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Multidisciplinary intensive rehabilitation treatment improves sleep quality in Parkinson's disease

Journal of clinical movement disorders 2015年第1期2卷 11页

作者： Giuseppe Frazzitta Roberto Maestri Davide Ferrazzoli Giulio Riboldazzi Rossana Bera Cecilia Fontanesi Roger P Rossi Gianni Pezzoli Maria F Ghilardi Department of Parkinson Disease Rehabilitation Moriggia-Pelascini Hospital Gravedona ed Uniti Fondazione Europea Ricerca Biomedica FERB "S.Isidoro" Hospital Trescore Balneario Italy Department of Parkinson Rehabilitation Ospedale Moriggia Pelascini Via Pelascini 3 Gravedona ed Uniti Como 22015 Italy. Department of Biomedical Engineering Scientific Institute of Montescano S. Maugeri Foundation IRCCS Montescano Italy. Department of Parkinson Disease Rehabilitation Moriggia-Pelascini Hospital Gravedona ed Uniti Fondazione Europea Ricerca Biomedica FERB "S.Isidoro" Hospital Trescore Balneario Italy. Center for Parkinson's Disease Macchi Foundation Varese and Department of Rehabilitation "Le Terrazze" Hospital Cunardo Italy. Department of Physiol. Pharmacol. & Neuroscience CUNY Medical School Harris Hall 08 CCNY 160 Convent Ave New York NY 10031 USA The Graduate Center Biology - Neuroscience PhD Program CUNY New York NY USA. Department of Physical Medicine & Rehabilitation JFK Johnson Rehabilitation Institute Edison NJ USA NYU Movement Disorder Center New York University New York NY USA. Parkinson Institute Istituti Clinici di Perfezionamento Milano Italy. Department of Physical Medicine & Rehabilitation JFK Johnson Rehabilitation Institute Edison NJ USA.

BACKGROUND:Sleep disturbances are among the most common non-motor symptoms of Parkinson's disease (PD), greatly interfering with daily activities and diminishing life quality. Pharmacological treatments have not been satisfactory because of side effects and interactions with anti-parkinsonian drugs. While studies have shown that regular exercise improves sleep quality in normal aging, there is no definitive evidence in PD. METHODS:In a retrospective study, we determined whether an intense physical and multidisciplinary exercise program improves sleep quality in a large group of patients with PD. We analyzed the scores of PD Sleep Scale (PDSS), which was administered twice, 28 days apart, to two groups of patients with PD of comparable age, gender, disease duration and pharmacological treatment. The control group (49 patients) did not receive rehabilitation, The treated group (89 patients) underwent a 28-day multidisciplinary intensive rehabilitation program (three one-hour daily sessions comprising cardiovascular warm-up, relaxation, muscle-stretching, balance and gait training, occupational therapy to improve daily living activities). RESULTS:At enrolment, control and treated groups had similar UPDRS and PDSS scores. At re-test, 28 days later, UPDRS and total PDSS scores improved in the treated (p < 0.0001) but not in the control group. In particular, the treated group showed significant improvement in PDSS scores for sleep quality, motor symptoms and daytime somnolence. The control group did not show improvement for any item. CONCLUSIONS:These results suggest that multidisciplinary intensive rehabilitation treatment may have a positive impact on many aspects of sleep in PD.

关键词： PDSS Plasticity Rehabilitation Sleep quality

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Innovative online training framework supporting immersive scenario-based simulation for clinical decision making and large healthcare community of practice

Innovative online training framework supporting immersive sc...

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1st International Workshop on Innovative Simulation for Health Care, IWISH 2012, Held at the International Multidisciplinary Modeling and Simulation Multiconference, I3M 2012

作者： Joy, Bruce Chung, Liz Harrison, Susan Gray, Tim Biagini, Marco Bardon, Nerida Kantianis, George VastPark Services Inc. United States VastPark Pty. Ltd. Australia Australian Centre for Health Innovation Australia Mathematics Engineering and Simulation PhD Program Genoa University Italy

ISBN: (纸本)9781629934846

There is reasonable doubt that current arrangements for clinical training will sustain projected increased requirements for health education. It is evident that Simulation Education provides a solution to this sustainability problem, and the increasing sophistication of Virtual world technologies create opportunities to migrate elements from traditional to online models, thus addressing the issues of cost of access to traditional Simulation Centres. However, creating exciting online environments in isolation is insufficient in addressing the complex requirements of undergraduate health care training. The authors propose that by balancing the focus between cognitive reasoning structure and the need to establish an emotional connection, they have delivered a high quality, learner-centric online world that increases the "real world readiness" for undergraduates. Furthermore, by delivering the tool through a supportive online community of practice, the learner has a sustainable, continuous opportunity to practice essential skills in a safe environment before entering the clinical environment.

