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Lab on a Chip 2013年第4期13卷 599-601页

作者： Francesco Piraino João Ribas Mehmet R. Dokmeci Ali Khademhosseini Bioengineering Department Politecnico di Milano Piazza Leonardo da Vinci 32 20133 Milano Italy Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge Massachusetts 02139 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Biocant-Center of Innovation and Biotechnology 3060-197 Cantanhede Portugal PhD Program in Experimental Biology and Biomedicine CNC-Centre for Neuroscience and Cell Biology 3004-517 Coimbra Portugal Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts 02115 USA World Premier International – Advanced Institute for Materials Research (WPI-AIMR) Tohoku University Sendai 980-8577 Japan

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Exploring the potential of the nano-based sunscreens and antioxidants for preventing and treating skin photoaging

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Chemosphere 2024年 347卷 140702页

作者： Lin, Chih-Hung Lin, Ming-Hsien Chung, Yu-Kuo Alalaiwe, Ahmed Hung, Chi-Feng Fang, Jia-You Center for General Education Chang Gung University of Science and Technology Kweishan Taoyuan Taiwan Department of Dermatology Chi Mei Medical Center Tainan Taiwan Graduate Institute of Biomedical Sciences Chang Gung University Kweishan Taoyuan Taiwan Department of Pharmaceutics College of Pharmacy Prince Sattam Bin Abdulaziz University Al Kharj Saudi Arabia School of Medicine Fu Jen Catholic University New Taipei City Taiwan PhD Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City Taiwan School of Pharmacy Kaohsiung Medical University Kaohsiung Taiwan Pharmaceutics Laboratory Graduate Institute of Natural Products Chang Gung University Kweishan Taoyuan Taiwan Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine Chang Gung University of Science and Technology Kweishan Taoyuan Taiwan Department of Anesthesiology Chang Gung Memorial Hospital Kweishan Taoyuan Taiwan

Excessive exposure to sunlight, especially UV irradiation, causes skin photodamage. Sunscreens, such as TiO2 and ZnO, can potentially prevent UV via scattering, reflection, and absorption. Topical antioxidants are another means of skin photoprotection. Developing nanoparticles for sunscreens and antioxidants is recommended for photoaging prevention and treatment as it can improve uncomfortable skin appearance, stability, penetration, and safety. This study reviewed the effects of nano-sized sunscreens and antioxidants on skin photoprevention by examining published studies and articles from PubMed, Scopus, and Google Scholar, which explore the topics of skin photoaging, skin senescence, UV radiation, keratinocyte, dermal fibroblast, sunscreen, antioxidant, and nanoparticle. The researchers of this study also summarized the nano-based UV filters and therapeutics for mitigating skin photoaging. The skin photodamage mechanisms are presented, followed by the introduction of current skin photoaging treatment. The different nanoparticle types used for topical delivery were also explored in this study. This is followed by the mechanisms of how nanoparticles improve the UV filters and antioxidant performance. Lastly, recent investigations were reviewed on nanoparticulate sunscreens and antioxidants in skin photoaging management. Sunscreens and antioxidants for topical application have different concepts. Topical antioxidants are ideal for permeating into the skin to exhibit free radical scavenging activity, while UV filters are prescribed to remain on the skin surface without absorption to exert the UV-blocking effect without causing toxicity. The nanoparticle design strategy for meeting the different needs of sunscreens and antioxidants is also explored in this study. Although the benefits of using nanoparticles for alleviating photodamage are well-established, more animal-based and clinical studies are necessary. © 2023 Elsevier Ltd

关键词： Antioxidants

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Facilitating light utilization and electron transfer of TiO2 nanotube arrays for catalyzing photoelectrochemical water reduction via acid etching and copper doping

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Materials Today Chemistry 2023年 34卷

作者： Hsu, Chuan-Chih Kubendhiran, Subbiramaniyan Lai, Jhih-Hong Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Hsiao, Yu-Cheng Wu, Yung-Fu Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 03 Ouagadougou Burkina Faso Gingen Technology Co. LTD Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan

