检索结果-内蒙古大学图书馆

Comparison of endoscopic third ventriculostomy versus cerebrospinal fluid shunt procedures for the treatment of pediatric hydrocephalus in Taiwan

引用

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2024年第9期40卷 2883-2891页

作者： Shu-Mei Chen Li-Ying Chen Jiann-Her Lin Nicole Salazar Tu-Hsueh Yeh Wei-Lun Lo Tai-Ngar Lui Yi-Chen Hsieh Li-Nien Chien Department of Neurosurgery Taipei Medical University Hospital Taipei Medical University Taipei Taiwan. Department of Surgery School of Medicine Taipei Medical University Taipei Taiwan. Health Data Analytics and Statistics Center Office of Data Science Taipei Medical University Taipei Taiwan. Julius L. Chambers Biomedical/Biotechnology Institute and Department of Biological & Biomedical Sciences North Carolina Central University Durham NC USA. Department of Neurology Taipei Medical University Hospital Taipei Taipei Medical University Taipei Taiwan. Department of Neurology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Neurosurgery Shuang Ho Hospital Taipei Medical University Taipei Taiwan. The PhD Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University 250 Wu-Hsing Street Taipei Taiwan. ychsieh@tmu.edu.tw. Institute of Health and Welfare Policy College of Medicine National Yang Ming Chiao Tung University No.155 Sec. 2 Linong St. Beitou District Taipei Taiwan. linien.chien@nycu.edu.tw. Graduate Institute of Data Science College of Management Taipei Medical University Taipei Taiwan. linien.chien@nycu.edu.tw.

PURPOSE:Pediatric hydrocephalus is the most common cause of surgically treatable neurological disease in children. Controversies exist whether endoscopic third ventriculostomy (ETV) or cerebrospinal fluid (CSF) shunt placement is the most appropriate treatment for pediatric hydrocephalus. This study aimed to compare the risk of re-operation and death between the two procedures. METHODS:We performed a retrospective population-based cohort study and included patients younger than 20-years-old who underwent CSF shunt or ETV for hydrocephalus from the Taiwan National Health Insurance Research Database. RESULTS:A total of 3,555 pediatric patients from 2004 to 2017 were selected, including 2,340 (65.8%) patients that received CSF shunt placement and 1215 (34.2%) patients that underwent ETV. The incidence of all-cause death was 3.31 per 100 person-year for CSF shunt group and 2.52 per 100 person-year for ETV group, with an adjusted hazard ratio (HR) of 0.79 (95% confidence interval [CI] = 0.66-0.94, p = 0.009). The cumulative incidence competing risk for reoperation was 31.2% for the CSF shunt group and 26.4% for the ETV group, with an adjusted subdistribution HR of 0.82 (95% CI = 0.70-0.96, p = 0.015). Subgroup analysis showed that ETV was beneficial for hydrocephalus coexisting with brain or spinal tumor, central nervous system infection, and intracranial hemorrhage. CONCLUSION:Our data indicates ETV is a better operative procedure for pediatric hydrocephalus when advanced surgical techniques and instruments are available.

关键词： Cerebrospinal shunt Pediatric hydrocephalus Reoperation Third ventriculostomy

来源：评论

学校读者我要写书评

暂无评论

Relationships between blood leukocyte mitochondrial DNA copy number and inflammatory cytokines in knee osteoarthritis

引用

Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2020年第1期21卷 42-52页

作者： Dong ZHAN Aree TANAVALEE Saran TANTAVISUT Srihatach NGARMUKOS Steven WEDWARDS Sittisak HONSAWEK Joint PhD Program in Biomedical Sciences and Biotechnology Faculty of MedicineChulalongkorn UniversityBangkok 10330Thailand Department of Biochemistry Osteoarthritis and Musculoskeleton Research UnitFaculty of MedicineKing Chulalongkorn Memorial HospitalThai Red Cross SocietyChulalongkorn UniversityBangkok 10330Thailand Department of Orthopaedics Vinai Parkpian Orthopaedic Research CenterFaculty of MedicineKing Chulalongkorn Memorial HospitalThai Red Cross SocietyChulalongkorn UniversityBangkok 10330Thailand Institute of Integrative Biology University of LiverpoolLiverpool L697ZBUK

