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Development of a traditional Chinese medicine-based agent for the treatment of cancer cachexia

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE 2022年第4期13卷 2073-2087页

作者： Wu, Kun-Chang Chu, Po-Chen Cheng, Yu-Jung Li, Chia-Ing Tian, Jingkui Wu, Hsing-Yu Wu, Szu-Hsien Lai, Yi-Chun Kao, Hsiang-Han Hsu, Ao-Lin Lin, Hsiang-Wen Lin, Chih-Hsueh China Med Univ Sch Pharm Coll Pharm Taichung Taiwan China Med Univ Res Ctr Healthy Aging Taichung Taiwan China Med Univ Dept Cosmeceut Taichung Taiwan China Med Univ Grad Inst Cosmeceut Taichung Taiwan China Med Univ Dept Phys Therapy Taichung Taiwan China Med Univ Grad Inst Rehabil Sci Taichung Taiwan China Med Univ Hosp Dept Rehabil Taichung Taiwan China Med Univ Sch Med Coll Med Taichung Taiwan China Med Univ Hosp Dept Med Res Taichung Taiwan Univ Chinese Acad Sci Zhejiang Canc Hosp Chinese Acad Sci Inst Canc & Basic MedCanc Hosp Hangzhou Peoples R China Zhejiang Univ Coll Biomed Engn & Instrument Sci Hangzhou Peoples R China Acad Sinica Inst Biol Chem Taipei Taiwan China Med Univ Inst New Drug Dev Taichung Taiwan China Med Univ Hosp Dept Family Med Taichung Taiwan China Med Univ PhD Program Aging Taichung Taiwan Univ Michigan Sch Med Dept Internal Med Div Geriatr & Palliat Med Ann Arbor MI USA China Med Univ Hosp Dept Pharm Taichung Taiwan Univ Illinois Coll Pharm Dept Pharm Syst Outcomes & Policy Chicago IL 60612 USA China Med Univ Hosp Dept Geriatr Med Taichung Taiwan

Background Despite recent advances in understanding the pathophysiology of cancer cachexia, prevention/treatment of this debilitating disease remains an unmet medical need. Methods We developed an integrated, multi-tiered strategy involving both in vitro and in vivo muscle atrophy platforms to identify traditional Chinese medicine (TCM)-based anti-cachectic agents. In the initial screening, we used inflammatory cytokine-induced atrophy of C2C12 myotubes as a phenotypic screening platform to assess the protective effects of TCMs. The selected TCMs were then evaluated for their abilities to protect Caenorhabditis elegans from age-related reduction of mobility and contractility, followed by the C-26 colon adenocarcinoma mouse model of cachexia to confirm the anti-muscle atrophy effects (body/skeletal muscle weights, fibre size distribution, grip strengths, and serum IL-6). Transcriptome analysis, quantitative real-time polymerase chain reaction, and immunoblotting were performed to gain understanding of the potential mechanism(s) by which effective TCM protected against C26 tumour-induced muscle atrophy. Results Of 29 widely used TCMs, Dioscorea radix (DR) and Mu Dan Pi (MDP) showed a complete protection (all P values, 0.0002) vis-a-vis C26 conditioned medium control in the myotube atrophy platform. MDP exhibited a unique ability to ameliorate age-associated decreases in worm mobility, accompanied by improved total body contractions, relative to control (P < 0.0001 and <0.01, respectively), which, however, was not noted with DR. This differential in vivo protective effect between MDP and DR was also confirmed in the C-26 mouse model. MDP at 1000 mg/kg (MDP-H) was effective in protecting body weight loss (P < 0.05) in C-26 tumour-bearing mice without changing food or water intake, accompanied by the restoration of the fibre size distribution of hindleg skeletal muscles (P < 0.0001) and the forelimb grip strength (P < 0.05). MDP-treated C-26-tumour-bearing mice were aler

关键词： Cachexia Traditional Chinese medicine Muscle atrophy C-26 tumour-bearing model Caenorhabditis elegans model

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Targeted metabolomics analysis of postoperative delirium

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SCIENTIFIC REPORTS 2021年第1期11卷 1-13页

