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BIOS-02. RECAPITULATE TUMOR DIVERSION AND SPATIAL PATTERNING IN GLIOBLASTOMA BACKGROUND

Neuro-Oncology 2023年第SUPPLEMENT_5期25卷 v20-v20页

作者： Lo, Wei-Lun Khoa, Hoang Dang Ta Chuang, Jian-Ying Division of Neurosurgery Shuang-Ho Hospital New Taipei City New Taipei Taiwan (Republic of China) PhD Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei Taipei Taiwan (Republic of China) International Master Program in Medical Neuroscience Taipei Medical University Taipei Taiwan (Republic of China)

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Translational models of stress and resilience: An applied neuroscience methodology review

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neuroscience Applied 2024年 3卷

作者： Albayrak, Zeynep Seda Vaz, Andreia Bordes, Joeri Ünlü, Selen Sep, Milou S.C. Vinkers, Christiaan H. Pinto, Luisa Yapici-Eser, Hale Koç University Hospital Department of Child and Adolescent Psychiatry Istanbul Turkey Koç University Graduate School of Health Sciences Neuroscience PhD Program Koç University Istanbul Turkey Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho Campus de Gualtar Braga 4710-057 Portugal ICVS/3B's–PT Government Associate Laboratory Braga 4710-057 Portugal Bn'ML Behavioral and Molecular Lab Campus de Gualtar Braga 4710-057 Portugal Neurocentre Magendie INSERM 1215 Université de Bordeaux Bordeaux France Koç University School of Medicine İstanbul Turkey Department of Psychiatry Amsterdam University Medical Centers Location Vrije Universiteit Amsterdam Netherlands GGZ InGeest Mental Health Care Amsterdam Netherlands Amsterdam Neuroscience Mood Anxiety Psychosis Sleep & Stress Program Amsterdam Netherlands Amsterdam Public Health Mental Health Program Amsterdam Netherlands Department of Psychiatry and Department of Anatomy and Neurosciences Amsterdam University Medical Center Location VUMC Amsterdam Netherlands Academic Working Place Depression GGZ InGeest Amsterdam Netherlands Amsterdam Neuroscience (Mood Anxiety Psychosis Stress & Sleep Program) and Amsterdam Public Health (Mental Health Program) Research Institutes Amsterdam Netherlands Koç University School of Medicine Department of Psychiatry İstanbul Turkey

Stress, encompassing psychological, physical, and physiological challenges, is an important factor affecting an individual's well-being and potentially leading to psychiatric, neurodegenerative, immune, and metabolic disorders. However, not everyone exposed to stress develops these conditions, highlighting the concept of resilience. Resilience is a dynamic process categorized into four dimensions: pre-existing resilience capacity, ongoing resilience processes, post-stress resilience outcomes, and recovery from psychopathologies. These dimensions involve genomic, cellular, and systemic interactions influenced by genetic factors, early life experiences, adult life experiences in addition to community/environmental factors, and health behaviors. The biological response to stress encompasses endocrine, autonomic, immunological, and behavioral components, modulated by stressor characteristics and individual traits. Due to the limitations in studying stress and resilience in humans, translational models using rodents and cell cultures are essential. Rodent models include acute, chronic, and traumatic stress paradigms, aiding the study of stress-related behavioral and molecular outcomes. Additionally, early life stress models, such as prenatal stress and maternal separation, provide insights into developmental impacts. In this review, first, rodent models for lifelong stress exposure will be summarized considering their validity, advantages, and limitations. Subsequently, an overview of models designed to enhance resilience capacity and process in rodents, and later the behavioral models employed to study the outcomes of resilience will be given. Lastly, the focus will be shifted to cell culture and iPSCs models. Finally, future considerations focused on improving translational models used to study stress and resilience will be discussed. It is aimed to provide an overview of designs for translational stress and resilience models to access more effective translational biom

关键词： Acute stress Behavior Chronic stress Resilience Rodent Stress

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P.861Gender-specific involvement of Methyl-CpG binding protein 2 in vulnerability to stress: evidence from a healthy cohort

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European Neuropsychopharmacology 2020年 40卷 S477-S478页

