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Significance 2018年第4期15卷 30-35页

作者： Mike Wininger Reva Johnson PhD has faculty appointments at the University of Hartford (Prosthetics Program) and Yale University (Department of Biostatistics) and is a statistician of clinical trials with the Department of Veterans Affairs. PhD is a professor in the Department of Mechanical Engineering and Bioengineering at Valparaiso University.

How Bayesian inference can decode movement intentions and control the next generation of powered prostheses. By Mike Wininger and Reva Johnson

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Sustainability appraisal of used vehicle trade policy options in sub-Saharan African countries

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Environmentalist 2009年第4期29卷 360-370页

作者： Kehbila, Anderson Gwanyebit Ertel, Jürgen Brent, Alan Colin Environmental and Resource Management PhD Program Department of Industrial Sustainability Brandenburg University of Technology Cottbus Germany Department of Industrial Sustainability Brandenburg University of Technology Cottbus Germany Chair of Life Cycle Engineering Graduate School of Technology Management University of Pretoria Pretoria South Africa

This paper examines the structure of contemporary vehicle mitigation commitments after lead gasoline phase out in sub-Sahara Africa. First, this paper reviews some of the leading domestic trade policy proposals (emission reduction actions) with regard to their expected technology impacts. Next, it assesses the options based on establishing benchmarks for measuring policy performance in curbing vehicle emissions simultaneously with core sustainable development priorities. Assessing these options identifies the key variables in designing mitigation commitments, offers criteria for evaluating different approaches and discusses the implications of the leading alternatives. This paper argues that a more pronounced dilemma of synergies exists between vehicle emissions reduction and core development concerns as the major players target emissions too narrowly. Finally, this paper sheds more light on strategies that could be employed simultaneously at the regional and domestic levels to enhance sustainable development as trade continues to grow and evolve. © Springer Science+Business Media, LLC 2008.

关键词： Clean air initiative Criteria analysis Sub-Sahara Africa Sustainability appraisal Trade policy Vehicle emissions

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Robust fuzzy PID controller design for dynamic systems with time delay

Robust fuzzy PID controller design for dynamic systems with ...

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IEEE International Symposium on Industrial Electronics (ISIE)

作者： Fernanda Lima Ginalber Serra Federal University of Maranhão PhD and Master Program in Electricity Engineering São Luis-MA Brasil

A robust fuzzy control design based on gain and phase margins specifications for nonlinear systems, with time delay, via multiobjective genetic algorithm, in the continuous time domain, is proposed. A Fuzzy C-Means (FCM) clustering algorithm estimates the antecedent parameters and the rule number of a Takagi-Sugeno fuzzy model, through from input and output data of the process, whereas the least squares algorithm estimates the consequent parameters. A multiobjective genetic strategy is defined to tune the fuzzy controller parameters, so the gain and phase margins of the fuzzy control system are close to the specified ones. The fuzzy PID controller was implemented on a real time acquisition data platform and compared with the PID controller Ziegler Nichols. The results demonstrate the effectiveness and practical viability of the proposed methodology.

关键词： Robustness Clustering algorithms Mathematical model Process control Fuzzy logic Fuzzy control Genetics

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The Microclimatic Influence of a Water Body on an Urban Environment

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Journal of Environmental Science and engineering(B) 2013年第8期2卷 453-459页

作者： Erico Masierc Lea Cristina Lucas de Souza Department of Civil Engineering Federal University of Sao Carlos PhD-Post Graduation Program of Urban Engineering Sao Carlos 13560 000 Brazil Department of Civil Engineering Federal University of Sao Carlos Professor of Post Graduation Program of Urban Engineering Sao Carlos 13560 000 Brazil

