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Phytocompounds from essential oil of Mentha aquatica L. cv. Lime prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRAS^Q61L keratinocytes and reprogramming macrophage activities

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Phytomedicine 2024年 122卷

作者： Chang, Chih-Ting Chen, Yu-Hsin Shyur, Lie-Fen Agricultural Biotechnology Research Center Academia Sinica Taipei 115 Taiwan Taichung District Research and Extension Station Council of Agriculture Executive Yuan Changhua 515 Taiwan PhD Program in Translational Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan Institute of BioPharmaceutical Sciences National Sun Yat-sen University Kaohsiung 804 Taiwan Graduate Institute of Integrated Medicine China Medical University Taichung 401 Taiwan

Background: Twenty to thirty percent of patients taking BRAF inhibitors such as vemurafenib (PLX4032) for melanoma develop cutaneous squamous cell carcinomas. Purpose: This study aimed to elucidate the chemopreventive effect of essential oil from Mentha aquatica L. cv. Lime (EO) and its major constituents, limonene and carvone (L + C) that made up 45.68% of the EO, against PLX4032-induced cutaneous side effects. Methods: PLX4032 accelerated skin papilloma formation and keratinocyte HRAS mutation in 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced two-stage skin carcinogenesis mouse model was used to evaluate the in vivo bioefficacy of EO and L + C. The effects and molecular mechanisms of EO and L + C on deregulating mouse PDV^HRASQ61L keratinocyte activities were demonstrated using a spectrum of bioactivity assays, western blotting, immunochemistry, and keratinocyte-macrophage co-culture assay. Results: Treatment with EO suppressed colony formation ability, cell migration, invasion, and induced G₂/M cell-cycle arrest and apoptosis in PDV^HRASQ61L keratinocytes, and L + C treatment inhibited colony formation, cell migration and invasion of PDV cells. In mouse skin irritated with DMBA/TPA (DT group) or DMBA/TPA with PLX4032 (DTP group), topical application of EO and L + C significantly delayed papilloma appearance and reduced papilloma incidence compared to DT or DTP controls. Histopathology results showed that EO and L + C treatment attenuated K14⁺ keratinocyte proliferation and paradoxical MAPK activation, and shifted the macrophage population from M2 (CD163⁺) to M1 (iNOS⁺) in the mouse skin microenvironment. The conditioned medium of EO or L + C pre-treated PDV keratinocytes promoted M₀ macrophages to differentiate from THP-1 cells into M1-like macrophages. Conclusion: This study demonstrates that EO and L + C in combination prevent PLX4032-induced cut

关键词： BRAF inhibitor Chemoprevention Macrophage reprogramming Mentha aquatica L. cv. Lime Skin carcinogenesis

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Plasma Phosphorylated-tau181 is a Predictor of Poststroke Cognitive Impairment: A Longitudinal Study

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Cerebral Circulation: Cognition and Behavior 2024年 6卷 100118-100118页

作者： Huang, Li-Kai Hu, Chaur-Jong Lo, Yu-Chun Hsieh, Yi-Chen Department of Neurology Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Department of Neurology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan PhD Program for Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan PhD Program in Biotechnology Research and Development College of Pharmacy Taipei Medical University Taipei Taiwan

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Low-dose imiquimod induces melanogenesis in melanoma cells through an ROS-mediated pathway

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Journal of Dermatological Science 2024年第1期113卷 18-25页

作者： Li, Zheng-Yi Chang, Shu-Hao Liu, Kuang-Ting Wu, Alaina Edelie Hsu, Chien-Sheng Huang, Shi-Wei Chung, Mu-Chi Wang, Shih-Chung Kao, Jun-Kai Chen, Yi-Ju Shieh, Jeng-Jer Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan Department of Pathology & Laboratory Medicine Taoyuan Armed Forces General Hospital Taoyuan Taiwan Frontier Molecular Medical Research Center in Children Changhua Christian Children Hospital Changhua County Taiwan Center for Cell Therapy and Translation Research China Medical University Hospital Taichung Taiwan Division of Nephrology Department of Medicine Taichung Veterans General Hospital Taichung Taiwan PhD Program in Translational Medicine National Chung Hsing University Taichung Taiwan Department of Biotechnology Asia University Taichung Taiwan Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan Division of Pediatric Hematology/Oncology Changhua Christian Children Hospital Changhua County Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Department of Dermatology Taichung Veterans General Hospital Taichung Taiwan Department of Education and Research Taichung Veterans General Hospital Taichung Taiwan

