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Correction to: ALS Cognitive Behavioral Screen‑Phone Version (ALS‑CBS™‑PhV): norms, psychometrics, and diagnostics in an Italian population sample

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Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2023年第1期44卷 419页

作者： Edoardo Nicolò Aiello Antonella Esposito Ilaria Giannone Lorenzo Diana Susan Woolley Jennifer Murphy Georgia Christodoulou Lucio Tremolizzo Nadia Bolognini Ildebrando Appollonio PhD Program in Neuroscience School of Medicine and Surgery University of Milano-Bicocca Monza Italy. e.aiello5@campus.unimib.it. Department of Psychology University of Milano-Bicocca Milan Italy. PhD Program in Neuroscience School of Medicine and Surgery University of Milano-Bicocca Monza Italy. Sutter Pacific Medical Foundation San Francisco CA USA. Biogen Cambridge MA USA. Institute for Health Promotion and Disease Prevention Research Keck School of Medicine University of Southern California Los Angeles CA USA. Neurology Section School of Medicine and Surgery University of Milano-Bicocca Monza Italy. Neuropsychological Laboratory IRCCS Istituto Auxologico Italiano Milan Italy.

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Construction of dual Z-scheme Ag3VO4–BiVO4/InVO4 photocatalysts using vanadium source from spent catalysts for contaminated water treatment and bacterial inactivation

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Chemosphere 2024年 363卷 142746页

作者： Lee, Kuen-Chan Hsu, Shih-Chieh Huang, Jen-Hsien Wang, Kuan-Syun Pang, Wei Kong Hu, Chih-Wei Jiang, Yi-Jhen Cho, Er-Chieh Weng, Huei Chu Liu, Ting-Yu Department of Science Education National Taipei University of Education No. 134 Sec. 2 Heping E. Road Da-an District Taipei City106 Taiwan PhD Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University 250 Wuxing Street Taipei City110 Taiwan Department of Chemical and Materials Engineering Tamkang University No. 151 Yingzhuan Road Tamsui District New Taipei City25137 Taiwan Department of Green Material Technology Green Technology Research Institute CPC Corporation No.2 Zuonan Rd. Nanzi District Kaohsiung City81126 Taiwan Department of Materials Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Faculty of Engineering Institute for Superconducting & Electronic Materials University of Wollongong WollongongNSW Australia National Synchrotron Radiation Research Center 101 Hsin-Ann Road Hsinchu Science Park Hsinchu30076 Taiwan School of Pharmacy College of Pharmacy Taipei Medical University 250 Wuxing Street Taipei City110 Taiwan Department of Mechanical Engineering Chung Yuan Christian University No. 200 Chungpei Road Chungli District Taoyuan City32023 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan City32003 Taiwan College of Engineering & Center for Sustainability and Energy Technologies Chang Gung University Taoyuan33302 Taiwan

Vanadate-based photocatalysts have recently attracted substantial attention owing to their outstanding photocatalytic activity for degrading organic pollutants and generating energy via photocatalytic processes. However, the relatively high price of vanadium has hindered the development of vanadate-based photocatalysts for various applications. Spent catalysts obtained from oil refineries typically contain a significant quantity of vanadium, making them valuable for recovery and utilization as precursors for the production of high-value-added photocatalysts. In this study, we transformed the V present in spent catalysts produced by the petrochemical industry into ternary vanadate-based photocatalysts [BiVO4/InVO4/Ag3VO4 (BVO/IVO/AVO, respectively)] designed for water remediation. The ternary composites revealed an enhanced photocatalytic capability, which was 1.42 and 5.1 times higher than those of the binary BVO/IVO and pristine AVO due to the facilitated charge separation. The ternary photocatalysts not only effectively treated wastewater containing various organic dyes, such as methylene blue (MB), rhodamine 6G (R6G), and brilliant green (BG), but also exhibited remarkable photocatalytic performance in the degradation of antibiotics, reduction of Cr(VI), and bacterial inactivation. This paper proposes a feasible route for recycling industrial waste as a source of vanadium to produce highly efficient vanadate-based photocatalysts. © 2024 Elsevier Ltd