关键词： Sustainable development

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Research highlights

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Lab on a Chip 2013年第10期13卷 1842-1845页

作者： João Ribas Mark W. Tibbitt Mehmet R. Dokmeci Ali Khademhosseini Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge Massachusetts 02139 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA PhD Program in Experimental Biology and Biomedicine CNC-Center for Neuroscience and Cell Biology and Institute for Interdisciplinary Research (IIIUC) University of Coimbra 3004-517 Coimbra Portugal Biocant–Center of Innovation and Biotechnology 3060-197 Cantanhede Portugal Department of Chemical and Biological Engineering University of Colorado Boulder Colorado 80303 USA Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts 02115 USA World Premier International–Advanced Institute for Materials Research (WPI-AIMR) Tohoku University Sendai 980-8577 Japan

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Lab on a Chip 2013年第4期13卷 599-601页

作者： Francesco Piraino João Ribas Mehmet R. Dokmeci Ali Khademhosseini Bioengineering Department Politecnico di Milano Piazza Leonardo da Vinci 32 20133 Milano Italy Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge Massachusetts 02139 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Biocant-Center of Innovation and Biotechnology 3060-197 Cantanhede Portugal PhD Program in Experimental Biology and Biomedicine CNC-Centre for Neuroscience and Cell Biology 3004-517 Coimbra Portugal Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts 02115 USA World Premier International – Advanced Institute for Materials Research (WPI-AIMR) Tohoku University Sendai 980-8577 Japan

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Characteristics of Leachate at Sukawinatan Landfill, Palembang, Indonesia

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Journal of Physics: Conference Series 2013年第1期423卷

作者： Eka Sri Yusmartini Dedi Setiabudidaya Ridwan Marsi Faizal PhD Candidate Postgraduate Program Sriwijaya University Indonesia Department of Physics Faculty of Mathematics and Science Sriwijaya University Indonesia Nuclear Industrial Materials Technology Centre Serpong Indonesia Faculty of Agriculture Sriwijaya University Indonesia Department of Chemical Engineering Faculty of Engineering Sriwijaya University Indonesia

Landfill (TPA) Sukawinatan Palembang is an open dumping system which covers an area of 25 hectares. This system may bring an environmental damage to the surrounding area because it does not provide leachate treatment. Leachate is the landfill waste that dissolves many compounds that contain pollutants from both organic substances and heavy metal origin. This paper presents the results of laboratory analysis on samples of leachate as well as shallow groundwater from the surrounding area. The results were compared to established quality standards to evaluate whether the leachate has influenced the quality of the shallow groundwater in the surrounding area. The results show that there are some indications that the quality of groundwater has been polluted by the leachate of both organic substances and heavy metals produced by the Sukawinatan landfill.

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Alternative approach for solving replenishment lot size problem with discontinuous issuing policy and rework

Alternative approach for solving replenishment lot size prob...

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作者： Chen, Kuang-Ku Wu, Mei-Fang Chiu, Singa Wang Lee, Chien-Hua Department of Accounting National Changhua University of Education Changhua 500 Taiwan PhD Program College of Business Feng Chia University Taichung 407 Taiwan Department of Business Administration Chaoyang University of Technology Taichung 413 Taiwan Department of Industrial Engineering and Management Chaoyang University of Technology Taichung 413 Taiwan

Conventional approach for solving the replenishment lot size problem is by using differential calculus on the long-run average production cost function with the need to prove optimality first. Recent studies proposed an algebraic approach to the solution of classic economic order quantity (EOQ) and the economic production quantity (EPQ) models without reference to the use of derivatives. This paper extends it to the solution of a specific EPQ model as was examined by Chiu et al. [Chiu, S. W, Chen, K. -K, Lin, H. -D. Numerical method for determination of the optimal lot size for amanufacturing system with discontinuous issuing policy and rework. International Journal forNumerical Methods in Biomedical engineering. doi: 10.1002/cnm.1369. (in Press;Published online March-10-2010).]. As a result, optimal replenishment lot size and a simplified optimal production-inventory cost formula for such a particular EPQ model can be derived without derivatives. This alternative approach may enable practitioners who with little knowledge of calculus to understand the realistic production systems with ease. © 2011 Elsevier Ltd. All rights reserved.