Photoelectrochemical catalytic capability mainly relies on light absorption and charge transfer efficiency. TiO2 nanotube array (TNA) having suitable band edges and one-dimensional hollow structure is regarded as one of efficient photoelectrocatalysts toward water reduction. In this study, two strategies are firstly applied to modify TNA as the photocatalyst of water reduction. Ti foils are etched by acid to produce multiple light reflections planes for improving light absorption, and Cu is doped in TNA to enhance charge transfer efficiency. The optimal Cu-doped TNA electrode on the acid-etched Ti foil presents a much smaller overpotential of 91 mV at 10 mA/cm2 compared with that of the undoped TNA (524 mV). A smaller Tafel slope of 134 mV/dec is obtained for the optimal Cu-doped TNA electrode than that of the undoped TNA (167 mV/dec). After measuring the photoelectrochemical performance for 1000 cycles, overpotential and charge-transfer resistance of modified TNA are largely reduced owing to activation. Current retention of 96.7% is achieved after continuously illuminating for 10 h. Highly improved photoelectrochemical catalytic ability of TNA modified by acid etching and Cu doping provides new pages for material modifications on substrate and active material. © 2023 Elsevier Ltd

关键词： Light absorption

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Corrigendum to "Comparative analysis of novel autoantibody isotypes against citrullinatedinter-alpha-trypsin inhibitor heavy chain 3 (ITIH3) 542-556 peptide in serum from Taiwanese females with rheumatoid arthritis, primary Sjögren's syndrome and secondary Sjögren's syndrome in rheumatoid arthritis" [J Proteomics 141: (2016) 1-11]

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Journal of proteomics 2019年 194卷 227页

作者： C C Liao P L Chou C W Cheng Y S Chang W M Chi K L Tsai W J Chen T S Kung C C Tai K W Lee Y C Chen C Y Lin Proteomics Research Center National Yang-Ming University Taipei 112 Taiwan. Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 330 Taiwan Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Department of Laboratory Medicine Taipei Medical University-Shuang-Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan. Department of Biotechnology and Animal Science National Ilan University Ilan 26047 Taiwan. School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan. PhD Program for Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei 11031 Taiwan. School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan PhD Program for Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei 11031 Taiwan. Electronic address: cylin@tmu.edu.tw.

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Metal ratio and bimetal nanoarchitectonics of ammonia-based fluoride complex induced nickel hydroxide and manganese oxide composites as active materials of an energy storage device

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Journal of Energy Storage 2024年 80卷

作者： Hsu, Chuan-Chih Yu, You Zher Wu, Chung-Hsien Lee, Pin-Yan Chen, Hung-Ming Husain, Sadang Kongvarhodom, Chutima Hsiao, Yu-Cheng Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Nickel and manganese compounds are widely applied as efficient battery-type active materials for energy storage devices, due to high theoretical capacities and abundant redox states for generating redox reactions to store charges. Morphology plays significant roles on energy storage ability. Structure directing agent (SDA) is widely reported to have ability for modulating configurations of active materials and to achieve excellent surface properties. In this work, it is the first time to use NH4BF4 and NH4HF2 as structure directing agents for synthesizing nickel manganese compounds derived from ZIF67 as active materials of energy storage devices. Bimetallic compounds are composed of nickel hydroxide and manganese oxide, which presents the favorable two-dimensional flower-like structure with high surface area and abundant redox states. The largest specific capacitance (CF) of 1358.2 F/g corresponding to the capacity of 226.4 mAh/g are achieved for the bimetallic compound synthesized using the Ni to Mn precursor ratio of 1 to 1 (NiMn11). The energy storage device assembled using NiMn11 and reduced graphene oxide on Ni foams presents a maximum energy density of 11.45 Wh/kg at the power density of 0.35 kW/kg, and excellent long-term stability with the CF retention of 85.6% and Coulombic efficiency of 87.5% after 10,000 cycles. © 2023

关键词： Fluorine compounds

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Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer’s disease

