检索结果-内蒙古大学图书馆

SSRN 2022年

作者： Lu, Yanhong Cheung, Shunyan Koh, Xiu Pei Xia, Xiaomin Jing, Hongmei Lee, Puiyin Kao, Shuh-Ji Gan, Jianping Dai, Minhan Liu, Hongbin SZU-HKUST Joint PhD Program in Marine Environmental Science Shenzhen University Shenzhen China Department of Ocean Science The Hong Kong University of Science and Technology Hong Kong Division of Environment and Sustainability The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou China CAS Key Laboratory for Experimental Study under Deep-sea Extreme Conditions Institute of Deep-sea Science and Engineering Chinese Academy of Sciences Sanya China State Key Laboratory of Marine Environmental Science Xiamen University China The Hong Kong University of Science and Technology Hong Kong

In 2017 summer, we observed a widespread bottom hypoxic zone at the lower estuary of the Pearl River estuary (PRE). We observed i) bacterial and AOA biomass accumulation, ii) oxygen consumption rates (respiration and nitrification) in the hypoxic zone. The potential microbial interaction of both oxygen-consuming microbes in the hypoxia remained unclear. To investigate the potential microbial interaction between AOA and heterotrophic bacteria in the hypoxic zone, we used bacterial and AOA communities (inferred from 16S rRNA gene and amoA gene, respectively) and multi-comparisons between the co-occurrence networks retrieved from DNA and RNA levels to reflect the pattern. We observed a highly diverse and active bacterial community in the hypoxia zone. The network topology revealed that Gammaproteobacteria, Bacteroidetes (Flavobacteriales), Alphaproteobacteria (Rhodobacterales and Rhodospirillales), Marinimicrobia, Cyanobacteria (Synechococcales), and AOA sublineages were module hubs and connectors, indicating that they were the keystone taxa of the microbial communities. The hub-subnetwork further showed robust co-occurrence between Gammaproteobacteria, Bacteroidetes (Flavobacteriales), Alphaproteobacteria (Rhodobacterales and Rhodospirillales), Marinimicrobia with AOA sublineages, and Nitrospinae (presumably NOB)) reflecting the formation of Degradation-Nitrification microbial assemblage in the hypoxia zone. The subnetworks revealed AOA ecotype-specific modularization and niche partitioning of different AOA sublineages. Interestingly, the recurring co-occurrence of SCM1-like II sublineages with Nitrospinae OTUs formed nitrifiers assemblage in the RNA subnetworks suggested an interaction via nitrite exchange. The Degradation-Nitrification microbial assemblage may contribute substantially to the oxygen consumption in the hypoxia formation in PRE. Our results provide new insight into the nitrifier-associated microbial assemblage that should be further explored in the mar

关键词： Bacteria

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Correction: Biomass derived nitrogen functionalized carbon nanodots for nanomolar determination of levofloxacin in pharmaceutical and water samples

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Mikrochimica acta 2023年第7期190卷 269页

作者： Velusamy Arul Natarajan Sampathkumar Sindhuja Kotteeswaran Ponnusamy Arul Ahmed Muteb Aljuwayid Mohamed A Habila Mani Govindasamy Department of Chemistry Sri Eshwar College of Engineering (Autonomous) Coimbatore 641 202 Tamil Nadu India. kvarulchem6@***. Department of Chemistry Korea University 145 Anam-Ro Seongbuk-Gu Seoul South Korea. kvarulchem6@***. Department of Chemistry SSM College of Arts and Science Dindigul 624002 Tamil Nadu India. International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. Department of Chemical Engineering and Biotechnology Institute of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei 106 Taiwan ROC. vpsarul@***. Department of Chemistry College of Science King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia. International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. govindasamy420700@***. Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. govindasamy420700@***. Department of Research and Innovation Saveetha School of Engineering SIMATS 602105 Chennai India. govindasamy420700@***.

