检索结果-内蒙古大学图书馆

Optical sensor for dissolved ammonia by embedding eosin Y in cellulose acetate and silicone rubber via the phase inversion method

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Microchemical Journal 2025年 213卷

作者： Putro, dimas Trio Sari, desy Purnama Chu, Cheng-Shane International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology Taishan Dist. New Taipei City 24301 Taiwan Department of Mechanical Engineering Ming Chi University of Technology Taishan Dist. New Taipei City 24301 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology Taishan Dist. New Taipei City 24301 Taiwan

This study presents the phase inversion method for fabricating a new optical sensing membrane designed for dissolved ammonia detection. Eosin Y was embedded into composite materials of cellulose acetate (CA) and silicone rubber to enhance optical performance and modify the membrane structure. Sensing performance was evaluated using luminescence quenching, which involved measuring changes in both intensity and wavelength. The fabricated membrane exhibited a microporous structure with pore diameters ranging from 1 to 10 µm, a quenching response (I₀/I₄₀₀) of 15.15, a response time (↓t₉₀) of 53 s, and effective detection at a concentration of 400 mM, a room temperature (20–25 °C), and ph 6.02, with sensing response slightly decreasing at elevated temperatures (up to 50 °C) and at ph 3.17 and 9.29. The nonlinear quenching response plot was converted into a linear form using the decibel (dB) formula, significantly improving linearity (R² = 0.9862). The membrane also exhibited excellent selectivity and the ability to detect in both gas and dissolved phases. Additionally, the sensing mechanism was investigated, revealing a combination of static and dynamic quenching, which led to an intensity decrease and a bathochromic shift of 16.56 nm. These findings highlight the potential of the developed optical sensor for rapid and highly selective ammonia monitoring in various environments. © 2025 Elsevier B.V.

关键词： Bathochromic shift dissolved ammonia detection Eosin Y Optical sensing membrane phase inversion method

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ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota

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Molecular Medicine 2025年第1期31卷 1-13页

作者： Liu, Yi-Hsuan Lee, Yueh-Lun Han, Chia-Li Lo, Yu-Chun Liao, Zih-An Shih, Yu-Syuan Lin, Yi-Wen Peng, Syue-Wei Lee, Kang-Yun Ho, Shu-Chuan Wu, Sheng-Ming Lin, Cheng-Wei Chung, Kian Fan Chang, Jer-Hwa Chuang, Hsiao-Chi School of Respiratory Therapy College of Medicine Taipei Medical University Taipei Taiwan Department of Microbiology and Immunology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Master Program in Clinical Genomics and Proteomics College of Pharmacy Taipei Medical University Taipei Taiwan The Ph.D. Program for Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Division of Pulmonary Medicine Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Division of Pulmonary Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan Department of Biochemistry and Molecular Cell Biology Taipei Medical University Taipei Taiwan National Heart and Lung Institute Imperial College London London UK Division of Pulmonary Medicine Department of Internal Medicine Wan Fang Hospital Taipei Medical University Taipei Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei Taiwan

Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), a Type 2 acute phase protein, is critical for resolving inflammation and promoting tissue repair. While its role in chronic respiratory diseases is recognized, its effects on asthma remain unclear. This study investigated the effects of ITIH4 on the modulation of lung and gut microbiota, the attenuation of allergic inflammation, and the improvement of respiratory outcomes in an asthma mouse model. Six-week-old male Balb/c mice were divided into five groups: control, ITIH4, ovalbumin (OVA), and two OVA + ITIH4 treatment groups at different doses. Lung function and oxygen saturation were measured, and bronchoalveolar lavage fluid (BALF) was analyzed for white blood cell counts and cytokines. Lung and gut microbiota were profiled using 16 S rRNA gene sequencing, and short-chain fatty acids (SCFAs) were measured using gas chromatography-mass spectrometry (GC-MS). Proteomic profiling of intestinal tissues was conducted to identify ITIH4-associated signaling pathways. ITIH4 administration significantly mitigated OVA-induced asthma symptoms by reducing weight loss, airway resistance, and tissue damping (p < 0.05). Histological analysis showed decreased airway wall thickening and lung injury scores (p < 0.05). ITIH4 also lowered BALF eosinophils and lymphocytes, IgE, and Th2 cytokines (IL-4, IL-5, and IL-13) (p < 0.05). ITIH4 treatment modulated microbiome composition, enriching Gram-positive taxa (Nocardioidaceae and Acholeplasmataceae) and depleting Gram-negative Helicobacteraceae (p < 0.05). SCFAs correlated with microbiome alterations, notably reduced 4-methylpentanoic acid levels (p < 0.05). Proteomic analysis revealed a dose-dependent activation of granzyme A signaling and suppression of metabolic and solute transport pathways. ITIH4 ameliorates asthma symptoms by modulating lung and gut microbiota, dampening Th2-driven inflammation, and restoring mucosal immune balance. These findings support IT