关键词： Differentiation (calculus)

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Design Management Review 2014年第1期25卷

作者： Woodie Flowers Sarah Stein Greenberg Richard K. Miller Srikant M. Datar Pappalardo Professor Emeritus of mechanical engineering at the Massachusetts Institute of Technology. He helped create MIT's renowned INTRODUCTION TO DESIGN COURSE. Flowers also received national recognition in his role as host for the PBS television series Scientific American Frontiers from 1990 to 1993 and received a New England EMMY Award for a special PBS program on design. He is a member of the National Academy of Engineering a Fellow of the American Association for the Advancement of Science and of the American Society of Mechanical Engineering and has received three honorary doctorates. He is a MacVicar Faculty Fellow for extraordinary contributions to undergraduate education at MIT where he is a member of the faculty advisory committee for MITX the Massachusetts Innovation & Technology Exchange. He was also the inaugural recipient of the Woodie Flowers Award from FIRST (For Inspiration and Recognition of Science and Technology). He recently received the Edward F. Church Medal and the Spira Outstanding Design Educator Award from ASME. Currently Flowers is a director or scientific advisor for four companies. He is also national advisor and chairman of the executive advisor board for FIRST. Has been managing director of the Hasso Plattner Institute of Design at Stanford University (also known as the d.school) since 2010. Previously she worked in the innovation practice of Monitor Group in the US and India and advised multinational companies on developing innovation capabilities. Her background includes developing new products and services in a number of emerging markets in Asia and Africa. In the classroom Stein Greenberg has co‐taught the d.school's foundational class Design Thinking Bootcamp and its renowned course on design for the developing world Entrepreneurial Design for Extreme Affordability. She recently launched an experimental new program featuring short‐format “pop‐up” classes. She holds an MBA from Stanford University and a BA in history from Oberlin College. Among other pursuits she s

Being a “gracious professional” is the key to leadership, whether you’re an engineer, a scientist, or an MIT professor. As managing director of Stanford University's ***, this Renaissance woman spends her time developing “adaptive learners.” Olin College's first president (and first employee) has plenty to say about engineering—and education. Rethinking the MBA at Harvard Business School.

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X-ray absorption spectroscopy studies for the determination of adsorption binding modes of selenium oxoanions onto iron and manganese based nanomaterials 21

X-ray absorption spectroscopy studies for the determination ...

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21st International Materials Research Congress, IMRC 2012

作者： Gonzalez, Christina M. Parsons, Jason G. Hernandez, Jeffrey Gardea-Torresdey, Jorge L. Department of Chemistry University of Texas at El Paso 500 W University Ave. El PasoTX79968 United States Environmental Science and Engineering PhD program University of Texas at El Paso 500 W University Ave. El PasoTX79968 United States Department of Chemistry University of Texas-Pan American 1201 W University Drive EdinburgTX78534 United States

ISBN: (纸本)9781510804845

Increasing concentrations of selenium oxoanions in the environment are placing many animals at risk for reproduction failure and deformities. The understanding of binding mechanisms of selenium oxoanions to iron and manganese based oxide minerals could lead to enhanced understanding of selenium mobility in the environment. In this study, the binding mechanisms of selenium oxoanions, selenite and selenate, to non microwave-assisted and microwave-assisted synthetic Fe3O4, Mn3O4. and MnFe2O4 nanomaterials were investigated through the use of X-ray absorption spectroscopy. The X-ray absorption near-edge structure (XANES) spectroscopy studies revealed the oxidation state of selenite and selenate remains the same after binding occurs to all nanomaterials in pH 2, 4, or 6 environments. The binding modes of selenite and selenate were determined to be bidentate binuclear through use of Extended x-ray absorption fine structure (EXAFS) and were independent of nanomaterials, synthetic technique, and pH. © 2012 Materials Research Society.

关键词： Magnetite

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Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

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Human molecular genetics 2016年第3期25卷 620-9页