Background: Melanogenesis is the process of melanin maturation which not only protects skin from UV radiation but also plays an important role in antigenicity of melanomas. Imiquimod (IMQ) is a toll-like receptor 7 (TLR7) agonist that exhibits antiviral and anticancer activity. Objective: To explore whether IMQ could induce melanogenesis in melanoma cells. Methods: The mouse melanoma cell line B16F10, the mouse immortalized melanocyte Melan-A, and human melanoma cell lines MNT-1, C32 and A375 were utilized in this study. The pigmented level was observed by the centrifuged cell pellet. The intracellular and extracellular melanin levels were examined in the absorbance in NaOH-extracted cell lysate and cell-cultured medium, respectively. The expression of melanogenesis related proteins was examined by immunoblotting. The intracellular cyclic AMP amount was evaluated by the cAMP Glo assay kit. The activity of phosphodiesterase 4B (PDE4B) was investigated by CREB reporter assay with overexpressed PDE4B or not. Results: We demonstrated that a low dose of IMQ could trigger melanogenesis in B16F10 cells. IMQ induced microphthalmia-associated transcription factor (MITF) nuclear translocation, upregulated the expression of melanogenesis-related proteins, increased tyrosinase (TYR) activity, and led to pigmentation in B16F10 cells. Next, we found that IMQ-induced melanogenesis was activated by excessive intracellular cAMP accumulation, which was regulated through IMQ-mediated PDE4B inhibition. Finally, IMQ-induced ROS production was found to be involved in melanogenesis by its control of PDE4B activity. Conclusions: Low dose of IMQ could activate melanogenesis through the ROS/PDE4B/PKA pathway in melanoma cells. © 2023 Japanese Society for Investigative Dermatology

关键词： Imiquimod Melanogenesis Reactive oxygen species

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Authors’ Response to Peer Reviews of “The Role of Animal-Assisted Therapy in Enhancing Patients’ Well-Being: Systematic Study of the Qualitative and Quantitative Evidence”

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JMIRx Med 2024年 5卷

作者： Ramendra Pati Pandey Himanshu Gunjan Riya Mukherjee Chung-Ming Chang School of Health Sciences & Technology University of Petroleum and Energy Studies Dehradun Uttarakhand India Graduate Institute of Biomedical Sciences Chang Gung University Taoyuan Taiwan Master & PhD Program in Biotechnology Industry Chang Gung University Taoyuan Taiwan Department of Medical Biotechnology and Laboratory Science Chang Gung University Taoyuan Taiwan

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Ludwigia octovalvis (Jacq.) P.H. Raven extract improves memory performance in mice with chronic kidney disease

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Phytomedicine Plus 2024年第2期4卷 100556-100556页

