Identifying transcription factor binding sites (TFBSs) is crucial for understanding the mechanism of transcriptional regulation. It is known that transcription factors (TFs) often cooperate to regulate genes. While tr...
详细信息
The state-transition matrix of the κ-th order Taylor approximation to the dynamic phasor and its first derivatives leads to a plurality of state-space representations to approach the bandpass signal model of a power ...
详细信息
Identifying transcription factor binding sites (TFBSs) is crucial for understanding the mechanism of transcriptional regulation. It is known that transcription factors (TFs) often cooperate to regulate genes. While tr...
详细信息
Identifying transcription factor binding sites (TFBSs) is crucial for understanding the mechanism of transcriptional regulation. It is known that transcription factors (TFs) often cooperate to regulate genes. While traditional approaches can be used to discover binding motifs of a group of co-regulated genes, they often fail to accurately assign motifs to the corresponding TFs. Here, we consider two TFs together to infer their TFBSs and their synergistic relationship simultaneously. The basic idea is that if two TFs interact, their TFBSs, if distinct, would be conserved across species and coincided in the promoter regions of the genes they co-regulated. Applying our method to Saccharomyces cerevisiae chromatin immunoprecipitation data, we predicted 110 TF pairs with statistically significant motif assignments. A majority of these TF pairs have literature support to be synergistic, and the designated motifs to TFs match well with their known consensus. We further examined the synergism of predicted TF pairs in seven experimental conditions using ANOVA, and identified significant interactions.
Maintenance is characterized as a highly complex field inside business and involves various disciplines: Management, Organization, Human Resources, Company Economy, Safety, Environmental Management and Knowledge of pr...
详细信息
The success of organizations operating in complex environments depends on how well its supply chain could adapt to disruptions caused by unanticipated events. Building this resilience requires the capability to identi...
详细信息
Changing technology and increased constituent demand for government services derive the need for governmental responsiveness. The government organisations in the developing countries will be under increased pressure t...
详细信息
Changing technology and increased constituent demand for government services derive the need for governmental responsiveness. The government organisations in the developing countries will be under increased pressure to change their bureaucratic systems to be able to respond rapidly to changing and increasing requirements and rapid technology advancements. This paper aims to present a conceptual framework for explaining the main barriers and drivers of public E-service development. Therefore, the framework provides a basic context within which the process and practice of E-Service can be implemented successfully in the public sector organisations. The framework is flexible enough to be adopted by governments at different levels;national or local by developing countries around the world.
Leaders in harnessing this innovative digital tool for architectural design and facilities management, Peggy Ho and Charles Matta review how the US General Services Administration developed BIM guidance to measure and...
Leaders in harnessing this innovative digital tool for architectural design and facilities management, Peggy Ho and Charles Matta review how the US General Services Administration developed BIM guidance to measure and validate the allocation of space, share building information with designers and contractors, evaluate energy‐efficiency and sustainability strategies, and test alternative schemes for interior circulation.
This paper reports differences in belonging and connection to various levels of community between distinctly different technical fields: electrical engineering, civil & environmental engineering, and computer scie...
详细信息
This paper shows a practical view about the behaviour of an industrial assembly in order to assess its availability and reliability. For that intention it will be used such a complex system like a Bioethanol Plant. A ...
详细信息
暂无评论