Osteoarthritis(OA)is a degenerative articular disorder manifested by cartilage destruction,subchondral sclerosis,osteophytes,and synovitis,resulting in chronic joint pain and physical disability in the *** purpose of this study was to investigate mitochondrial DNA copy number(mtDNACN)and inflammatory cytokines in primary knee OA patients and healthy volunteers.A total of 204 knee OA patients and 169 age-matched healthy volunteers were *** relative blood leukocyte mtDNACN was assessed by quantitative real-time polymerase chain reaction(qRT-PCR),and ten inflammatory cytokines in their plasma were detected by multiplex *** leukocyte mtDNACN in the OA group was significantly lower than that in the control *** mtDNACN in the control group was negatively correlated with their age(r=−0.380,P<0.0001),whereas mtDNACN in the OA group was positively correlated with their age(r=0.198,P<0.001).Plasma interleukin-4(IL-4)and IL-6 were significantly higher in the knee OA group than in the control *** plasma IL-6 level was positively correlated with blood leukocyte mtDNACN in the OA group(r=0.547,P=0.0014).IL-5 showed as a major factor(coefficient 0.69)in the second dimension of principle components analysis(PCA)-transformed data and was significantly higher in the OA group(P<0.001)as well as negatively correlated with mtDNACN(r=−0.577,P<0.001).These findings suggest that elevation of plasma IL-4 and IL-6 and a relative reduction in mtDNACN might be effective biomarkers for knee ***-5 is a plausible factor responsible for decreasing blood leukocyte mtDNACN in knee OA patients.

关键词： Inflammatory cytokine Blood leukocyte Knee Mitochondrial DNA copy number Osteoarthritis

来源：评论

学校读者我要写书评

暂无评论

Metal ratio and bimetal nanoarchitectonics of ammonia-based fluoride complex induced nickel hydroxide and manganese oxide composites as active materials of an energy storage device

引用

Journal of Energy Storage 2024年 80卷

作者： Hsu, Chuan-Chih Yu, You Zher Wu, Chung-Hsien Lee, Pin-Yan Chen, Hung-Ming Husain, Sadang Kongvarhodom, Chutima Hsiao, Yu-Cheng Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Nickel and manganese compounds are widely applied as efficient battery-type active materials for energy storage devices, due to high theoretical capacities and abundant redox states for generating redox reactions to store charges. Morphology plays significant roles on energy storage ability. Structure directing agent (SDA) is widely reported to have ability for modulating configurations of active materials and to achieve excellent surface properties. In this work, it is the first time to use NH4BF4 and NH4HF2 as structure directing agents for synthesizing nickel manganese compounds derived from ZIF67 as active materials of energy storage devices. Bimetallic compounds are composed of nickel hydroxide and manganese oxide, which presents the favorable two-dimensional flower-like structure with high surface area and abundant redox states. The largest specific capacitance (CF) of 1358.2 F/g corresponding to the capacity of 226.4 mAh/g are achieved for the bimetallic compound synthesized using the Ni to Mn precursor ratio of 1 to 1 (NiMn11). The energy storage device assembled using NiMn11 and reduced graphene oxide on Ni foams presents a maximum energy density of 11.45 Wh/kg at the power density of 0.35 kW/kg, and excellent long-term stability with the CF retention of 85.6% and Coulombic efficiency of 87.5% after 10,000 cycles. © 2023

关键词： Fluorine compounds

来源：评论

学校读者我要写书评

暂无评论

Non-meningeal, non-pulmonary cryptococcosis with limited posterior uveitis in a kidney organ transplant recipient with antibody-mediated rejection: a case report

引用

BMC Ophthalmology 2023年第1期23卷 409-409页

作者： Lu, Yi-An Lin, Chun-Hsien Chang, Chia-Jen Shu, Kuo-Hsiung Chung, Mu-Chi Chou, Chien-Chih Department of Ophthalmology Taichung Veterans General Hospital 1650 Boulevard Sect. 4 Taichung 407219 Taiwan Division of Nephrology Department of Internal Medicine Lin Shin Hospital No.36 Sec. 3 Huizhong Rd. Nantun District Taichung City 40867 Taiwan Division of Nephrology Department of Medicine Taichung Veterans General Hospital 1650 Boulevard Sect. 4 Taichung 407219 Taiwan PhD Program in Translational Medicine National Chung Hsing University Taichung Taiwan Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan College of Medicine National Chung Hsing University Taichung Taiwan