The paper aims to investigate the potential of a water body to influence in lowering the warmth in the city of Sao Jose do Rio Preto, Brazil, due to the evaporative cooling effects. In order to verify its potential, three collecting points of temperature and humidity were placed in an urban area close to the municipal dam. The first one was placed on the dam margin, the second one, 50 m distant of the margin and, the third one, 100 m distant. The data were taken during December 2010 and then compared to the climate data of the Climate Station of CIIAGRO-Integrated Center of Agro Meteorological. The results show that the closer the collection point is to the water body, and the lower is the temperature variation. The humidity taxes verified at the closest point to the water body indicate values higher than those ones collected at the most distant point. The insertion of moisture through the water bodies in an urban environment demonstrated to be a strategy that improved the thermal conditions and has to be considered for urban planners to establish strategies of urban occupation.

关键词： Water body thermal comfort evaporative cooling.

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A multimodal integrative approach to model transcriptional addiction of thyroid cancer on RUNX2

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Cancer Communications 2022年第9期42卷 892-896页

作者： Emanuele Vitale Elisabetta Sauta Mila Gugnoni Federica Torricelli Veronica Manicardi Alessia Ciarrocchi Laboratory of Translational Research Azienda Unità Sanitaria Locale-IRCCS di Reggio EmiliaReggio Emilia 42123Italy Clinical and Experimental Medicine PhD Program University of Modena and Reggio EmiliaModena 41121Italy Department of Electrical Computer and Biomedical EngineeringUniversity of PaviaPavia 27100Italy

Dear Editor Aberrant gene expression sustains massive proliferation and stress adaptation under the regulation of oncogenic transcription factors(TFs)whose binding across the genome orchestrates in space and time *** dependency defines the addiction of cancer cells to TFs on top of the regulatory hierarchy governing cancer dysregulated programs[1].These factors and their dependent mechanisms are an attractive and unexplored reservoir of potential targets for new anticancer ***,while the transcriptional landscape of many cancer-supportive TFs has been revealed,this information remains purely descriptive and confined to in vitro *** foster transferability,new approaches that integrate clinical data into the transcriptional networks are needed.

关键词： addiction modal reservoir

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Targeting multiple signaling pathways:the new approach to acute myeloid leukemia therapy

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Signal Transduction and Targeted Therapy 2021年第1期6卷 41-69页

作者： Jenna LCarter Katie Hege Jay Yang Hasini AKalpage Yongwei Su Holly Edwards Maik Hüttemann Jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMIUSA MD/PhD Program Wayne State University School of MedicineDetroitMIUSA Department of Oncology Wayne State University School of MedicineDetroitMIUSA Molecular Therapeutics Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State University School of MedicineDetroitMIUSA National Engineering Laboratory for AIDS Vaccine Key Laboratory for Molecular Enzymology and EngineeringThe Ministry of EducationSchool of Life SciencesJilin UniversityChangchunChina Division of Pediatric Hematology/Oncology Children’s Hospital of MichiganDetroitMIUSA Department of Pediatrics Wayne State University School of MedicineDetroitMIUSA

Acute myeloid leukemia(AML)is the most common form of acute leukemia in adults and the second most common form of acute leukemia in *** this,very little improvement in survival rates has been achieved over the past few *** is partially due to the heterogeneity of AML and the need for more targeted therapeutics than the traditional cytotoxic chemotherapies that have been a mainstay in therapy for the past 50 *** the past 20 years,research has been diversifying the approach to treating AML by investigating molecular pathways uniquely relevant to AML cell proliferation and *** we review the development of novel therapeutics in targeting apoptosis,receptor tyrosine kinase(RTK)signaling,hedgehog(HH)pathway,mitochondrial function,DNA repair,and c-Myc *** has been an impressive effort into better understanding the diversity of AML cell characteristics and here we highlight important preclinical studies that have supported therapeutic development and continue to promote new ways to target AML *** addition,we describe clinical investigations that have led to FDA approval of new targeted AML therapies and ongoing clinical trials of novel therapies targeting AML survival *** also describe the complexity of targeting leukemia stem cells(LSCs)as an approach to addressing relapse and remission in AML and targetable pathways that are unique to LSC *** comprehensive review details what we currently understand about the signaling pathways that support AML cell survival and the exceptional ways in which we disrupt them.