关键词： Water pollution

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Correction to: Demographic and clinical determinants of neck pain in idiopathic cervical dystonia

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Journal of neural transmission (Vienna, Austria : 1996) 2021年第6期128卷 869-870页

作者： Michele Tinazzi Roberto Erro Marcello Mario Mascia Marcello Esposito Tommaso Ercoli Gina Ferrazzano Francesca Di Biasio Roberta Pellicciari Roberto Eleopra Francesco Bono Laura Bertolasi Paolo Barone Cesa Lorella Maria Scaglione Antonio Pisani Maria Concetta Altavista Maria Sofia Cotelli Roberto Ceravolo Giovanni Cossu Maurizio Zibetti Mario Coletti Moja Paolo Girlanda Luca Maderna Alberto Albanese Martina Petracca Luca Magistrelli Salvatore Misceo Brigida Minafra Marcello Romano Giovanna Maddalena Squintani Nicola Modugno Marco Aguggia Daniela Cassano Anna Castagna Francesca Morgante Alfredo Berardelli Giovanni Defazio Neurology Unit Department of Neuroscience Biomedicine and Movement University of Verona Verona Italy. Department of Medicine Surgery and Dentistry "Scuola Medica Salernitana" University of Salerno Baronissi SA Italy. Neurology Unit Department of Medical Science and Public Health Institute of Neurology University of Cagliari Cagliari Italy. Clinical Neurophysiology Unit Cardarelli Hospital Naples Italy. Neurology Unit Department of Medical Science and Public Health Institute of Neurology University of Cagliari Cagliari Italy. ercolitommaso@***. Department of Human Neurosciences Sapienza University of Rome Rome Italy. Ospedale Policlinico San Martino IRCCS Genoa Italy. Department of Basic Science Neuroscience and Sense Organs Aldo Moro University of Bari 70124 Bari Italy. Neurology Unit 1 Fondazione IRCSS Istituto Neurologico "Carlo Besta" Milan Italy. Center for Botulinum Toxin Therapy Neurology Unit A.O.U. Mater Domini Catanzaro Italy. Neurology Unit University Hospital Verona Italy. IRCCS Institute of Neurological Sciences Bologna Italy. Neurology Department of Systems Medicine University of Rome Tor Vergata Rome Italy. Neurology Unit San Filippo Neri Hospital ASL Roma 1 Rome Italy. Neurology Unit ASST Valcamonica Esine Italy. Neurology Unit Department of Clinical and Experimental Medicine University of Pisa Pisa Italy. Neurology Service and Stroke Unit Department of Neuroscience AO Brotzu Cagliari Italy. Department of Neuroscience 'Rita Levi Montalcini' University of Turin Turin Italy. Neurology Unit Umberto I Hospital Turin Italy. Department of Experimental and Clinical Medicine University of Messina Messina Italy. Department of Neurology and Laboratory of Neuroscience IRCCS Istituto Auxologico Italiano Milan Italy. Department of Neurology IRCCS Humanitas Research Hospital Rozzano Milan Italy. Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy. Institute of Neurology Università Cattolica del Sacro Cuore Rome I

The original version of this article unfortunately contained a mistake.

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26th Annual Computational neuroscience Meeting (CNS*2017) of the Organization for Computational neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC neuroscience 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

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Journal of neuroinflammation 2018年第1期15卷 169页