Background: Cryptococcosis is one of the most frequent fungal eye infections in patients with immunosuppression. Currently, treatment approaches for non-meningeal, non-pulmonary cryptococcosis are based on those used for cryptococcal meningitis or pneumonia. Case presentation: We present a rare case of non-meningeal, non-pulmonary cryptococcosis with clinical manifestations limited to one eye of a cadaveric kidney transplant recipient with chronic-active antibody-mediated rejection. Typical manifestations, diagnosis, and treatments, including antifungal therapies, adjunctive therapies, and immunosuppression reduction, are discussed. After timely diagnosis and treatment, her visual acuity recovered to baseline without recurrence or sequelae of cryptococcosis. Conclusions: Clinicians should be aware of rare presentations of fungal infections, especially when a kidney transplant recipient with rejection has been treated with intensive immunosuppressants. Early diagnosis with individualized therapies may have a favorable prognosis. © 2023, BioMed Central Ltd., part of Springer Nature.

关键词： Amphotericin B Case report Choroiditis Cryptococcal infection Double filtration plasmapheresis Fluconazole Immunosuppressant Kidney transplant Solid organ transplant Uveitis

来源：评论

学校读者我要写书评

暂无评论

Facilitating light utilization and electron transfer of TiO2 nanotube arrays for catalyzing photoelectrochemical water reduction via acid etching and copper doping

引用

Materials Today Chemistry 2023年 34卷

作者： Hsu, Chuan-Chih Kubendhiran, Subbiramaniyan Lai, Jhih-Hong Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Hsiao, Yu-Cheng Wu, Yung-Fu Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 03 Ouagadougou Burkina Faso Gingen Technology Co. LTD Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan

Photoelectrochemical catalytic capability mainly relies on light absorption and charge transfer efficiency. TiO2 nanotube array (TNA) having suitable band edges and one-dimensional hollow structure is regarded as one of efficient photoelectrocatalysts toward water reduction. In this study, two strategies are firstly applied to modify TNA as the photocatalyst of water reduction. Ti foils are etched by acid to produce multiple light reflections planes for improving light absorption, and Cu is doped in TNA to enhance charge transfer efficiency. The optimal Cu-doped TNA electrode on the acid-etched Ti foil presents a much smaller overpotential of 91 mV at 10 mA/cm2 compared with that of the undoped TNA (524 mV). A smaller Tafel slope of 134 mV/dec is obtained for the optimal Cu-doped TNA electrode than that of the undoped TNA (167 mV/dec). After measuring the photoelectrochemical performance for 1000 cycles, overpotential and charge-transfer resistance of modified TNA are largely reduced owing to activation. Current retention of 96.7% is achieved after continuously illuminating for 10 h. Highly improved photoelectrochemical catalytic ability of TNA modified by acid etching and Cu doping provides new pages for material modifications on substrate and active material. © 2023 Elsevier Ltd

关键词： Light absorption

来源：评论

学校读者我要写书评

暂无评论

Antimicrobial surveillance: A 20-year history of the SMART approach to addressing global antimicrobial resistance into the future

引用

International Journal of Antimicrobial Agents 2023年第6期62卷 107014-107014页

作者： Cantón, Rafael Gottlieb, Thomas Coombs, Geoffrey W. Woo, Patrick C.Y. Korman, Tony M. Garcia-Castillo, Maria Daley, Denise Bauer, Karri A. Wong, Michael Wolf, Dominik J. Siddiqui, Fakhar Motyl, Mary Servicio de Microbiología Hospital Universitario Ramón y Cajal and Instituto de Investigación Sanitaria (IRYCIS) Madrid Spain CIBER de Enfermedades Infecciosas (CIBERINFEC) Instituto de Salud Carlos III Madrid Spain Department of Infectious Diseases and Microbiology Concord Hospital Concord NSW Australia Royal Perth Hospital and Fiona Stanley Hospital Murdoch WA Australia Murdoch University Murdoch WA Australia PhD Program in Translational Medicine and Department of Life Sciences National Chung Hsing University Taichung 402 Taiwan The iEGG and Animal Biotechnology Research Center National Chung Hsing University Taichung 402 Taiwan Department of Microbiology Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong PathWest Laboratory Medicine Fiona Stanley Hospital Murdoch WA Australia and the Australian Group on Antimicrobial Resistance South Perth WA Australia Merck & Co. Inc. 126 E Lincoln Avenue Rahway 07065 NJ United States

