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arXiv 2025年

作者： Park, Junseok Maury, Eduardo A. Oh, Changhoon Shin, Donghoon Denisko, Danielle Lee, Eunjung Alice Division of Genetics and Genomics Boston Children’s Hospital 3 Blackfan Circle BostonMA United States Department of Pediatrics Harvard Medical School 25 Shattuck St BostonMA United States Bioinformatics Integrative Genomics Program Harvard/MIT MD-PHD Program Harvard Medical School BostonMA United States Program in Medical and Population Genetics Broad Institute of MIT and Harvard CambridgeMA United States Graduate School of Information Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul Korea Republic of Department of Human Centered Design and Engineering University of Washington SeattleWA United States Department of Biomedical Informatics Harvard Medical School BostonMA United States

Advances in genome sequencing technologies generate massive amounts of sequence data that are increasingly analyzed and shared through public repositories. On-demand infrastructure services on cloud computing platforms enable the processing of such large-scale genomic sequence data in distributed processing environments with a significant reduction in analysis time. However, parallel processing on cloud computing platforms presents many challenges to researchers, even skillful bioinformaticians. In particular, it is difficult to design a computing architecture optimized to reduce the cost of computing and disk storage as genomic data analysis pipelines often employ many heterogeneous tools with different resource requirements. To address these issues, we developed GenomeFlow, a tool for automated development of computing architecture and resource optimization on Google Cloud Platform, which allows users to process a large number of samples at minimal cost. We outline multiple use cases of GenomeFlow demonstrating its utility to significantly reduce computing time and cost associated with analyzing genomic and transcriptomic data from hundreds to tens of thousands of samples from several consortia. Here, we describe a step-by-step protocol on how to use GenomeFlow for a common genomic data processing task. We introduce this example protocol geared toward a bioinformatician with little experience in cloud computing. © 2025, CC BY.

关键词： Cloud platforms

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Low-cost real-time environmental noise monitoring system design and implementation

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International Journal of Environmental Studies 2024年第3期81卷 1045-1057页

作者： Hamamcı, Samet Feyyaz Doğru, Ahmet Özgür Graduate School Geographical Information Technologies PhD Program Istanbul Technical University Istanbul Turkey Faculty of Civil Engineering Department of Geomatics Engineering Istanbul Technical University Istanbul Turkey

Environmental noise has a negative impact on human health and well-being. Real-time noise monitoring for effective noise control and management helps to identify noise sources and areas with high noise pollution, and potential mitigation strategies in urban planning. This paper reports work with a pilot scale system that can continuously collect noise data to assess noise levels accurately for real-time monitoring of environmental noise, focusing on hardware and software aspects and potential applications. The system permits the transfer of measurement data to the central server computer, with storage and display there, with the code written using Python. This system includes Web integration, with open source technologies to provide data access, and is based on Wi-Fi communication and a Control Card with Wi-Fi technology. © 2023 Informa UK Limited, trading as Taylor & Francis Group.

关键词： Noise pollution

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ARCH: Automatic Roaming-contract Handler for Seamless 6G System to Provide Trusted and Highly Available Network Access 23

ARCH: Automatic Roaming-contract Handler for Seamless 6G Sys...

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29th Annual International Conference on Mobile Computing and Networking, MobiCom 2023

作者： Tenn, Kíng-Pîng Ho, Po-Han Chen, Hong-Yen Lin, Tsung-Nan Department of Electrical Engineering PhD Program in Cybersecurity National Taiwan University Taipei60005429 Taiwan

ISBN: (纸本)9781450399906

It is expected to be pervasive sensors to integrate physical and digital world. Low-latency and wide-covering networks are hence urged, which lead to costly infrastructure. We are proposing ARCH based on smart contract and Self-sovereign Identity (SSI), to provide telecoms a trusted and transparent multilateral platform sharing their infrastructure to decrease the deployment and agency cost, and carbon emission. © 2023 Owner/Author(s).

关键词： Smart contract

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Help me help you: Building a support network for minority engineering students

Help me help you: Building a support network for minority en...

