51卷 11286-11296页

作者： Lukaviciute, L. Lukowiak, A. Stankeviciute, Z. Junka, A. Mortimer, M. Zarkov, A. Yang, J.-C. Ganceviciene, R. Kareiva, A. Faculty of Chemistry and Geosciences Vilnius University Naugarduko st. 24 Vilnius03225 Lithuania Institute of Low Temperature and Structure Research Polish Academy of Sciences Okolna 2 Wroclaw50422 Poland Department of Pharmaceutical Microbiology and Parasitology Wroclaw Medical University Borowska 211A Wroclaw50556 Poland Laboratory of Environmental Toxicology National Institute of Chemical Physics and Biophysics Akadeemia tee 23 Tallinn12618 Estonia Graduate Institute of Nanomedicine and Medical Engineering International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Research Center of Biomedical Device Research Center of Digital Oral Science and Technology Taipei Medical University Taiwan Faculty of Medicine Vilnius University M.K. Ciurlionio st. 21 Vilnius03101 Lithuania

Calcium hydroxyapatite (C10(PO4)6(OH)2;CHAp) and metal-substituted samples (Fe:CHAp, Cu:CHAp, and Zn:CHAp) were synthesized using a recently developed method. This method involved the wet precipitation of amorphous calcium phosphate (ACP), followed by solid-state reaction synthesis of α-tricalcium phosphate (α-TCP), and finally hydrothermal synthesis of CHAp. The effect of Fe3+, Cu2+, and Zn2+ substitution on the phase purity and antimicrobial properties of CHAp are summarized in this study. Notably, it highlights the phase purity of CHAp and Zn:CHAp (in the presence of Fe3+ and Cu2+ ions, the α- and β-TCP phases have formed) as well as the antimicrobial activity of Zn:CHAp and Cu:CHAp against Staphylococcus aureus and Candida albicans. The synthesized nanosized CHAp, Fe:CHAp, Cu:CHAp, and Zn:CHAp samples were used as additives in the preparation of skin creams. In vitro biological studies of the resulting skin creams demonstrated their antimicrobial activity against Pseudomonas aeruginosa, and showed a reduction in osteoblasts cells viability of in the range of 20–40 %. The addition of zinc enhances antimicrobial efficacy but reduces biocompatibility, while copper maintains both high antimicrobial activity and biocompatibility, making it more suitable for the development of medical or cosmetic materials. dermal creams containing CHAp with copper and iron ions also show significant antimicrobial activity while preserving good cell viability. These results highlight the importance of optimizing the balance between antimicrobial effectiveness and biocompatibility in these materials. © 2024

关键词： Biocompatibility

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3d-Printable photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue engineering

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ACS Applied materials and Interfaces 2025年第20期17卷 29455-29468页

作者： Chen, Chieh-Ying Hope Gadia Moreno, Ruaina Lily Wang, Po-Yao Nguyen, Thanh Sang Wu, Jia-Lin Chen, Kuan-Hao Chen, Chih-Hwa Lin, Chia-Ying Wong, Pei-Chun Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei11031 Taiwan International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Trauma Hue Central Hospital Hue530000 Viet Nam Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Orthopedics Research Center Taipei Medical University Hospital Taipei11031 Taiwan Centers for Regional Anesthesia and Pain Medicine Wan Fang Hospital Taipei Medical University Taipei11096 Taiwan Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei23561 Taiwan Convergent Bioscience and Technology Institute Department of Biomedical Engineering and Informatics Indiana University IndianapolisIN46202 United States

Three-dimensional (3d) printing technology has revolutionized the design and fabrication of bone scaffolds, offering precise and customizable solutions for bone tissue engineering. In this study, we developed polycaprolactone (PCL) scaffolds that incorporated gold plasmonic blackbodies (AuPBs) to harness photothermal properties for temperature-controlled bone regeneration. The AuPB-PCL scaffolds demonstrated enhanced mechanical strength, a tunable thermal response under near-infrared (NIR) laser irradiation, and improved osteogenic potential. photothermal stimulation effectively modulated cellular responses, promoting osteoblast proliferation, alkaline phosphatase (ALP) activity, and mineralization. Notably, mild hyperthermia (39-41 °C) induced by laser irradiation optimized osteogenesis, while excessive temperatures (≥42.5 °C) impaired cellular function due to mitochondrial stress and oxidative damage. These findings highlight the potential of AuPB-PCL scaffolds for controlled photothermal bone regeneration, offering a promising strategy for precise, completely noninvasive stimulation of bone repair. © 2025 The Authors. Published by American chemical Society.

