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Hericium erinaceus extracts promote neuronal differentiation and excitability through nootropic metabolite activity

Biomedicine & Pharmacotherapy 2025年 188卷 118204-118204页

作者： Brandalise, Federico Priori, Erica Cecilia Giammello, Francesca Venuti, MariaTeresa Ratto, Daniela Goppa, Lorenzo Locatelli, Carlo Alessandro Savino, Elena Roda, Elisa Rossi, Paola Department of Biomedical Sciences Division of Neuroscience and Clinical Pharmacology University of Cagliari Cittadella Universitaria di Monserrato Monserrato 09042 Italy Department of Biology and Biotechnology “L. Spallanzani” University of Pavia Pavia 27100 Italy PhD Program in Genetics Molecular and Cellular Biology University of Pavia Italy Department of Earth and Environmental Sciences (DSTA) University of Pavia Pavia 27100 Italy PhD Program in Earth and Environmental Sciences University of Pavia Italy Laboratory of Clinical & Experimental Toxicology Pavia Poison Centre National Toxicology Information Centre Toxicology Unit Istituti Clinici Scientifici Maugeri IRCCS Pavia Pavia 27100 Italy

AbstractThis study investigates the effects of a blend of Hericium erinaceus (lion's mane mushroom) extract on the differentiation of SH-SY5Y cells, a human neuroblastoma cell line, revealing potential therapeutic implications for neuroblastoma management. Treatment with this blend induced cells differentiation towards a neuron-like profile, as evidenced by enhanced neuronal excitability and upregulation of neuronal markers, such as βIII-tubulin and synaptotagmin. Additionally, the treatment significantly reduced PCNA, a key regulator of proliferation, alongside a decrease in stemness markers, indicating a shift toward a more mature and less proliferative phenotype. These findings demonstrate the ability of Hericium erinaceus to promote neuronal differentiation and inhibit proliferation in neuroblastoma cells, highlighting its therapeutic potential for managing neuroblastoma and potentially other neurological disorders. The results suggest that Hericium erinaceus may serve as a promising candidate for the development of novel neuroregenerative therapies.

关键词： TPA 12-O tetradecanoylphorbol-13-acetate He Hericium erinaceus MTT assay 3 4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide assay Cm Membrane capacitance Rm Membrane resistance Vm Resting membrane potential TTX Tetrodotoxin VGSC Voltage-gated sodium channel I-V plots Current-voltage plots SNARE Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor PCNA Proliferating Cell Nuclear Antigen Neuroblastoma SH-SY5Y Hericium erinaceus Neuronal differentiation Patch clamp Voltage-gated sodium currents Cell proliferation Action potential Erinacines Hericenones Voltage-Gated Sodium Channel

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Evaluating Arthropod Community Composition, Diversity and Metal Content from Maize Grown on Dredged Sediments

SSRN

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SSRN 2024年

作者： McKean, Michael Julian, Ashley López, Juan Manuel Perilla Stevenson, Louise M. Simonis, Molly Stireman, John O. Rúa, Megan A. Wright State University Department of Earth and Environmental Sciences DaytonOH United States Wright State University Environmental Sciences PhD Program DaytonOH United States Environmental Sciences Division Oak Ridge National Laboratory Oak RidgeTN United States Wright State University Department of Biological Sciences DaytonOH United States Department of Biological Sciences Wright State University 3640 Colonel Glenn Hwy DaytonOH45435 United States

Research on the relationship of arthropod community diversity or composition with the use of cover crops and soil amendments is limited, despite the widespread application of these soil management strategies. Such research may be particularly important for soil amendments because of the potential for arthropods to bioaccumulate metals or other contaminants. However, the use of a cover crop in conjunction with soil amendments may not only improve the success of a crop but may also decrease bioaccumulation potential by removing contaminants from soils. In this study we investigated how the use of a cover crop (winter cereal rye;Secale cereal) on 100% dredged sediments from the Toledo Harbor altered arthropod diversity, composition and metal concentrations on corn (Zea mays). We further compared these values to those from a nearby traditionally farmed field that did not use a cover crop or soil amendment prior to corn planting. To do so, we surveyed aboveground arthropods along three transects and used pitfall traps for 21 weeks in the dredged sediment plots and two weeks in the traditionally farmed agricultural field. We identified these specimens to species/morphospecies and assigned trophic level based on literature values. Finally, we measured metal concentrations on a subset of arthropods from the dredged sediments and agricultural soil. We observed similar arthropod communities on corn grown on dredged sediments compared to corn grown on traditionally farmed agricultural soil. We further found that the use of a cover crop on 100% dredged sediments did not significantly alter arthropod communities, despite an apparent reduction in arthropod abundance in the cover crop plot compared to the non-cover crop plot. Finally, metal concentrations were similar between arthropods collected from dredged sediments compared to arthropods of the same trophic level collected from traditionally farmed agricultural soils. Our work suggests dredged sediments do not negatively affec

