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TARGETING CORTICAL MOTOR REGIONS WITH TRANSCRANIAL STATIC MAGNETIC FIELD STIMULATION TO REDUCE CORTICOSPINAL EXCITABILITY

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IBRO Neuroscience Reports 2023年 15卷 S296-S296页

作者： Cristina Pagge Jaime Caballero-Insaurriaga Antonio Oliviero Guglielmo Foffani Claudia Ammann Fundación de Investigación HM Hospitales Centro Integral De Neurociencias Ac Hm Cinac Móstoles Spain Autonoma de Madrid University-Cajal Institute Phd Program In Neuroscience Madrid Spain Universidad Politécnica de Madrid Phd Program In Biomedical Engineering Madrid Spain Hospital Nacional de Parapléjicos Fennsi Group TOLEDO Spain Instituto de Salud Carlos III Ciberned Madrid Spain SESCAM Hospital Nacional De Parapléjicos Toledo Spain Camilo José Cela University of Madrid Faculty Of Health Madrid Spain

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Enhancing patient self-management after a first stroke: An application of the wearable devices and the health management platform

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Disability and Health Journal 2023年第1期16卷 101392-101392页

作者： Wu, Jia-Min Chen, Hsin-Shui Chen, Hsin-Han Cheng, Bor-Wen Huang, Chiu-Wen Chung, Ming-Hung Department of Industrial Engineering and Management National Yunlin University of Science and Technology No.123 University Road Section 3 Douliou Yunlin City 64002 Taiwan PhD Program for Aging College of Medicine China Medical University No. 100 Sec. 1 Jingmao Rd Beitun Dist Taichung City 406040 Taiwan Department of Physical Medicine & Rehabilitation National Taiwan University Hospital Yunlin Branch No.579 Sec. 2 Yunlin Rd Douliu City Yunlin County 640 Taiwan School of Medicine China Medical University No. 91 Xueshi Rd North District Taichung City 404333 Taiwan

Background: Post-stroke disability restricts a patient's physical activity, affects the patient's quality of life, and leads to higher medical costs. Therefore, it is essential to promote patients' continuous exercise during this period of recovery. Objective: This study aimed to verify the effectiveness of applying a health management platform combined with wearable devices to enhance stroke patients’ self-management of recovery and to allow comparisons with active care intervention management. Method: This quasi-experimental study aimed at examining those participants who had sustained a stroke for the first time. A 90-day experiment was implemented with the intervention of monitoring and active care from the researchers who also interviewed the selected participants at the end of the study. A total of 26 participants were examined (14 in the experimental group and 12 in the control group). Result: The participants in the experimental group made significant progress between the pre- and post-tests. Firstly, their six-minute walking distance improved by 89.5 m (p < 0.001). Secondly, their sit-to-stand transfers in 60 s improved 2.85 times (p = 0.017), and their Berg balance test improved by 6.36 points (p = 0.003). Finally, the Partners in Health scale (PIH) scores also improved. According to the data collected in the interviews, the researchers' intervention improved the patients’ self-management ability. Conclusion: The short-term physical performance in the experimental group after the intervention was better than that in the control group. In clinical practice, it is suggested that continuous interaction between medical staff and patients be sustained while applying wearable devices to promote the patient's self-management ability. © 2022 The Authors

关键词： Health management Self-management Stroke Wearable device

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Neuropsychological differential diagnosis of Alzheimer's disease and Lewy body dementia: A systematic review

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Neurologia 2024年

作者： Julio-Ramos, T. Mora-Castelleto, V. Foncea-González, C. Adames-Valencia, C. Cigarroa, I. Méndez-Orellana, C. Toloza-Ramirez, D. PhD Program in Health Sciences and Engineering Universidad de Valparaiso Valparaiso Chile Fonoaudióloga Pontificia Universidad Católica de Chile Santiago Chile Fonoaudióloga Centro Vida Sur Puerto Montt Chile Escuela de Kinesiología Facultad de Ciencias de la Salud Universidad Católica Silva Henríquez Santiago Chile Carrera de Fonoaudiología Departamento Ciencias de la Salud Facultad de Medicina Pontificia Universidad Católica de Chile Santiago Chile Exercise and Rehabilitation Sciences Institute School of Speech Therapy Faculty of Rehabilitation Sciences Universidad Andres Bello Santiago Chile Interdisciplinary Center for Neuroscience Faculty of Medicine Pontificia Universidad Católica de Chile Santiago Chile