作者： Megan F Duffy Timothy J Collier Joseph R Patterson Christopher J Kemp Kelvin C Luk Malú G Tansey Katrina L Paumier Nicholas M Kanaan D Luke Fischer Nicole K Polinski Olivia L Barth Jacob W Howe Nishant N Vaikath Nour K Majbour Omar M A El-Agnaf Caryl E Sortwell Department of Translational Science and Molecular Medicine Michigan State University 400 Monroe Avenue NW Grand Rapids MI 49503-2532 USA. Neuroscience Graduate Training Program Michigan State University Grand Rapids MI USA. Mercy Health Hauenstein Neuroscience Medical Center Grand Rapids MI USA. Center for Neurodegenerative Disease Research Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Physiology Emory University School of Medicine Atlanta GA USA. MD/PhD Program Michigan State University Grand Rapids MI USA. Neurological Disorders Research Center Qatar Biomedical Research Institute (QBRI) Hamad Bin Khalifa University (HBKU) Education City Qatar. Life Sciences Division College of Science and Engineering Hamad Bin Khalifa University (HBKU) Education City Qatar. Department of Translational Science and Molecular Medicine Michigan State University 400 Monroe Avenue NW Grand Rapids MI 49503-2532 USA. caryl.sortwell@hc.msu.edu. Mercy Health Hauenstein Neuroscience Medical Center Grand Rapids MI USA. caryl.sortwell@hc.msu.edu.

After publication of the original article [1] it was noted that the name of author, D. Luke Fisher, was erroneously typeset in both the PDF and online formats of the manuscript as Luke D. Fisher.

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Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells

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Phytomedicine 2023年 116卷

作者： Jen-Chih Tseng Bi-Juan Wang Ya-Pei Wang Ying-Yu Kuo Jen-Kun Chen Tzyh-Chyuan Hour Li-Kuo Kuo Po-Jen Hsiao Chien-Chih Yeh Cheng-Li Kao Li-Jane Shih Chih-Pin Chuu Institute of Cellular and System Medicine National Health Research Institutes Miaoli County 35053 Taiwan Immunology Research Center National Health Research Institutes Miaoli County 35053 Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County 35053 Taiwan Neuroscience Research Center Kaohsiung Medical University Kaohsiung 80737 Taiwan Department of Biochemistry School of Medicine Kaohsiung Medical University Kaohsiung 80737 Taiwan Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung 80737 Taiwan Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Mackay Memorial Hospital Taipei City 104217 Taiwan Department of Nursing Mackay Medical College Taipei City Taiwan Division of Nephrology Department of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan 325 Taiwan Division of Nephrology Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei 114 Taiwan Department of Education and Medical Research Taoyuan Armed Forces General Hospital Taoyuan Taiwan Division of Colon and Rectal Surgery Department of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Division of Urology Departments of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Division of Urology Department of Surgery Taoyuan Armed Forces General Hospital Taoyuan Taiwan Graduate Institute of Medical Science National Defense Medical Center Taipei 114 Taiwan Department of Life Sciences National Central University Taoyuan 32031 Taiwan PhD Program for Aging and Graduate Institute of Basic Medical Science China Medical University Taichung City 40402 Taiwan Biotechnology Center National Chung Hsing University Taichung City 40227 Taiwan

Background Epidermal growth factor receptor (EGFR) is upregulated in prostate cancer (PCa). However, suppression of EGFR did not improve the patient outcome, possibly due to the activation of PI3K/Akt signaling in PCa. Compounds able to suppress both PI3K/Akt and EGFR signaling may be effective for treating advanced PCa. Purpose We examined if caffeic acid phenethyl ester (CAPE) simultaneously suppresses the EGFR and Akt signaling, migration and tumor growth in PCa cells. Methods Wound healing assay, transwell migration assay and xenograft mice model were used to determine the effects of CAPE on migration and proliferation of PCa cells. Western blot, immunoprecipitation, and immunohistochemistry staining were performed to determine the effects of CAPE on EGFR and Akt signaling. Results CAPE treatment decreased the gene expression of HRAS, RAF1, AKT2, GSK3A , and EGF and the protein expression of phospho-EGFR (Y845, Y1069, Y1148, Y1173), phospho-FAK, Akt, and ERK1/2 in PCa cells. CAPE treatment inhibited the EGF-induced migration of PCa cells. Combined treatment of CAPE with EGFR inhibitor gefitinib showed additive inhibition on migration and proliferation of PCa cells. Injection of CAPE (15 mg/kg/3 days) for 14 days suppressed the tumor growth of prostate xenografts in nude mice as well as suppressed the levels of Ki67, phospho-EGFR Y845, MMP-9, phospho-Akt S473, phospho-Akt T308, Ras, and Raf-1 in prostate xenografts. Conclusions Our study suggested that CAPE can simultaneously suppress the EGFR and Akt signaling in PCa cells and is a potential therapeutic agent for advanced PCa.

