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arXiv 2022年

作者： Satapathy, Sitakanta Liu, Bin Deshmukh, Prathmesh Molinaro, Paul M. Dirnberger, Florian Khatoniar, Mandeep Koder, Ronald L. Menon, Vinod M. Department of Physics Center for Discovery and Innovation The City College of New York 85 St. Nicholas Terrace New YorkNY10031 United States The PhD Program in Physics The Graduate Center of the City University of New York 365 5th Ave New YorkNY10016 United States Department of Electrical Engineering and Computer Science University of Michigan Ann ArborMI48109 United States

Fluorescent proteins (FPs) have recently emerged as a serious contender for realizing ultra-low threshold room temperature exciton-polariton condensation and lasing. Our contribution investigates the thermalization of FP microcavity exciton-polaritons upon optical pumping under ambient conditions. We realize polariton cooling using a new FP molecule, called mScarlet, coupled strongly to the optical modes in a Fabry-Pérot cavity. Interestingly, at the threshold excitation energy (fluence) of ~9 nJ/pulse (15.6 mJ/cm2), we observe an effective temperature, Teff ~350 ± 35 K close to the lattice temperature indicative of strongly thermalized exciton-polaritons at equilibrium. This efficient thermalization results from the interplay of radiative pumping facilitated by the energetics of the lower polariton branch and the cavity Qfactor. Direct evidence for dramatic switching from an equilibrium state into a metastable state is observed for the organic cavity polariton device at room temperature via deviation from the Maxwell-Boltzmann statistics at k1 = 0 above the threshold. Thermalized polariton gases in organic systems at equilibrium hold substantial promise for designing room temperature polaritonic circuits, switches, and lattices for analog simulation. © 2022, CC BY-NC-SA.

关键词： Polariton

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Multiplexed Serial Imaging of Immunotherapy Response with Serrs Nanoprobes

Multiplexed Serial Imaging of Immunotherapy Response with Se...

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IEEE International Symposium on Biomedical Imaging

作者： Naxhije Berisha Konstantinos Plakas Matthieu Gigoux Taha Merghoub Chrysafis Andreou Hunter College of the City University of New York New York NY USA PhD Program in Chemistry The Graduate Center of the City University of New York NY USA Memorial Sloan Kettering Cancer Center New York NY USA Department of Chemistry University at Buffalo The State University of New York Buffalo NY USA Weill Cornell Medicine New York NY USA Department of Electrical and Computer Engineering University of Cyprus Nicosia Cyprus

ISBN: (数字)9798350313338

ISBN: (纸本)9798350313345

With the advent of new and promising cancer therapies, and with increased interest in precision medicine, there is an urgent need to develop non-invasive technologies that evaluate heterogeneity in treatment response. We demonstrate an 8-plex imaging platform based on surface enhanced resonance Raman scattering nanoparticles (SERRS NPs) to monitor the expression of 4 immunomarkers before and after treatment with checkpoint blockade therapy with anti-CTLA4 and anti-PD-1 antibodies in immunotherapy models of colon (CT26) and breast (4T1) cancers. We found that CT26 tumors showed an early treatment response, while the typically refractory 4T1 tumors demonstrated an unexpected treatment response, suggesting that the nanoparticles may have synergistically contributed to the treatment. Serial imaging of multiple markers during therapy can help predict treatment efficacy and uncover new theranostic adjuvants.

关键词： Nanoparticles Multiplexing Precision medicine Raman scattering Immunotherapy Resonance Surface treatment

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Towards innovative electrodiagnosis tests to investigate neuromuscular excitability dysfunction in critically ill patients: an agreement study

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Research on Biomedical engineering 2023年第4期39卷 949-958页

作者： Silva, Paulo Eugênio Martins, Henrique Resende de Deus Macedo, José Roberto de Queiroz, Alessandra Vasconcelos Ultra de Aguiar, Agda Martins, Emerson Fachin Physical Therapy Division Hospital de Base do Distrito Federal. Instituto de Gestão Estratégica de Saúde do Distrito Federal SMHS Área Especial Quadra 101 DF BrasíliaCEP 70.330-150 Brazil Universidade de São Paulo Faculdade de Medicina SP São Paulo Brazil Graduate Program in Electrical Engineering Universidade Federal de Minas Gerais MG Belo Horizonte Brazil Health Sciences and Technologies PhD Program University of Brasilia DF Brasília Brazil Intensive Care Division Hospital de Base do Distrito Federal Instituto de Gestão Estratégica de Saúde do Distrito Federal DF Brasília Brazil Physical Therapy Division Hospital Regional de Ceilândia Secretaria de Estado de Saúde do Distrito Federal DF Brasília Brazil Physical Therapy Division Hospital de Base do Distrito Federal Instituto de Gestão Estratégica de Saúde do Distrito Federal DF Brasília Brazil Graduate Programs in Health Sciences and Technologies and in Rehabilitation Sciences Physical Therapy Department Faculdade de Ceilândia Universidade de Brasília DF Brasília Brazil