作者： Tripp, Bridget A. Dillon, Simon T. Yuan, Min Asara, John M. Vasunilashorn, Sarinnapha M. Fong, Tamara G. Metzger, Eran D. Inouye, Sharon K. Xie, Zhongcong Ngo, Long H. Marcantonio, Edward R. Libermann, Towia A. Otu, Hasan H. Univ Nebraska Dept Elect & Comp Engn Nebraska Hall E419POB 880511 Lincoln NE 68588 USA Univ Nebraska PhD Program Complex Biosyst Lincoln NE 68588 USA Beth Israel Deaconess Med Ctr Prote Bioinformat & Syst Biol Ctr Boston MA 02215 USA Harvard Med Sch Boston MA 02115 USA Beth Israel Deaconess Med Ctr Div Signal Transduct & Mass Spectrometry Core Boston MA 02215 USA Beth Israel Deaconess Med Ctr Dept Med Boston MA 02215 USA Harvard TH Chan Sch Publ Hlth Boston MA USA Beth Israel Deaconess Med Ctr Dept Neurol Boston MA 02215 USA Hebrew SeniorLife Marcus Inst Aging Res Aging Brain Ctr Boston MA USA Hebrew SeniorLife Dept Med Boston MA USA Beth Israel Deaconess Med Ctr Dept Psychiat Boston MA 02215 USA Massachusetts Gen Hosp Dept Anesthesia Crit Care & Pain Med Boston MA 02114 USA

Postoperative delirium is the most common complication among older adults undergoing major surgery. The pathophysiology of delirium is poorly understood, and no blood-based, predictive markers are available. We characterized the plasma metabolome of 52 delirium cases and 52 matched controls from the Successful aging after Elective Surgery (SAGES) cohort (N=560) of patients >= 70 years old without dementia undergoing scheduled major non-cardiac surgery. We applied targeted mass spectrometry with internal standards and pooled controls using a nested matched case-control study preoperatively (PREOP) and on postoperative day 2 (POD2) to identify potential delirium risk and disease markers. Univariate analyses identified 37 PREOP and 53 POD2 metabolites associated with delirium and multivariate analyses achieved significant separation between the two groups with an 11-metabolite prediction model at PREOP (AUC=83.80%). Systems biology analysis using the metabolites with differential concentrations rendered "valine, leucine, and isoleucine biosynthesis" at PREOP and "citrate cycle" at POD2 as the most significantly enriched pathways (false discovery rate<0.05). Perturbations in energy metabolism and amino acid synthesis pathways may be associated with postoperative delirium and suggest potential mechanisms for delirium pathogenesis. Our results could lead to the development of a metabolomic delirium predictor.

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Genotyping of methicillin-resistant Staphylococcus aureus isolates causing invasive infections using spa typing and their correlation with antimicrobial susceptibility

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INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 2022年第3期59卷 106525-106525页

作者： Wang, Wei-Yao Hsueh, Po-Ren Tsao, Shih-Ming Chung Shan Med Univ Sch Med Taichung Taiwan Chung Shan Med Univ Hosp Dept Internal Med 110Sect 1Jianguo North Rd Taichung 40201 Taiwan Cent Taiwan Univ Sci & Technol Dept Med Lab Sci & Biotechnol Taichung Taiwan China Med Univ Hosp Dept Lab Med Taichung Taiwan China Med Univ Hosp Dept Internal Med Taichung Taiwan China Med Univ Sch Med Taichung Taiwan China Med Univ Sch Med PhD Program Aging Taichung Taiwan

Correlation of antimicrobial susceptibility patterns with particular spa types could help physicians select appropriate antibiotics for the treatment of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections. The aim of this study was to investigate invasive MRSA isolates through delineating the molecular typing results and correlating them with antibiotic susceptibility testing results. A total of 670 non duplicate mecA-positive MRSA isolates from patients with invasive infections were collected from a 5-year nationwide antimicrobial surveillance programme [Tigecycline In vitro Surveillance in Taiwan (TIST)] and 58 spa types were identified among 639 isolates (95.4%) by determining the allelic profile of the spa gene using PCR and nucleotide sequencing. Six major spa types, including spa t002 ( n = 103;15.4%) and t037 ( n = 253, 37.8%), were classified as healthcare-associated MRSA (HA-MRSA;53.1%), while t437 ( n = 151;22.5%), t441 ( n = 13;1.9%), t1081 ( n = 19;2.8%) and t3525 ( n = 14;2.1%) were classified as community associated MRSA (CA-MRSA;29.4%). Antimicrobial susceptibility was determined by agar dilution or broth microdilution for various antibiotics, and Etest was also used both for daptomycin and vancomycin. The declining trend in vancomycin minimum inhibitory concentration (MIC) was in parallel with an increasing frequency of CA-MRSA. Antibiotic susceptibility patterns were correlated with particular spa types and this correlation could help physicians select appropriate antibiotics for the treatment of invasive MRSA infections. (c) 2022 Published by Elsevier Ltd.