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120th ASEE Annual Conference and Exposition

作者： Lee Jr., Walter Curtis Cross, Kelly J. Virginia Tech United States Engineering Education PhD Program Virginia Tech United States

Help Me Help You (HMHY) was developed during the 2011-2012 academic year as a group-mentoring program for African-American students in the Virginia Tech College of engineering. HMHY was based on the VT PACT, a retention program developed during the 2005-2006 academic year for first-year African-American men. The Pact, a book written by Drs. Sampson Davis, George Jenkins, and Rameck Hunt, inspired the VT PACT and was used as a framework for the program. Although students found the program beneficial, the program lost momentum and was discontinued after the graduation of the first-cohort and program facilitator. HMHY was developed to be a revamped and updated version of the VT PACT program and was open to both men and women. The focus and goals of HMHY were specifically designed to promote selfsustaining components (i.e. create a culture within the college where helping one another became a social norm and common practice), and prevent the discontinuity from occurring again. The purpose of this paper is to discuss the development and assessment of this innovative retention program. The paper begins with a brief overview of the retention strategy. Next, HMHY is described in detail. Then the assessment strategy will be discussed as well as how the support program impacted the participating students. The paper concludes with advice for others interested in starting a similar program. © American Society for engineering Education, 2013.

关键词： Students

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Extracellular respiration is a latent energy metabolism in Escherichia coli

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Cell 2025年第11期188卷 2907-2924.e23页

作者： Kundu, Biki Bapi Krishnan, Jayanth Szubin, Richard Patel, Arjun Palsson, Bernhard O. Zielinski, Daniel C. Ajo-Franklin, Caroline M. PhD Program in Systems Synthetic and Physical Biology Rice University Houston 77005 TX United States Department of Bioengineering University of California San Diego La Jolla 92093 CA United States Novo Nordisk Foundation Center for Biosustainability Technical University of Denmark Kemitorvet Building 220 Kgs. Lyngby 2800 Denmark Departments of Biosciences Bioengineering Chemical and Biomolecular Engineering and The Rice Synthetic Biology Institute Rice University Houston 77005 TX United States

Diverse microbes utilize redox shuttles to exchange electrons with their environment through mediated extracellular electron transfer (EET), supporting anaerobic survival. Although mediated EET has been leveraged for bioelectrocatalysis for decades, fundamental questions remain about how these redox shuttles are reduced within cells and their role in cellular bioenergetics. Here, we integrate genome editing, electrochemistry, and systems biology to investigate the mechanism and bioenergetics of mediated EET in Escherichia coli, elusive for over two decades. In the absence of alternative electron sinks, the redox cycling of 2-hydroxy-1,4-naphthoquinone (HNQ) via the cytoplasmic nitroreductases NfsB and NfsA enables E. coli respiration on an extracellular electrode. E. coli also exhibits rapid genetic adaptation in the outer membrane porin OmpC, enhancing HNQ-mediated EET levels coupled to growth. This work demonstrates that E. coli can grow independently of classic electron transport chains and fermentation, unveiling a potentially widespread new type of anaerobic energy metabolism. © 2025 Elsevier Inc.

关键词： adaptive laboratory evolution anaerobic metabolism electron shuttles extracellular electron transfer flux balance analysis iModulon analysis nitroreductases redox homeostasis

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DIFFERENCES IN THE GAIT CHARACTERISTICS OF PATIENTS WITH DIABETES AND PERIPHERAL NEUROPATHY COMPARED WITH AGE-MATCHED CONTROLS - RESPONSE

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PHYSICAL THERAPY 1994年第4期74卷 312-313页

作者： MUELLER, MJ MINOR, SD SAHRMANN, SA SCHAAF, JA STRUBE, MJ MJ Mueller PhD PT is Assistant Professor Program in Physical Therapy Washington University School of Medicine 660 S Euclid Box 8083 St Louis MO 63110 (USA). SD Minor PhD PT is Assistant Professor Program in Physical Therapy Washington University School of Medicine. SA Sahrmann PhD PT FAPTA is Associate Professor Program in Physical Therapy Washington University School of Medicine. JA Schaaf PhD is Visiting Research Associate and Lecturer Department of Mechanical and Aeronautical Engineering University of California Davis CA 95616. He was Hunter Assistant Professor of Mechanical Design Mechanical Engineering Washington University at the time of this study. MJ Strube PhD is Professor of Psychology Washington University.