Antimicrobial resistance (AMR) is a major global public health threat, particularly affecting patients in resource-poor settings. Comprehensive surveillance programmes are essential to reducing the high mortality and morbidity associated with AMR and are integral to informing treatment decisions and guidelines, appraising the effectiveness of intervention strategies and directing development of new antibacterial agents. Various surveillance programmes exist worldwide, including those administered by government bodies or funded by the pharmaceutical industry. One of the largest and longest running industry-sponsored AMR surveillance programme is the Study for Monitoring Antimicrobial Resistance Trends (SMART), which recently completed its 20th year. The SMART database has grown to almost 500 000 isolates from over 200 sites in more than 60 countries, encompassing all major geographic regions and including many sites in low- and middle-income countries. The SMART surveillance programme has evolved in scope over time, including additional antibacterial agents, pathogens and infection sites, in line with changing epidemiology and medical need. Surveillance data from SMART and similar programmes have been used successfully to detect emerging resistance threats and AMR patterns in specific countries and regions, thus informing national and local clinical treatment guidelines. The SMART database can be accessed readily by physicians and researchers globally, which may be especially valuable to those from countries with limited healthcare resources, where surveillance and resistance data are rarely collected. Continued participation from as many sites as possible worldwide and maintenance of adequate funding are critical factors to fully realising the potential of large-scale AMR surveillance programmes into the future. © 2023

关键词： Antibacterial agents Antimicrobial resistance Epidemiology Global Gram-negative pathogens

来源：评论

学校读者我要写书评

暂无评论

Distinct viral reservoirs and immune signatures in individuals on long-term antiretroviral therapy with perinatally acquired HIV-1

引用

Cell Reports Medicine 2025年 102150页

作者： Bone, Benjamin Cotugno, Nicola Pighi, Chiara Rotili, Arianna Hong, Seohyun Carrere, Leah Morrocchi, Elena Pascucci, Giuseppe Rubens Gao, Ce Colantoni, Nicole Sun, Weiwei Leone, Giovanna Collins, David R. Olatotse, Mpho J. Del Principe, Giovanna Tan, Toong Seng Lancien, Melanie Neri, Alessia Sessa, Libera Olivieri, Giulio Shapiro, Kailey Roseto, Isabelle Koofhethile, Catherine Emili, Elena Bernardi, Stefania Chahroudi, Ann Rossi, Paolo Walker, Bruce D. Yu, Xu G. Lichterfeld, Mathias Palma, Paolo The Ragon Institute of MGH MIT and Harvard Boston MA United States Infectious Disease Division Brigham Women's Hospital Boston MA United States Clinical Immunology and Vaccinology Unit IRCCS Bambino Gesù Children's Hospital Rome Italy Chair of Paediatrics Department of Systems Medicine University of Rome “Tor Vergata” Rome Italy PhD Program in Immunology Molecular Medicine and Applied Biotechnology University of Rome “Tor Vergata” Rome Italy Transfusion Unit IRCCS Bambino Gesù Children's Hospital Rome Italy Infectious Diseases Unit IRCCS Bambino Gesù Children's Hospital Rome Italy Department of Pediatrics Emory University School of Medicine Atlanta GA United States

Early initiation of antiretroviral therapy (ART) following HIV-1 infection restricts the size of the latent reservoir, following both horizontal and vertical infections. Here, we comprehensively profile the reservoirs and immunological milieus of nine young adults who acquired HIV-1 perinatally and remained on suppressive long-term ART (median: 20 years) since infancy (LeukoHIV cohort). Genome-intact reservoirs are markedly smaller compared to a cohort of adults on suppressive ART started in adulthood, with some LeukoHIV individuals characterized by an absence or near absence of intact proviruses in up to a billion peripheral blood mononuclear cells (PBMCs). Higher frequencies of functional CD56^bright natural killer (NK) cells with increased cytotoxic activity are detectable in the LeukoHIV cohort compared to an adult reference cohort, while one LeukoHIV participant displayed a potent HIV-1-specific CD8⁺ T cell response. Collectively, our data suggest that long-term ART initiated in early life following perinatal transmission may facilitate an immune environment better equipped to restrict the HIV-1 reservoir. © 2025 The Authors

关键词： children deep latency HIV leukophoresis long-term ART MIP-seq natural killer cells perinatal infection provirus reservoir

来源：评论

学校读者我要写书评

暂无评论

Unprecedented anti-inflammatory biscembranoids with 3-hydroperoxy-3-methylcyclohex-1-ene moiety isolated from aquaculture Sarcophyton trocheliophorum