Introduction: Alzheimer's disease (AD) reports heterogeneity of neuropsychological symptoms misleading the differential diagnosis with other forms of dementia, such as dementia with Lewy bodies (DLB). About 50% of DLB patients are misdiagnosed as AD cases. Likewise, the diagnosis of both diseases is mainly based on clinical characteristics. However, differentiating AD of those with DLB based on neuropsychological symptoms and anatomical and functional brain changes remains challenging. Aim: To establish the main neuropsychological, anatomical, and functional similarities and differences in patients with AD and DLB. Methods: The present study followed the PRISMA guidelines and included studies from the PubMed, Scopus, and Web of Sciences databases, published between January 2000 and July 2022. Results: Forty-one articles were included in this systematic review for critical analysis. Our results suggest that the cognitive key domains to consider in the differential diagnosis are memory, executive function, attention, visuospatial/visuoconstructive skills, and verbal fluency (both semantic and phonological). The stage and severity of both diseases would be essential for differential diagnosis. On the other hand, the anatomical and functional changes suggest a similar atrophy pattern between AD and DLB in the frontal, parietal, temporal, hippocampal, and precuneus regions. Conclusion: The differential diagnosis between AD and DLB is challenging in clinical practice. Therefore, our results suggest exploring cognitive linguistic markers along with correlating these markers with anatomical and functional brain changes. © 2024 Sociedad Española de Neurología;Introducción: La enfermedad de Alzheimer (EA) reporta heterogeneidad de síntomas neuropsicológicos. Esto conduce a errores diagnósticos con otras formas de demencia, como la demencia por cuerpos de Lewy (DPCL). De hecho, alrededor del 50% de los pacientes con DPCL son confundidos como casos de EA. Si bien el diagnóstico

关键词： Alzheimer's disease Dementia with Lewy bodies Differential diagnosis Neural correlate Neuropsychological assessment

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Measuring the Land-Sea Coupling Coordination Degree of the Coastal Zone and Its Optimization Strategy:A Case Study of the Coastal Zone in Xiamen

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China City Planning Review 2020年第1期29卷 8-19页

作者： Lin Xiaoru Lü Yiping Liu Qing Assistant Professor Master''s Supervisor Department of Urban Planning School of Architecture and Civil Engineering Xiamen University Postdoctoral Fellow UNC Program on Chinese Cities Xiamen P. R. China Postgraduate Department of Urban Planning Xiamen University Xiamen P R China PhD Candidate Heilongjiang Cold Region Urban-Rural Human Settlements Science Key Laboratory School of Architecture Harbin Institute of Technology Harbin P. R. China

Currently,China has entered the period of land-sea coordinated planning,yet there are few studies on the interaction between land use intensity and sea eco-security in coastal ***,taking the coastal zone of Xiamen as an example,this paper develops a comprehensive system to evaluate the coupling degree between spatial utilization intensity and eco-security based on the coupling degree theory in *** the paper quantitatively analyzes and identifies the coupling coordination degree of various shore sections into four categories:well-coordinated and highly-coupled,moderately-coordinated and moderately-coupled,moderately-coordinated and slightly-coupled,and primary-level coordinated and ***,it puts forward spatial planning guidelines for the four types of shore sections on the basis of land-sea ***,reserved ecological section should follow the principle of giving priority to the marine ecosystem,and strictly protecting the ecosystem and controlling development;ecological promotion section should follow the principle of optimizing land development based on the sea resources,and reserving space for transformation;restricted development section should follow the principle of land-sea balance,and only allowing low-impact development activities to achieve synchronous land-sea development;development leverage section should follow the principle of optimizing marine development based on land resources,giving full play to the advantages of coastal resources and featured coastal space,and achieving spatial optimization in accordance with people-oriented principles and local *** research intends to provide a scientific basis for coastal zone planning and decision-making and a paradigm guide for gulf cities to coordinate the marine ecosystem and land development.