关键词： Crops

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Elemental Characterization of Ambient Particulate Matter for a Globally Distributed Monitoring Network: Methodology and Implications

ACS ES&T air

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ACS ES&T air 2024年第4期1卷 283-293页

作者： Xuan Liu Jay R Turner Christopher R Oxford Jacob McNeill Brenna Walsh Emmie Le Roy Crystal L Weagle Emily Stone Haihui Zhu Wenyu Liu Zilin Wei Nicole P Hyslop Jason Giacomo Ann M Dillner Abdus Salam Al-Amin Hossen Zubayer Islam Ihab Abboud Clement Akoshile Omar Amador-Muñoz Nguyen Xuan Anh Araya Asfaw Rajasekhar Balasubramanian Rachel Ying-Wen Chang Craig Coburn Sagnik Dey David J Diner Jinlu Dong Tareq Farrah Paterne Gahungu Rebecca M Garland Michel Grutter de la Mora Sina Hasheminassab Juanette John Jhoon Kim Jong Sung Kim Kristy Langerman Pei-Chen Lee Puji Lestari Yang Liu Tesfaye Mamo Mathieu Martins Olga L Mayol-Bracero Mogesh Naidoo Sang Seo Park Yoav Schechner Robyn Schofield Sachchida N Tripathi Eli Windwer Ming-Tsang Wu Qiang Zhang Michael Brauer Yinon Rudich Randall V Martin Department of Energy Environmental & Chemical Engineering Washington University in St. Louis St. Louis Missouri 63130 United States. Air Quality Research Center University of California Davis Davis California 95616 United States. Department of Chemistry University of Dhaka Dhaka 1000 Bangladesh. Air Quality Research Division Environment and Climate Change Canada Toronto Ontario M3H 5T4 Canada. Department of Physics University of Ilorin Ilorin 240003 Nigeria. Instituto de Ciencias de la Atmósfera y Cambio Climático Universidad Nacional Autónoma de México Mexico City 04510 Mexico. Institute of Geophysics Vietnam Academy of Science and Technology Hanoi 11307 Vietnam. Institute of Geophysics and Space Science Addis Ababa University Addis Ababa 1176 Ethiopia. Department of Civil and Environmental Engineering National University of Singapore Singapore 117576 Singapore. Department of Physics and Atmospheric Science Dalhousie University Halifax Nova Scotia B3H 4R2 Canada. Department of Geography and Environment University of Lethbridge Lethbridge Alberta T1K 3M4 Canada. Centre for Atmospheric Sciences Indian Institute of Technology Delhi New Delhi 110016 India. Jet Propulsion Laboratory California Institute of Technology Pasadena California 91109 United States. School of Environment Tsinghua University Beijing 100084 People's Republic of China. Research Laboratories Khalifa University Abu Dhabi 127788 United Arab Emirates. Institute of Applied Statistics University of Burundi Bujumbura BP1550 Burundi. Council for Scientific and Industrial Research Pretoria 0001 South Africa. Unit for Environmental Sciences and Management North-West University Potchefstroom 2531 South Africa. Department of Geography Geo-Informatics and Meteorology University of Pretoria Pretoria 0002 South Africa. Department of Atmospheric Sciences Yonsei University Seoul 03722 Republic of Korea. Department of Community Health and Epidemiology Dalhousie University Halifax Nova Scotia B3

Global ground-level measurements of elements in ambient particulate matter (PM) can provide valuable information to understand the distribution of dust and trace elements, assess health impacts, and investigate emission sources. We use X-ray fluorescence spectroscopy to characterize the elemental composition of PM samples collected from 27 globally distributed sites in the Surface PARTiculate mAtter Network (SPARTAN) over 2019-2023. Consistent protocols are applied to collect all samples and analyze them at one central laboratory, which facilitates comparison across different sites. Multiple quality assurance measures are performed, including applying reference materials that resemble typical PM samples, acceptance testing, and routine quality control. Method detection limits and uncertainties are estimated. Concentrations of dust and trace element oxides (TEO) are determined from the elemental dataset. In addition to sites in arid regions, a moderately high mean dust concentration (6 μg/m) in PM is also found in Dhaka (Bangladesh) along with a high average TEO level (6 μg/m). High carcinogenic risk (>1 cancer case per 100000 adults) from airborne arsenic is observed in Dhaka (Bangladesh), Kanpur (India), and Hanoi (Vietnam). Industries of informal lead-acid battery and e-waste recycling as well as coal-fired brick kilns likely contribute to the elevated trace element concentrations found in Dhaka.

