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Comprehensive evaluation of benign and malignant etiologies of different serous effusions with the International System for Reporting Serous Fluid Cytopathology: A multi-institutional study in Taiwan

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Cancer cytopathology 2024年第3期132卷 169-178页

作者： Chun-Han Lu Chih-Yi Liu Jie-Yang Jhuang Chien-Chin Chen Department of Medical Education Ditmanson Medical Foundation Chia-Yi Christian Hospital Chiayi City Taiwan. Division of Pathology Sijhih Cathay General Hospital New Taipei City Taiwan. Department of Pathology Mackay Memorial Hospital Taipei City Taiwan. Department of Pathology Ditmanson Medical Foundation Chia-Yi Christian Hospital Chiayi City Taiwan. PhD Program in Translational Medicine Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung City Taiwan. Department of Biotechnology and Bioindustry Sciences College of Bioscience and Biotechnology National Cheng Kung University Tainan City Taiwan. Department of Cosmetic Science Chia Nan University of Pharmacy and Science Tainan City Taiwan.

BACKGROUND:The International System for Reporting Serous Fluid Cytopathology (ISRSFC) was introduced globally in 2019 in response to the absence of a standardized reporting system for serous fluid cytology. This study presents experiences implementing this system across three distinct hospitals in Taiwan. METHODS:A total of 6177 serous fluid specimens in three hospitals in Taiwan between 2018 and 2020 were retrospectively reviewed and reclassified according to the ISRSFC. Cytohistological correlation and chart review were further performed to investigate etiologies and risks of malignancy (ROMs). RESULTS:Reclassification showed that 34 (0.7%) of 4838 pleural effusions were nondiagnostic (ND), 4086 (84.5%) were negative for malignancy (NFM), 201 (4.2%) were atypia of undetermined significance (AUS), 92 (1.9%) were suspicious for malignancy (SFM), and 425 (8.8%) were malignant (MAL). The 1231 ascites cases contained 13 (1.1%) ND, 1004 (81.6%) NFM, 53 (4.3%) AUS, 31 (2.5%) SFM, and 130 (10.6%) MAL specimens. In pleural effusions, the ROM was 2.9% for ND, 14.0% for NFM, 52.2% for AUS, 85.9% for SFM, and 95.1% for MAL. In ascites, it was 15.4% for ND, 19.1% for NFM, 52.8% for AUS, 83.9% for SFM, and 92.3% for MAL. In pericardial effusions, it was 0.0% for ND, 11.6% for NFM, 30.8% for AUS, 100.0% for SFM, and 95.2% for MAL. Different effusions' most common benign and malignant etiologies were also disclosed. CONCLUSIONS:These multi-institutional data have determined the diagnostic usefulness of the ISRSFC, which provides pathologists and physicians with invaluable assistance in correctly classifying effusions for further management.

关键词： International System for Reporting Serous Fluid Cytopathology ascites cytology effusion pericardial pleura

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Structure-based design, synthesis and biological evaluation of N-substituted 6H-thiochromeno[2,3–c]quinolin-12(12H)-one as potential breast cancer drugs

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Arabian Journal of Chemistry 2024年第1期17卷

作者： Sumitra, Maryam Rachmawati Chen, Lung-Ching Tsai, Wei-Chen Ansar, Muhamad Lawal, Bashir Mokgautsi, Ntlotlang Guh, Jih-Hwa Wu, Alexander T.H Huang, Hsu-Shan PhD Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei11031 Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei11031 Taiwan Division of Cardiology Department of Internal Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei11101 Taiwan School of Medicine Fu Jen Catholic University New Taipei24205 Taiwan School of Pharmacy National Defense Medical Center Taipei11490 Taiwan Clinical Drug Development of Herbal Medicine Taipei Medical University Taipei11031 Taiwan The PhD Program of Translational Medicine College of Science and Technology Taipei Medical University Taipei11031 Taiwan Clinical Research Center Taipei Medical University Hospital Taipei Medical University Taipei11031 Taiwan Graduate Institute of Medical Sciences National Defense Medical Center Taipei11490 Taiwan School of Pharmacy National Taiwan University No. 33 Linsen S. Rd. Zhongzheng Dist. Taipei10025 Taiwan Biotechnology Research and Development College of Pharmacy Taipei Medical University Taipei11031 Taiwan