Nature Aging

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Nature Aging 2025年 1-18页

作者： Heo, Gyujin Xu, Ying Wang, Erming Ali, Muhammad Oh, Hamilton Se-Hwee Moran-Losada, Patricia Anastasi, Federica González Escalante, Armand Puerta, Raquel Song, Soomin Timsina, Jigyasha Liu, Menghan Western, Daniel Gong, Katherine Chen, Yike Kohlfeld, Pat Flynn, Allison Thomas, Alvin G. Lowery, Joseph Morris, John C. Holtzman, David M. Perlmutter, Joel S. Schindler, Suzanne E. Vilor-Tejedor, Natalia Suárez-Calvet, Marc García-González, Pablo Marquié, Marta Fernández, Maria Victoria Boada, Mercè Cano, Amanda Ruiz, Agustín Zhang, Bin Bennett, David A. Benzinger, Tammie Wyss-Coray, Tony Ibanez, Laura Sung, Yun Ju Cruchaga, Carlos Department of Psychiatry Washington University School of Medicine St. Louis MO United States NeuroGenomics and Informatics Center Washington University St. Louis MO United States Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York NY United States Mount Sinai Center for Transformative Disease Modeling Icahn School of Medicine at Mount Sinai New York NY United States Graduate Program in Stem Cell and Regenerative Medicine Stanford University Stanford CA United States The Phil and Penny Knight Initiative for Brain Resilience Stanford University Stanford CA United States Wu Tsai Neurosciences Institute Stanford University Stanford CA United States Department of Neurology and Neurological Sciences Stanford University School of Medicine Stanford CA United States Barcelonaβeta Brain Research Center (BBRC) Pasqual Maragall Foundation Barcelona Spain Hospital del Mar Research Institute Barcelona Spain Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology (BIST) Barcelona Spain Department of Medicine and Life Sciences Universitat Pompeu Fabra Barcelona Spain Ace Alzheimer Center Barcelona Universitat Internacional de Catalunya Barcelona Spain PhD Program in Biotechnology Faculty of Pharmacy and Food Sciences University of Barcelona Barcelona Spain Department of Neurology Washington University School of Medicine St. Louis MO United States Hope Center for Neurologic Diseases Washington University St. Louis MO United States Knight Alzheimer’s Disease Research Center Washington University St. Louis MO United States Department of Radiology Washington University School of Medicine St. Louis MO United States Department of Genetics Radboud UMC Nijmegen Netherlands Servei de Neurologia Hospital del Mar Barcelona Spain Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED) National Institute of Health Carlos III Madrid Spain Glenn Biggs Institute for Alzheimer’s & Ne

Proteomic studies have been instrumental in identifying brain, cerebrospinal fluid and plasma proteins associated with Alzheimer’s disease (AD). Here, we comprehensively examined 6,905 aptamers corresponding to 6,106 unique proteins in plasma in more than 3,300 well-characterized individuals to identify new proteins, pathways and predictive models for AD. We identified 416 proteins (294 new) associated with clinical AD status and validated the findings in two external datasets representing more than 7,000 samples. AD-related proteins reflected blood–brain barrier disruption and other processes implicated in AD, such as lipid dysregulation or immune responses. A machine learning model was used to identify a set of seven proteins that were highly predictive of both clinical AD (area under the curve (AUC) of >0.72) and biomarker-defined AD status (AUC of >0.88), which were replicated in multiple external cohorts and orthogonal platforms. These findings underscore the potential of using plasma proteins as biomarkers for the early detection and monitoring of AD and for guiding treatment decisions. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2025.