关键词： Fiber bonding

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dual functional antibacterial nanofiber membranes: Polyhexamethylene biguanide-integrated alginate-chitosan-dye modified polyamide 56 for single-use biomedical applications

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International Journal of Biological Macromolecules 2025年 310卷 143331页

作者： Liao, Ting-Cjia Le, Quang-Vinh Hanh, Nguyen The duc Liu, Bing-Lan Srinophakun, Penjit Prapainainar, Paweena Chiu, Chen-Yaw Wang, Chi-Yun Ng, I-Son Chen, Kuei-Hsiang Chang, Yu-Kaung of Biochemical Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Center for Environmental Sustainability and Human Health Ming Chi University of Technology Taishan New Taipei City243303 Taiwan Department of Applied Chemistry Chaoyang University of Technology Taichung413310 Taiwan National Center of Excellence for Petroleum Petrochemicals and Advance Material Department of Chemical Engineering Faculty of Engineering Kasetsart University Chatuchak Bangkok10900 Thailand Center for Advanced Studies in Nanotechnology for Chemical Food and Agricultural Industries Kasetsart University Chatuchak Bangkok10900 Thailand Department of Chemical Engineering Ming Chi University of Technology New Taipei City243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Departmental of Chemical Engineering National Cheng Kung University Tainan70101 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Zhongli Dist. Taoyuan City320315 Taiwan

Polyamide 56 (PA56) nanofiber membranes were functionalized with alginate (AG), chitosan (CS), reactive dyes (RG19, RR141), and poly(hexamethylene biguanide) (phMB) to develop multifunctional antimicrobial membranes for single-use applications. The resulting membranes, PA56-AG-CS-RG19-phMB and PA56-AG-CS-RR141-phMB, achieved high antibacterial efficiencies of 97.12 % and 90.65 %, respectively, against Escherichia coli, demonstrating potent bacterial inhibition. The antimicrobial performance results from a synergistic dual mechanism. Chitosan disrupts bacterial adhesion and biofilm formation through electrostatic interactions, while phMB compromises membrane integrity and interferes with intracellular processes. This combined action enhances bactericidal efficacy. The functionalization strategy also maintained excellent biocompatibility, with minimal cytotoxicity observed in L929 fibroblasts. Optimized concentrations of AG and CS were systematically evaluated to ensure balanced antibacterial performance and mechanical stability. These membranes, designed for single-use, exhibited significantly reduced antibacterial activity upon reuse, supporting their intended application. Overall, the integration of chemical and physical antimicrobial strategies within a nanofiber matrix presents a novel and effective approach. This strategy enables the development of next-generation materials suitable for real-world single-use biomedical applications, including wound dressings, food packaging, and protective textiles. © 2025 Elsevier B.V.

关键词： Escherichia coli

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Wireless, self‑powered phototrophic algaerobot‑infused nanotherapeutic hydrogels for enhanced diabetic wound healing

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chemical engineering Journal 2025年 515卷

作者： Huang, Wei-Yung Kang, Jiunn-Horng Chen, Yan-Ting Liang, Jia-Wei Hoai Hoang, Lan pham Nguyen, Hieu Trung Chuang, Andrew E.-Y. Graduate Institute of Biomedical Materials and Tissue Engineering International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City23561 Taiwan International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei110 Taiwan Department of Physical Medicine and Rehabilitation School of Medicine College of Medicine Taipei Medical University No.250 Wuxing Street Xinyi District Taipei110 Taiwan Department of Physical Medicine and Rehabilitation Taipei Medical University Hospital Taipei110 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City700000 Viet Nam Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei11031 Taiwan

diabetic wounds present a significant clinical challenge due to impaired immunity, hypoxia, poor neovascularization, and chronic inflammation, often resulting in severe complications such as amputation. Conventional therapies, including hyperbaric oxygen, antioxidants, and electrical stimulation, face limitations in delivering sustained and safe oxygen, hydrogen, and electrical stimulation to the wound site. This study introduces a groundbreaking approach by integrating phototrophic algae robots (AR) into a methylcellulose (MC) hydrogel, combined with platelet-derived extracellular vesicles (pEVs) and conductive glycol chitosan-polypyrrole nanoparticles (GCS-PPy NPs), forming a multifunctional composite system (MC-pEV-AR-GCS-PPy NPs). This advanced composite addresses the limitations of traditional treatments by integrating continuous, self-powered hydrogen and oxygen generation, electrical stimulation, and hyperthermia, all triggered by light-activated, electromagnetically driven mechanisms. photosynthetic algae robots offer a sustainable solution for the generation of hydrogen and oxygen, effectively targeting the prevalent issues of hypoxia and the deficit frequently encountered in diabetic wounds. This innovative approach improves therapeutic outcomes through the integration of electrochemical processes and nanophototherapeutics, creating a multimodal platform. This platform not only promotes tissue regeneration and angiogenesis but also alleviates hypoxic conditions, modulates immune responses, and addresses key challenges associated with chronic wound healing. Incorporating pEVs amplifies the regenerative potential of the system, accelerating wound healing and promoting tissue regeneration. This self-powered platform not only reduces inflammation and suppresses M1 macrophage bioactivity but also regulates immune responses, creating an optimized healing environment. The MC-pEV-AR-GCS-PPy NPs composite represents a promising translational approach to diabetic wo

