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Overcoming Cytosolic Delivery Barriers of Proteins Using Denatured Protein-Conjugated Mesoporous Silica Nanoparticles

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ACS Applied Materials and Interfaces 2023年第1期15卷 432-451页

作者： Dembélé, Julien Liao, Jou-Hsuan Liu, Tsang-Pai Chen, Yi-Ping Graduate Institute of Biomedical Materials & Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Laboratory of Toxicology Environment and Health Doctorate School of Health University Joseph Ki-Zerbo Ouaga03 BP 7021 Burkina Faso Department of Chemistry National Taiwan University Taipei10617 Taiwan Department of Surgery Mackay Memorial Hospital Taipei10449 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Intracellular delivery of therapeutic proteins has increased advantages over current small-molecule drugs and gene therapies, especially in therapeutic efficacies for a broad spectrum of diseases. Hence, developing the protein therapeutics approach provides a needed alternative. Here, we designed a mesoporous silica nanoparticle (MSN)-mediated protein delivery approach and demonstrated effective intracellular delivery of the denatured superoxide dismutase (SOD) protein, overcoming the delivery challenges and achieving higher enzymatic activity than native SOD-conjugated MSNs. The denatured SOD-conjugated MSN delivery strategy provides benefits of reduced size and steric hindrance, increased protein flexibility without distorting its secondary structure, exposure of the cell-penetrating peptide transactivator of transcription for enhanced efficient delivery, and a change in the corona protein composition, enabling cytosolic delivery. After delivery, SOD displayed a specific activity around threefold higher than in our previous reports. Furthermore, the in vivo biosafety and therapeutic potential for neuron therapy were evaluated, demonstrating the biocompatibility and the effective antioxidant effect in Neuro-2a cells that protected neurite outgrowth from paraquat-induced reactive oxygen species attack. This study offers an opportunity to realize the druggable possibility of cytosolic proteins using MSNs. © 2022 American Chemical Society.

关键词： Peptides

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Free water surface constructed wetlands: review of pollutant removal performance and modeling approaches

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Environmental Science and Pollution Research 2024年第32期31卷 44649-44668页

作者： Gaballah, Mohamed S. Yousefyani, Hooshyar Karami, Mohammadjavad Lammers, Roderick W. School of Engineering and Technology Central Michigan University Mount PleasantMI48859 United States National Institute of Oceanography and Fisheries Cairo Egypt Earth & amp Ecosystem Science PhD Program Central Michigan University Mount PleasantMI48859 United States Institute for Great Lakes Research Central Michigan University Mount PleasantMI48859 United States

Free water surface constructed wetlands (FWSCWs) for the treatment of various wastewater types have evolved significantly over the last few decades. With an increasing need and interest in FWSCWs applications worldwide due to their cost-effectiveness and other benefits, this paper reviews recent literature on FWSCWs' ability to remove different types of pollutants such as nutrients (i.e., TN, TP, NH4-N), heavy metals (i.e., Fe, Zn, and Ni), antibiotics (i.e., oxytetracycline, ciprofloxacin, doxycycline, sulfamethazine, and ofloxacin), and pesticides (i.e., Atrazine, S-Metolachlor, imidacloprid, lambda-cyhalothrin, diuron 3,4-dichloroanilin, Simazine, and Atrazine) that may co-exist in wetland inflow, and discusses approaches for simulating hydraulic and pollutant removal processes. A bibliometric analysis of recent literature reveals that China has the highest number of publications, followed by the USA. The collected data show that FWSCWs can remove an average of 61.6%, 67.8%, 54.7%, and 72.85% of inflowing nutrients, heavy metals, antibiotics, and pesticides, respectively. Optimizing each pollutant removal process requires specific design parameters. Removing heavy metal requires the lowest hydraulic retention time (HRT) (average of 4.78 days), removing pesticides requires the lowest water depth (average of 0.34 m), and nutrient removal requires the largest system size. Vegetation, especially Typha spp. and Phragmites spp., play an important role in FWSCWs' system performance, making significant contributions to the removal process. Various modeling approaches (i.e., black-box and process-based) were comprehensively reviewed, revealing the need for including the internal process mechanisms related to the biological processes along with plants spp., that supported by a further research with field study validations. This work presents a state-of-the-art, systematic, and comparative discussion on the efficiency of FWSCWs in removing different pollutants, main design

关键词： Wetlands

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Passivation of Perovskite Films Using Ionic Liquids

Passivation of Perovskite Films Using Ionic Liquids

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2022 Advances in Science and engineering Technology International Conferences, ASET 2022