Purpose: Early diagnosis of ICU-acquired weakness can support the ICU team in applying appropriate interventions which may lead to better results at clinical and functional outcomes. Thus, interest has increased in non-invasive and more feasible methods to diagnose neuromuscular dysfunction, such as the stimulus electrodiagnosis test (SET) and strength-duration test (SDT). The aim of the present study was to assess the agreement of the SET and SDT carried out automatically using an innovative method. Methods: We performed a prospective observational study to determine the agreement of SET and SDT, performed automatically using a biofeedback circuit to detect muscle contractions, comprised of an accelerometer module connected to an electrical stimulator. These tests were applied in healthy and critically ill participants. Results: Twenty-one participants were analyzed in the study, and 168 assessments of SET and SDT were performed. The Bland-Altman analysis of automatic SET and SDT in the control group showed a low bias of −25 (95% CI, −94.3 to 44.3 μs) and 0.6 (95% CI, −1.9 to 3.1 μC) respectively. In the critically ill group, automatic SET and SDT presented a low bias of −104.5 (95% CI, −1716 to 1507μs) and −12.6 (95% CI, −119.4 to 94.1 μC) respectively. Conclusions: We demonstrated that an innovative method to carry out SET and SDT automatically presents low agreement bias and good to excellent reliability. © 2023, The Author(s), under exclusive licence to The Brazilian Society of Biomedical engineering.

关键词： Intensive care units

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Triaxial MMG investigation during FES-induced cycle movements

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Journal of Physics: Conference Series 2016年第1期705卷

作者： M C Gelain G N Nogueira-Neto P Nohama P M Gewehr Master's student of Electrical Engineering and Industrial Informatics at UTFPR (Rehabilitation engineering laboratory phone: +55 (41) 3310-4489) Brazil PhD in Biomedical Engineering researcher and professor of Computer Engineering at Pontifícia Universidade Católica do Paraná (PUCPR) Brazil PhD in Biomedical Engineering researcher and full professor at the PPGTS stricto sensu program at Pontifícia Universidade Católica do Paraná (PUCPR) Brazil PhD in Medical Physics Bioengineering and professor of Biomedical engineering at UTFPR Brazil

Spinal cord injury is damage to the spinal cord that results in loss of functions, causes muscle, joint and bone deficits, moreover it increases the muscle tone level. FEScycling is an alternative rehabilitation process to conserve the musculoskeletal system affected by the injury in the functional state. The aim of this study is to get the legs bilaterally synchronized by FES and compare MMG signal responses. The preliminary protocol consists of five consecutive contractions. The first and the last contractions were discarded and the three intermediate contractions were analyzed. A ratio between MMG values of muscle responses during propulsion and return of pedalling phases was calculated for each cycle and each leg. The applied FES profile consisted of pulse and burst on time of 250 us and 5 ms and frequencies of 1000 Hz and 20 Hz, respectively. Results showed that greater MMG RMS values tend to occur during the propulsion phase than in the return phase. MMG Z axis of RLL and MMG X axis of LLL were the axes that presented the greatest ratios. The MMG RMS signal showed that greater values tend to occur during the propulsion phase than in the return phase of the same thigh.

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A Framework for Interpretability in Machine Learning for Medical Imaging

arXiv

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arXiv 2023年

作者： Wang, Alan Q. Karaman, Batuhan K. Kim, Heejong Rosenthal, Jacob Saluja, Rachit Young, Sean I. Sabuncu, Mert R. School of Electrical and Computer Engineering Cornell University Cornell Tech New YorkNY10044 United States Department of Radiology Weill Cornell Medical School New YorkNY10065 United States Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program New YorkNY10065 United States Martinos Center for Biomedical Imaging Harvard Medical School BostonMA02129 United States Computer Science and Artificial Intelligence Laboratory MIT CambridgeMA02139 United States

Interpretability for machine learning models in medical imaging (MLMI) is an important direction of research. However, there is a general sense of murkiness in what interpretability means. Why does the need for interpretability in MLMI arise? What goals does one actually seek to address when interpretability is needed? To answer these questions, we identify a need to formalize the goals and elements of interpretability in MLMI. By reasoning about real-world tasks and goals common in both medical image analysis and its intersection with machine learning, we identify five core elements of interpretability: localization, visual recognizability, physical attribution, model transparency, and actionability. From this, we arrive at a framework for interpretability in MLMI, which serves as a step-by-step guide to approaching interpretability in this context. Overall, this paper formalizes interpretability needs in the context of medical imaging, and our applied perspective clarifies concrete MLMI-specific goals and considerations in order to guide method design and improve real-world usage. Our goal is to provide practical and didactic information for model designers and practitioners, inspire developers of models in the medical imaging field to reason more deeply about what interpretability is achieving, and suggest future directions of interpretability research. © 2023, CC0.