关键词： Hyperthermia therapy

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Transdermally administered nanozymes-infused F127/methylcellulose hydrogel for osteoarthritis relief via immunomodulatory pathways

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International Journal of Biological Macromolecules 2025年 314卷 144114页

作者： Chen, Chih-Kuang Chiu, Hui-Wen Nguyen, Hieu Trung Lu, Hsien-Tsung Chuang, Andrew E.-Y. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan School of Medicine Chang Gung University Taoyuan Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City700000 Viet Nam Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Orthopedic Taipei Medical University Hospital Taipei City11031 Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City235603 Taiwan

Osteoarthritis (OA) is a debilitating condition characterized by chronic inflammation, oxidative stress, hypoxia, angiogenesis-driven pain, and cartilage degradation, thus presenting significant therapeutic challenges. Herein, we introduce a wearable percutaneous hydrogel (Pluronic F127/methylcellulose) encapsulation platform, designed to address the multifaceted pathology of OA through a synergistic integration of multifunctional components. This nanomedicine-hydrogel system incorporates platelet-derived extracellular vesicles (pEVs) for inflammation delivery, phototherapeutic molybdenum disulfide (MoS2), capsaicin (CAP) and diferuloylmethane (dIF) for potent anti-inflammatory and antioxidative effects and hydrogen-bonded organic frameworks (HOFs) to enhance drug encapsulation and conductivity. Experimental findings demonstrated the pEV/MoS2/dIF/CAP NZHOF@F127/MC's ability to mitigate inflammation by promoting macrophage polarization from the M1 to the M2 phenotype, alleviate oxidative stress, inhibit angiogenesis, and modulate hypoxic microenvironments through the percutaneous phototherapeutic pEV/MoS2/dIF/CAP NZ-HOF@F127/MC. In vivo studies in a rat model of OA revealed substantial reductions in joint inflammation, enhanced cartilage regeneration, and improved mobility following near-infrared (NIR)-triggered phototherapy. The pEV/MoS2/dIF/CAP NZ-HOF@F127/MC's multifaceted mechanisms, including precise drug delivery, controlled release, and on-demand photo-responsiveness, underscore its transformative potential for OA management. These findings present a promising therapeutic strategy for OA, addressing inflammation, oxidative stress, and joint lesion mitigation, with strong potential for clinical translation. © 2025 Elsevier B.V.

关键词： Controlled drug delivery

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Size-controlled immunomodulatory and vaccine adjuvant potentials of self-assembled hyaluronic acid nanoparticles: Activation and recruitment of immune cells

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International Journal of Biological Macromolecules 2025年 314卷 144265页

作者： Chu, Po-Cheng Birhan, Yihenew Simegniew Zhao, Min-Han Syu, Wei-Jhe Chen, Po-Yen Lin, Yu-Tsen Lai, Ping-Shan Department of Chemistry National Chung Hsing University Taichung 402 Taiwan Basic Research and Development Department Powin Biomedical Co. Ltd. Taichung 428 Taiwan Department of Chemistry College of Natural and Computational Sciences Debre Markos University P.O. Box 269 Debre Markos Ethiopia Department of Chemical and Biomolecular Engineering University of Maryland College Park 20742 MD United States Ph.D. Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung 402 Taiwan