关键词： coastal zone coupling coordination eco-security land-sea coordination Xiamen

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Assessment of circulating extracellular vesicles from calorie-restricted mice and humans in ischaemic injury models

Journal of Extracellular Biology

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Journal of Extracellular Biology 2023年第5期2卷 e86页

作者： Jaimes, Manuel S. V. Liao, Chia-Te Chen, Max M. Czosseck, Andreas Lee, Tsung-Lin Chou, Yu-Hsiang Chen, Yung-Ming Lin, Shuei-Liong Lai, James J. Lundy, David J. Graduate Institute of Biomedical Materials & Tissue Engineering Taipei Medical University Taipei Taiwan Division of Nephrology Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei Taiwan Division of Nephrology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan TMU Research Center of Urology and Kidney (TMU-RCUK) Taipei Medical University Taipei Taiwan Division of Nephrology Department of Internal Medicine National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan Department of Bioengineering University of Washington Seattle WA United States Department of Materials Science and Engineering National Taiwan University of Science and Technology Taipei Taiwan International PhD Program in Biomedical Engineering Taipei Medical University Taipei Taiwan Center for Cell Therapy Taipei Medical University Hospital Taipei Taiwan

Calorie restriction (CR) and fasting affect lifespan, disease susceptibility and response to acute injury across multiple animal models, including ischaemic injuries such as myocardial infarction or kidney hypoxia. The cargo and function of circulating extracellular vesicles (EV) respond to changes in host physiology, including exercise, injury, and other interventions. Thus, we hypothesised that EVs induced following CR may reflect some of the beneficial properties of CR itself. In a pilot study, EVs were isolated from mice following 21 days of 30 % CR, and from eight human donors after 72 h water-only fasting. EV size, concentration and morphology were profiled by NTA, western blot and cryoEM, and their function was assessed using multiple assays related to ischaemic diseases. We found that EVs from post-fasting samples better protected cardiac cells from hypoxia/reperfusion (H/R) injury compared to pre-fasting EVs. However, there was no difference when used to treat H/R-injured kidney epithelial cells. Post-fasting derived EVs slowed the rate of fibroblast migration and slightly reduced macrophage inflammatory gene expression compared to pre-fasting derived EVs. Lastly, we compared miRNA cargos of pre- and post-fasting human serum EVs and found significant changes in a small number of miRNAs. We conclude that fasting appears to influence EV cargo and function, with varied effects worthy of further exploration. © 2023 The Authors. Journal of Extracellular Biology published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.

关键词： calorie restriction cardiomyocyte diet extracellular vesicle fasting hypoxia ketone macrophage microRNA serum

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Efficient colorimetric point-of-care detection and imaging of multiple biomolecules utilizing photonic liquid crystal composite on gold nanoisland thin films for label-free sensing

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AIP Advances 2024年第7期14卷

作者： Luh, Hui-Tzung Hsu, Chuan-Chih Chene, Fu-Lun Chang, Huan-Chi Hsieh, Sung-Tsang Lai, Dar-Ming Hsiao, Yu-Cheng Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Division of Neurosurgery Department of Surgery National Taiwan University Hospital Hsin-Chu Branch Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Division of Infectious Diseases Department of Internal Medicine Wan Fang Hospital Taipei Medical University Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University uMeal Co. Ltd. Department of Neurology National Taiwan University Hospital National Taiwan University College of Medicine Division of Neurosurgery Department of Surgery National Taiwan University Hospital Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering International PhD Program for Biomedical Engineering Taipei Medical University Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University

