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A multimodal integrative approach to model transcriptional addiction of thyroid cancer on RUNX2

Cancer Communications 2022年第9期42卷 892-896页

作者： Emanuele Vitale Elisabetta Sauta Mila Gugnoni Federica Torricelli Veronica Manicardi Alessia Ciarrocchi Laboratory of Translational Research Azienda Unità Sanitaria Locale-IRCCS di Reggio EmiliaReggio Emilia 42123Italy Clinical and Experimental Medicine PhD Program University of Modena and Reggio EmiliaModena 41121Italy Department of Electrical Computer and Biomedical EngineeringUniversity of PaviaPavia 27100Italy

Dear Editor Aberrant gene expression sustains massive proliferation and stress adaptation under the regulation of oncogenic transcription factors(TFs)whose binding across the genome orchestrates in space and time *** dependency defines the addiction of cancer cells to TFs on top of the regulatory hierarchy governing cancer dysregulated programs[1].These factors and their dependent mechanisms are an attractive and unexplored reservoir of potential targets for new anticancer ***,while the transcriptional landscape of many cancer-supportive TFs has been revealed,this information remains purely descriptive and confined to in vitro *** foster transferability,new approaches that integrate clinical data into the transcriptional networks are needed.

关键词： addiction modal reservoir

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Targeting multiple signaling pathways:the new approach to acute myeloid leukemia therapy

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Signal Transduction and Targeted Therapy 2021年第1期6卷 41-69页

作者： Jenna LCarter Katie Hege Jay Yang Hasini AKalpage Yongwei Su Holly Edwards Maik Hüttemann Jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMIUSA MD/PhD Program Wayne State University School of MedicineDetroitMIUSA Department of Oncology Wayne State University School of MedicineDetroitMIUSA Molecular Therapeutics Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State University School of MedicineDetroitMIUSA National Engineering Laboratory for AIDS Vaccine Key Laboratory for Molecular Enzymology and EngineeringThe Ministry of EducationSchool of Life SciencesJilin UniversityChangchunChina Division of Pediatric Hematology/Oncology Children’s Hospital of MichiganDetroitMIUSA Department of Pediatrics Wayne State University School of MedicineDetroitMIUSA

Acute myeloid leukemia(AML)is the most common form of acute leukemia in adults and the second most common form of acute leukemia in *** this,very little improvement in survival rates has been achieved over the past few *** is partially due to the heterogeneity of AML and the need for more targeted therapeutics than the traditional cytotoxic chemotherapies that have been a mainstay in therapy for the past 50 *** the past 20 years,research has been diversifying the approach to treating AML by investigating molecular pathways uniquely relevant to AML cell proliferation and *** we review the development of novel therapeutics in targeting apoptosis,receptor tyrosine kinase(RTK)signaling,hedgehog(HH)pathway,mitochondrial function,DNA repair,and c-Myc *** has been an impressive effort into better understanding the diversity of AML cell characteristics and here we highlight important preclinical studies that have supported therapeutic development and continue to promote new ways to target AML *** addition,we describe clinical investigations that have led to FDA approval of new targeted AML therapies and ongoing clinical trials of novel therapies targeting AML survival *** also describe the complexity of targeting leukemia stem cells(LSCs)as an approach to addressing relapse and remission in AML and targetable pathways that are unique to LSC *** comprehensive review details what we currently understand about the signaling pathways that support AML cell survival and the exceptional ways in which we disrupt them.

关键词： myeloid approach approval

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Vulnerability Assessment for IoT Nodes Using OpenBTS and Software Defined Radios

Vulnerability Assessment for IoT Nodes Using OpenBTS and Sof...

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International Conference on Signal Processing and Information Security (ICSPIS)

作者： Jose de Jesus Rugeles Uribe Edward Paul Guillen Applied Sciences PhD program Universidad Militar Nueva Granada Bogotá Colombia Telecommunications Engineering program Universidad Militar Nueva Granada Bogota Colombia

ISBN: (数字)9781728189987

ISBN: (纸本)9781728189994

Large-scale cyber attacks using IoT devices have increased in recent years. One of the strategies to deal with this problem is the use of penetration test techniques. The aim of this study was to develop a vulnerability assessment for an IoT M2M node that uses GSM technology. A test scenario was designed consisting of a GMS network created using USRP N210 and OpenBTS radios in a multicell configuration. An IoT-GSM node was designed from a sim8001 radio module, used in several M2M devices. The IoT node stores the measurements of the radio bases operational parameters that make up the GSM network. An algorithm for controlling an attacking base radio was designed using the OpenBTS API, which allows the deployment of a “man in the middle” attack. The entire test deployment can be carried out remotely. Analysis of the results of the measurements obtained lets us understand the attack's behavior in detail and determine the IoT-GSM node's vulnerability. The results obtained show the potential of SDR and OpenBTS technology as penetration test tools to analyze vulnerabilities of IoT systems.