Tetraheterocyclic compounds, derived from natural sources and contemporary pharmaceuticals, have shown promise as multitarget therapeutic agents. However, their mechanisms of action remain partially understood. In this study, we synthesized a series of 6H-thiochromeno[2,3-c]quinolin-12(12H)-one derivative, totaling 26 compounds, and assessed their potential for therapeutic application. We evaluated their effects on cell proliferation and conducted NCI-60 cell panel assays. MTT assays revealed that select compounds exhibited notable antiproliferative activity against two breast cancer cell lines (MCF-7 and MDA-MB-468). Notably, compounds 17 and 18 displayed the highest cytotoxicity against these cell lines. Furthermore, one-dose assays of the NCI-60 human tumor cell line screening program identified compounds 6, 7, 16, 18, 20, 24, 25, and 30 for further investigation. Subsequent five-dose cytotoxicity studies focused on compounds 18 and 20, which met the threshold inhibition criteria across a panel of cell lines. Our study highlights the effectiveness of compounds 18 and 20 in targeting breast cancer cell lines. Molecular docking simulations revealed that these compounds bind to the active sites of topoisomerase I (TOPO I). Our findings suggest that these novel compounds are promising anticancer agents, particularly against breast cancer, and are worthy of consideration as lead pharmacological candidates. © 2023 The Authors

关键词： Cell proliferation

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Phytocompounds from essential oil of Mentha aquatica L. cv. Lime prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRAS^Q61L keratinocytes and reprogramming macrophage activities

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Phytomedicine 2024年 122卷

作者： Chang, Chih-Ting Chen, Yu-Hsin Shyur, Lie-Fen Agricultural Biotechnology Research Center Academia Sinica Taipei 115 Taiwan Taichung District Research and Extension Station Council of Agriculture Executive Yuan Changhua 515 Taiwan PhD Program in Translational Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan Institute of BioPharmaceutical Sciences National Sun Yat-sen University Kaohsiung 804 Taiwan Graduate Institute of Integrated Medicine China Medical University Taichung 401 Taiwan

Background: Twenty to thirty percent of patients taking BRAF inhibitors such as vemurafenib (PLX4032) for melanoma develop cutaneous squamous cell carcinomas. Purpose: This study aimed to elucidate the chemopreventive effect of essential oil from Mentha aquatica L. cv. Lime (EO) and its major constituents, limonene and carvone (L + C) that made up 45.68% of the EO, against PLX4032-induced cutaneous side effects. Methods: PLX4032 accelerated skin papilloma formation and keratinocyte HRAS mutation in 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced two-stage skin carcinogenesis mouse model was used to evaluate the in vivo bioefficacy of EO and L + C. The effects and molecular mechanisms of EO and L + C on deregulating mouse PDV^HRASQ61L keratinocyte activities were demonstrated using a spectrum of bioactivity assays, western blotting, immunochemistry, and keratinocyte-macrophage co-culture assay. Results: Treatment with EO suppressed colony formation ability, cell migration, invasion, and induced G₂/M cell-cycle arrest and apoptosis in PDV^HRASQ61L keratinocytes, and L + C treatment inhibited colony formation, cell migration and invasion of PDV cells. In mouse skin irritated with DMBA/TPA (DT group) or DMBA/TPA with PLX4032 (DTP group), topical application of EO and L + C significantly delayed papilloma appearance and reduced papilloma incidence compared to DT or DTP controls. Histopathology results showed that EO and L + C treatment attenuated K14⁺ keratinocyte proliferation and paradoxical MAPK activation, and shifted the macrophage population from M2 (CD163⁺) to M1 (iNOS⁺) in the mouse skin microenvironment. The conditioned medium of EO or L + C pre-treated PDV keratinocytes promoted M₀ macrophages to differentiate from THP-1 cells into M1-like macrophages. Conclusion: This study demonstrates that EO and L + C in combination prevent PLX4032-induced cut