Background and *** with diabetes and peripheral neuropathy have a high incidence of injuries while walking. Biomechanical analysis of their walking may lead to treatments to reduce these injuries. The purpose of this study was to compare (1) the gait characteristics, (2) the plantar-flexor peak torques, and (3) the ankle range of motion of subjects with diabetes mellitus (DM) and peripheral neuropathy with those of age-matched *** subjects, 10 with DM and a history of peripheral neuropathy (DM group) (mean age=58 years, SD=15, range=35–75) and 10 subjects without diabetes (NODM group) (mean age=57 years, SD=11, range=37–68), were *** following data were collected on all subjects: ankle joint mobility, plantar-flexor peak torque (ankle strength), kinematics of the trunk and lower extremity during normal walking, and ground reaction forces. Moments and power at the ankle, knee, and hip during walking were calculated using a two-dimensional link-segment *** DM group subjects showed less ankle mobility, ankle moment, ankle power, velocity, and stride length during walking than the NODM group subjects. A significant decrease in ankle strength and mobility appeared to be the primary factor contributing to the altered walking patterns of the DM *** and *** DM group subjects appeared to pull their legs forward using hip flexor muscles (hip strategy) rather than pushing the legs forward using plantar-flexor muscles (ankle strategy), as seen in the NODM group subjects. Implications for treatment are presented to attempt to reduce the number of injuries during walking in patients with DM and peripheral neuropathy.

关键词： Biomechanics Diabetes mellitus Gait analysis Joint mobility Kinetics Muscle performance

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Network maintenance contribution in terms of intellectual capital on distribution network services providers

Network maintenance contribution in terms of intellectual ca...

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European Safety and Reliability Annual Conference: Reliability, Risk and Safety: Back to the Future, ESREL 2010

作者： Gómez, J.F. González, V. Parra, C. Crespo, A. Industrial Management PhD Program School of Engineering University of Seville Spain Industrial Management School of Engineering University of Seville Spain

ISBN: (纸本)9780415604277

Maintenance is characterized as a highly complex field inside business and involves various disciplines: Management, Organization, Human Resources, Company Economy, Safety, Environmental Management and Knowledge of production throughout the chain. In Distribution Network Services Providers (DNSP), such as distribution companies of water, energy, gas, telecommunications, etc, customer oriented organizations, maintenance is a key department by its contribution to look after the interests or satisfy the needs of clients and profits of enterprises. In order to optimize maintenance, the human capital is one of the best tools through their skills, attitudes and interests. It has to appreciate technical aspects, personal flexibility, changes, adaptation, creativity, learning capacity, willingness to team work in equipment, ability of decision and easiness to work in multiple and interrelated operations. Therefore, the knowledge of the maintenance staff is a strategic asset for the company and it can be considered as a competitive advantage within the service sector. These aspects must be evaluated in order to place correctly the contribution of maintenance within the company valuation and future plans. Thus, in this paper, we will try to evaluate quantitatively the maintenance organization in a dependability scope, but with the intention to go beyond the balance score card to understand the capacity and potential to generate present and future value according to the maintenance management. In this sense, we have to consider the dependability scope as a measure of the intellectual capital of the maintenance organization. © 2010 Taylor & Francis Group.