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Microwave dielectric and structural characteristics in Li2O-B2O3-SiO2 glass ceramics

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Ceramics International 2025年

作者： Qiu, Jun-Yan Tu, Chi-Shun Huang, Szu-Ting Li, Yongxiang Chen, Pin-Yi Chen, Cheng-Sao Montecillo, Rhys Feng, Kuei-Chih International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan Department of Physics Fu Jen Catholic University New Taipei City Taiwan Department of Mechanical Engineering Ming Chi University of Technology New Taipei City Taiwan School of Engineering RMIT University MelbourneVIC3000 Australia Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City Taiwan Department of Mechanical Engineering Hwa Hsia University of Technology New Taipei City Taiwan

Advancements in high-frequency communication devices have emphasized miniaturization and low energy consumption. This work focuses on developing microwave dielectric materials characterized by an ultra-low dielectric constant and low dielectric loss coefficient. In this study, B2O3 and Li2O were added into the SiO2 matrix to form the LBS glass-ceramics. The B2O3-added SiO2 shows a formation of α-cristobalite phase, and the Li2O additive in the B2O3-SiO2 glass-ceramics sintered at 900 °C reveal a primary quartz phase with a secondary phase Li2Si2O5, that partially transformed into Li2SiO3 in the specimen sintered at 950 °C. The LBS12 (x = 12 wt%) show stronger Raman peaks of Li2Si2O5 and Li2SiO3, indicating increase of highly-crystallized Si-O network. As the quartz phase diminishes, Li2Si2O5 and Li2SiO3 begin to develop in the glass-ceramic matrix. dense microstructures and well-formed crystalline grains were observed in the LBS glass-ceramics. The quality factors were primarily affected by grain size and density. The Li2Si2O5 additive in the LBS glass-ceramics can reduce dielectric permittivity (Εr) and increase Q × f, particularly at higher frequencies. A low Εr of 4.7–5, a high Q × f of 2600 GHz, and a hardness of 249 MHV were achieved in the LBS12 sintered at 900 °C. These LBS glass-ceramics exhibit potential for use in low-temperature co-fired ceramic (LTCC) applications in high-frequency communication devices. © 2025

关键词： Sintering

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Harnessing the bishomolithocholic acid scaffold for selective sialyltransferase inhibition: A targeted approach to suppress breast cancer metastasis

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European Journal of Medicinal Chemistry 2025年 292卷 117674页

作者： Perez, Ser John Lynon P. Hsu, Zih-Fan Chang, Tzu-Ting Chen, Chia-Ling Li, Wen-Shan Institute of Chemistry Academia Sinica Taipei 115 Taiwan Department of Applied Chemistry National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Sustainable Chemical Science and Technology Taiwan International Graduate Program Academia Sinica Taipei 115 Taiwan Biomedical Translation Research Center Academia Sinica Taipei 115 Taiwan Department of Chemistry National Taiwan Normal University Taipei 116 Taiwan Department of Medicinal and Applied Chemistry College of Life Science Kaohsiung Medical University Kaohsiung 807 Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei 110 Taiwan Doctoral Degree Program in Marine Biotechnology National Sun Yat-Sen University Kaohsiung 804 Taiwan