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The gastroesophageal junction – A gap in tissue engineering

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Journal of Immunology and Regenerative Medicine 2023年 20卷

作者： Caleb Vogt Ilitch Diaz-Gutierrez Angela Panoskaltsis-Mortari University of Minnesota – Twin Cities Medical Scientist Training Program Biomedical Engineering PhD Program 312 Church St. SE 7-105 Nils Hasselmo Hall Minneapolis MN 55455 USA University of Minnesota – Twin Cities Department of Surgery Division of Thoracic and Foregut Surgery 420 Delaware St. SE MMC 207 Minneapolis MN 55455 USA University of Minnesota – Twin Cities Department of Pediatrics Division of Blood and Marrow Transplant & Cellular Therapy MMC 366 Mayo 8366A (Campus Delivery Code) 420 Delaware St SE Minneapolis MN 55455 USA

The gastroesophageal junction (GEJ) plays a critical role in preventing reflux of stomach contents into the esophagus and airways, but currently there are no options for replacement. Surgical resection of the GEJ or lower esophagus requires reanastomosis through a gastric conduit or intestinal interposition, but these surgeries are associated with significant morbidity and mortality related to loss of the one-way valve function. Despite significant progress made in tissue-engineering for the body of the esophagus, little has been done for the stomach and no attempts have been made to reconstruct a GEJ. A detailed understanding of the GEJ anatomy and physiology complemented by knowledge of approaches used in tissue engineering of the esophagus and stomach is foundational to future attempts to address this gap in the field. These topics, as well as anticipated obstacles, are addressed in this review.

关键词： Tissue engineering Esophagus Gastroesophageal junction GEJ Gastroesophageal Junction GEJHPZ Gastroesophageal Junction High-Pressure Zone LECS Lower Esophageal Circular Sphincter UGS Upper Gastric Sphincter GEFV Gastroesophageal Flap Valve EMR Endoscopic Mucosal Resection

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Super Resolution for Improved Positioning of an MRI-Guided Spinal Cellular Injection Robot

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Journal of Medical Robotics Research 2021年第1-2期6卷

作者： Martinez, Daniel Enrique Meinhold, Waiman Oshinski, John Hu, Ai-Ping Ueda, Jun Robotics PhD Program Georgia Institute of Technology North Ave NW Atlanta 30332 GA United States Department of Radiology Emory University 201 Dowman Dr Atlanta 30322 GA United States Intelligent Sustainable Technologies Division Georgia Tech Research Institute 640 Strong Street Atlanta 30318 GA United States George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology North Ave NW Atlanta 30332 GA United States

This paper presents the development of a magnetic resonance imaging (MRI)-conditional needle positioning robot designed for spinal cellular injection. High-accuracy targeting performance is achieved by the combination of a high precision, parallel-plane, needle-orientation mechanism utilizing linear piezoelectric actuators with an iterative super-resolution (SR) visual navigation algorithm using multi-planar MR imaging. In previous work, the authors have developed an MRI conditional robot with positioning performance exceeding the standard resolution of MRI, rendering the MRI resolution the limit for navigation. This paper further explores the application of SR to images for robot guidance, evaluating positioning performance through simulations and experimentally in benchtop and MRI experiments. © 2021 World Scientific Publishing Company.

关键词： cellular therapeutics magnetic resonance imaging needle steering spinal cord Super resolution surgical robots visual robot guidance

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Genome-scale metabolic networks in time and space

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Current Opinion in Systems Biology 2018年 8卷 51-58页

作者： Øyås, Ove Stelling, Jörg Department of Biosystems Science and Engineering and SIB Swiss Institute of Bioinformatics ETH Zurich Basel Switzerland Systems Biology PhD Program Life Science Zurich Graduate School Zurich Switzerland

Constraint-based models (CBMs) are key tools for elucidating the behavior of genome-scale metabolic networks, but the assumption of steady state hinders their application to spatiotemporally varying and multicellular systems. Models that integrate CBMs with kinetics to allow dynamic simulation through dynamic flux balance analysis (DFBA) can circumvent this problem as well as the limitations of purely kinetic models. With many technical barriers for DFBA overcome in recent years, applications traditionally focused on metabolic engineering have expanded to address problems such as evolution of microbial communities, functions of biomedically relevant biofilms, and diet effects on Parkinson's disease. By addressing substantial computational challenges, we expect that such hybrid metabolic models will pave the way towards whole-cell modeling. © 2017 Elsevier Ltd

关键词： Constraint-based models Dynamic flux balance analysis Genome-scale models Metabolic networks Multi-scale models