作者： Wang, Hao-Wei Huang, Yi-Hsuan Tung, Hsiao-Jou Lin, Wei-Sheng Chiu, Hao-Chieh Lin, Shuei-Liong Fan, Shou-Zen Wang, Pei-Yu Hsieh Yu Enterprise Co. Ltd. Taipei Taiwan Graduate Institute of Brain and Mind Sciences College of Medicine National Taiwan University Taipei Taiwan Department of Pediatrics Taipei Veterans General Hospital Taipei Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology College of Medicine National Taiwan University Taipei Taiwan Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan Department of Anesthesiology National Taiwan University Hospital National Taiwan University Taipei Taiwan Department of Anesthesiology En Chu Kong Hospital Taipei Taiwan Neurobiology and Cognitive Science Center National Taiwan University Taipei Taiwan PhD. Program in Translational Medicine National Taiwan University and Academia Sinica Taipei Taiwan PhD. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Background: Chronic kidney disease (CKD) is a significant global health concern often accompanied by cognitive impairment in affected patients. Ludwigia octovalvis extract (LOE) is a traditional medicine widely used for various conditions, including renal disease and its associated complications. However, the pharmacological effects and underlying mechanisms of LOE on CKD remain unclear. Methods: Adult male mice underwent a 4-week oral adenine-induced CKD model, followed by daily administration of either a vehicle, losartan, or LOE for 1 to 2 months. A battery of behavioral tests was conducted to examine CKD-associated cognitive impairments. Additionally, RNA sequencing, Golgi staining, and immunohistochemistry were performed to decipher the underlying mechanisms. Results: Neither losartan nor LOE supplementation could reverse adenine-induced kidney damage. However, during behavioral tests, both losartan and LOE treatments improved memory performance in mice without affecting emotional status and general locomotor activity. Transcriptome profiling and histological analyses revealed altered dendritic arborization and increased spine density of dentate granule cells, along with augmented adult hippocampal neurogenesis, contributing to the improved memory performance of mice treated with LOE. Conclusion: Our study provides comprehensive neurobehavioral and molecular evidence supporting the potential use of LOE for future CKD-associated memory dysfunction treatment. © 2024 The Author(s)

关键词： Adenine Cognitive dysfunction Neurogenesis

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Modifying BiVO4 as a photocatalyst for water oxidation using constant-duration alkaline-etched post treatments

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New Journal of Chemistry 2023年第2期48卷 569-577页

作者： Hsu, Chuan-Chih Chuang, Kai-Jie Huang, Hsiao-Wen Pan, Bo-Jin Chen, Hung-Ming Husain, Sadang Yougbaré, Sibidou Hsiao, Yu-Cheng Wu, Yung-Fu Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Gingen Technology Co. Ltd. Rm. 7 10F. No. 189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia /Nanoro Ouagadougou03 Burkina Faso International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan

BiVO4 with suitable band edges and a small band gap is considered an efficient photocatalyst for the oxygen evolution reaction (OER), but short charge-transfer lengths limit its photocatalytic ability. Increasing active sites can essentially enhance oxidation reactions and photocatalytic ability. The alkaline etching technique can refine the surface properties of BiVO4 by introducing oxygen vacancies and possibly establishing a heterojunction, but suitable alkaline etching methods are rarely discussed. In this study, three alkaline etching methods, including hydrothermal, soaking, and electrodeposition processes, are first applied for a constant duration to tailor the surface properties of BiVO4 as a photocatalyst for the OER. Alkaline-etched BiVO4 prepared using hydrothermal and soaking processes shows better photocatalytic abilities due to the generation of additional oxygen vacancies, while poor photocatalytic ability is found for that fabricated using electrodeposition due to the formation of less photocatalytic VO2. The highest photocurrent density of 2.38 mA cm−2 is obtained at 1.23 V versus a reversible hydrogen electrode in an electrolyte without a hole scavenger for the BiVO4 etched in the hydrothermal process, while the untreated BiVO4 presents a photocurrent density of 0.58 mA cm−2. A photocurrent retention of 92.3% is achieved after 5000 seconds of continuous illumination. The study supplies blueprints for establishing effective alkaline etching methods for enhancing the photocatalytic ability of BiVO4, with the exception of time costs. © 2024 The Royal Society of Chemistry.

关键词： Charge transfer

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The Role of Animal-Assisted Therapy in Enhancing Patients' Well-Being: Systematic Study of the Qualitative and Quantitative Evidence

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JMIRx med 2024年 5卷 e51787页

作者： Ramendra Pati Pandey Riya Mukherjee Chung-Ming Chang School of Health Sciences & Technology University of Petroleum and Energy Studies Dehradun Uttarakhand India. Graduate Institute of Biomedical Sciences Chang Gung University Taoyuan Taiwan. Master & PhD Program in Biotechnology Industry Chang Gung University Taoyuan Taiwan. Department of Medical Biotechnology and Laboratory Science Chang Gung University Taoyuan Taiwan.