关键词： Methicillin-resistant Staphylococcus aureus MRSA spa typing Minimum inhibitory concentration Antibiogram Invasive infections

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JOURNAL OF INFECTION 2022年第6期85卷 E175-E176页

作者： Lee, Jia-Arng Lee, Tai-fen Huang, Yu-Tsung Hsueh, Po-Ren Natl Taiwan Univ Natl Taiwan Univ Hosp Dept Lab Med Coll Med Taipei Taiwan Natl Taiwan Univ Grad Inst Clin Lab Sci & Med Biotechnol Taipei Taiwan China Med Univ China Med Univ Hosp Sch Med Dept Lab Med Taichung Taiwan China Med Univ China Med Univ Hosp Sch Med Dept Internal Med Taichung Taiwan China Med Univ Coll Med PhD Program Aging Taichung Taiwan

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Psychological stress and epigenetic aging in older men: The VA normative aging study

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Translational Medicine of aging 2023年第1期7卷 66-74页

作者： Nwanaji-Enwerem, Jamaji C. Cardenas, Andres Gao, Xu Wang, Cuicui Vokonas, Pantel Spiro, Avron Osborne, Anwar D. Kosheleva, Anna Hou, Lifang Baccarelli, Andrea A. Schwartz, Joel Gangarosa Department of Environmental Health Emory Rollins School of Public Health Atlanta GA United States Department of Emergency Medicine Emory University School of Medicine Atlanta GA United States Department of Epidemiology and Population Health Stanford School of Medicine Stanford CA United States Department of Occupational and Environmental Health Sciences Peking University Beijing China Department of Environmental Health Harvard T.H. Chan School of Public Health and MD/PhD Program Harvard Medical School Boston MA United States Veterans Affairs Boston Healthcare System and the Department of Medicine Boston University School of Medicine VA Normative Aging Study Boston MA United States Massachusetts Veterans Epidemiology and Research Information Center VA Boston Healthcare System Boston MA United States Department of Epidemiology Boston University School of Public Health Boston MA United States Department of Psychiatry Boston University School of Medicine Boston MA United States Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL United States Department of Environmental Health Sciences Columbia Mailman School of Public Health New York NY United States

Psychological stress remains an important risk factor for morbidity and mortality throughout the life course. However, there have been counterintuitive findings reported in previous studies of older persons that examine the relationships of perceived psychological stress with DNA methylation-based markers of aging, which also serve as predictors of morbidity and mortality (epigenetic age/clocks). We aimed to replicate and expand findings from existing work by examining relationships of self-reported stress with nine epigenetic clocks: Hannum, Horvath, Intrinsic, Extrinsic, SkinBloodClock, PhenoAge, GrimAge, DNAm Telomere Length, and Pace of aging. We analyzed data from 607 male participants (mean age 73.2 years) of the VA Normative aging Study with one to two study visits from 1999 to 2007 (observations = 956). Stress was assessed via the 14-item Perceived Stress Scale (PSS). Epigenetic age was calculated from DNA methylation measured in leukocytes with the HumanMethylation450 BeadChip. In linear mixed effects models adjusted for demographic/lifestyle/health factors, a standard deviation (sd) increase in PSS was associated with Horvath (β = −0.35-years, 95%CI: −0.61, −0.09, P = 0.008) and Intrinsic (β = −0.40-years, 95%CI: −0.67, −0.13, P = 0.004) epigenetic age deceleration. However, in models limited to participants with the highest levels of stress (≥75th-percentile), Horvath (β = 2.29-years, 95%CI: 0.16, 4.41, P = 0.04) and Intrinsic (β = 2.06-years, 95%CI: −0.17, 4.28, P = 0.07) age acceleration associations were observed. Our results reinforce the complexity of psychological stress and epigenetic aging relationships and lay a foundation for future studies that explore longitudinal relationships with other adult stress metrics and factors that can influence stress such as resilience measures. © 2023 The Authors