作者： Alashkar, Adnan Ibrahim, Taleb Khamis, Mustafa Hai Alami, Abdul American University of Sharjah Materials Science and Engineering PhD Program Sharjah United Arab Emirates American University of Sharjah Department of Chemical Engineering Sharjah United Arab Emirates American University of Sharjah Department of Biology Chemistry and Enviromental Sciences Sharjah United Arab Emirates University of Sharjah Department of Sustainable and Renewable Energy Engineering Sharjah United Arab Emirates

ISBN: (纸本)9781665418010

In this paper, the carrier recombination, and dynamics of Perovskite Solar Cells (PSC) are investigated. Ionic Liquids (IL) are presented in the bulk perovskite in an attempt to improve the dynamics of the charge transport layer. Time Resolved Photoluminescence (TRPL) is utilized to study the fast electronic decay of the perovskite samples and the influence of the IL on the stability of the perovskite film. The ILs are added to the perovskite in three ratios (5%, 10%, and 20%). The results showed that the presence of the ILs increases the electron lifetime inside the perovskite layer. In addition, 10% IL/perovskite displayed the highest increase of 72% in the lifetime. Where, for higher ratios, the lifetime started deteriorating. © 2022 IEEE.

关键词： Ionic liquids

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CONDUCTIVITY STUDIES IN MXENE-PVDF COMPOSITE MEMBRANES FOR PEM FUEL CELLS APPLICATIONS 50

CONDUCTIVITY STUDIES IN MXENE-PVDF COMPOSITE MEMBRANES FOR P...

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50th International Conference on Computers and Industrial engineering: Sustainable Digital Transformation, CIE 2023

作者： Shaikh, Ryan Al Al-Othman, Amani Nancarrow, Paul Tawalbeh, Muhammad Shamayleh, Abdulrahim Engineering Systems and Management PhD Program American University of Sharjah Sharjah United Arab Emirates Department of Chemical and Biological Engineering American University of Sharjah Sharjah United Arab Emirates University of Sharjah P. O. Box Sharjah27272 United Arab Emirates Department of Industrial Engineering American University of Sharjah Sharjah United Arab Emirates

ISBN: (纸本)9781713886952

Energy supply and demand are at the core of one of the pressing problems worldwide as the present energy production is still dominated by non-renewable resources. The need to meet the goals for the climate has motivated the energy sector to embrace cleaner and greener electro-energy systems. Proton exchange membrane (PEM) fuel cells, also known as polymer-electrolyte membrane fuel cells, have lately attracted more attention from various sectors due to their exceptional advantages, including high theoretical efficiency, low operating temperatures, and low-to-zero emissions. Therefore, they can be successfully used in a variety of applications. Hence, a novel membrane that possesses adequate proton conductivity is required. Therefore, in this work, MXene was investigated as a potential proton conductor. MXene/PVDF based membrane was synthesized with different concentrations 3, 5, 8, 10, 13 and 15 wt.% respectively, and evaluated for their proton conduction using electrochemical impedance spectroscopy (EIS). The values of the conductivity obtained were:3.22× x10- 3, 6.2× x10-3, 0.025, 0.041, 3.77×10-3 and 4.2 ×10-3 S/cm, respectively. The results of this study show that the synthesized membranes in this work appear to be promising for PEM fuel cells applications. © 2023 Computers and Industrial engineering. All rights reserved.

关键词： Proton conductivity

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Impact of biomass in Egypt on climate change

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Natural Science 2013年第6期5卷 678-684页

作者： Dalia Adel Nakhla Mohamed Galal Hassan Salah El Haggar Department of Mechanical Engineering School of Sciences and Engineering The American University in Cairo Cairo Egypt Department of Petroleum Engineering School of Sciences and Engineering The American University in Cairo Cairo Egypt Environmental Engineering PhD Program School of Sciences and Engineering The American University in Cairo Cairo Egypt