关键词： GSM Machine-to-machine communications Signal processing algorithms Tools Signal processing Internet of Things Software radio

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Sustainable flower-like Cu-Ni metal-organic frameworks catalyst for enhanced electrochemical sensing and photocatalytic degradation of antibiotic pollutants

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Microchemical Journal 2025年 214卷

作者： N.S.K. Gowthaman Ameer Farithkhan E. Narayanamoorthi Ponnusamy Arul Chinnathambi Nandhini Vellaichamy Balakumar S. Selvarajan School of Engineering Monash University Bandar Sunway Selangor 47500 Malaysia Center for Advanced Energy Materials SRM TRP Engineering College Tiruchirapalli 621 105 Tamil Nadu India Center for Research Easwari Engineering College Chennai 600 089 Tamil Nadu India School of Materials Science and Engineering Pusan National University Busan 46241 Republic of Korea International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Institute of Biochemical and Biomedical Engineering Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 106 Taiwan Department of Materials Engineering Ming Chi University of Technology New Taipei City 24303 Taiwan Department of Chemistry Sri Ramakrishna College of Arts & Science Coimbatore 641 006 Tamil Nadu India Department of Chemistry Theni Kammavar Sangam College of Arts & Science Theni 625 531 Tamil Nadu India

Massive usage of antibiotics harms the environment through animals’ excrement and squeezes open-wellbeing issues. Enrofloxacin (EF), an antimicrobial agent, treats bacterial diseases and infections in cattle, poultry and exotic animals and exhibits harmful side effects. The present work proposed a sensitive and rapid electrochemical scaffold based on the Cu-Ni bimetallic-organic framework (Cu-Ni-MOF) for the detection of harmful EF in real-time applications. The Cu-Ni-MOF was synthesized through solvothermal approach with the support of a multifunctional organic ligand, 4,4-biphenyldicarboxylicacid and characterized through various analytical tools. The electrochemical sensor for EF detection was constructed by drop-casting the Cu-Ni-MOF on a glassy carbon electrode and the fabricated sensor exhibited higher catalytic activity when compared to the parental counterparts by exhibiting 1.7-fold higher current for EF oxidation. Further, the fabricated sensor is highly active in the linear range response of 200 nM–2 mM with a limit of detection of 15.17 nM and sensitivity of 638.71 µA mM cm −2 under optimized environments. The higher electrocatalytic activity of the Cu-Ni-MOF electrode synergistically stems from the strong interaction between Cu 2+ of the MOF and pyridone and carboxylate moieties of the EF and facile electron transition facilitated by Ni 2+ . The practicability of the sensor was evaluated in milk, egg and river water samples and the obtained results were validated with Liquid Chromatography-Mass Spectrometric technique. Furthermore, the prepared catalyst was utilized for the photochemical decontamination of EF and the present Cu-Ni-MOF catalyst delivered excellent photocatalytic activity in the decontamination of EF under visible light at ambient temperature.

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Recruitment strategies for gender equity: Lessons from Cohort 1 ADVANCE institutions

Recruitment strategies for gender equity: Lessons from Cohor...

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118th ASEE Annual Conference and Exposition

作者： Zajicek, Anna M. Morimoto, Shauna A. Terdalkar, Aparna S. Hunt, Valerie H. Rencis, Joseph J. Lisnic, Rodica Department of Sociology and Criminal Justice University of Arkansas United States Department of Political Science Public Policy PhD Program University of Arkansas United States Department of Mechanical Engineering University of Arkansas Fayetteville United States

The NSF ADVANCE program represents one of the most far reaching gender equity efforts implemented jointly by a government agency and institutions of higher education. Focusing on science, technology, engineering, and mathematics (STEM) disciplines, in 2001, an inaugural group of universities received NSF ADVANCE Institutional Transformation (IT) awards to increase the representation of women faculty in science and engineering. To date, a total of five cohorts of 44 institutions of higher education have received the award, and the 19 institutions comprising the 2001 and 2003 cohorts have completed their five-year projects. In this paper, we examine the effectiveness of recruitment programs and practices developed by Cohort 1 ADVANCE institutions in an effort to increase the representation of women faculty. Towards this end, we focus on changes in the number of women faculty at the assistant professor rank in colleges of engineering at seven Cohort 1 ADVANCE institutions. We examine performance during both the 2001-2006 grant period, and the sustained impact of ADVANCE by examining the trajectory of colleges of engineering up through the three years following receipt of the grant (2006-2009). Using these changes as an indicator of the effectiveness of recruitment programs, we determine which colleges of engineering associated with Cohort 1 universities show stronger performance. Subsequently, we compare the key components of recruitment programs initiated at both stronger and weaker performing institutions during the ADVANCE grant period. Our analysis of changes during the grant period reveals that four out of seven colleges of engineering added between four and seven women to the faculty at the assistant professor rank, and two institutions added one female assistant professor each. Georgia Tech's College of engineering, where the number of female assistant professors fell by four, constitutes an exception to this overall trend. A longer term view (2001-2009) reveals

关键词： engineering education

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Economics of energy storage in a residential consumer context

Economics of energy storage in a residential consumer contex...