关键词： BRAF inhibitor Chemoprevention Macrophage reprogramming Mentha aquatica L. cv. Lime Skin carcinogenesis

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Author Correction: SCON-a Short Conditional intrON for conditional knockout with one-step zygote injection

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Experimental & molecular medicine 2023年第6期55卷 1278-1280页

作者： Szu-Hsien Sam Wu Heetak Lee Réka Szép-Bakonyi Gabriele Colozza Ayse Boese Krista R Gert Natalia Hallay Ji-Hyun Lee Jihoon Kim Yi Zhu Margot M Linssen Sandra Pilat-Carotta Peter Hohenstein Hans-Christian Theussl Andrea Pauli Bon-Kyoung Koo Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) Vienna BioCenter (VBC) Dr. Bohr-Gasse 3 1030 Vienna Austria. samwu202@***. Vienna BioCenter PhD Program Doctoral School of the University at University of Vienna and Medical University of Vienna 1030 Vienna Austria. samwu202@***. Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) Vienna BioCenter (VBC) Dr. Bohr-Gasse 3 1030 Vienna Austria. Center for Genome Engineering Institute for Basic Science Expo-ro 55 Yuseong-gu Daejeon 34126 Republic of Korea. Vienna BioCenter PhD Program Doctoral School of the University at University of Vienna and Medical University of Vienna 1030 Vienna Austria. Research Institute of Molecular Pathology (IMP) Vienna BioCenter (VBC) Campus-Vienna-BioCenter 1 1030 Vienna Austria. Department of Medical and Biological Sciences Catholic University of Korea Bucheon 14662 South Korea. Transgenic Facility Leiden Central Animal Facility Leiden University Medical Center Postbus 9600 2300 RC Leiden The Netherlands. IMP/IMBA Transgenic Service Institute of Molecular Pathology (IMP) Vienna Austria. Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) Vienna BioCenter (VBC) Dr. Bohr-Gasse 3 1030 Vienna Austria. koobk@ibs.re.kr. Center for Genome Engineering Institute for Basic Science Expo-ro 55 Yuseong-gu Daejeon 34126 Republic of Korea. koobk@ibs.re.kr.

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Low-dose imiquimod induces melanogenesis in melanoma cells through an ROS-mediated pathway

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Journal of Dermatological Science 2024年第1期113卷 18-25页

作者： Li, Zheng-Yi Chang, Shu-Hao Liu, Kuang-Ting Wu, Alaina Edelie Hsu, Chien-Sheng Huang, Shi-Wei Chung, Mu-Chi Wang, Shih-Chung Kao, Jun-Kai Chen, Yi-Ju Shieh, Jeng-Jer Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan Department of Pathology & Laboratory Medicine Taoyuan Armed Forces General Hospital Taoyuan Taiwan Frontier Molecular Medical Research Center in Children Changhua Christian Children Hospital Changhua County Taiwan Center for Cell Therapy and Translation Research China Medical University Hospital Taichung Taiwan Division of Nephrology Department of Medicine Taichung Veterans General Hospital Taichung Taiwan PhD Program in Translational Medicine National Chung Hsing University Taichung Taiwan Department of Biotechnology Asia University Taichung Taiwan Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan Division of Pediatric Hematology/Oncology Changhua Christian Children Hospital Changhua County Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Department of Dermatology Taichung Veterans General Hospital Taichung Taiwan Department of Education and Research Taichung Veterans General Hospital Taichung Taiwan