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Unprecedented anti-inflammatory biscembranoids with 3-hydroperoxy-3-methylcyclohex-1-ene moiety isolated from aquaculture Sarcophyton trocheliophorum

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Aquaculture Reports 2023年 33卷

作者： Peng, Bo-Rong Nguyen, Ngoc Bao An Chen, Lo-Yun El-Shazly, Mohamed Hwang, Tsong-Long Su, Jui-Hsin Lai, Kuei-Hung Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei 11031 Taiwan PhD Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Department of Pharmacognosy Faculty of Pharmacy Ain-Shams University Organization of African Unity Street Cairo Abassia 11566 Egypt Research Center for Chinese Herbal Medicine College of Human Ecology Chang Gung University of Science and Technology Taoyuan 33303 Taiwan Graduate Institute of Health Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan 33303 Taiwan Department of Anaesthesiology Chang Gung Memorial Hospital Taoyuan 33305 Taiwan Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan 33302 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City 24301 Taiwan National Museum of Marine Biology & Aquarium Pingtung 94450 Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 80424 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei 11031 Taiwan

Recent advancements in the discovery of natural products have made significant progress in rapidly identifying known compounds from complex extracts using advanced spectroscopic technologies. Among these methods, one powerful approach called MS/MS molecular networking (MN) organizes chemical similarity based on MS/MS fragmentation data, serving as a valuable complement to traditional dereplication strategies. In our ongoing research focused on lead discovery from a sustainable medicinal source, an aquaculture soft coral Sarcophyton trocheliophorum, the MN profiling approach revealed the chemical diversity of biscembranoid analogs. By analyzing the MN pattern, biscembranoid derivatives with unique MS/MS fragments were prioritized for further investigation. Two novel biscembranoids, sarcotroxide A (1) and B (2), were successfully obtained through targeted isolation. These novel biscembranes contained an unprecedented 3-hydroperoxy-3-methylcyclohex-1-ene moiety compared with all biscembranoid analogs. The chemical structures of the two new biscembranoids were confirmed through spectroscopic analyses and in silico calculations. Their anti-inflammatory properties were assessed against the generation of superoxide anion (O₂^•−) and elastase release in activated human neutrophils. Sarcotroxides A (1) and B (2) exhibited anti-inflammatory activity by inhibiting O₂^•− accumulation (with 43.67% and 61.62% inhibition) and elastase release (with 38.21% and 61.62% inhibition) at 10 µM. These findings validated the potential of these biscembranoids from the cultured S. trocheliophorum as promising candidates for the future development of anti-inflammatory agents specifically designed to target neutrophils. © 2023 The Authors

关键词： Anti-inflammation Aquaculture soft coral Biscembranoid Neutrophil Sarcophyton trocheliophorum

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Non-meningeal, non-pulmonary cryptococcosis with limited posterior uveitis in a kidney organ transplant recipient with antibody-mediated rejection: a case report

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BMC Ophthalmology 2023年第1期23卷 409-409页

作者： Lu, Yi-An Lin, Chun-Hsien Chang, Chia-Jen Shu, Kuo-Hsiung Chung, Mu-Chi Chou, Chien-Chih Department of Ophthalmology Taichung Veterans General Hospital 1650 Boulevard Sect. 4 Taichung 407219 Taiwan Division of Nephrology Department of Internal Medicine Lin Shin Hospital No.36 Sec. 3 Huizhong Rd. Nantun District Taichung City 40867 Taiwan Division of Nephrology Department of Medicine Taichung Veterans General Hospital 1650 Boulevard Sect. 4 Taichung 407219 Taiwan PhD Program in Translational Medicine National Chung Hsing University Taichung Taiwan Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan College of Medicine National Chung Hsing University Taichung Taiwan

Background: Cryptococcosis is one of the most frequent fungal eye infections in patients with immunosuppression. Currently, treatment approaches for non-meningeal, non-pulmonary cryptococcosis are based on those used for cryptococcal meningitis or pneumonia. Case presentation: We present a rare case of non-meningeal, non-pulmonary cryptococcosis with clinical manifestations limited to one eye of a cadaveric kidney transplant recipient with chronic-active antibody-mediated rejection. Typical manifestations, diagnosis, and treatments, including antifungal therapies, adjunctive therapies, and immunosuppression reduction, are discussed. After timely diagnosis and treatment, her visual acuity recovered to baseline without recurrence or sequelae of cryptococcosis. Conclusions: Clinicians should be aware of rare presentations of fungal infections, especially when a kidney transplant recipient with rejection has been treated with intensive immunosuppressants. Early diagnosis with individualized therapies may have a favorable prognosis. © 2023, BioMed Central Ltd., part of Springer Nature.