Accurate and timely identification of infections is crucial for effective treatment and controlling disease spread. While single biomarkers have traditionally served diagnostic purposes, their sensitivity and specificity limitations call for a more comprehensive approach. Simultaneous detection of multiple biomolecules shows promise in improving accuracy, expediting analysis, and enhancing pathology screening. Therefore, there is a pressing need to develop a noninvasive biosensor capable of quantifying various infection-associated biomarkers concurrently, such as albumin proteins and bacterial molecules. In this endeavor, a novel biosensor has been developed, leveraging a color-indicating optical platform that utilizes gold nanoisland films (AuNIFs) enveloped by cholesteric liquid crystals (CLCs). The integration of CLCs and AuNIFs capitalizes on their sensitive interfacial interactions, highlighting the potential for robust biosensing. Changes in biomolecule concentrations induce discernible alterations in the CLCs-AuNIFs interface alignment, profoundly impacting the hybrid plasmonic-photonic behavior of AuNIFs. The resulting CLCs-AuNIFs biosensor demonstrates exceptional sensitivity and precision in detecting E. coli concentrations and albumin levels. Notably, the biosensor achieves a label-free limit of detection, with an impressive sensitivity of 1 × 10⁶ CFU/ml for E. coli and 10 ng/ml for bovine serum albumin (BSA). This innovative biosensor offers rapid detection, visual clarity, label-free operation, and the ability to detect multiple concentrations of both microbial agents and albumin. Changes in biomolecule concentrations induce noticeable shifts in interface alignment, thereby modulating the hybrid plasmonic-photonic dynamics of AuNIFs. The potential applications of this advancement span biomedical, microbial, and industrial sectors. This unified biosensor has the potential to revolutionize infection-related diagnostics and containment measures,

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AN ALGEBRAIC CHARACTERIZATION OF k–COLORABILITY

arXiv

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arXiv 2020年

作者： Flores, Ramón Kahrobaei, Delaram Koberda, Thomas Department of Geometry and Topology University of Seville Spain Department of Computer Science University of York UK New York University Tandon School of Engineering PhD Program in Computer Science CUNY Graduate Center Mathematics Department University of Virginia CharlottesvilleVA22904

We characterize k–colorability of a simplicial graph via the intrinsic algebraic structure of the associated right-angled Artin group. As a consequence, we show that a certain problem about the existence of homomorphisms from right-angled Artin groups to products of free groups is NP–complete. Copyright © 2020, The Authors. All rights reserved.

关键词： Algebra

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A new capnellene skeleton from the octocoral Capnella imbricata (Quoy & Gaimard, 1833)

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Journal of Molecular Structure 2023年 1271卷

作者： Wu, I-Ting Fan, Yu-Chen Lin, Guan-Zhou Wang, Yi-Lin Hwang, Tsong-Long Lai, Kuei-Hung Chung, Hsu-Ming Department of Applied Chemistry National Pingtung University Pingtung900391 Taiwan Graduate Institute of Biomedical Sciences Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan33305 Taiwan Research Center for Chinese Herbal Medicine Graduate Institute of Healthy Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan33305 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Department of Anesthesiology Chang Gung Memorial Hospital Taoyuan333 Taiwan PhD Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei11031 Taiwan Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei11031 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei11031 Taiwan

Chemical investigations on the ethyl acetate extract of the octocoral Capnella imbricata collected from the waters of Taiwan, which led to the isolation of three capnellenes (1–3), including one new metabolite, 9(12)-capnellene-8β,10α,15-triol (1), along with two known metabolites, 9(12)-capnellene-5α,8β,10α-triol (2), and 9(12)-capnellene-8β,10α-diol (3). The structures of the isolated metabolites were elucidated through extensive spectroscopic analyses, while the relative stereochemistry of 3 was confirmed by a single-crystal X-ray diffraction analysis for the first time in this study. Compounds 1–3 were evaluated in terms of their anti-inflammatory activity by examining their inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils. © 2022 Elsevier B.V.

关键词： Metabolites

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Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2

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Nature Communications 2024年第1期15卷 7463页

作者： Wang, Rong-Hsuan Chen, Pin-Ru Chen, Yue-Ting Chen, Yi-Chang Chu, Yu-Hsin Chien, Chia-Chen Chien, Po-Chen Lo, Shao-Yun Wang, Zhong-Liang Tsou, Min-Chen Chen, Ssu-Yu Chiu, Guang-Shen Chen, Wen-Ling Wu, Yi-Hsuan Wang, Lily Hui-Ching Wang, Wen-Ching Lin, Shu-Yi Kung, Hsing-Jien Wang, Lu-Hai Cheng, Hui-Chun Lin, Kai-Ti Institute of Biotechnology National Tsing Hua University Hsinchu Taiwan Institute of Bioinformatics and Structural Biology National Tsing Hua University Hsinchu Taiwan Institute of Molecular and Genomic Medicine National Health Research Institutes Zhunan Taiwan Institute of Molecular and Cellular Biology National Tsing Hua University Hsinchu Taiwan Department of Medical Science National Tsing Hua University Hsinchu Taiwan School of Medicine National Tsing Hua University Hsinchu Taiwan Department of Life Science National Tsing Hua University Hsinchu Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Zhunan Taiwan College of Medical Science and Technology PhD Program for Cancer Biology and Drug Discovery Taipei Medical University Taipei Taiwan Chiese Medicine Research Center and Institute of Integrated Medicine China Medical University Taichung City Taiwan