关键词： Machine learning

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Correction to: Design framework for a seamless smart glove using a digital knitting system

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Fashion and Textiles 2021年第1期8卷 1-1页

作者： Song, Yewon Lee, Seulah Choi, Yuna Han, Sora Won, Hyuna Sung, Tae-Hyun Choi, Youngjin Bae, Jihyun PhD Candidate Department of Electrical Engineering Hanyang University Seoul South Korea Post Doctoral Researcher Department of Electrical and Electronic Engineering Hanyang University Ansan South Korea Graduate Student Department of Electrical and Electronic Engineering Hanyang University Ansan South Korea Graduate Student Human-Tech Convergence Program Department of Clothing & Textiles Hanyang University Seoul South Korea Professor Department of Electrical Engineering Hanyang University Seoul South Korea Professor Department of Electrical and Electronic Engineering Hanyang University Ansan South Korea Associate Professor Human-Tech Convergence Program Department of Clothing & Textiles Hanyang University Seoul South Korea

An amendment to this paper has been published and can be accessed via the original article.

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FULL-WAVE SOLUTION OF DIELECTRIC LOADED WAVE-GUIDES AND SHIELDED MICROSTRIPS UTILIZING FINITE-DIFFERENCE AND THE CONJUGATE-GRADIENT METHOD

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INTERNATIONAL JOURNAL OF MICROWAVE AND MILLIMETER-WAVE COMPUTER-AIDED engineering 1991年第4期1卷 346-357页

作者： NARAYANAN, V MANELA, M LADE, RK SARKAR, TK Department of Electrical and Computer Engineering Syracuse University Syracuse New York 13244-1240 Viswanathan Narayanan was born in Bangalore India on December 14 1965. He received the BE degree in Electronics and Communications from B.M.S. College of Engineering Bangalore in 1988. He joined the Department of Electrical Engineering at Syracuse University for his graduate studies in 1989 where he is currently a research assistant. His research interests are in microwave measurements numerical electromagnetics and signal processing. Biographies and photos are not available for M. Manela and R. K. Lade. Tapan K. Sarkar (Sf69-M'76-SM'X1) was born in Calcutta. India on August 2 1948. He received the BTech degree from the Indian Institute of Technology Kharagpur India in 1969 the MScE degree from the University of New Brunswick Fredericton Canada in 1971. and the MS and PhD degrees from Syracuse University. Syracuse NY in 1975. From 1975-1976 he was with the TACO Division of the General Instruments Corporation. He was with the Rochester Institute of Technology (Rochester NY) from 1976-1985. He was a Research Fellow at the Gordon Mckay Laboratory Harvard University Cambridge MA from 1977 to 1978. He is now a Professor in the Department of Electrical and Computer Engineering Syracuse University. His current research interests deal with numerical solutions of operator equations arising in electromagnetics and signal processing with application to system design. He obtained one of the “ best solution” awards in May 1977 at the Rome Air Development Center (RADC) Spectral Estimation Workshop. He has authored or coauthored more than 154 journal articles and conference papers and has written chapters in eight books. Dr. Sarkar is a registered professional engineer in the state of New York. He received the Best Paper Award of the IEEE Transactions on Electromagnetic Compatibility in 1979. He was an Associate Editor for feature articles of the lEEE Antennas arid Propagation Sociefy Newsletter and was

Dynamic analysis of waveguide structures containing dielectric and metal strips is presented. The analysis utilizes a finite difference frequency domain procedure to reduce the problem to a symmetric matrix eigenvalue problem. Since the matrix is also sparse, the eigenvalue problem can be solved quickly and efficiently using the conjugate gradient method resulting in considerable savings in computer storage and time. Comparison is made with the analytical solution for the loaded dielectric waveguide case. For the microstrip case, we get both waveguide modes and quasi-TEM modes. The quasi-TEM modes in the limit of zero frequency are checked with the static analysis which also uses finite difference. Some of the quasi-TEM modes are spurious. This article describes their origin and discusses how to eliminate them. Numerical results are presented to illustrate the principles.