作者： Cosentino, L. Zidda, F. Witt, S. De Filippis, B. Flor, H. Istituto Superiore di Sanità Center for Behavioral Sciences and Mental Health Rome Italy Sapenza University of Roma PhD program in Behavioral Neuroscience Roma Italy Central Institute of Mental Health- Medical Faculty Mannheim- Heidelberg University Department of Cognitive and Clinical Neuroscience Mannheim Germany Central Institute of Mental Health- Medical Faculty Mannheim- Heidelberg University Department of Genetic Epidemiology in Psychiatry Mannheim Germany

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Research highlights

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Lab on a Chip 2013年第10期13卷 1842-1845页

作者： João Ribas Mark W. Tibbitt Mehmet R. Dokmeci Ali Khademhosseini Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge Massachusetts 02139 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA PhD Program in Experimental Biology and Biomedicine CNC-Center for Neuroscience and Cell Biology and Institute for Interdisciplinary Research (IIIUC) University of Coimbra 3004-517 Coimbra Portugal Biocant–Center of Innovation and Biotechnology 3060-197 Cantanhede Portugal Department of Chemical and Biological Engineering University of Colorado Boulder Colorado 80303 USA Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts 02115 USA World Premier International–Advanced Institute for Materials Research (WPI-AIMR) Tohoku University Sendai 980-8577 Japan

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Research highlights

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Lab on a Chip 2013年第4期13卷 599-601页

作者： Francesco Piraino João Ribas Mehmet R. Dokmeci Ali Khademhosseini Bioengineering Department Politecnico di Milano Piazza Leonardo da Vinci 32 20133 Milano Italy Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge Massachusetts 02139 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Biocant-Center of Innovation and Biotechnology 3060-197 Cantanhede Portugal PhD Program in Experimental Biology and Biomedicine CNC-Centre for Neuroscience and Cell Biology 3004-517 Coimbra Portugal Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts 02115 USA World Premier International – Advanced Institute for Materials Research (WPI-AIMR) Tohoku University Sendai 980-8577 Japan

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Cover Image, Volume 28, Issue 7

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Hippocampus 2018年第7期28卷

作者： Ina P. Pavlova Shannon C. Shipley Marcos Lanio René Hen Christine A. Denny Division of Integrative Neuroscience Research Foundation for Mental Hygiene Inc. (RFMH)/New York State Psychiatric Institute (NYSPI) New York New York 10032 Department of Neuroscience MD-PhD Program College of Physicians and Surgeons Columbia University Medical Center New York New York 10032 Department of Psychiatry Columbia University New York New York 10032

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Symmetries and synchronization from whole-neural activity in C. elegans connectome: Integration of functional and structural networks

arXiv

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arXiv 2024年

作者： Avila, Bryant Augusto, Pedro Phillips, David Gili, Tommaso Zimmer, Manuel Makse, Hernán A. Levich Institute and Physics Department City College of New York New YorkNY10031 United States Vienna Austria Vienna Biocenter PhD Program Doctoral School the University of Vienna Medical University of Vienna Vienna Austria Mechanical Engineering Department University of New Mexico AlbuquerqueNM87131 United States Networks Unit IMT Scuola Alti Studi Lucca Piazza San Francesco 15 Lucca55100 Italy Department of Radiology Neuroradiology Service Memorial Sloan Kettering Cancer Center New YorkNY10065 United States CUNY Neuroscience Graduate Center City University of New York New YorkNY10031 United States

Understanding the dynamical behavior of complex systems from their underlying network architectures is a long-standing question in complexity theory. Therefore, many metrics have been devised to extract network features like motifs, centrality, and modularity measures. It has previously been proposed that network symmetries are of particular importance since they are expected to underly the synchronization of a system’s units, which is ubiquitously observed in nervous system activity patterns. However, perfectly symmetrical structures are difficult to assess in noisy measurements of biological systems, like neuronal connectomes. Here, we devise a principled method to infer network symmetries from combined connectome and neuronal activity data. Using nervous system-wide population activity recordings of the *** backward locomotor system, we infer structures in the connectome called fibration symmetries, which can explain which group of neurons synchronize their activity. Our analysis suggests functional building blocks in the animal’s motor periphery, providing new testable hypotheses on how descending interneuron circuits communicate with the motor periphery to control behavior. Our approach opens a new door to exploring the structure-function relations in other complex systems, like the nervous systems of larger animals. © 2024, CC BY.