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A Questionnaire on Materialisms

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OCTOBER 2016年第155期 3-110页

作者： [Anonymous] EMILY APTER is Chair of the Department of Comparative Literature at NYU and coeditor of the Dictionary of Untranslatables: A Philosophical Lexicon (Princeton 2014). ED ATKINS is an artist who lives in Berlin. ARMEN AVANESSIAN is a philosopher and the editor-in-chief at Merve Verlag Berlin founder of . BILL BROWN author of “Thing Theory” (Critical Inquiry 28 Autumn 2001) and Other Things (Chicago 2015) teaches at the University of Chicago. GIULIANA BRUNO is Emmet Blakeney Gleason Professor of Visual and Environmental Studies at Harvard University. JULIA Bryan-Wilson is Associate Professor of Contemporary Art at UC Berkeley. D. GRAHAM BURNETT writes and makes things. He teaches at Princeton and is an editor at Cabinet. MEL Y. CHEN is Associate Professor of Gender and Women's Studies at UC Berkeley and the author of Animacies (Duke 2012). ANDREW COLE is professor of English and director of the Gauss Seminars at Princeton University. His most recent book is The Birth of Theory (Chicago 2014). CHRISTOPH COX is Professor of Philosophy at Hampshire College. SUHAIL MALIK is co-director of MFA Fine Art Goldsmiths London and author of On the Necessity of Art's Exit from Contemporary Art (Urbanomic 2016). T. J. DEMOS is Professor in the Department of the History of Art and Visual Culture University of California Santa Cruz and Director of its Center for Creative Ecologies. JEFF DOLVEN teaches English at Princeton University and is an editor-at-large at Cabinet magazine. DAVID T. DORIS is Associate Professor at the University of Michigan directly above the center of the Earth. He wrote Vigilant Things (Washington 2011). HELMUT DRAXLER is professor for Art Theory at the University of Applied Arts in Vienna. PATRICIA FALGUIÈRES is a professor at the École des Hautes Études en Sciences Sociales (EHESS) Paris. PETER GALISON is the Joseph Pellegrino University Professor in History of Science and Physics at Harvard University. ALEXANDER R. GALLOWAY teaches media theory at New York University. RACHEL HAIDU is Asso

Recent philosophical tendencies of Actor-Network Theory, Object-Oriented Ontology, and Speculative Realism have profoundly challenged the centrality of subjectivity in the humanities, and many artists and curators, particularly in the UK, Germany, and the United States, appear deeply influenced by this shift from epistemology to ontology. October editors asked artists, historians, and philosophers invested in these projectsfrom Graham Harman and Alexander R. Galloway to Armen Avanessian and Patricia Falguieres to Ed Atkins and Amie Siegelto explore what the rewards and risks of assigning agency to objects may be, and how, or if, such new materialisms can be productive for making and thinking about art today.

关键词： Objectivity in art Materialism Art & society

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Author Correction: Ongoing declines for the world's amphibians in the face of emerging threats