Background: Melanogenesis is the process of melanin maturation which not only protects skin from UV radiation but also plays an important role in antigenicity of melanomas. Imiquimod (IMQ) is a toll-like receptor 7 (TLR7) agonist that exhibits antiviral and anticancer activity. Objective: To explore whether IMQ could induce melanogenesis in melanoma cells. Methods: The mouse melanoma cell line B16F10, the mouse immortalized melanocyte Melan-A, and human melanoma cell lines MNT-1, C32 and A375 were utilized in this study. The pigmented level was observed by the centrifuged cell pellet. The intracellular and extracellular melanin levels were examined in the absorbance in NaOH-extracted cell lysate and cell-cultured medium, respectively. The expression of melanogenesis related proteins was examined by immunoblotting. The intracellular cyclic AMP amount was evaluated by the cAMP Glo assay kit. The activity of phosphodiesterase 4B (PDE4B) was investigated by CREB reporter assay with overexpressed PDE4B or not. Results: We demonstrated that a low dose of IMQ could trigger melanogenesis in B16F10 cells. IMQ induced microphthalmia-associated transcription factor (MITF) nuclear translocation, upregulated the expression of melanogenesis-related proteins, increased tyrosinase (TYR) activity, and led to pigmentation in B16F10 cells. Next, we found that IMQ-induced melanogenesis was activated by excessive intracellular cAMP accumulation, which was regulated through IMQ-mediated PDE4B inhibition. Finally, IMQ-induced ROS production was found to be involved in melanogenesis by its control of PDE4B activity. Conclusions: Low dose of IMQ could activate melanogenesis through the ROS/PDE4B/PKA pathway in melanoma cells. © 2023 Japanese Society for Investigative Dermatology

关键词： Imiquimod Melanogenesis Reactive oxygen species

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Ludwigia octovalvis (Jacq.) P.H. Raven extract improves memory performance in mice with chronic kidney disease

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Phytomedicine Plus 2024年第2期4卷 100556-100556页

作者： Wang, Hao-Wei Huang, Yi-Hsuan Tung, Hsiao-Jou Lin, Wei-Sheng Chiu, Hao-Chieh Lin, Shuei-Liong Fan, Shou-Zen Wang, Pei-Yu Hsieh Yu Enterprise Co. Ltd. Taipei Taiwan Graduate Institute of Brain and Mind Sciences College of Medicine National Taiwan University Taipei Taiwan Department of Pediatrics Taipei Veterans General Hospital Taipei Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology College of Medicine National Taiwan University Taipei Taiwan Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan Department of Anesthesiology National Taiwan University Hospital National Taiwan University Taipei Taiwan Department of Anesthesiology En Chu Kong Hospital Taipei Taiwan Neurobiology and Cognitive Science Center National Taiwan University Taipei Taiwan PhD. Program in Translational Medicine National Taiwan University and Academia Sinica Taipei Taiwan PhD. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Background: Chronic kidney disease (CKD) is a significant global health concern often accompanied by cognitive impairment in affected patients. Ludwigia octovalvis extract (LOE) is a traditional medicine widely used for various conditions, including renal disease and its associated complications. However, the pharmacological effects and underlying mechanisms of LOE on CKD remain unclear. Methods: Adult male mice underwent a 4-week oral adenine-induced CKD model, followed by daily administration of either a vehicle, losartan, or LOE for 1 to 2 months. A battery of behavioral tests was conducted to examine CKD-associated cognitive impairments. Additionally, RNA sequencing, Golgi staining, and immunohistochemistry were performed to decipher the underlying mechanisms. Results: Neither losartan nor LOE supplementation could reverse adenine-induced kidney damage. However, during behavioral tests, both losartan and LOE treatments improved memory performance in mice without affecting emotional status and general locomotor activity. Transcriptome profiling and histological analyses revealed altered dendritic arborization and increased spine density of dentate granule cells, along with augmented adult hippocampal neurogenesis, contributing to the improved memory performance of mice treated with LOE. Conclusion: Our study provides comprehensive neurobehavioral and molecular evidence supporting the potential use of LOE for future CKD-associated memory dysfunction treatment. © 2024 The Author(s)

关键词： Adenine Cognitive dysfunction Neurogenesis

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Smoking and Risk of Colorectal Cancer Sub-classified by Tumor-infiltrating T Cells (vol 111, pg 42, 2019)

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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 2019年第12期111卷 1365-1365页