关键词： myeloid approach approval

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Sustainable flower-like Cu-Ni metal-organic frameworks catalyst for enhanced electrochemical sensing and photocatalytic degradation of antibiotic pollutants

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Microchemical Journal 2025年 214卷

作者： N.S.K. Gowthaman Ameer Farithkhan E. Narayanamoorthi Ponnusamy Arul Chinnathambi Nandhini Vellaichamy Balakumar S. Selvarajan School of Engineering Monash University Bandar Sunway Selangor 47500 Malaysia Center for Advanced Energy Materials SRM TRP Engineering College Tiruchirapalli 621 105 Tamil Nadu India Center for Research Easwari Engineering College Chennai 600 089 Tamil Nadu India School of Materials Science and Engineering Pusan National University Busan 46241 Republic of Korea International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Institute of Biochemical and Biomedical Engineering Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 106 Taiwan Department of Materials Engineering Ming Chi University of Technology New Taipei City 24303 Taiwan Department of Chemistry Sri Ramakrishna College of Arts & Science Coimbatore 641 006 Tamil Nadu India Department of Chemistry Theni Kammavar Sangam College of Arts & Science Theni 625 531 Tamil Nadu India

Massive usage of antibiotics harms the environment through animals’ excrement and squeezes open-wellbeing issues. Enrofloxacin (EF), an antimicrobial agent, treats bacterial diseases and infections in cattle, poultry and exotic animals and exhibits harmful side effects. The present work proposed a sensitive and rapid electrochemical scaffold based on the Cu-Ni bimetallic-organic framework (Cu-Ni-MOF) for the detection of harmful EF in real-time applications. The Cu-Ni-MOF was synthesized through solvothermal approach with the support of a multifunctional organic ligand, 4,4-biphenyldicarboxylicacid and characterized through various analytical tools. The electrochemical sensor for EF detection was constructed by drop-casting the Cu-Ni-MOF on a glassy carbon electrode and the fabricated sensor exhibited higher catalytic activity when compared to the parental counterparts by exhibiting 1.7-fold higher current for EF oxidation. Further, the fabricated sensor is highly active in the linear range response of 200 nM–2 mM with a limit of detection of 15.17 nM and sensitivity of 638.71 µA mM cm −2 under optimized environments. The higher electrocatalytic activity of the Cu-Ni-MOF electrode synergistically stems from the strong interaction between Cu 2+ of the MOF and pyridone and carboxylate moieties of the EF and facile electron transition facilitated by Ni 2+ . The practicability of the sensor was evaluated in milk, egg and river water samples and the obtained results were validated with Liquid Chromatography-Mass Spectrometric technique. Furthermore, the prepared catalyst was utilized for the photochemical decontamination of EF and the present Cu-Ni-MOF catalyst delivered excellent photocatalytic activity in the decontamination of EF under visible light at ambient temperature.

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Vulnerability Assessment for IoT Nodes Using OpenBTS and Software Defined Radios

Vulnerability Assessment for IoT Nodes Using OpenBTS and Sof...

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International Conference on Signal Processing and Information Security (ICSPIS)

作者： Jose de Jesus Rugeles Uribe Edward Paul Guillen Applied Sciences PhD program Universidad Militar Nueva Granada Bogotá Colombia Telecommunications Engineering program Universidad Militar Nueva Granada Bogota Colombia