Most cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation to aerobic glycolysis for energy production. By reducing enzyme activity of pyruvate kinase M2 (PKM2), cancer cells attain a greater fraction of glycolytic metabolites for macromolecule synthesis needed for rapid proliferation. Here we demonstrate that hydrogen sulfide (H₂S) destabilizes the PKM2 tetramer into monomer/dimer through sulfhydration at cysteines, notably at C326, leading to reduced PKM2 enzyme activity and increased PKM2-mediated transcriptional activation. Blocking PKM2 sulfhydration at C326 through amino acid mutation stabilizes the PKM2 tetramer and crystal structure further revealing the tetramer organization of PKM2-C326S. The PKM2-C326S mutant in cancer cells rewires glucose metabolism to mitochondrial respiration, significantly inhibiting tumor growth. In this work, we demonstrate that PKM2 sulfhydration by H₂S inactivates PKM2 activity to promote tumorigenesis and inhibiting this process could be a potential therapeutic approach for targeting cancer metabolism. © The Author(s) 2024.

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Sustainable flower-like Cu-Ni metal-organic frameworks catalyst for enhanced electrochemical sensing and photocatalytic degradation of antibiotic pollutants

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Microchemical Journal 2025年 214卷

作者： N.S.K. Gowthaman Ameer Farithkhan E. Narayanamoorthi Ponnusamy Arul Chinnathambi Nandhini Vellaichamy Balakumar S. Selvarajan School of Engineering Monash University Bandar Sunway Selangor 47500 Malaysia Center for Advanced Energy Materials SRM TRP Engineering College Tiruchirapalli 621 105 Tamil Nadu India Center for Research Easwari Engineering College Chennai 600 089 Tamil Nadu India School of Materials Science and Engineering Pusan National University Busan 46241 Republic of Korea International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Institute of Biochemical and Biomedical Engineering Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 106 Taiwan Department of Materials Engineering Ming Chi University of Technology New Taipei City 24303 Taiwan Department of Chemistry Sri Ramakrishna College of Arts & Science Coimbatore 641 006 Tamil Nadu India Department of Chemistry Theni Kammavar Sangam College of Arts & Science Theni 625 531 Tamil Nadu India

Massive usage of antibiotics harms the environment through animals’ excrement and squeezes open-wellbeing issues. Enrofloxacin (EF), an antimicrobial agent, treats bacterial diseases and infections in cattle, poultry and exotic animals and exhibits harmful side effects. The present work proposed a sensitive and rapid electrochemical scaffold based on the Cu-Ni bimetallic-organic framework (Cu-Ni-MOF) for the detection of harmful EF in real-time applications. The Cu-Ni-MOF was synthesized through solvothermal approach with the support of a multifunctional organic ligand, 4,4-biphenyldicarboxylicacid and characterized through various analytical tools. The electrochemical sensor for EF detection was constructed by drop-casting the Cu-Ni-MOF on a glassy carbon electrode and the fabricated sensor exhibited higher catalytic activity when compared to the parental counterparts by exhibiting 1.7-fold higher current for EF oxidation. Further, the fabricated sensor is highly active in the linear range response of 200 nM–2 mM with a limit of detection of 15.17 nM and sensitivity of 638.71 µA mM cm −2 under optimized environments. The higher electrocatalytic activity of the Cu-Ni-MOF electrode synergistically stems from the strong interaction between Cu 2+ of the MOF and pyridone and carboxylate moieties of the EF and facile electron transition facilitated by Ni 2+ . The practicability of the sensor was evaluated in milk, egg and river water samples and the obtained results were validated with Liquid Chromatography-Mass Spectrometric technique. Furthermore, the prepared catalyst was utilized for the photochemical decontamination of EF and the present Cu-Ni-MOF catalyst delivered excellent photocatalytic activity in the decontamination of EF under visible light at ambient temperature.

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