关键词： Synchronization

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Clinical trials of new drugs for Alzheimer disease: a 2020-2023 update

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Journal of biomedical science 2023年第1期30卷 83页

作者： Li-Kai Huang Yi-Chun Kuan Ho-Wei Lin Chaur-Jong Hu PhD Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University No. 291 Zhong Zheng Road Zhonghe District New Taipei City Taiwan. Taipei Neuroscience Institute Taipei Medical University New Taipei City Taiwan. Dementia Center and Department of Neurology Shuang-Ho Hospital Taipei Medical University New Taipei City Taiwan. Department of Neurology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Biomedical Engineering National Taiwan University Taipei Taiwan. School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. PhD Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University No. 291 Zhong Zheng Road Zhonghe District New Taipei City Taiwan. chaurjongh@tmu.edu.tw. Taipei Neuroscience Institute Taipei Medical University New Taipei City Taiwan. chaurjongh@tmu.edu.tw. Dementia Center and Department of Neurology Shuang-Ho Hospital Taipei Medical University New Taipei City Taiwan. chaurjongh@tmu.edu.tw. Department of Neurology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. chaurjongh@tmu.edu.tw.

Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet medical need worldwide. The pathogenesis of AD involves various pathophysiological events, including the accumulation of amyloid and tau, neuro-inflammation, and neuronal injury. Clinical trials focusing on new drugs for AD were documented in 2020, but subsequent developments have emerged since then. Notably, the US-FDA has approved Aducanumab and Lecanemab, both antibodies targeting amyloid, marking the end of a nearly two-decade period without new AD drugs. In this comprehensive report, we review all trials listed in ***, elucidating their underlying mechanisms and study designs. Ongoing clinical trials are investigating numerous promising new drugs for AD. The main trends in these trials involve pathophysiology-based, disease-modifying therapies and the recruitment of participants in earlier stages of the disease. These trends underscore the significance of conducting fundamental research on pathophysiology, prevention, and intervention prior to the occurrence of brain damage caused by AD.

关键词： Alzheimer disease Anti-amyloid Anti-tau Clinical trials Cognitive enhancement Neuroinflammation Neuroprotection

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Use of sensors systems to monitor the mobility of elderly

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Journal of Physics: Conference Series 2013年第1期477卷

作者： M R Marques T M Raymundo C S Santana Master student at Post Graduate Program Interunits Bioengineering EESC/FMRP/IQSC – University of Sao Paulo Brazil Master of Science Professor Dr. at Neuroscience and Behavioral Science Department – Ribeirao Preto Medical School University of Sao Paulo and Post Graduate Program Interunits Bioengineering EESC/FMRP/IQSC – University of Sao Paulo Brazil PhD student at Post Graduate Program Interunits Bioengineering EESC/FMRP/IQSC – University of Sao Paulo Brazil

Even presenting risk of falls or mobility difficulties, many seniors prefer to live independently as long as possible. Thus, there is a need for solutions to enable independent living safely and to strengthen family support. Among them are the collection devices that assist in monitoring and quality of life of seniors. This paper aims to conduct a survey of devices developed to capture signal monitoring and mobility aid for the elderly. The devices were grouped into a main category (sensors) followed by secondary categories in relation to the type of use of the sensors (aid device with sensors, robotics and smart homes). Data were analyzed descriptively, listing the products with the types of use. The study raised a total of 22 products. It is observed that most of the feedback systems is to use sensor systems alone, without being used in sets with other technologies like assistive devices or robotics. Most of the technologies has been developed for detecting falls, and fewer tasks are transfer and mobility in the community. We emphasize the importance of unity of catchment systems signals with assistive technologies, in addition to monitoring the elderly provide direct aid in performing the task performed.

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P.374 Glucocorticoid receptor deletion in microglia alters neuroinflammatory response to stress

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European Neuropsychopharmacology 2020年 40卷 S214-S215页

作者： Bon, G. Matte Poggini, S. Albanese, N. Ciano Abdallah, F. Garofalo, S. Picard, K. Maggi, L. Limatola, C. Tremblay, M.E. Branchi, I. Istituto Superiore di Sanità Center for Behavioral Sciences and Mental Health Rome Italy Sapienza University of Rome PhD program in Behavioral Neuroscience Rome Italy Sapienza University of Rome Department of Physiology and Pharmacology “V. Erspamer” Rome Italy Université Laval Department of Molecular Medicine Quebec Canada University of Victoria Division of Medical Sciences British Columbia Canada

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