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International Conference on European Electricity Market, EEM

作者： Dennis Metz João Tomé Saraiva PDSSE Program FEUP/MIT PhD Program University of Porto Porto Portugal INESC TEC / DEEC Faculty of Engineering University of Porto Porto Portugal

With the increase of electricity tariffs and the decreasing costs for distributed generation technologies, more and more residential consumers are deploying local generation systems to satisfy their electricity demand in order to reduce overall cost. Typically, however, a mismatch between electricity generation and demand remains. Storage systems enable consumers to reduce this mismatch by storing locally generated electricity for later consumption, instead of feeding excess generation into the grid. This paper analyzes the economics of storage installations in a residential consumer context. A linear program is presented to determine the optimal dispatch, and Simulated Annealing is used to identify the cost minimizing system configuration. The developed approach is tested for a multi-family house in Germany.

关键词： Cogeneration Mathematical model Photovoltaic systems Investment Simulated annealing Context Distributed power generation

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Overcoming Cytosolic Delivery Barriers of Proteins Using Denatured Protein-Conjugated Mesoporous Silica Nanoparticles

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ACS Applied Materials and Interfaces 2023年第1期15卷 432-451页

作者： Dembélé, Julien Liao, Jou-Hsuan Liu, Tsang-Pai Chen, Yi-Ping Graduate Institute of Biomedical Materials & Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Laboratory of Toxicology Environment and Health Doctorate School of Health University Joseph Ki-Zerbo Ouaga03 BP 7021 Burkina Faso Department of Chemistry National Taiwan University Taipei10617 Taiwan Department of Surgery Mackay Memorial Hospital Taipei10449 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Intracellular delivery of therapeutic proteins has increased advantages over current small-molecule drugs and gene therapies, especially in therapeutic efficacies for a broad spectrum of diseases. Hence, developing the protein therapeutics approach provides a needed alternative. Here, we designed a mesoporous silica nanoparticle (MSN)-mediated protein delivery approach and demonstrated effective intracellular delivery of the denatured superoxide dismutase (SOD) protein, overcoming the delivery challenges and achieving higher enzymatic activity than native SOD-conjugated MSNs. The denatured SOD-conjugated MSN delivery strategy provides benefits of reduced size and steric hindrance, increased protein flexibility without distorting its secondary structure, exposure of the cell-penetrating peptide transactivator of transcription for enhanced efficient delivery, and a change in the corona protein composition, enabling cytosolic delivery. After delivery, SOD displayed a specific activity around threefold higher than in our previous reports. Furthermore, the in vivo biosafety and therapeutic potential for neuron therapy were evaluated, demonstrating the biocompatibility and the effective antioxidant effect in Neuro-2a cells that protected neurite outgrowth from paraquat-induced reactive oxygen species attack. This study offers an opportunity to realize the druggable possibility of cytosolic proteins using MSNs. © 2022 American Chemical Society.

关键词： Peptides

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Free water surface constructed wetlands: review of pollutant removal performance and modeling approaches

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Environmental Science and Pollution Research 2024年第32期31卷 44649-44668页

作者： Gaballah, Mohamed S. Yousefyani, Hooshyar Karami, Mohammadjavad Lammers, Roderick W. School of Engineering and Technology Central Michigan University Mount PleasantMI48859 United States National Institute of Oceanography and Fisheries Cairo Egypt Earth & amp Ecosystem Science PhD Program Central Michigan University Mount PleasantMI48859 United States Institute for Great Lakes Research Central Michigan University Mount PleasantMI48859 United States