引用

Aquaculture Reports 2023年 33卷

作者： Peng, Bo-Rong Nguyen, Ngoc Bao An Chen, Lo-Yun El-Shazly, Mohamed Hwang, Tsong-Long Su, Jui-Hsin Lai, Kuei-Hung Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei 11031 Taiwan PhD Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Department of Pharmacognosy Faculty of Pharmacy Ain-Shams University Organization of African Unity Street Cairo Abassia 11566 Egypt Research Center for Chinese Herbal Medicine College of Human Ecology Chang Gung University of Science and Technology Taoyuan 33303 Taiwan Graduate Institute of Health Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan 33303 Taiwan Department of Anaesthesiology Chang Gung Memorial Hospital Taoyuan 33305 Taiwan Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan 33302 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City 24301 Taiwan National Museum of Marine Biology & Aquarium Pingtung 94450 Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 80424 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei 11031 Taiwan

Recent advancements in the discovery of natural products have made significant progress in rapidly identifying known compounds from complex extracts using advanced spectroscopic technologies. Among these methods, one powerful approach called MS/MS molecular networking (MN) organizes chemical similarity based on MS/MS fragmentation data, serving as a valuable complement to traditional dereplication strategies. In our ongoing research focused on lead discovery from a sustainable medicinal source, an aquaculture soft coral Sarcophyton trocheliophorum, the MN profiling approach revealed the chemical diversity of biscembranoid analogs. By analyzing the MN pattern, biscembranoid derivatives with unique MS/MS fragments were prioritized for further investigation. Two novel biscembranoids, sarcotroxide A (1) and B (2), were successfully obtained through targeted isolation. These novel biscembranes contained an unprecedented 3-hydroperoxy-3-methylcyclohex-1-ene moiety compared with all biscembranoid analogs. The chemical structures of the two new biscembranoids were confirmed through spectroscopic analyses and in silico calculations. Their anti-inflammatory properties were assessed against the generation of superoxide anion (O₂^•−) and elastase release in activated human neutrophils. Sarcotroxides A (1) and B (2) exhibited anti-inflammatory activity by inhibiting O₂^•− accumulation (with 43.67% and 61.62% inhibition) and elastase release (with 38.21% and 61.62% inhibition) at 10 µM. These findings validated the potential of these biscembranoids from the cultured S. trocheliophorum as promising candidates for the future development of anti-inflammatory agents specifically designed to target neutrophils. © 2023 The Authors

关键词： Anti-inflammation Aquaculture soft coral Biscembranoid Neutrophil Sarcophyton trocheliophorum

来源：评论

学校读者我要写书评

暂无评论

In vitro activity of cefepime-zidebactam, ceftolozane-tazobactam, ceftazidime-avibactam, imipenem-relebactam, and other comparators against imipenem-non-susceptible Pseudomonas aeruginosa in Taiwan, 2022

引用

International journal of antimicrobial agents 2025年 107550页

作者： Yu-Lin Lee Mei-Chen Tan Pei-Jing Chen Yih-Ru Shiau Hui-Ying Wang Jui-Fen Lai I-Wen Huang Ya-Sung Yang Shu-Chen Kuo Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan PhD Program in Medical Biotechnology Institute of Genomics and Bioinformatics National Chung-Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taichung Taiwan. National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Miaoli Taiwan. Division of Infectious Diseases and Tropical Medicine Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan. Institute of Preventive Medicine National Defense Medical Center Taipei Taiwan. Electronic address: ysyoung4097@***. National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Miaoli Taiwan. Electronic address: sckuo@nhri.edu.tw.

OBJECTIVES:The global expansion of antimicrobial-resistant Pseudomonas aeruginosa, particularly imipenem-non-susceptible (INS) strains poses a formidable health threat. The COVID-19 pandemic has exacerbated antimicrobial resistance trends. We compared the pre- and post-pandemic antibiotic resistance patterns of INS-P. aeruginosa in Taiwan. METHODS:We analyzed 503 P. aeruginosa isolates collected through the Taiwan Surveillance of Antimicrobial Resistance (TSAR) program during 2022. Minimum inhibitory concentrations of various antibiotics were determined by using broth microdilution. Carbapenemase-encoding genes were identified via multiplex PCR. Antimicrobial resistance trends were compared with data from 2018. RESULTS:INS-P. aeruginosa comprised 16.9% (85/503) of isolates and exhibited high-level multi-drug resistance. Novel β-lactam-β-lactamase inhibitor combinations (BL-BLIs) demonstrated the highest activity, with 89.4% of INS isolates susceptible to cefepime-zidebactam. The susceptibility rates of INS-P. aeruginosa isolates to other BL-BLIs and comparators declined between 2018 and 2022. Specifically, susceptibility to ceftazidime-avibactam and imipenem-relebactam decreased from 81.5% and 85.2% during 2018 to 64.7% and 63.5% during 2022, respectively (both p<0.05). Additionally, only 70.6% of isolates obtained during 2022 were susceptible to ceftolozane-tazobactam. Carbapenemase genes were detected in 10.6% of isolates, with a notable increase in bla and bla prevalence compared to pre-pandemic data. CONCLUSION:The COVID-19 pandemic intensified resistance trends in INS-P. aeruginosa in Taiwan, with increasing prevalence and diversity of carbapenemase-encoding genes. Continuous monitoring and expanded research are essential to combat evolving resistance patterns.