关键词： Biological age DNA methylation DNAm age Epigenetic clock Perceived stress Trauma

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Leu²⁷IGF-II-induced hypertrophy in H9c2 cardiomyoblasts is ameliorated by saffron by regulation of calcineurin/NFAT and CaMKIIδ signaling

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ENVIRONMENTAL TOXICOLOGY 2021年第12期36卷 2475-2483页

作者： Lin, Chin-Yi Shibu, Marthandam Asokan Wen, Renee Day, Cecilia Hsuan Chen, Ray-Jade Kuo, Chia-Hua Ho, Tsung-Jung Viswanadha, Vijaya Padma Kuo, Wei-Wen Huang, Chih-Yang China Med Univ PhD Program Aging Taichung Taiwan Yuan Sheng Hosp Dept Chinese Med Changhua Taiwan Buddhist Tzu Chi Med Fdn Hualien Tzu Chi Hosp Cardiovasc & Mitochondria Related Dis Res Ctr Hualien Taiwan Walnut High Sch Walnut CA USA Taipei City Hosp Dept Dermatol Taipei Taiwan China Med Univ Dept Biol Sci & Technol Coll Biopharmaceut & Food Sci Taichung Taiwan Mei Ho Univ Dept Nursing Pingtung Taiwan Taipei Med Univ Dept Surg Sch Med Coll Med Taipei Taiwan Univ Taipei Lab Exercise Biochem Taipei Taiwan Buddhist Tzu Chi Med Fdn Hualien Tzu Chi Hosp Dept Chinese Med Hualien Taiwan Buddhist Tzu Chi Med Fdn Integrat Ctr Tradit Chinese & Modern Med Hualien Tzu Chi Hosp Hualien Taiwan Tzu Chi Univ Sch Postbaccalaureate Chinese Med Coll Med Hualien Taiwan Bharathiar Univ Dept Biotechnol Coimbatore Tamil Nadu India China Med Univ Dept Biol Sci & Technol Taichung Taiwan China Med Univ PhD Program Biotechnol Ind Taichung Taiwan China Med Univ Grad Inst Biomed Sci Taichung Taiwan Tzu Chi Univ Sci & Technol Ctr Gen Educ Buddhist Tzu Chi Med Fdn Hualien Taiwan China Med Univ Hosp Dept Med Res Taichung Taiwan Asia Univ Dept Biotechnol Taichung Taiwan

The insulin-like growth factor II receptor (IGF-IIR) induces myocardial hypertrophy under various pathological conditions like diabetes and hypertension via G protein receptors like G alpha q or G alpha s. Increased expression of the ligand IGF II and IGF-IIR induces pathological hypertrophy through downstream signaling mediators such as calcineurin, nuclear factor of activated T cells 3 and calcium-calmodulin (CaM)-dependent kinase II (CaMKII)-histone deacetylase 4 (HDAC4). The dried stigma of Crocus sativus L. (saffron) has a long repute as a traditional medicine against various disorders. In the present study, we have investigated whether C. sativus extract (CSE) canameliorate Leu(27)IGF-II triggered hypertrophy and have elucidated the underlying mechanism of protection. Additionally, the effects of oleic acid (OA), an activator of calcineurin and CaMKII was investigated thereof. The results demonstrate that CSE can ameliorate Leu(27)IGF-II-induced hypertrophy seemingly through regulation of calcineurin-NFAT3 and CaMKII-HDAC4 signaling cascade.