关键词： Prostate cancer Caffeic acid phenethyl ester Metastasis Epidermal growth factor receptor Fak Akt CAPE caffeic acid phenethyl ester CRPC castration-resistant prostate cancer EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition GAPDH glyceraldehyde-3-phosphate dehydrogenase mTOR mammalian target of rapamycin PCa prostate cancer PI3K phosphoinositide 3-kinase PSA prostate specific antigen PSMA prostate specific-membrane antigen PTEN phosphatase and tensin homolog

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Relevance of Blood Cellular Indices with Inflammatory Cytokines in Patients with Pulmonary Embolism

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Blood 2024年 144卷 2638-2638页

作者： Fakiha Siddiqui Amir Darki Bulent Kantarcioglu Debra Hoppensteadt Moorman Jawed Fareed Alfonso Tafur Manuel Monreal PhD Program in Health Sciences UCAM - Universidad Católica San Antonio de Murcia Murcia Spain Department of Pathology & Laboratory Medicine Cardiovascular Research Institute Health Science Division Loyola University Chicago Maywood IL Department of Cardiology Cardiovascular Research Institute Health Science Division Loyola University Medical Center Maywood IL Department of Pathology and Laboratory Medicine Loyola University Chicago Maywood IL Department of Pathology & Laboratory Medicine and Department of Pharmacology and Neuroscience Cardiovascular Research Institute Health Science Division Loyola University Chicago Maywood IL Department of Molecular Pharmacology and Neuroscience Department of Pathology and Laboratory Medicine Cardiovascular Research Institute Health Science Division Loyola University Chicago Maywood IL Department of Medicine Vascular Medicine Endeavor Health NorthShore University Health System. Evanston IL Chair for the Study of Thromboembolic Disease Faculty of Health Sciences. UCAM - Universidad Católica San Antonio de Murcia. Murcia Spain Hospital Universitari Germans Trias I Pujol Badalona ESP

3,800 characters. Relevance of blood cellular indices with inflammatory cytokines in patients with pulmonary embolism. Fakiha Siddiqui, Amir Darki, Bulent Kantarcioglu, Debra Hoppensteadt, Jawed Fareed, Alfonso Tafur, Manuel Monreal. Introduction Pulmonary embolism (PE) is a life-threatening condition and a leading cause of vascular disease and cardiovascular death worldwide, around 25% of the cases with PE encountered sudden death. Recently, blood cellular indices such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII, NLR*platelets) have emerged as reliable tool in assessing inflammation and immune response and can serve as a predictor of disease severity and prognosis for PE. Elevated NLR is related with an increase's inflammatory response, PLR reflects platelet activation, a prothrombotic state and adverse outcomes, while SII is linked with pronounced inflammatory state together with platelet activation. We have previously demonstrated the prognostic value of cellular indices in a large cohort of PE patients in RIETE Registry (Siddiqui, F., Tafur, A., Hussain, M., et al. The prognostic value of blood cellular indices in pulmonary embolism. American journal of hematology , 10.1002/ajh.27379. Advance online publication. https://***/10.1002/ajh.27379). This integrated study focused on the role of inflammation in patients with PE by profiling cellular indices and inflammatory cytokines and their relevance with outcome as all-cause mortality within the 30 days of diagnosis of PE. Material and Method: In the cohort of 197 PE patients, blood cellular indices and levels of biomarker of inflammation were compared to controls. Furthermore, the relevance of cellular indices and biomarkers was determined. Patients with clinically confirmed diagnosis of PE were enrolled in the Loyola PERT program, and citrated blood samples were collected. Control samples (n= 50) from 25 male and 25 female were ac