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Nature 2024年第7993期625卷 E2页

作者： Jennifer A Luedtke Janice Chanson Kelsey Neam Louise Hobin Adriano O Maciel Alessandro Catenazzi Amaël Borzée Amir Hamidy Anchalee Aowphol Anderson Jean Ángel Sosa-Bartuano Ansel Fong G Anslem de Silva Antoine Fouquet Ariadne Angulo Artem A Kidov Arturo Muñoz Saravia Arvin C Diesmos Atsushi Tominaga Biraj Shrestha Brian Gratwicke Burhan Tjaturadi Carlos C Martínez Rivera Carlos R Vásquez Almazán Celsa Señaris S R Chandramouli Christine Strüssmann Claudia Fabiola Cortez Fernández Claudio Azat Conrad J Hoskin Craig Hilton-Taylor Damion L Whyte David J Gower Deanna H Olson Diego F Cisneros-Heredia Diego José Santana Elizah Nagombi Elnaz Najafi-Majd Evan S H Quah Federico Bolaños Feng Xie Francisco Brusquetti Francisco S Álvarez Franco Andreone Frank Glaw Franklin Enrique Castañeda Fred Kraus Gabriela Parra-Olea Gerardo Chaves Guido F Medina-Rangel Gustavo González-Durán H Mauricio Ortega-Andrade Iberê F Machado Indraneil Das Iuri Ribeiro Dias J Nicolas Urbina-Cardona Jelka Crnobrnja-Isailović Jian-Huan Yang Jiang Jianping Jigme Tshelthrim Wangyal Jodi J L Rowley John Measey Karthikeyan Vasudevan Kin Onn Chan Kotambylu Vasudeva Gururaja Kristiina Ovaska Lauren C Warr Luis Canseco-Márquez Luís Felipe Toledo Luis M Díaz M Monirul H Khan Madhava Meegaskumbura Manuel E Acevedo Marcelo Felgueiras Napoli Marcos A Ponce Marcos Vaira Margarita Lampo Mario H Yánez-Muñoz Mark D Scherz Mark-Oliver Rödel Masafumi Matsui Maxon Fildor Mirza D Kusrini Mohammad Firoz Ahmed Muhammad Rais N'Goran G Kouamé Nieves García Nono Legrand Gonwouo Patricia A Burrowes Paul Y Imbun Philipp Wagner Philippe J R Kok Rafael L Joglar Renoir J Auguste Reuber Albuquerque Brandão Roberto Ibáñez Rudolf von May S Blair Hedges S D Biju S R Ganesh Sally Wren Sandeep Das Sandra V Flechas Sara L Ashpole Silvia J Robleto-Hernández Simon P Loader Sixto J Incháustegui Sonali Garg Somphouthone Phimmachak Stephen J Richards Tahar Slimani Tamara Osborne-Naikatini Tatianne P F Abreu-Jardim Thais H Condez Thiago R De Carvalho Timothy P Cutajar Todd W Pierson Truong Re:wild Austin TX USA. jluedtke@***. IUCN SSC Amphibian Specialist Group Toronto Ontario Canada. jluedtke@***. Re:wild Austin TX USA. IUCN SSC Amphibian Specialist Group Toronto Ontario Canada. Museu Paraense Emílio Goeldi CZO/Herpetologia Belém Brazil. Florida International University Miami FL USA. Centro de Ornitologia y Biodiversidad (CORBIDI) Lima Peru. Laboratory of Animal Behaviour and Conservation College of Life Sciences Nanjing Forestry University Nanjing People's Republic of China. Laboratory of Herpetology Museum Zoologicum Bogoriense Research Center for Biosystematics and Evolution National Research and Innovation Agency (BRIN) Cibinong Indonesia. Department of Zoology Faculty of Science Kasetsart University Bangkok Thailand. Action Pour la Sauvegarde de l'Ecologie en Haïti (ACSEH) Les Cayes Haiti. Environmental Protection In the Caribbean (EPIC) Maho Sint Maarten. Museo de Vertebrados de la Universidad de Panamá Ciudad de Panama Panama. Centro Oriental de Ecosistemas y Biodiversidad (BIOECO) Museo de Historia Natural "Tomás Romay" Santiago de Cuba Cuba. IUCN SSC Amphibian Specialist Group Sri Lanka Gampola Sri Lanka. Laboratoire Évolution & Diversité Biologique UMR 5174 Université Toulouse III Paul Sabatier Toulouse France. Russian State Agrarian University-MTAA Moscow Russia. IUCN SSC Amphibian Specialist Group Bolivia La Paz Bolivia. Animal Nutrition Unit Department of Veterinary and Biosciences Ghent University Ghent Belgium. ASEAN Centre for Biodiversity University of the Philippines Los Baños Laguna Philippines. HerpWatch Pilipinas Manila Philippines. Faculty of Education University of the Ryukyus Okinawa Japan. Graduate School of Engineering and Science University of the Ryukyus Okinawa Japan. SAVE THE FROGS! Laguna Beach CA USA. The University of Texas at Arlington Arlington TX USA. Smithsonian Conservation Biology Institute Front Royal VA USA. Center for Environmental Studies Sanata Dharma University (CESSDU) Yogya

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