关键词： calcineurin CaMKII cardiac hypertrophy NFATc3 saffron

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Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole-brain modeling

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ALZHEIMERS & DEMENTIA 2024年第5期20卷 3228-3250页

作者： Coronel-Oliveros, Carlos Gomez, Raul Gonzalez Ranasinghe, Kamalini Sainz-Ballesteros, Agustin Legaz, Agustina Fittipaldi, Sol Cruzat, Josephine Herzog, Ruben Yener, Gorsev Parra, Mario Aguillon, David Lopera, Francisco Santamaria-Garcia, Hernando Moguilner, Sebastian Medel, Vicente Orio, Patricio Whelan, Robert Tagliazucchi, Enzo Prado, Pavel Ibanez, Agustin Univ Adolfo Ibanez Latin Amer Brain Hlth Inst BrainLat Santiago Chile Univ Calif San Francisco UCSFA Global Brain Hlth Inst GBHI San Francisco CA USA Trinity Coll Dublin Dublin Ireland Univ Valparaiso Ctr Interdisciplinario Neurociencia Valparaiso CIN Valparaiso Chile Univ Adolfo Ibanez Ctr Social & Cognit Neurosci Sch Psychol Santiago Chile Univ Calif San Francisco Memory & Aging Ctr Dept Neurol San Francisco CA USA Univ San Andres Cognit Neurosci Ctr CNC Victoria Buenos Aires Argentina Izmir Univ Econ Fac Med Sakarya Turkiye Dokuz Eylul Univ Brain Dynam Multidisciplinary Res Ctr Alsancak Turkiye Univ Strathclyde Sch Psychol Sci & Hlth Glasgow Scotland Univ Antioquia Neurosci Res Grp Bogota Colombia Pontificia Univ Javeriana PhD Program Neurosci Bogota Colombia Hosp Univ San Ignacio Ctr Memory & Cognit Intellectus Bogota Colombia Univ Sydney Brain & Mind Ctr Sydney NSW Australia Univ Chile Dept Neurosci Santiago Chile Univ Valparaiso Fac Ciencias Inst Neurociencia Valparaiso Chile Univ Buenos Aires Buenos Aires Phys Inst Intendente Guiraldes 2160Ciudad Univ Buenos Aires Argentina Univ Buenos Aires Phys Dept Intendente Guiraldes 2160Ciudad Univ Buenos Aires Argentina Univ San Sebastian Escuela Fonoaudiol Fac Odontol & Ciencias Rehabil Santiago Region Metropol Chile Trinity Coll Dublin Inst Neurosci Dublin Ireland Univ San Sebastian Escuela Fonoaudiol Fac Odontol & Ciencias Rehabil Ricardo Cumming 40 Santiago 8340593 Region Metropol Chile

INTRODUCTIONAlzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) lack mechanistic biophysical modeling in diverse, underrepresented populations. Electroencephalography (EEG) is a high temporal resolution, cost-effective technique for studying dementia globally, but lacks mechanistic models and produces non-replicable *** developed a generative whole-brain model that combines EEG source-level metaconnectivity, anatomical priors, and a perturbational approach. This model was applied to Global South participants (AD, bvFTD, and healthy controls).RESULTSMetaconnectivity outperformed pairwise connectivity and revealed more viscous dynamics in patients, with altered metaconnectivity patterns associated with multimodal disease presentation. The biophysical model showed that connectome disintegration and hypoexcitability triggered altered metaconnectivity dynamics and identified critical regions for brain stimulation. We replicated the main results in a second subset of participants for validation with unharmonized, heterogeneous recording *** results provide a novel agenda for developing mechanistic model-inspired characterization and therapies in clinical, translational, and computational neuroscience settings.

关键词： Alzheimer's disease electroencephalography frontotemporal dementia hypoexcitation metaconnectivity neurodegeneration structural connectivity whole-brain modeling

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Multicenter surveillance of in vitro activities of cefepime-zidebactam, cefepime-enmetazobactam, omadacycline, eravacycline, and comparator antibiotics against Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii complex causing bloodstream infection in Taiwan, 2020

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EXPERT REVIEW OF ANTI-INFECTIVE THERAPY 2022年第6期20卷 941-953页