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Author Correction: Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation

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Nature communications 2024年第1期15卷 7618页

作者： Fan Li Jazlyn Gallego Natasha N Tirko Jenna Greaser Derek Bashe Rudra Patel Eric Shaker Grace E Van Valkenburg Alanoud S Alsubhi Steven Wellman Vanshika Singh Camila Garcia Padilla Kyle W Gheres John I Broussard Roger Bagwell Maureen Mulvihill Takashi D Y Kozai Department of Bioengineering University of Pittsburgh Pittsburgh PA USA. Center for Neural Basis of Cognition Pittsburgh PA USA. Computational Modeling and Simulation PhD Program University of Pittsburgh Pittsburgh PA USA. Department of Biochemistry and Molecular Biology Pennsylvania State University University Park PA USA. Actuated Medical Bellefonte PA USA. Washington University in St. Louis St. Louis MO USA. Department of Neuroscience University of Pittsburgh Pittsburgh PA USA. Columbia University New York NY USA. Department of Bioengineering University of Pittsburgh Pittsburgh PA USA. TK.Kozai@pitt.edu. Center for Neural Basis of Cognition Pittsburgh PA USA. TK.Kozai@pitt.edu. Center for Neuroscience University of Pittsburgh Pittsburgh PA USA. TK.Kozai@pitt.edu. McGowan Institute of Regenerative Medicine University of Pittsburgh Pittsburgh PA USA. TK.Kozai@pitt.edu. NeuroTech Center University of Pittsburgh Brain Institute Pittsburgh PA USA. TK.Kozai@pitt.edu.

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Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study

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Psychiatry Research 2024年 342卷 115972-115972页