ISBN: (数字)9781728189987

ISBN: (纸本)9781728189994

Large-scale cyber attacks using IoT devices have increased in recent years. One of the strategies to deal with this problem is the use of penetration test techniques. The aim of this study was to develop a vulnerability assessment for an IoT M2M node that uses GSM technology. A test scenario was designed consisting of a GMS network created using USRP N210 and OpenBTS radios in a multicell configuration. An IoT-GSM node was designed from a sim8001 radio module, used in several M2M devices. The IoT node stores the measurements of the radio bases operational parameters that make up the GSM network. An algorithm for controlling an attacking base radio was designed using the OpenBTS API, which allows the deployment of a “man in the middle” attack. The entire test deployment can be carried out remotely. Analysis of the results of the measurements obtained lets us understand the attack's behavior in detail and determine the IoT-GSM node's vulnerability. The results obtained show the potential of SDR and OpenBTS technology as penetration test tools to analyze vulnerabilities of IoT systems.

关键词： GSM Machine-to-machine communications Signal processing algorithms Tools Signal processing Internet of Things Software radio

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Recruitment strategies for gender equity: Lessons from Cohort 1 ADVANCE institutions

Recruitment strategies for gender equity: Lessons from Cohor...

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118th ASEE Annual Conference and Exposition

作者： Zajicek, Anna M. Morimoto, Shauna A. Terdalkar, Aparna S. Hunt, Valerie H. Rencis, Joseph J. Lisnic, Rodica Department of Sociology and Criminal Justice University of Arkansas United States Department of Political Science Public Policy PhD Program University of Arkansas United States Department of Mechanical Engineering University of Arkansas Fayetteville United States

The NSF ADVANCE program represents one of the most far reaching gender equity efforts implemented jointly by a government agency and institutions of higher education. Focusing on science, technology, engineering, and mathematics (STEM) disciplines, in 2001, an inaugural group of universities received NSF ADVANCE Institutional Transformation (IT) awards to increase the representation of women faculty in science and engineering. To date, a total of five cohorts of 44 institutions of higher education have received the award, and the 19 institutions comprising the 2001 and 2003 cohorts have completed their five-year projects. In this paper, we examine the effectiveness of recruitment programs and practices developed by Cohort 1 ADVANCE institutions in an effort to increase the representation of women faculty. Towards this end, we focus on changes in the number of women faculty at the assistant professor rank in colleges of engineering at seven Cohort 1 ADVANCE institutions. We examine performance during both the 2001-2006 grant period, and the sustained impact of ADVANCE by examining the trajectory of colleges of engineering up through the three years following receipt of the grant (2006-2009). Using these changes as an indicator of the effectiveness of recruitment programs, we determine which colleges of engineering associated with Cohort 1 universities show stronger performance. Subsequently, we compare the key components of recruitment programs initiated at both stronger and weaker performing institutions during the ADVANCE grant period. Our analysis of changes during the grant period reveals that four out of seven colleges of engineering added between four and seven women to the faculty at the assistant professor rank, and two institutions added one female assistant professor each. Georgia Tech's College of engineering, where the number of female assistant professors fell by four, constitutes an exception to this overall trend. A longer term view (2001-2009) reveals

关键词： engineering education

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Economics of energy storage in a residential consumer context

Economics of energy storage in a residential consumer contex...

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International Conference on European Electricity Market, EEM

作者： Dennis Metz João Tomé Saraiva PDSSE Program FEUP/MIT PhD Program University of Porto Porto Portugal INESC TEC / DEEC Faculty of Engineering University of Porto Porto Portugal

With the increase of electricity tariffs and the decreasing costs for distributed generation technologies, more and more residential consumers are deploying local generation systems to satisfy their electricity demand in order to reduce overall cost. Typically, however, a mismatch between electricity generation and demand remains. Storage systems enable consumers to reduce this mismatch by storing locally generated electricity for later consumption, instead of feeding excess generation into the grid. This paper analyzes the economics of storage installations in a residential consumer context. A linear program is presented to determine the optimal dispatch, and Simulated Annealing is used to identify the cost minimizing system configuration. The developed approach is tested for a multi-family house in Germany.

关键词： Cogeneration Mathematical model Photovoltaic systems Investment Simulated annealing Context Distributed power generation

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