Background:Animal-assisted therapy, also known as pet therapy, is a therapeutic intervention that involves animals to enhance the well-being of individuals across various populations and settings. Objective:This systematic study aims to assess the outcomes of animal-assisted therapy interventions and explore the associated policies. Methods:A total of 16 papers published between 2015 and 2023 were selected for analysis. These papers were chosen based on their relevance to the research topic of animal-assisted therapy and their availability in scholarly databases. Thematic synthesis and meta-analysis were used to synthesize the qualitative and quantitative data extracted from the selected papers. Results:The analysis included 16 studies that met the inclusion criteria and were deemed to be of moderate or higher quality. Among these studies, 4 demonstrated positive results for therapeutic mediation and one for supportive mediation in psychiatric disorders. Additionally, all studies showed positive outcomes for depression and neurological disorders. Regarding stress and anxiety, 3 studies indicated supportive mediation, while 2 studies showed activating mediation. Conclusions:The overall assessment of animal-assisted therapy shows promise as an effective intervention in promoting well-being among diverse populations. Further research and the establishment of standardized outcome assessment measures and comprehensive policies are essential for advancing the field and maximizing the benefits of animal-assisted therapy.

关键词： animal-assisted therapy outcome assessment pet therapy policies systematic study

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Novel synthesis of ZIF67 derived cobalt and nickel oxides induced by ammonium tetrafluoroborate as electroactive material of battery supercapacitor hybrids

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Journal of Energy Storage 2023年 68卷

作者： Kuo, Tsung-Rong Draviana, Hanny Tika Hsu, Chia-Shuo Chung, Ren-Jei Chen, Min-Wen Wang, Su-Ching Lee, Pin-Yan Yougbaré, Sibidou Lin, Lu-Yin Wu, Yung-Fu International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering National Taiwan University of Science and Technology Taipei106 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan BP 218 11 Nanoro Burkina Faso Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan

Cobalt and nickel oxides with large theoretical capacitance, high redox activity and low-cost features are widely applied as electroactive material of battery supercapacitor hybrids (BSH) to reduce energy consumption and create renewable energy. Synthesizing cobalt and nickel oxides using zeolitic imidazolate framework 67 (ZIF67) can enhance conductivity and electroactivity and maintain surface area and porosity of ZIF67. Structure directing agent (SDA) can control morphology and improve electrochemical performance. It is attractive to apply SDA for controlling morphology of oxidized ZIF67 and achieving excellent energy storage. In this work, ammonium tetrafluoroborate (NH4BF4) is firstly applied as SDA to synthesize ZIF67 derivative, which is then annealed to form leaf-like cobalt and nickel oxides as electroactive material. The optimal oxidized ZIF67 derivative shows a larger specific capacitance (CF) of 828.9 F/g than those of 519.9 and 5.0 F/g respectively for the oxidized ZIF67 and pristine ZIF67 electrodes, due to preferable leaf-like structure and (311) facet for the former case. A BSH with oxidized ZIF67 derivative positive electrode and graphene negative electrode shows maximum energy density of 10.2 Wh/kg at 357 W/kg, and CF retention of 91% and Coulombic efficiency of 97% after 10,000 cycles. The novel SDA of NH4BF4 is expected to design other efficient electroactive materials for effective energy storage. © 2023 Elsevier Ltd

关键词： Nickel oxide

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Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata

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Phytochemistry Letters 2024年 61卷 115-119页