作者： Zhaoming Wang Wei Jie Seow Kouya Shiraishi Chao A Hsiung Keitaro Matsuo Jie Liu Kexin Chen Taiki Yamji Yang Yang I-Shou Chang Chen Wu Yun-Chul Hong Laurie Burdett Kathleen Wyatt Charles C Chung Shengchao A Li Meredith Yeager Amy Hutchinson Wei Hu Neil Caporaso Maria T Landi Nilanjan Chatterjee Minsun Song Joseph F Fraumeni Takashi Kohno Jun Yokota Hideo Kunitoh Kyota Ashikawa Yukihide Momozawa Yataro Daigo Tetsuya Mitsudomi Yasushi Yatabe Toyoaki Hida Zhibin Hu Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Zhihua Yin Xuelian Li Yangwu Ren Peng Guan Jiang Chang Wen Tan Chien-Jen Chen Gee-Chen Chang Ying-Huang Tsai Wu-Chou Su Kuan-Yu Chen Ming-Shyan Huang Yuh-Min Chen Hong Zheng Haixin Li Ping Cui Huan Guo Ping Xu Li Liu Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Gening Jiang Ke Fei Jae Yong Park Yeul Hong Kim Jae Sook Sung Kyong Hwa Park Young Tae Kim Yoo Jin Jung Chang Hyun Kang In Kyu Park Hee Nam Kim Hyo-Sung Jeon Jin Eun Choi Yi Young Choi Jin Hee Kim In-Jae Oh Young-Chul Kim Sook Whan Sung Jun Suk Kim Ho-Il Yoon Sun-Seog Kweon Min-Ho Shin Adeline Seow Ying Chen Wei-Yen Lim Jianjun Liu Maria Pik Wong Victor Ho Fun Lee Bryan A Bassig Margaret Tucker Sonja I Berndt Wong-Ho Chow Bu-Tian Ji Junwen Wang Jun Xu Alan Dart Loon Sihoe James C M Ho John K C Chan Jiu-Cun Wang Daru Lu Xueying Zhao Zhenhong Zhao Junjie Wu Hongyan Chen Li Jin Fusheng Wei Guoping Wu She-Juan An Xu-Chao Zhang Jian Su Yi-Long Wu Yu-Tang Gao Yong-Bing Xiang Xingzhou He Jihua Li Wei Zheng Xiao-Ou Shu Qiuyin Cai Robert Klein William Pao Charles Lawrence H Dean Hosgood Chin-Fu Hsiao Li-Hsin Chien Ying-Hsiang Chen Chung-Hsing Chen Wen-Chang Wang Chih-Yi Chen Chih-Liang Wang Chong-Jen Yu Hui-Ling Chen Yu-Chun Su Fang-Yu Tsai Yi-Song Chen Yao-Jen Li Tsung-Ying Yang Chien-Chung Lin Pan-Chyr Yang Tangchun Wu Dongxin Lin Baosen Zhou Jinming Yu Hongbing Shen Michiaki Kubo Stephen J Chanock Nathaniel Rothman Qing Lan Cancer Genomics Research Laboratory Leidos Biomedical Research Inc. Gaithersburg MD USA Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA wangzha@mail.nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA. Division of Genome Biology National Cancer Center Hospital Tokyo Japan. Institute of Population Health Sciences. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Department of Oncology Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences Jinan China. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China. Epidemiology and Prevention Group Research Center for Cancer Prevention and Screening National Cancer Center Tokyo Japan. Shanghai Pulmonary Hospital Shanghai China. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Department of Preventive Medicine. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc. Gaithersburg MD USA Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville MD USA. Cancer Genome Biology Group Institute of Predictive and Personalized Medicine of Cancer Barcelona Spain. Department of Medical Oncology Japanese Red Cross Medical Center Tokyo Japan. Laboratory for Genotyping Development RIKEN Center for Integrative Medical Sciences Yokohama Japan. Laboratory of Molecular Medicine Human Genome Center Institute of Medical Science University of Tokyo Tokyo Japan. Division of Thoracic Surgery Kinki University School of Medicine

Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10(-13)), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10(-10)) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10(-9)). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.

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Fault Detection and Isolation for Nonlinear Systems via HOSM Multiple-Observer *

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IFAC Proceedings Volumes 2012年第20期45卷 534-539页

作者： H. Ríos C. Edwards J. Davila L. Fridman National Autonomous University of Mexico Program of PhD in Electrical Engineering Engineering Faculty C.P. 04510 Mexico D.F Control and Instrumentation Research Group Department of Engineering University of Leicester University Road Leicester LE1 7RH UK National Polytechnic Institute Section of Graduate Studies and Research ESIME-UPT C.P. 07340 Mexico D.F Department of Automatic Control CINVESTAV-IPN Mexico D.F. AP-14-740 on leave on National Autonomous University of Mexico Engineering Department of Control and Robotics Division of Electrical Engineering Engineering Faculty C.P. 04510 Mexico D.F

The fault detection and isolation problem is studied for a class of nonlinear systems. Under structural conditions, a bank of High-Order Sliding-Mode observers is proposed. The value of the equivalent output injection is used for detecting and isolating particular faults in the system. The proposed method provides finite-time isolation of actuator and plant faults. Simulation results support the proposed approach.

关键词： High-order Sliding-Mode Observers Fault Detection Fault Isolation

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