Free water surface constructed wetlands (FWSCWs) for the treatment of various wastewater types have evolved significantly over the last few decades. With an increasing need and interest in FWSCWs applications worldwide due to their cost-effectiveness and other benefits, this paper reviews recent literature on FWSCWs' ability to remove different types of pollutants such as nutrients (i.e., TN, TP, NH4-N), heavy metals (i.e., Fe, Zn, and Ni), antibiotics (i.e., oxytetracycline, ciprofloxacin, doxycycline, sulfamethazine, and ofloxacin), and pesticides (i.e., Atrazine, S-Metolachlor, imidacloprid, lambda-cyhalothrin, diuron 3,4-dichloroanilin, Simazine, and Atrazine) that may co-exist in wetland inflow, and discusses approaches for simulating hydraulic and pollutant removal processes. A bibliometric analysis of recent literature reveals that China has the highest number of publications, followed by the USA. The collected data show that FWSCWs can remove an average of 61.6%, 67.8%, 54.7%, and 72.85% of inflowing nutrients, heavy metals, antibiotics, and pesticides, respectively. Optimizing each pollutant removal process requires specific design parameters. Removing heavy metal requires the lowest hydraulic retention time (HRT) (average of 4.78 days), removing pesticides requires the lowest water depth (average of 0.34 m), and nutrient removal requires the largest system size. Vegetation, especially Typha spp. and Phragmites spp., play an important role in FWSCWs' system performance, making significant contributions to the removal process. Various modeling approaches (i.e., black-box and process-based) were comprehensively reviewed, revealing the need for including the internal process mechanisms related to the biological processes along with plants spp., that supported by a further research with field study validations. This work presents a state-of-the-art, systematic, and comparative discussion on the efficiency of FWSCWs in removing different pollutants, main design

关键词： Wetlands

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Passivation of Perovskite Films Using Ionic Liquids

Passivation of Perovskite Films Using Ionic Liquids

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2022 Advances in Science and engineering Technology International Conferences, ASET 2022

作者： Alashkar, Adnan Ibrahim, Taleb Khamis, Mustafa Hai Alami, Abdul American University of Sharjah Materials Science and Engineering PhD Program Sharjah United Arab Emirates American University of Sharjah Department of Chemical Engineering Sharjah United Arab Emirates American University of Sharjah Department of Biology Chemistry and Enviromental Sciences Sharjah United Arab Emirates University of Sharjah Department of Sustainable and Renewable Energy Engineering Sharjah United Arab Emirates

ISBN: (纸本)9781665418010

In this paper, the carrier recombination, and dynamics of Perovskite Solar Cells (PSC) are investigated. Ionic Liquids (IL) are presented in the bulk perovskite in an attempt to improve the dynamics of the charge transport layer. Time Resolved Photoluminescence (TRPL) is utilized to study the fast electronic decay of the perovskite samples and the influence of the IL on the stability of the perovskite film. The ILs are added to the perovskite in three ratios (5%, 10%, and 20%). The results showed that the presence of the ILs increases the electron lifetime inside the perovskite layer. In addition, 10% IL/perovskite displayed the highest increase of 72% in the lifetime. Where, for higher ratios, the lifetime started deteriorating. © 2022 IEEE.

关键词： Ionic liquids

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CONDUCTIVITY STUDIES IN MXENE-PVDF COMPOSITE MEMBRANES FOR PEM FUEL CELLS APPLICATIONS 50

CONDUCTIVITY STUDIES IN MXENE-PVDF COMPOSITE MEMBRANES FOR P...

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50th International Conference on Computers and Industrial engineering: Sustainable Digital Transformation, CIE 2023

作者： Shaikh, Ryan Al Al-Othman, Amani Nancarrow, Paul Tawalbeh, Muhammad Shamayleh, Abdulrahim Engineering Systems and Management PhD Program American University of Sharjah Sharjah United Arab Emirates Department of Chemical and Biological Engineering American University of Sharjah Sharjah United Arab Emirates University of Sharjah P. O. Box Sharjah27272 United Arab Emirates Department of Industrial Engineering American University of Sharjah Sharjah United Arab Emirates

ISBN: (纸本)9781713886952

Energy supply and demand are at the core of one of the pressing problems worldwide as the present energy production is still dominated by non-renewable resources. The need to meet the goals for the climate has motivated the energy sector to embrace cleaner and greener electro-energy systems. Proton exchange membrane (PEM) fuel cells, also known as polymer-electrolyte membrane fuel cells, have lately attracted more attention from various sectors due to their exceptional advantages, including high theoretical efficiency, low operating temperatures, and low-to-zero emissions. Therefore, they can be successfully used in a variety of applications. Hence, a novel membrane that possesses adequate proton conductivity is required. Therefore, in this work, MXene was investigated as a potential proton conductor. MXene/PVDF based membrane was synthesized with different concentrations 3, 5, 8, 10, 13 and 15 wt.% respectively, and evaluated for their proton conduction using electrochemical impedance spectroscopy (EIS). The values of the conductivity obtained were:3.22× x10- 3, 6.2× x10-3, 0.025, 0.041, 3.77×10-3 and 4.2 ×10-3 S/cm, respectively. The results of this study show that the synthesized membranes in this work appear to be promising for PEM fuel cells applications. © 2023 Computers and Industrial engineering. All rights reserved.

关键词： Proton conductivity

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