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Correction: Ubiquitin carboxyl-terminal hydrolase 11 promotes autophagy by de-ubiquitinating and stabilizing Beclin-1

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Genome Instability & Disease 2023年第5期4卷 303-303页

作者： Li, Zheng Rao, Shaohong Song, Chunwei Zhu, Min Zhao, Hongchang Yuan, Shuping Peng, Bin Xu, Xingzhi Guangdong Key Laboratory for Genome Stability & Disease Prevention and Carson International Cancer Center Marshall Laboratory of Biomedical Engineering Shenzhen University School of Medicine Shenzhen China Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical Ultrasound School of Biomedical Engineering Shenzhen University Medical School Shenzhen China College of Life Sciences Capital Normal University Beijing China Institute of Translational Medicine College of Medicine Qingdao University Qingdao China Shenzhen University-Friedrich Schiller Universität Jena Joint PhD Program in Biomedical Sciences Shenzhen University School of Medicine Shenzhen China

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Epigenetic factor competition reshapes the EMT landscape

arXiv

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arXiv 2022年

作者： Ali Al-Radhawi, M. Tripathi, Shubham Zhang, Yun Sontag, Eduardo D. Levine, Herbert Department of Electrical and Computer Engineering Northeastern University BostonMA02115 United States Center for Theoretical Biological Physics Northeastern University BostonMA02115 United States PhD Program in Systems Synthetic and Physical Biology Rice University HoustonTX77005 United States Whitehead Institute for Biomedical Research CambridgeMA02142 United States Department of Bioengineering Northeastern University BostonMA02115 United States Department of Physics Northeastern University BostonMA02115 United States Laboratory of Systems Pharmacology Harvard Medical School BostonMA02115 United States State Key Laboratory of Molecular Oncology National Cancer Center National Clinical Research Center for Cancer Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing100021 China

The emergence of and transitions between distinct phenotypes in isogenic cells can be attributed to the intricate interplay of epigenetic marks, external signals, and gene regulatory elements. These elements include chromatin remodelers, histone modifiers, transcription factors, and regulatory RNAs. Mathematical models known as Gene Regulatory Networks (GRNs) are an increasingly important tool to unravel the workings of such complex networks. In such models, epigenetic factors are usually proposed to act on the chromatin regions directly involved in the expression of relevant genes. However, it has been well-established that these factors operate globally and compete with each other for targets genome-wide. Therefore, a perturbation of the activity of a regulator can redistribute epigenetic marks across the genome and modulate the levels of competing regulators. In this paper, we propose a conceptual and mathematical modeling framework that incorporates both local and global competition effects between antagonistic epigenetic regulators in addition to local transcription factors, and show the counter-intuitive consequences of such interactions. We apply our approach to recent experimental findings on the Epithelial-Mesenchymal Transition (EMT). We show that it can explain the puzzling experimental data as well provide new verifiable predictions. © 2022, CC BY-NC-ND.

关键词： Transcription factors

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Retrieval practice and spacing: Effects on long-term learning among engineering precalculus students 125

Retrieval practice and spacing: Effects on long-term learnin...

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125th ASEE Annual Conference and Exposition

作者： Hopkins, Robin F. Lyle, Keith Brandon Ralston, Patricia A. Bego, Campbell R. Hieb, Jeffrey Lloyd Experimental Psychology PhD Program University of Louisville United States Department of Engineering Fundamentals University of Louisville United States Cognitive Science University of Louisville United States

Mathematical competency is vital to success in engineering. Competency requires not only short-term mastery of mathematical concepts, but also long-term retention. Research in cognitive psychology shows that the more times information is retrieved from memory, the more likely it is to be remembered over the long-term. Research also shows that increasing the amount of time between retrievals increases long-term retention. Which of these interventions-increasing the amount or the temporal spacing of retrieval practice-has the greater impact on long-term retention? Supported by NSF's Improving Undergraduate STEM Education (IUSE) program, we answered this question by independently manipulating the amount and the spacing of retrieval practice in a precalculus course for engineering students. This was done by varying the number of quiz questions concerning key precalculus objectives (amount of practice) and varying whether those questions were massed on a single quiz or distributed across quizzes in multiple weeks (spacing of practice). Long-term retention was assessed in a test of precalculus knowledge administered one month after the end of the precalculus course. We found that students were significantly more likely to retain precalculus objectives when quiz questions had been spaced versus massed. Increasing the number of quiz questions did not significantly affect retention. These findings suggest that educators wishing to increase students' long-term retention of mathematics knowledge should increase the spacing, rather than the amount, of retrieval practice in their courses. © American Society for engineering Education, 2018.