作者： Cheng, Ting-Yu Yang, Chia-Jung Chen, Po-Jen Chen, Yu-Li Peng, Bo-Rong Kung, Te-An Wen, Zhi-Hong Lai, Kuei-Hung Chung, Hsu-Ming Department of Applied Chemistry National Pingtung University Pingtung 900393 Taiwan Clinical Immunology Laboratory Department of Medical Research E-Da Hospital I-Shou University Kaohsiung 824005 Taiwan Research Center for Chinese Herbal Medicine Graduate Institute of Healthy Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan 33305 Taiwan Graduate Institute of Biomedical Sciences Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan 33305 Taiwan Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Institute of Food Safety Management National Pingtung University of Science and Technology Pingtung 91201 Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 804201 Taiwan Institute of BioPharmaceutical Sciences National Sun Yat-sen University Kaohsiung 804201 Taiwan PhD Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei 11031 Taiwan

Two new non-withanolidal steroids with a cross-conjugated dienone structural unit in ring A, capnesterones A (1) and B (2), were isolated from the soft coral Capnella imbricata in the southeast waters of Taiwan. The compounds' structures were elucidated through a comprehensive analysis of spectroscopic data, including IR, ESIMS, ¹H NMR, and ¹³C NMR, and through comparison with previous literature. At a concentration of 10 μM, steroids 1 and 2 exhibited reductions in iNOS levels (60 % and 82 %) compared to LPS-stimulated control cells, along with increased release (134 % and 110 %) against COX-2 protein expressions. © 2024 Phytochemical Society of Europe

关键词： Capnella imbricata COX-2 INOS Steroid

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Structure-based design, synthesis and biological evaluation of N-substituted 6H-thiochromeno[2,3–c]quinolin-12(12H)-one as potential breast cancer drugs

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Arabian Journal of Chemistry 2024年第1期17卷

作者： Sumitra, Maryam Rachmawati Chen, Lung-Ching Tsai, Wei-Chen Ansar, Muhamad Lawal, Bashir Mokgautsi, Ntlotlang Guh, Jih-Hwa Wu, Alexander T.H Huang, Hsu-Shan PhD Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei11031 Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei11031 Taiwan Division of Cardiology Department of Internal Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei11101 Taiwan School of Medicine Fu Jen Catholic University New Taipei24205 Taiwan School of Pharmacy National Defense Medical Center Taipei11490 Taiwan Clinical Drug Development of Herbal Medicine Taipei Medical University Taipei11031 Taiwan The PhD Program of Translational Medicine College of Science and Technology Taipei Medical University Taipei11031 Taiwan Clinical Research Center Taipei Medical University Hospital Taipei Medical University Taipei11031 Taiwan Graduate Institute of Medical Sciences National Defense Medical Center Taipei11490 Taiwan School of Pharmacy National Taiwan University No. 33 Linsen S. Rd. Zhongzheng Dist. Taipei10025 Taiwan Biotechnology Research and Development College of Pharmacy Taipei Medical University Taipei11031 Taiwan

Tetraheterocyclic compounds, derived from natural sources and contemporary pharmaceuticals, have shown promise as multitarget therapeutic agents. However, their mechanisms of action remain partially understood. In this study, we synthesized a series of 6H-thiochromeno[2,3-c]quinolin-12(12H)-one derivative, totaling 26 compounds, and assessed their potential for therapeutic application. We evaluated their effects on cell proliferation and conducted NCI-60 cell panel assays. MTT assays revealed that select compounds exhibited notable antiproliferative activity against two breast cancer cell lines (MCF-7 and MDA-MB-468). Notably, compounds 17 and 18 displayed the highest cytotoxicity against these cell lines. Furthermore, one-dose assays of the NCI-60 human tumor cell line screening program identified compounds 6, 7, 16, 18, 20, 24, 25, and 30 for further investigation. Subsequent five-dose cytotoxicity studies focused on compounds 18 and 20, which met the threshold inhibition criteria across a panel of cell lines. Our study highlights the effectiveness of compounds 18 and 20 in targeting breast cancer cell lines. Molecular docking simulations revealed that these compounds bind to the active sites of topoisomerase I (TOPO I). Our findings suggest that these novel compounds are promising anticancer agents, particularly against breast cancer, and are worthy of consideration as lead pharmacological candidates. © 2023 The Authors

关键词： Cell proliferation

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