作者： Jean, Shio-Shin Ko, Wen-Chien Lu, Min-Chi Lee, Wen-Sen Hsueh, Po-Ren Tajen Univ Coll Pharm & Hlth Care Dept Pharm Pingtung Taiwan Min Sheng Gen Hosp Dept Emergency Taoyuan Taiwan Min Sheng Gen Hosp Dept Crit Care Med Taoyuan Taiwan Natl Cheng Kung Univ Coll Med Dept Med Tainan Taiwan China Med Univ Sch Med Dept Microbiol & Immunol Taichung Taiwan Taipei Med Univ Wan Fang Hosp Dept Internal Med Div Infect Dis Taipei Taiwan Taipei Med Univ Coll Med Sch Med Dept Internal Med Taipei Taiwan China Med Univ China Med Univ Hosp Sch Med Dept Lab Med Taichung Taiwan China Med Univ China Med Univ Hosp Sch Med Dept Internal Med Taichung Taiwan China Med Univ Sch Med Taichung Taiwan China Med Univ Sch Med PhD Program Aging Taichung Taiwan Natl Taiwan Univ Natl Taiwan Univ Hosp Dept Lab Med Coll Med Taipei Taiwan Natl Taiwan Univ Natl Taiwan Univ Hosp Dept Internal Med Coll Med Taipei Taiwan

Objectives To determine the in vitro activities of novel and comparator antibiotics against Gram-negative bacteria (GNB) in Taiwan. Methods Isolates of Escherichia coli (n = 335), Klebsiella pneumoniae (n = 316;144 isolates with hyperviscosity characteristics), Pseudomonas aeruginosa (n = 271), Acinetobacter baumannii complex (n = 187), and non-typhoidal Salmonella species (n = 226), Shigella species (n = 13) from miscellaneous culture sources were collected in 2020 in Taiwan. The MICs of the isolates to test antibiotics were determined using the broth microdilution method. GeneXpert was used to detect genes encoding carbapenemases among the carbapenem-non-susceptible (NS) Enterobacterales isolates. Results The MIC values of the cefepime-enmetazobactam combination against extended-spectrum beta-lactamase-producing E. coli and K. pneumoniae isolates (MIC90 <= 0.5 mg/L), bla(KPC)-harboring E. coli isolates (0.25 mg/L;n = 2), and 80% of bla(OXA-48)-like gene-harboring K. pneumoniae isolates (<= 2 mg/L) were low. The MIC ranges of the cefepime-zidebactam against carbapenemase-producing Enterobacterales isolates (irrespective of the carbapenemase type [MIC90 <= 4 mg/L]) and carbapenem-NS or ceftolozane-tazobactam-NS P. aeruginosa isolates (MIC90 value, 8 mg/L) were significantly lower than those of the cefepime-enmetazobactam. Conclusions The efficacy of novel antibiotics against important drug-resistant GNB must be monitored and validated during the clinical treatment of patients.

关键词： Carbapenemase cefepime-enmetazobactam cefepime-zidebactam omadacycline gram-negative bacteria

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Enhancing patient self-management after a first stroke: An application of the wearable devices and the health management platform

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Disability and Health Journal 2023年第1期16卷 101392-101392页

作者： Wu, Jia-Min Chen, Hsin-Shui Chen, Hsin-Han Cheng, Bor-Wen Huang, Chiu-Wen Chung, Ming-Hung Department of Industrial Engineering and Management National Yunlin University of Science and Technology No.123 University Road Section 3 Douliou Yunlin City 64002 Taiwan PhD Program for Aging College of Medicine China Medical University No. 100 Sec. 1 Jingmao Rd Beitun Dist Taichung City 406040 Taiwan Department of Physical Medicine & Rehabilitation National Taiwan University Hospital Yunlin Branch No.579 Sec. 2 Yunlin Rd Douliu City Yunlin County 640 Taiwan School of Medicine China Medical University No. 91 Xueshi Rd North District Taichung City 404333 Taiwan