作者： Solmi, Marco Thompson, Trevor Estradé, Andrés Agorastos, Agorastos Radua, Joaquim Cortese, Samuele Dragioti, Elena Vancampfort, Davy Thygesen, Lau Caspar Aschauer, Harald Schlögelhofer, Monika Aschauer, Elena Schneeberger, Andres Huber, Christian G. Hasler, Gregor Conus, Philippe Cuénod, Kim Q. Do von Känel, Roland Arrondo, Gonzalo Fusar-Poli, Paolo Gorwood, Philip Llorca, Pierre-Michel Krebs, Marie-Odile Scanferla, Elisabetta Kishimoto, Taishiro Rabbani, Golam Skonieczna-Żydecka, Karolina Brambilla, Paolo Favaro, Angela Takamiya, Akihiro Zoccante, Leonardo Colizzi, Marco Bourgin, Julie Kamiński, Karol Moghadasin, Maryam Seedat, Soraya Matthews, Evan Wells, John Vassilopoulou, Emilia Gadelha, Ary Su, Kuan-Pin Kwon, Jun Soo Kim, Minah Lee, Tae Young Papsuev, Oleg Manková, Denisa Boscutti, Andrea Gerunda, Cristiano Saccon, Diego Righi, Elena Monaco, Francesco Croatto, Giovanni Cereda, Guido Demurtas, Jacopo Brondino, Natascia Veronese, Nicola Enrico, Paolo Politi, Pierluigi Ciappolino, Valentina Pfennig, Andrea Bechdolf, Andreas Meyer-Lindenberg, Andreas Kahl, Kai G. Domschke, Katharina Bauer, Michael Koutsouleris, Nikolaos Winter, Sibylle Borgwardt, Stefan Bitter, Istvan Balazs, Judit Czobor, Pál Unoka, Zsolt Mavridis, Dimitris Tsamakis, Konstantinos Bozikas, Vasilios P. Tunvirachaisakul, Chavit Maes, Michael Rungnirundorn, Teerayuth Supasitthumrong, Thitiporn Haque, Ariful Brunoni, Andre R. Costardi, Carlos Gustavo Schuch, Felipe Barreto Polanczyk, Guilherme Luiz, Jhoanne Merlyn Fonseca, Lais Aparicio, Luana V. Valvassori, Samira S. Nordentoft, Merete Vendsborg, Per Hoffmann, Sofie Have Sehli, Jihed Sartorius, Norman Heuss, Sabina Guinart, Daniel Hamilton, Jane Kane, John Rubio, Jose Sand, Michael Koyanagi, Ai Solanes, Aleix Andreu-Bernabeu, Alvaro Cáceres, Antonia San José Arango, Celso Díaz-Caneja, Covadonga M. Hidalgo-Mazzei, Diego Vieta, Eduard Gonzalez-Peñas, Javier Fortea, Lydia Parellada, Mara Fullana, Miquel A. Verdolini, Norma Andrlíková, Eva Janků, Karolina Millan, Mark J. Honciuc, Mihaela Moniuszko-Mal University of Ottawa Department of Psychiatry ON Canada The Ottawa Hospital Department of Mental Health ON Canada Ottawa Hospital Research Institute (OHRI) Neurosciences Program Ottawa Ontario Canada Early Psychosis: Interventions and Clinical-detection (EPIC) Lab Department of Psychosis Studies Institute of Psychiatry Psychology & Neuroscience King's College London London United Kingdom Centre for Innovation in Mental Health-Developmental Lab School of Psychology University of Southampton and NHS Trust Southampton United Kingdom Charité Universitätsmedizin Berlin Department of Child and Adolescent Psychiatry Berlin Germany Centre for Chronic Illness and Ageing University of Greenwich London United Kingdom University of Southampton Centre for Innovation in Mental Health Southampton United Kingdom Universidad Católica Department of Psychology Montevideo Uruguay Aristotle University of Thessaloniki II. Dept. of Psychiatry Division of Neurosciences Medical School Faculty of Health Sciences Greece Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Imaging of Mood- and Anxiety-Related Disorders (IMARD) University of Barcelona CIBERSAM Instituto de Salud Carlos III Barcelona Spain Karolinska Institutet Centre for Psychiatric Research and Education Department of Clinical Neuroscience Stockholm Sweden Linköping University Pain and Rehabilitation Centre and Department of Health Medicine and Caring Sciences Linköping Sweden University of Ioannina Research Laboratory Psychology of Patients Families & Health Professionals Department of Nursing School of Health Sciences Ioannina Greece Katholieke Universiteit Leuven (KU Leuven) Department of Rehabilitation Sciences Leuven Belgium National Institute of Public Health University of Southern Denmark Denmark BioPsyC - Biopsychosocial Corporation Non-profit association for Research Funding Ltd. Vienna Austria University of California San Diego California United States University of Basel Universitä

International studies measuring wellbeing/multidimensional mental health before/ during the COVID-19 pandemic, including representative samples for >2 years, identifying risk groups and coping strategies are lacking. COH-FIT is an online, international, anonymous survey measuring changes in well-being (WHO-5) and a composite psychopathology P-score, and their associations with COVID-19 deaths/restrictions, 12 a-priori defined risk individual/cumulative factors, and coping strategies during COVID-19 pandemic (26/04/2020-26/06/2022) in 30 languages (representative, weighted non-representative, adults). T-test, χ², penalized cubic splines, linear regression, correlation analyses were conducted. Analyzing 121,066/142,364 initiated surveys, WHO-5/P-score worsened intra-pandemic by 11.1±21.1/13.2±17.9 points (effect size d=0.50/0.60) (comparable results in representative/weighted non-probability samples). Persons with WHO-5 scores indicative of depression screening (<50, 13% to 32%) and major depression (<29, 3% to 12%) significantly increased. WHO-5 worsened from those with mental disorders, female sex, COVID-19-related loss, low-income country location, physical disorders, healthcare worker occupations, large city location, COVID-19 infection, unemployment, first-generation immigration, to age=18-29 with a cumulative effect. Similar findings emerged for P-score. Changes were significantly but minimally related to COVID-19 deaths, returning to near-pre-pandemic values after >2 years. The most subjectively effective coping strategies were exercise and walking, internet use, social contacts. Identified risk groups, coping strategies and outcome trajectories can inform global public health strategies. © 2024 The Authors