关键词： Waveguides

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Spatial atlas of the mouse central nervous system at molecular resolution (vol 622, pg 552, 2023)

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NATURE 2024年第7993期625卷 E6-E6页

作者： Shi, Hailing He, Yichun Zhou, Yiming Huang, Jiahao Maher, Kamal Wang, Brandon Tang, Zefang Luo, Shuchen Tan, Peng Wu, Morgan Lin, Zuwan Ren, Jingyi Thapa, Yaman Tang, Xin Chan, Ken Y. Deverman, Benjamin E. Shen, Hao Liu, Albert Liu, Jia Wang, Xiao Broad Institute of MIT and Harvard Cambridge MA USA Department of Chemistry Massachusetts Institute of Technology Cambridge MA USA John A. Paulson School of Engineering and Applied Sciences Harvard University Boston MA USA Computational and Systems Biology PhD Program Massachusetts Institute of Technology Cambridge MA USA Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA USA Department of Biology Massachusetts Institute of Technology Cambridge MA USA Klarman Cell Observatory Broad Institute of MIT and Harvard Cambridge MA USA Department of Chemistry and Chemical Biology Harvard University Cambridge MA USA Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge MA USA

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Educational use of a microwave electromagnetic analysis of 3-D planar structures

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Computer Applications in engineering Education 1993年第3期1卷 243-243页

作者： Rautio, J.C. Sonnet Software Inc. Suite 203 135 Old Cove Road Liverpool NY 13090 Dr. James C. Rautio:founded Sonnet Software a developer of 3-D planar electromagnetic microwave software in 1983 with support from the David Sarnoff Research Center Hewlett Packard General Electric and Syracuse University. He has served as a visiting member of the faculty at Syracuse University and as an adjunct faculty member at Cornell University teaching microwave and computer courses as well as pursuing research in electromagnetics. Dr. Rautio previously worked in General Electric's Space Division and Electronics Laboratory. He designed microwave circuits including filters for a Landsat receiver and various GaAs microwave integrated circuits. He also developed microwave and millimeter wave automated measurement equipment and wrote a large microwave circuit analysis program. Dr. Rautio holds a BS in Electrical Engineering from Cornell University an MS in Systems Engineering from the University of Pennsylvania and a PhD in Electrical Engineering from Syracuse University

The use of an electromagnetic analysis of 3-D planar structures is described with respect to the educational requirements of students from the college freshman level through the graduate level. The analysis is intended primarily for microwave use; however, there is also significant potential interest from the student of high speed digital design. The analysis is used for passive planar circuits with any number of layers. The third dimension is represented by vias. A mature graphical user interface is provided allowing rapid capture of structure geometry, color visualization, and animation of the resulting current distributions. The software is also explicitly designed to work in conjunction with popular circuit theory based microwave software and with SPICE.

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Windows computer laboratory as a tutorial for undergraduate electromagnetics

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Computer Applications in engineering Education 1995年第3期3卷 183-183页

作者： McCulloch, J. Keddy, W.A. Stuchly, M.A. University of Victoria Department of Electrical and Computer Engineering University of Victoria Victoria British Columbia Canada Janet McCulloch:is a native of Toronto Canada where she briefly attended both York University and the University of Toronto before she set off on a year-long adventure through the Middle East and North Africa. When she returned to Canada she relocated to California. She spent a number of years living both in Los Angeles and coastal Northern California interspersed with several extended trips through the United States Mexico and Central America. Ms. McCulloch moved to Victoria British Columbia in 1989 and a year later registered in the cooperative education program in Electrical Engineering at the University of Victoria. She is presently in the fifth and final year of the program and has her sights set on graduate school. Besides the work described in this article she has been very much involved in the use of technology to assist in the delivery of curriculum at the senior secondary level. She lives on a country property a half-hour from the University with her husband her horse and three cats. W. Alfred Keddy:is an applications programmer/analyst for the Department of Electrical and Computer Engineering at the University of Victoria. He received a BEng (1988) in Electrical Engineering and an MASc (1994) from the University of Victoria. His research interests include distributed systems image processing local area networks VLSI and DSP system design for computation and communication and human–computer interface design. Maria A. Stuchly:received an MSc in Electrical Engineering in 1962 from Warsaw Technical University and a PhD in Electrical Engineering from the Polish Academy of Sciences in 1970. Between the years of 1962 and 1970 she was with the Warsaw Technical University an Institute of the Polish Academy of Sciences. After immigrating to Canada during 1970 her first position was with the University of Manitoba. In 1976 she became employed by the Bureau of Radi

Contents and implementation of a computer laboratory for undergraduate electromagnetics are described. The laboratory consists of four 3-hour sessions covering vector calculus, Maxwell's equations (integral and differential forms), wave propagation in materials, and wave behavior at planar interfaces. Each session contains theory (in the Help file), animations (where relevant) and a quiz. The program runs on IBM compatible 486-based PCs in a Windows environment and uses the Borland C ++ 4.0 compiler.

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