ST6GAL1 plays a crucial role in the progression of triple-negative breast cancer (TNBC), highlighting its potential as a therapeutic target for this aggressive cancer subtype. due to the high metastatic potential of TNBC and the limitations of current therapies, selective and potent ST6GAL1 inhibitors are urgently needed. In this study, a scaffold-hopping approach from lithocholic acid to bishomolithocholic acid successfully led to the discovery of novel ST6GAL1 inhibitors, SPP-037 and HZF01, with enhanced biological activity and selectivity. Both compounds significantly inhibited MdA-MB-231 cell migration, HUVEC tube formation, tumor growth, and metastasis in vitro and in vivo. Molecular docking studies revealed key interactions between the ST inhibitors and ST6GAL1, supporting their enhanced selectivity and binding affinity. Additionally, SPP-037 and HZF01 were found to block integrin α2,6-sialylation, disrupting integrin activation and downstream signaling pathways involving the phosphorylation of focal adhesion kinase (FAK) and paxillin, which are critical for cell migration. These results underscore the potential of targeting ST6GAL1 to suppress tumor progression and metastasis, offering a promising avenue for treating aggressive breast cancer. © 2025 Elsevier Masson SAS

关键词： Bishomolithocholic acid Breast cancer metastasis Integrin-FAK-Paxillin axis N-glycan sialylation Sialyltransferase inhibitor ST6GAL1

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Achieving high surface bioactivity and adhesion in Ti-6Al-4V alloy via anodic oxidation and electrophoretic deposition

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Ceramics International 2025年

作者： Wu, Yu-Jie Wang, Chi-Yun Mana-ay, Haidee Tu, Chi-Shun Lai, Po-Liang Chen, Pin-Yi International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Physics Fu Jen Catholic University New Taipei City24205 Taiwan Bone and Joint Research Center Department of Orthopedic Surgery Chang Gung Memorial Hospital Taoyuan City33305 Taiwan Department of Mechanical Engineering Chang Gung University Taoyuan City33302 Taiwan Department of Physics Silliman University Dumaguete City6200 Philippines

This study combines 3d printing, anodic oxidation (AO), and electrophoretic deposition (Ed) technologies to develop Ti-6Al-4V alloy (abbreviated as Ti64) with high hydrophilicity, adhesion, and bioactivity. Titanium oxide nanotubes formed by AO treatment on the Ti64 surface exhibited reduced contact angles from 53 ° to 10 °. The adhesion of the calcium (Ca) layer through the integrated technology of the AO and Ed treatments (herein abbreviated as AEd) displays an optimal adhesive force of over 30 N on the Ti64 surface, which is attributed to the stable chemical bond due to the formation of OH− ions on the substrate after the AO treatment and the subsequent oxidation reaction of the Ca2+ ions to form a predominantly Ca(OH)2 layer after the Ed treatment. Moreover, the AEd treatment forms tiny needle-like structures that can effectively promote osteogenic differentiation. The expressions of the osteocyte marker genes (i.e., OCN, OPN, and dMP1) were improved after the AEd treatment, showing increased osteogenic differentiation into mature bone tissue. This work presents the AEd treatment as a valuable surface modification technique to boost the surface bioactivity of Ti64 for clinical orthopedic applications. © 2025

关键词： Anodic oxidation

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A Critique of Traditional Relationship Models

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Cambridge Quarterly of Healthcare Ethics 1994年第1期3卷 27-37页

作者： Loewy, Roberta Springer A Ph.D. candidate in the Philosophy Department and a Teaching Associate in the Medical Humanities Program Loyola University of Chicago

Today's ever-widening expert/novice gap–in technology generally but in healthcare technology especially–has been implicated as both cause and consequence of a sharp rise in fundamental misunderstandings between medical professionals and lay populace. Recently created social roles (e.g., clinical medical ethicists) and institutions (e.g., hospital ethics committees) have further prompted critics to suggest that a multiplication of “disinterested” experts not only fails to resolve such misunderstandings, it compounds them. As a result, it should come as no surprise that the problem of paternalistic expertise has emerged as an ethical issue of immense interest from both a theoretical and practical standpoint. For this reason, a critical inquiry in healthcare today centers on finding a practical model that most adequately and accurately characterizes patient–physician relationships.