关键词： Covid-19 Mental health P-factor Pandemic Psychiatry Psychopathology Survey Well-being WHO-5

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Multidisciplinary intensive rehabilitation treatment improves sleep quality in Parkinson's disease

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Journal of clinical movement disorders 2015年第1期2卷 11页

作者： Giuseppe Frazzitta Roberto Maestri Davide Ferrazzoli Giulio Riboldazzi Rossana Bera Cecilia Fontanesi Roger P Rossi Gianni Pezzoli Maria F Ghilardi Department of Parkinson Disease Rehabilitation Moriggia-Pelascini Hospital Gravedona ed Uniti Fondazione Europea Ricerca Biomedica FERB "S.Isidoro" Hospital Trescore Balneario Italy Department of Parkinson Rehabilitation Ospedale Moriggia Pelascini Via Pelascini 3 Gravedona ed Uniti Como 22015 Italy. Department of Biomedical Engineering Scientific Institute of Montescano S. Maugeri Foundation IRCCS Montescano Italy. Department of Parkinson Disease Rehabilitation Moriggia-Pelascini Hospital Gravedona ed Uniti Fondazione Europea Ricerca Biomedica FERB "S.Isidoro" Hospital Trescore Balneario Italy. Center for Parkinson's Disease Macchi Foundation Varese and Department of Rehabilitation "Le Terrazze" Hospital Cunardo Italy. Department of Physiol. Pharmacol. & Neuroscience CUNY Medical School Harris Hall 08 CCNY 160 Convent Ave New York NY 10031 USA The Graduate Center Biology - Neuroscience PhD Program CUNY New York NY USA. Department of Physical Medicine & Rehabilitation JFK Johnson Rehabilitation Institute Edison NJ USA NYU Movement Disorder Center New York University New York NY USA. Parkinson Institute Istituti Clinici di Perfezionamento Milano Italy. Department of Physical Medicine & Rehabilitation JFK Johnson Rehabilitation Institute Edison NJ USA.

BACKGROUND:Sleep disturbances are among the most common non-motor symptoms of Parkinson's disease (PD), greatly interfering with daily activities and diminishing life quality. Pharmacological treatments have not been satisfactory because of side effects and interactions with anti-parkinsonian drugs. While studies have shown that regular exercise improves sleep quality in normal aging, there is no definitive evidence in PD. METHODS:In a retrospective study, we determined whether an intense physical and multidisciplinary exercise program improves sleep quality in a large group of patients with PD. We analyzed the scores of PD Sleep Scale (PDSS), which was administered twice, 28 days apart, to two groups of patients with PD of comparable age, gender, disease duration and pharmacological treatment. The control group (49 patients) did not receive rehabilitation, The treated group (89 patients) underwent a 28-day multidisciplinary intensive rehabilitation program (three one-hour daily sessions comprising cardiovascular warm-up, relaxation, muscle-stretching, balance and gait training, occupational therapy to improve daily living activities). RESULTS:At enrolment, control and treated groups had similar UPDRS and PDSS scores. At re-test, 28 days later, UPDRS and total PDSS scores improved in the treated (p < 0.0001) but not in the control group. In particular, the treated group showed significant improvement in PDSS scores for sleep quality, motor symptoms and daytime somnolence. The control group did not show improvement for any item. CONCLUSIONS:These results suggest that multidisciplinary intensive rehabilitation treatment may have a positive impact on many aspects of sleep in PD.

关键词： PDSS Plasticity Rehabilitation Sleep quality

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