Immunotherapy has paramount importance in treating chronic immune diseases, and vaccine development. Hyaluronic acid (HA) has been shown to elicit molecular weight-related distinct immune responses. Nonetheless, the particle size-dependent immunomodulatory effects of hyaluronic acid nanoparticles (HA-NPs) remain blurred. Thus, the present study aimed at investigating the effect of polymer configuration and particle size of HA-NPs assembled from HA_36K-OdA and HA_360k-OdA analogs in modulating macrophage-related immune activities. In the in vitro experiments, HA-NPs of HA_36k-OdA analogs garnered significantly enhanced nitrite production with low interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) secretion in macrophages. Furthermore, smaller (< 200 nm) HA_36k-OdA NPs activated Cd11b⁺ cells whereas a ∼ 130 nm HA_36k-OdA15 NPs preferentially induced Cd11c⁺ cells in vivo, indicating the influence of particle size on the antigen-presenting cells (APCs) recruitment. Interestingly, self-assembled HA_36k-OdA15 NPs without ovalbumin (OVA) activated immature dendritic cells (dCs) and augmented their migration toward the lymph nodes (LNs). Notably, HA_36k-OdA15-activated macrophages behaved like M1 phenotype macrophages. Overall, our findings garnered valuable insights about the design and application of HA-NPs for modulating the immune responses in nanoscale materials-based immunotherapy. © 2025

关键词： Hyaluronic acid Immunomodulatory Immunotherapy Size-dependent Vaccine

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High-Efficiency Microinverter With Interleaved Switching and Asymmetrical Unipolar Modulation 6

High-Efficiency Microinverter With Interleaved Switching and...

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6th International Future Energy Electronics Conference, IFEEC 2023

作者： Lu, Che-Yu Hsieh, Ming-Yueh National United University Department of Electrical Engineering Miaoli Taiwan National United University Ph.D. Program in Materials and Chemical Engineering Miaoli Taiwan

ISBN: (纸本)9798350339888

This paper introduces a high-efficiency two-stage power microinverter. In the dc-dc stage, a three-phase interleaved inverse buck-type converter is adopted to regulate the dc-bus voltage and improve the input ripples. A band-stop filter and a PR controller are employed to eliminate the double-line frequency ripple. Furthermore, a highly reliable inverter combines an H-bridge topology and two low-frequency switches. Interleaved switching and asymmetrical unipolar modulation are used to improve conversion efficiency. The high and low switching frequency legs synchronization minimizes distortion on the output voltage waveform. Finally, all control algorithms are implemented in a TI dSP TMS320F28069 chip. A 2 kW prototype utilizing GaN devices has been developed and verified. The average efficiency of the overall system achieves 98%. © 2023 IEEE.

关键词： Gallium nitride

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PVA-based bioinks for 3d bioprinting: A comprehensive review of their applications in tissue engineering

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Bioprinting 2025年 49卷

作者： Narges Johari Zary Adabavazeh Francesco Baino Materials Engineering Group Golpayegan College of Engineering Isfahan University of Technology Golpayegan Iran Ph.D. Program Graduate Institute of Precision Manufacturing National Chin-Yi University of Technology Taichung Taiwan ROC Institute of Materials Physics and Engineering Department of Applied Science and Technology Politecnico di Torino Torino Italy

3d bioprinting is an innovative approach that overcomes the limitations of traditional methods for creating cell-laden biomaterials and constructs. It allows for the fabrication of complex and biologically active tissue structures. This review aims to provide a comprehensive evaluation of polyvinyl alcohol (PVA)-based bioinks within a 3d bioprinting framework. PVA-based bioinks exhibit remarkable properties, such as biocompatibility, biodegradability, and the ability to enhance cell growth and differentiation. These properties make them appropriate for many tissue engineering applications. The study evaluates the physicochemical and biological properties of PVA bioinks, including how they combine with other materials such as gelatin, chitin, chitosan, alginate, agarose, cellulose, κ-carrageenan, methacrylate, nanoparticles, mineral additives, carbon nanotubes, graphene oxide, and extracellular matrix components. Furthermore, this review evaluates the benefits of market availability and enhanced printing resolution, in addition to the challenges posed by complexity, dependency on support baths, and the risk of contamination. The objective of this review is to draw attention to the capabilities of PVA-based bioinks and provide guidelines for future research to improve the effectiveness of these materials in tissue engineering and regenerative medicine.

关键词： Bioprinting Bioink Polyvinyl alcohol PVA-based bioinks

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Self-Healable Sandfish Scale-Inspired Scalable Triboelectric Layer for Hybrid Energy Harvesting in desert Environment (Small 4/2025)

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Small 2025年第4期21卷

作者： An-Rong Chen Parag Parashar Manish Kumar Sharma Jing-Siang Shih Hsuan-Yu Yeh Yen-Jui Lin Kuldeep Kaswan Kai-Po Fan Po-Yu Chen Zong-Hong Lin Department of Materials Science and Engineering National Tsing Hua University Hsinchu 30013 Taiwan Department of Biomedical Engineering National Taiwan University Taipei 10617 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu 30013 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu 30013 Taiwan

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