Egypt is one of the most vulnerable countries to climate change due to the expected detrimental impacts on coastal zones, agriculture, water security as well as indirect social and health impacts. Egypt is responsible for 0.57% of the global greenhouse gas (GHG) emissions. Although Egypt is a non-annex I country not requiring any specific emission reduction or limitation targets under the Kyoto protocol, its National plans have included mitigation measures to reduce its greenhouse gases. The main sectors contributing to climate change in Egypt are energy, industry, agriculture and waste. Waste, on the other hand, has been accumulating in the streets of Egypt and along its water banks causing considerable air, soil and water pollution and indirect detrimental health impacts. However, this waste which is composed of organic municipal waste, agricultural residues, agro-industrial waste, animal manure and sewage sludge are valuable biomass resources. Utilizing the waste resources of Egypt especially the biomass or the organic component of this waste will not only solve some of the pressing economic needs of Egypt such as animal fodder, fertilizer and fuel but will also alleviate environmental burdens through decreasing air pollution and greenhouse gas emissions in the sector of waste as well as those of energy, industry and agriculture. This paper quantifies the biomass resources in Egypt generated from different waste resources. Then it demonstrates the efforts that Egypt made to contribute to global greenhouse gas emissions reductions through the Kyoto Protocol’s clean development mechanism (CDM). The projects in the waste sector already established in Egypt and approved as CDM projects are listed, which are related to waste management facilities and those which are waste to energy projects. Finally, a list of mitigation projects as proposed by the Egyptian government to decrease GHGs as related to the waste sector are enumerated.

关键词： Waste Climate Change Biomass Egypt

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Desalination Alternative Technology in Conjunction with Membrane Capacitive Deionization (MCDI): A Literature Review Article

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Journal of Environmental Protection 2021年第3期12卷 218-236页

作者： Ahmed J. Aldalou Yunes K. Mogheir Water Technology PhD Program Islamic University of Gaza & AL-Azhar University Gaza Palestine Civil and Environmental Engineering Department Islamic University of Gaza Gaza Palestine

Water and energy shortages came due to rapid population growth, living standards and rapid development in the agriculture and industrial sectors. Desalination tends to be one of the most promising water solutions;however, it is a process of intense energy. Membrane Capacitive Deionization (MCDI) has received considerable interest as a promising desalination technology, and MCDI research has increased significantly over the last 10 years. In addition, there are no guidelines for the design of Capacitive Deionization (CDI) implementation strategies for individual applications. This study, therefore;provides an alternative of CDI’s recent application developments, with emphasis placed on hybrid systems to address the technological needs of different relevant fields. The MCDI’s energy consumption is compared with the reverse osmosis literature data based on experimental data from laboratory-scale system. The study demonstrates that MCDI technology is a promising technology in the next few years with an extreme competition in water recovery, energy consumption and salt removal for reverse osmosis.

关键词： Capacity Deionization Membrane Capacitive Deionization Desalination Reverse Osmosis (RO)

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Towards cross-modal causal structure and representation learning 2

Towards cross-modal causal structure and representation lear...

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2nd Machine Learning for Health Symposium, ML4H 2022

作者： Mao, Haiyi Liu, Hongfu Xiaotian Dou, Jason Benos, Panayiotis V. Joint CMU-Pitt PhD Program in Computational Biology University of Pittsburgh United States Michtom School of Computer Science Brandeis University United States Department of Electrical and Computer Engineering University of Pittsburgh United States Department of Epidemiology University of Florida United States

Does the SARS-CoV-2 virus cause patients' chest X-Rays ground-glass opacities? Does an IDH-mutation cause differences in patients' MRI images? Conventional causal discovery algorithms, although well developed to uncover the cause-effect relationships on structured data, cannot elucidate causal relations between unstructured images and structured scalar variables due to the complexity of the former. In this paper, we consider causal discovery between images and structured (scalar) variables. Specifically, we derive low dimensional image representations to analyze with structured variables. We propose a two-module amortized variational algorithm named Cross-Modal Variational Causal representation and structure Learning (CMCL). CMCL jointly learns identifiable representations given a set of independent structured variables and causal relations via formulating latent representations and structured variables into a direct acyclic graph. Moreover, we further enforce counterfactual invariance/variance onto representations. We demonstrate that CMCL outperforms other related methods on synthetic datasets and validate causal relations on semi-synthetic datasets by visualization. © 2022 P.N. Argaw, E. Healey & I.S. Kohane.

关键词： Coronavirus

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Upper Airway Resistance Changes from Inspiration to Expiration during Wakefulness is a Predictor of Sleep Apnea: A Pilot Study

Upper Airway Resistance Changes from Inspiration to Expirati...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： R. Soltanzadeh Z. Moussavi PhD student of Biomedical Engineering University of Manitoba Winnipeg MB Canada professor and director of Biomedical Engineering Program University of Manitoba Winnipeg MB Canada