关键词： Analytical Approach philosophical Approach Professional Patient Relationship

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Increased body mass index may have more happiness, life satisfaction, and self-rated health in the aging process: A 10-year longitudinal study

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Geriatric Nursing 2025年 64卷

作者： Hsin-Yen YEN Gong-Hong LIN Hao-Yun HUANG School of Gerontology and Long-term Care College of Nursing Taipei Medical University Taiwan International Ph.D. Program in Gerontology and Long-Term Care College of Nursing Taipei Medical University Taiwan Mater Hospital Brisbane QLD Australia

Understanding intricate relationships among various determinants of overall well-being is crucial for promoting healthy aging. The body mass index (BMI), happiness, life satisfaction, and self-rated health are key indicators of well-being in older adults. However, the dynamic interplay among these factors and the BMI was previously unclear. This study aimed to investigate longitudinal associations between the BMI and happiness, life satisfaction, and self-rated health. The study design was a 10-year longitudinal study. data were retrieved from the database of the Panel Study of Family dynamics, Taiwan. In total, 1298 participants with a mean age of 64.71 years at the time of the first wave served as the main sample for the secondary data analysis. Parallel latent growth modeling was performed to assess relationships between the BMI and various indicators over time. Results for all participants showed that the intercept of the BMI was positively associated with the intercepts of happiness (β=0.260, p = 0.038) and life satisfaction (β=0.274, p = 0.021) and negatively associated with the intercept of self-rated health (β=-0.145, p = 0.041). The slope of the BMI was positively associated with the slopes of happiness (β=0.003, p = 0.036), life satisfaction (β=0.005, p < 0.001), and self-rated health (β=0.002, p = 0.007). All indices suggested a satisfactory model fit. These findings suggested that a slight increase in the BMI may be beneficial for the well-being of older adults, leading to a happier, healthier, and more satisfying later life.

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Global Clock Coordination by the Brain Clock in the Suprachiasmatic Nucleus Through Relay and Amplification of diffusible and Neural Signaling

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European Journal of Neuroscience 2025年第8期61卷

作者： Silver, Rae Yao, Yifan Myung, Jihwan Department of Psychology Columbia University New York NY United States Department of Neuroscience and Behavior Barnard College New York NY United States Department of Pathology and Cell Biology Columbia University Medical School New York NY United States Zuckerman Institute Affiliate Columbia University New York NY United States Graduate Institute of Mind Brain and Consciousness Taipei Medical University New Taipei City Taiwan Graduate Institute of Medical Sciences Taipei Medical University Taipei Taiwan Ph.D. Program in Neuroscience of Cognition and Consciousness Taipei Medical University New Taipei City Taiwan

The brain clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus receives direct retinal input, thereby providing the entire body with an internal representation of external solar time. The pathways by which this small nucleus signals so broadly involve co-occurring nervous and diffusible output signals, although the latter are less understood. Portal pathways, such as the well-known pituitary portal pathway, provide a mechanism, whereby signals of neural origin can reach local, specialized targets without suffering dilution in the systemic blood supply. Newly discovered vascular pathways involve direct connections between each of the sensory circumventricular nuclei at its point of attachment to the brain. These nuclei line the brain's ventricles, and their leaky blood vessels and large perivascular spaces represent a route, whereby secretions from the SCN can be relayed and then amplified, providing a pathway to achieve global coordination of circadian clock signaling. This review provides a narrative that incorporates our understanding of SCN neural and diffusible output signals, with particular emphasis on the contribution of brain fluidic compartments and the fluids therein. © 2025 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