关键词： Amphotericin B Case report Choroiditis Cryptococcal infection Double filtration plasmapheresis Fluconazole Immunosuppressant Kidney transplant Solid organ transplant Uveitis

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The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases

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Clinical immunology (Orlando, Fla.) 2024年 260卷 109897页

作者： Hsing-Fang Lu Chen-Hsing Chou Ying-Ju Lin Shunsuke Uchiyama Chikashi Terao Yu-Wen Wang Jai-Sing Yang Ting-Yuan Liu Henry Sung-Ching Wong Sean Chun-Chang Chen Fuu-Jen Tsai Department of Medical Research China Medical University Hospital Taichung 404327 Taiwan Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan. PhD Program for Health Science and Industry College of Health Care China Medical University Taichung Taiwan Department of Health Services Administration China Medical University Taichung Taiwan. Genetic Center Department of Medical Research China Medical University Hospital Taichung Taiwan School of Chinese Medicine China Medical University Taichung Taiwan. Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan Clinical Research Center Shizuoka General Hospital Shizuoka Japan The Department of Applied Genetics The School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan. Department of Medical Research China Medical University Hospital Taichung 404327 Taiwan. Department of Medical Research China Medical University Hospital China Medical University Taichung 404327 Taiwan. Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan. School of Chinese Medicine China Medical University Taichung Taiwan Department of Biotechnology and Bioinformatics Asia University Taichung Taiwan. Electronic address: d0704@mail.cmuh.org.tw.

Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and several genome-wide association studies (GWASs) have demonstrated the association between genes and IgE level. In this study, we conducted the largest genome-wide association study of IgE involving a Taiwanese Han population. Eight independent variants exhibited genome-wide significance. Among them, an intronic SNP of CD28, rs1181388, and an intergenic SNP, rs1002957030, on 11q23.2 were identified as novel signals for IgE. Seven of the loci were replicated successfully in a meta-analysis using data on Japanese population. Among all the human leukocyte antigen (HLA) regions, HLA-DQA1*03:02 - HLA-DQB1*03:03 was the most significant haplotype (OR = 1.25, SE = 0.02, FDR = 1.6 × 10), corresponding to HLA-DQA1 Asp160 and HLA-DQB1 Leu87 amino acid residues. The genetic correlation showed significance between IgE and allergic diseases including asthma, atopic dermatitis, and pollinosis. IgE PRS was significantly correlated with total IgE levels. Furthermore, the top decile IgE polygenic risk score (PRS) group had the highest risk of asthma for the Taiwan Biobank and Biobank Japan cohorts. IgE PRS may be used to aid in predicting the occurrence of allergic reactions before symptoms occur and biomarkers are detectable. Our study provided a more comprehensive understanding of the impact of genomic variants, including complex HLA alleles, on serum IgE levels.

关键词： Allergy genome-wide association study human leukocyte antigen immunoglobulin E

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Correction: Biomass derived nitrogen functionalized carbon nanodots for nanomolar determination of levofloxacin in pharmaceutical and water samples

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Mikrochimica acta 2023年第7期190卷 269页

作者： Velusamy Arul Natarajan Sampathkumar Sindhuja Kotteeswaran Ponnusamy Arul Ahmed Muteb Aljuwayid Mohamed A Habila Mani Govindasamy Department of Chemistry Sri Eshwar College of Engineering (Autonomous) Coimbatore 641 202 Tamil Nadu India. kvarulchem6@***. Department of Chemistry Korea University 145 Anam-Ro Seongbuk-Gu Seoul South Korea. kvarulchem6@***. Department of Chemistry SSM College of Arts and Science Dindigul 624002 Tamil Nadu India. International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. Department of Chemical Engineering and Biotechnology Institute of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei 106 Taiwan ROC. vpsarul@***. Department of Chemistry College of Science King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia. International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. govindasamy420700@***. Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. govindasamy420700@***. Department of Research and Innovation Saveetha School of Engineering SIMATS 602105 Chennai India. govindasamy420700@***.

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