Background: Post-stroke disability restricts a patient's physical activity, affects the patient's quality of life, and leads to higher medical costs. Therefore, it is essential to promote patients' continuous exercise during this period of recovery. Objective: This study aimed to verify the effectiveness of applying a health management platform combined with wearable devices to enhance stroke patients’ self-management of recovery and to allow comparisons with active care intervention management. Method: This quasi-experimental study aimed at examining those participants who had sustained a stroke for the first time. A 90-day experiment was implemented with the intervention of monitoring and active care from the researchers who also interviewed the selected participants at the end of the study. A total of 26 participants were examined (14 in the experimental group and 12 in the control group). Result: The participants in the experimental group made significant progress between the pre- and post-tests. Firstly, their six-minute walking distance improved by 89.5 m (p < 0.001). Secondly, their sit-to-stand transfers in 60 s improved 2.85 times (p = 0.017), and their Berg balance test improved by 6.36 points (p = 0.003). Finally, the Partners in Health scale (PIH) scores also improved. According to the data collected in the interviews, the researchers' intervention improved the patients’ self-management ability. Conclusion: The short-term physical performance in the experimental group after the intervention was better than that in the control group. In clinical practice, it is suggested that continuous interaction between medical staff and patients be sustained while applying wearable devices to promote the patient's self-management ability. © 2022 The Authors

关键词： Health management Self-management Stroke Wearable device

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Geographic differences in susceptibility profiles of potential non-class B carbapenemase-producing Enterobacterales isolates against ceftazidime-avibactam, meropenem-vaborbactam, colistin, amikacin, gentamicin, and tigecycline: Data from the Antimicrobial Testing Leadership and Surveillance, 2018-2022

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INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 2024年第6期64卷 107363-107363页

作者： Jean, Shio-Shin Ko, Wen-Chien Liu, I-Min Hsieh, Po-Chuen Hsueh, Po-Ren Tajen Univ Coll Pharm & Hlth Care Dept Pharm Pingtung Taiwan Min Sheng Gen Hosp Dept Internal Med Taoyuan Taiwan Min Sheng Gen Hosp Dept Crit Care Med Taoyuan Taiwan Natl Cheng Kung Univ Coll Med Dept Med Tainan Taiwan China Med Univ China Med Univ Hosp Dept Lab Med 2 Yude Rd Taichung 40447 Taiwan China Med Univ China Med Univ Hosp Dept Internal Med 2 Yude Rd Taichung 40447 Taiwan China Med Univ Sch Med PhD Program Aging Taichung Taiwan China Med Univ Sch Med Dept Lab Med Taichung Taiwan Natl Taiwan Univ Natl Taiwan Univ Hosp Coll Med Dept Lab Med Taipei Taiwan Natl Taiwan Univ Natl Taiwan Univ Hosp Coll Med Dept Internal Med Taipei Taiwan

To evaluate the susceptibility profiles of regional meropenem-resistant potential non-class B carbapenemase-producing Enterobacterales (CPE) isolates (without confirmation by phenotypic tests) against important antibiotics, we extracted data from the 2018-2022 Antimicrobial Testing Leadership and Surveillance. This data included susceptibility information of meropenem-resistant potential nonclass B CPE isolates against indicated antibiotics - amikacin, gentamicin, ceftazidime-avibactam, colistin, meropenem-vaborbactam, and tigecycline - from sepsis patients hospitalized in intensive care units across six major regions. Carbapenemase-encoding genes of the tested CPE isolates, determined by multiplex PCR and Sanger sequencing, were also analyzed. Susceptibility breakpoints recommended by Clinical and Laboratory Standards Institute 2024 and US FDA criteria (for tigecycline only) against Enterobacterales were employed. A total of 1500 potential non-class B CPE isolates (89% of which were Klebsiella pneumoniae ) were tested globally. Resistance rates to amikacin and gentamicin against the evaluated isolates were statistically higher in Africa/the Middle East, Europe, and India compared to other regions. A similar pattern was observed in the susceptibility of these potential CPE isolates to ceftazidime-avibactam and meropenem-vaborbactam. High colistin resistance rates were noted in Asia, Latin America, and Europe (29%-35%). Furthermore, the proportions of potential CPE isolates carrying genes encoding blaOXA variants were notably higher among the tested CPE isolates in India, Europe, and Africa/the Middle East regions (99.2%, 53.3%, and 96.7%, respectively) compared to other regions. Trends in resistance to important antibiotics among potential non-class B CPE isolates warrant close monitoring. (c) 2024 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights are reserved, including those for text and data mining, AI training, and similar technolo

关键词： Carbapenemase-producing enterobacterales Amikacin Colistin Ceftazidime-avibactam Meropenem-vaborbactam Oxacillinase

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