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Prediction tools for assessing functional impacts of gene mutations in Clear Cell Renal Cell Carcinoma: A comparative study

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Computers in Biology and Medicine 2025年第PT A期192卷 110187-110187页

作者： Yang, Cheng-Hong Lin, Guan-Cheng Wu, Chih-Hsien Chen, Jin-Bor Chuang, Li-Yeh Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan Division of Nephrology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taiwan Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan Taiwan

Renal cell carcinoma (RCC) is a well-known malignancy characterized by specific gene mutations that elevate its occurrence. It can be categorized into clear cell RCC (ccRCC), papillary RCC, and chromophobe RCC, which account for approximately 85 % of all primary RCC cases. The mutations typically involve single-nucleotide variants (SNVs) that lead to amino acid substitutions, which influence various biological functions, including gene expression. Therefore, predicting the functional consequences of RCC-related single-nucleotide polymorphisms (SNPs), including substitutions, insertions, deletions, and duplications, is crucial for the effective clinical management of RCC. In recent years, the accessibility and popularity of tools for predicting SNP functional variations have grown, especially in research concerning the potential risks associated with key gene mutations in cancer. Accordingly, this study focused on commonly mutated genes in ccRCC, namely VHL, BAP1, PBRM1, and SETd2. Public data from sources such as The Cancer Genome Atlas and the National Center for biotechnology Information were used to identify 61 gene mutation positions. Nine nonsynonymous mutation prediction tools were used for analysis, namely SIFT, Polyphen-2, Mutation Assessor, Fathmm, MutPred, CHASM, Revel, Provean, and SNP&GO. The tools were evaluated by their statistical performance, prediction distribution, and receiver operating characteristic curves. The three tools with the highest accuracy for predicting the functional consequences of mutations in the four frequently mutated genes associated with ccRCC were SIFT (accuracy of 0.75), Provean (0.7), and Polyphen-2 (0.69). These findings offer valuable insights into predicting ccRCC-related gene mutation effects, but further research and validation are essential to support their clinical applications. © 2025

关键词： Transcription

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3d-Printable photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue Engineering

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ACS Applied Materials and Interfaces 2025年第20期17卷 29455-29468页

作者： Chen, Chieh-Ying Hope Gadia Moreno, Ruaina Lily Wang, Po-Yao Nguyen, Thanh Sang Wu, Jia-Lin Chen, Kuan-Hao Chen, Chih-Hwa Lin, Chia-Ying Wong, Pei-Chun Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei11031 Taiwan International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Trauma Hue Central Hospital Hue530000 Viet Nam Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Orthopedics Research Center Taipei Medical University Hospital Taipei11031 Taiwan Centers for Regional Anesthesia and Pain Medicine Wan Fang Hospital Taipei Medical University Taipei11096 Taiwan Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei23561 Taiwan Convergent Bioscience and Technology Institute Department of Biomedical Engineering and Informatics Indiana University IndianapolisIN46202 United States

Three-dimensional (3d) printing technology has revolutionized the design and fabrication of bone scaffolds, offering precise and customizable solutions for bone tissue engineering. In this study, we developed polycaprolactone (PCL) scaffolds that incorporated gold plasmonic blackbodies (AuPBs) to harness photothermal properties for temperature-controlled bone regeneration. The AuPB-PCL scaffolds demonstrated enhanced mechanical strength, a tunable thermal response under near-infrared (NIR) laser irradiation, and improved osteogenic potential. photothermal stimulation effectively modulated cellular responses, promoting osteoblast proliferation, alkaline phosphatase (ALP) activity, and mineralization. Notably, mild hyperthermia (39-41 °C) induced by laser irradiation optimized osteogenesis, while excessive temperatures (≥42.5 °C) impaired cellular function due to mitochondrial stress and oxidative damage. These findings highlight the potential of AuPB-PCL scaffolds for controlled photothermal bone regeneration, offering a promising strategy for precise, completely noninvasive stimulation of bone repair. © 2025 The Authors. Published by American Chemical Society.

关键词： Fiber bonding

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