关键词： Competition

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Characterisation and issues with the use of a conductivity meter to monitor the level of liquid in a cane diffuser bed

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Transactions of the Royal Society of South Africa 2020年第3期75卷 282-294页

作者： Segura Angel, Diana Maritza Fonseca, Rafael F. PhD in Sciences in the Mechanical Engineering Program Brazil University of São Paulo Av. Trab São-Carlense Brazil

The extraction of sucrose in a cane diffuser depends mainly on the percolation rate, and its optimisation requires the monitoring and control of the liquid holdup with the cane bed. However, most conventional methods that measure liquid levels are not suitable for this application. Operators control the observed liquid level through diffusers’ sight glasses, adjusting the spray position according to visual inspections. The method is inefficient, and a more accurate and reliable measurement process should be implemented towards maximising the sucrose extraction. This article proposes a novel methodology that uses conductance measurements as indicators of the liquid level in cane beds. Conductance, observed liquid level and flow rate variations were analysed under several conditions, such as steady and unsteady states. The effects of the main variables on the observed liquid level and their mathematical relationship were assessed for the validation of the measurements, and experimental tests were conducted on a BMA cane diffuser at Maidstone factory in South Africa. The results are reproducible and show conductance can qualitatively characterise a flooded cane bed. © 2020 Royal Society of South Africa.

关键词： cane bed height conductance flooding liquid level variation in operating conditions

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Vulnerability Assessment for IoT Nodes Using OpenBTS and Software Defined Radios 3

Vulnerability Assessment for IoT Nodes Using OpenBTS and Sof...

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3rd International Conference on Signal Processing and Information Security, ICSPIS 2020

作者： De Jesus Rugeles Uribe, Jose Guillen, Edward Paul Applied Sciences PhD Program Universidad Militar Nueva Granada Bogotá Colombia Telecommunications Engineering Program Universidad Militar Nueva Granada Bogota Colombia

ISBN: (纸本)9781728189987

Large-scale cyber attacks using IoT devices have increased in recent years. One of the strategies to deal with this problem is the use of penetration test techniques. The aim of this study was to develop a vulnerability assessment for an IoT M2M node that uses GSM technology. A test scenario was designed consisting of a GMS network created using USRP N210 and OpenBTS radios in a multicell configuration. An IoT-GSM node was designed from a sim8001 radio module, used in several M2M devices. The IoT node stores the measurements of the radio bases operational parameters that make up the GSM network. An algorithm for controlling an attacking base radio was designed using the OpenBTS API, which allows the deployment of a 'man in the middle' attack. The entire test deployment can be carried out remotely. Analysis of the results of the measurements obtained lets us understand the attack's behavior in detail and determine the IoT-GSM node's vulnerability. The results obtained show the potential of SDR and OpenBTS technology as penetration test tools to analyze vulnerabilities of IoT systems. © 2020 IEEE.

关键词： Internet of things

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The role of gender in belonging and sense of community

The role of gender in belonging and sense of community

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39th Annual Frontiers in Education Conference: Imagining and engineering Future CSET Education, FIE 2009

作者： Kissinger, Jeff Campbell, Ryan C. Lombrozo, Aaron Wilson, Denise Department of Electrcial Engineering University of Washington United States Individual PhD Program Graduate School University of Washington United States

ISBN: (纸本)9781424447152

This paper reports differences in belonging and connection to various levels of community between distinctly different technical fields: electrical engineering, civil & environmental engineering, and computer science. Established (reliable and validated) constructs have been used to assess community strength in these three fields at a major research university. The results emphasize gender differences within fields and between technical fields. Belonging (and sense of community) has been implicated in drop-out rates and lack of engagement in grades K-12;likewise, isolation (lack of belonging) has been cited as a persistent reason that female undergraduates leave engineering early in their programs. Our results show that sense of belonging (and connection to community) is consistently higher for women in engineering fields where women are present in higher numbers. In addition, these important affective constructs are higher overall in fields where women are more highly represented. These results may suggest that greater numbers of women enable a stronger sense of community or alternatively, the inherent nature of the field provides increased opportunity for belonging and developing a strong sense of community. In either case, related technical fields with stronger community can serve as role models for those that demonstrate less robust connection to community in helping these fields to improve their recruitment and retention of women. ©2009 IEEE.

关键词： Professional aspects

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