ISBN: (纸本)9781424492695

Upper airway structure is known to be affected in individuals with obstructive sleep apnea (OSA). In this pilot study, we investigated whether the changes of upper airway resistance (UAR) within a breathing phase, estimated from tracheal breathing sounds and airflow, is a predictor of OSA severity. Tracheal breathing sounds and airflow of 15 individuals in three groups of mild, moderate and severe OSA during wakefulness, recorded in supine position, were used in this study. The grouping of the study subjects were done based on their apnea/hypopnea index (AHI) per hour, prospectively. The breathing sounds and airflow were recorded simultaneously with full overnight polysomnography (PSG) assessment. The sounds of 3 noise-free breathing cycles were extracted and sequestered into inspiratory and expiratory phase segments manually for each study subject. The power spectra of the sound signals of each respiratory phase were calculated in 15ms windows with 50% overlap between adjacent windows. The UAR was then estimated as the ratio of the energy of power spectrum of each window within 100 to 2500 Hz, and its corresponding airflow. Then, the variance of the short-time windows' UAR, Var(UAR) during each respiratory phase was calculated. The ratio of the Var(UAR) in logarithmic scale between inspiration and expiration was found to be significantly different (p<0.01) between the three OSA groups;also it was found to be highly correlated with AHL These results are congruent with the hypothesis that the upper airway patency is not kept constant in OSA population, and suggest the change in acoustic UAR during wakefulness maybe considered as a predictor of OSA.

关键词： estimated tracheal breathing acoustic

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Dynamic Problem Solving for Assessment of Strategic engineering Capabilities 20

Dynamic Problem Solving for Assessment of Strategic Engineer...

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20th International Conference on Modeling and Applied Simulation, MAS 2021

作者： Bruzzone, Agostino G. Massei, Marina Sciomachen, Anna Franca Mazal, Jan di Castelbianco, Paolo Scotto Cepolina, Elvezia STRATEGOS Simulation Team via Opera Pia 15 Genova16145 Italy Strategic Engineering International PhD Program Genoa University via F. Vivaldi 5 Genova16126 Italy Simulation Team & DISPO Genoa University Genova16124 Italy

ISBN: (纸本)9788885741614

This paper addresses the opportunities provided by Strategic engineering as well as an innovative model devoted to support assessment of young scientists applying for this educational path;considering the highly trans-disciplinary nature of this discipline and the big requests from Industries and Institutions, the authors developed a simple set of problems to be evaluate candidates and conduct preliminary assessment as well as screening on them. The paper outlines the structure of this approach and the most critical aspects putting in evidence that this approach could be relocated for other positions and that simulation base assessment of capabilities is a promising sector for future developments in education and training. © 2021 The Authors.

关键词： Education and Training Modelling and Simulation Potential Assessment Strategic engineering

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Estimation challenges of lateral pressures in retaining structures using granular recycled tire aggregates as backfill

Estimation challenges of lateral pressures in retaining stru...

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2014 Congress on Geo-Characterization and Modeling for Sustainability, Geo-Congress 2014

作者： Garcia-Theran, Mauricio Pando, Miguel A. Celis, Hebenly Abdoun, Tarek Infrastructure and Environmental Systems PhD Program University of North Carolina at Charlotte 9201 University City Blvd Charlotte NC 28223 United States School of Civil Engineering Universidad Industrial de Santander Bucaramanga Colombia Department of Civil and Environmental Engineering Rensselaer Polytechnic Institute 110 Eighth Street Troy NY United States

ISBN: (纸本)9780784413272

The civil engineering community is a leader in national and international efforts toward sustainability, recycling, and reuse of materials. For example, asphalt is the most recycled material on earth, which is approximately 13 times the newsprint recycling and 27 times the glass bottles recycling. Recycled materials that have been used as borrow materials for embankment construction and retaining wall backfills include recycled asphalt, recycled concrete, tire-derived aggregates (TDA), blast furnace slag, steel slag, coal bottom ash/ boiler slag, flue gas desulfurization scrubber, cullet glass, and roofing shingles. Some of these recycled materials offer potential environmental, technical, and economical benefits for retaining-wall applications. For example, when compared with natural soils, many may offer the advantage of reduced lateral earth pressures and foundation settlement due to smaller unit weight and potentially higher drainage capacity. However, implicit in some of these options is the applicability of conventional soil mechanical principles in the design and technical assessment. In this paper we present experimental data from laboratory and model tests (centrifuge and model retaining walls) that highlight the challenges involved when trying to predict lateral pressures induced by a recycled wall backfill composed of tire derived aggregate. A key difference of this type of granular material is related to the nature of their particles, which are deformable and can exhibit viscous behavior. The experimental results are compared with classical lateral earth theories for active, passive, and at-rest conditions. The manuscript also includes an assessment of the time dependency of the at-rest pressures induced by TDA backfill. © 2014 American Society of Civil Engineers.

关键词： Glass

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