关键词： Carbapenem-resistant Pseudomonas aeruginosa TSAR Surveillance β-lactam-β-lactamase inhibitor combination

来源：评论

学校读者我要写书评

暂无评论

Brown Adipose Tissue undergoes pathological perturbations and shapes C2C12 myoblast homeostasis in the SOD1-G93A mouse model of Amyotrophic Lateral Sclerosis

引用

Heliyon 2025年第3期11卷 e41801页

作者： Rosina, Marco Scaricamazza, Silvia Riggio, Flaminia Fenili, Gianmarco Giannessi, Flavia Matteocci, Alessandro Nesci, Valentina Salvatori, Illari Angelini, Daniela F. Aquilano, Katia Chiurchiù, Valerio Lettieri Barbato, Daniele Mercuri, Nicola Biagio Valle, Cristiana Ferri, Alberto Unit of Neurology Fondazione PTV Policlinico Tor Vergata Viale Oxford 81 Rome 00133 Italy Laboratory of Neurochemistry IRCCS Fondazione Santa Lucia Via del fosso di fiorano 64 Rome 00143 Italy Institute of Translational Pharmacology National Research Council Via del fosso del cavaliere 100 Rome 00133 Italy Department of Biology and Biotechnology “Charles Darwin” University of Roma “La Sapienza” Rome 00161 Italy Department of Movement Human and Health Sciences University of Rome "Foro Italico” Piazza Lauro de Bosis 6 Rome 00135 Italy Laboratory of Molecular Virology and Antimicrobial Immunity Department of Science Roma Tre University Rome 00146 Italy Neuroimmunology Unit IRCCS Fondazione Santa Lucia Via del fosso di fiorano 64 Rome 00143 Italy Laboratory of Resolution of Neuroinflammation IRCCS Fondazione Santa Lucia Via del fosso di fiorano 64 Rome 00143 Italy PhD program in Immunology Molecular Medicine and Applied biotechnologies University of Rome “Tor Vergata” Rome 00133 Italy Department of Systems Medicine University of Roma “Tor Vergata” Rome 00133 Italy Department of Experimental Medicine University of Roma “La Sapienza” Rome 00161 Italy Department of Biology University of Rome “Tor Vergata” via della ricerca scientifica Rome 00133 Italy Laboratory of Experimental Neurology IRCCS Fondazione Santa Lucia Via del fosso di fiorano 64 Rome 00143 Italy

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the selective loss of motor neurons. The contribution of peripheral organs remains incompletely understood. We focused our attention on brown adipose tissue (BAT) and its secreted extracellular vesicles (EVs) given their role in regulating systemic energy balance. In this study, we employed a multi-omics approach, including RNA sequencing (GEO identifier GSE273052) and proteomics (ProteomeXchange identifier PXD054147), to investigate the alterations in BAT and its EVs in the SOD1-G93A mouse model of ALS. Our results revealed consistent changes in the proteomic and transcriptomic profiles of BAT from SOD1-G93A mice, highlighting alterations such as mitochondrial dysfunction and impaired differentiation capacity. Specifically, primary brown adipocytes (PBAs) from SOD1-G93A mice exhibited differentiation impairment, respiratory defects, and alterations in mitochondrial dynamics. Furthermore, the BAT-derived EVs from SOD1-G93A mice displayed distinct changes in size distribution and cargo content. In parallel, such EVs negatively impacted the differentiation and homeostasis of C2C12 murine myoblasts, as well as induced atrophy in C2C12-derived myotubes. These findings suggest that BAT undergoes pathological perturbations in ALS mouse model and could impact on skeletal muscle homeostasis through the secretion of dysfunctional EVs. © 2025 The Authors

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：