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Transparent, low-autofluorescence microECoG device for simultaneous Ca2+ imaging and cortical electrophysiology in vivo

Transparent, low-autofluorescence microECoG device for simul...

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作者： Zátonyi, A. Madarász, M. Szabó, O. Lőrincz, T. Hodován, R. Rózsa, B. Fekete, Z. Research Group for Implantable Microsystems Faculty of Information Technology and Bionics Pázmány Péter Catholic University Budapest Hungary Microsystems Laboratory Institute for Technical Physics and Material Sciences Centre for Energy Research HAS Budapest Hungary Doctoral School of Chemical Engineering and Material Sciences University of Pannonia Veszprém Hungary Laboratory of 3D Functional Network and Dendritic Imaging Institute of Experimental Medicine HAS Budapest Hungary János Szentágothai PhD Program Semmelweis University Budapest Hungary Roska Tamás Doctoral School of Sciences and Technology Pázmány Péter Catholic University Budapest Hungary

Objective. Multimodal neuroimaging approaches are beneficial to discover brain functionalities at high spatial and temporal resolution. In our work, a novel material composition of a microECoG device relying on Parylene HT and indium-tin-oxide (ITO) is presented, which facilitates two-photon imaging of Ca2+ signals and concurrent recording of cortical EEG. Approach. Long-term stability of the interfaces of the transparent microdevice is confirmed in vitro by electrochemical and mechanical tests. The outstanding optical properties, like high transmittance and low auto-fluorescent are proven by fluorimetric measurements. Spatial resolution of fluorescent two-photon imaging through the microECoG device is presented in transgenic hippocampal slices, while concurrent recording of Ca2+ signals and cortical EEG is demonstrated in vivo. Photoartefacts and photodegradation of the materials are also investigated in detail to provide safety guidelines for further use in two-photon in vivo imaging schemes. Main results. Two-photon imaging of Ca signals can be safely performed through the proposed transparent ECoG device, without significant distortion in the dimensions of detected neuronal structures or in the temporal signaling. In chronic use, we demonstrated that fluorescent Ca signals of individual neurons can be clearly recorded even after 51 d. Significance. Our results give a firm indication that highly transparent microECoG electrode arrays made of Parylene HT/ITO/Parylene HT multilayer are excellent candidates for synergetic recording of optical signals and EEG from intact brains with high resolution and are free of electrical and optical artefacts. © 2020 IOP Publishing Ltd.

关键词： Electrophysiology

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Front Cover: Emergence of Non-photoresponsive Catalytic Techniques for Environmental Remediation and Energy Generation (Chem. Asian J. 9/2023)

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Chemistry – An Asian Journal 2023年第9期18卷

作者： Manish Kumar Sharma Dr. Imran Khan Kuldeep Kaswan Dr. Snigdha Roy Barman Prof. Dr. Subhajit Saha Wu-Chiao Hsieh Prof. Dr. Yu-Lun Chueh Prof. Dr. Yu-Lin Wang Prof. Dr. Sangmin Lee Prof. Dr. Dukhyun Choi Prof. Dr. Zong-Hong Lin Department of Materials Science and Engineering National Tsing Hua University Hsinchu 30013 Taiwan Institute of NanoEngineering and Microsystems National Tsing Hua University Hsinchu 30013 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu 30013 Taiwan Department of Renewable Energy Maulana Abul Kalam Azad University of Technology West Bengal 741249 India Department of Obstetrics and Gynecology Chang Gung Memorial Hospital and College of Medicine Chang Gung University Taoyuan 333 Taiwan Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu 30013 Taiwan School of Mechanical Engineering Chung-Ang University Seoul 06974 South Korea Department of Mechanical Engineering Sungkyunkwan University Suwon 16419 South Korea Department of Biomedical Engineering National Taiwan University Taipei 10617 Taiwan

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