作者： Hamada, Tsuyoshi Department of Oncologic Pathology Department of Medical Oncology Dana-Farber Cancer Institute and Harvard Medical School Boston MAProgram in Molecular Pathological Epidemiology Department of Pathology Department of Oncologic Pathology Clinical and Translational Epidemiology Unit and Division of Gastroenterology Massachusetts General Hospital and Harvard Medical School Boston MA Clinical and Translational Epidemiology Unit and Division of Gastroenterology Massachusetts General Hospital and Harvard Medical School Boston MADepartment of Nutrition Clinical and Translational Epidemiology Unit and Division of Gastroenterology Massachusetts General Hospital and Harvard Medical School Boston MADepartment of NutritionDivision of Public Health Sciences Department of Surgery Washington University School of Medicine St. Louis MO Department of Oncologic Pathology Department of Medical Oncology Dana-Farber Cancer Institute and Harvard Medical School Boston MA Department of Oncologic Pathology Department of Oncologic PathologyDepartment of NutritionDivision of Public Health Sciences Department of Surgery Washington University School of Medicine St. Louis MODepartment of Epidemiology and Biostatistics and the Ministry of Education Key Lab of Environment and Health School of Public Health Huazhong University of Science and Technology Hubei P.R. China Department of Oncologic PathologyDepartment of Medical Oncology Chinese PLA General Hospital Beijing P.R. China Department of Oncologic Pathology Department of Oncologic PathologyCollege of Pharmacy Zhejiang Chinese Medical University Zhejiang P.R. China Department of Oncologic Pathology Department of Gastroenterology Rheumatology and Clinical Immunology Sapporo Medical University School of Medicine Sapporo Japan Department of NutritionDepartment of Food Science and Biotechnology Dongguk University Goyang the Republic of Korea Department of Medical Oncology Dana-Farber Cancer Institute and Harvard Medical School Boston MADepartment of

BackgroundEvidence indicates not only carcinogenic effect of cigarette smoking but also its immunosuppressive effect. We hypothesized that the association of smoking with colorectal cancer risk might be stronger for tumors with lower anti-tumor adaptive immune *** follow-up of 134 981 participants (3 490 851 person-years) in the Nurses’ Health Study and Health Professionals Follow-up Study, we documented 729 rectal and colon cancer cases with available data on T-cell densities in tumor microenvironment. Using the duplication-method Cox regression model, we examined a differential association of smoking status with risk of colorectal carcinoma subclassified by densities of CD3⁺ cells, CD8⁺ cells, CD45RO (PTPRC)⁺ cells, or FOXP3⁺ cells. All statistical tests were *** association of smoking status with colorectal cancer risk differed by CD3⁺ cell density (P_{heterogeneity} = .007). Compared with never smokers, multivariable-adjusted hazard ratios for CD3⁺ cell-low colorectal cancer were 1.38 (95% confidence interval = 1.09 to 1.75) in former smokers and 1.59 (95% confidence interval = 1.14 to 2.23) in current smokers (P_trend = .002, across smoking status categories). In contrast, smoking status was not associated with CD3⁺ cell-high cancer risk (P_trend = .52). This differential association appeared consistent in strata of microsatellite instability, CpG island methylator phenotype, or BRAF mutation status. There was no statistically significant differential association according to densities of CD8⁺ cells, CD45RO⁺ cells, or FOXP3⁺ cells (P_{heterogeneity} > .04, with adjusted α of 0.01).ConclusionsColorectal cancer risk increased by smoking was stronger for tumors with lower T-lymphocyte response, suggesting an interplay of smoking and immunity in colorectal carcinogenesis.

关键词： Association (Psychology) cancer risk Smoking Colorectal Cancer Cancer of Colon Cigarette Smoking Immunosuppression (Physiology) Adaptive Immune Response Tumours T-Lymphocytes cigarette smoke

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Comparison of endoscopic third ventriculostomy versus cerebrospinal fluid shunt procedures for the treatment of pediatric hydrocephalus in Taiwan

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Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2024年第9期40卷 2883-2891页

作者： Shu-Mei Chen Li-Ying Chen Jiann-Her Lin Nicole Salazar Tu-Hsueh Yeh Wei-Lun Lo Tai-Ngar Lui Yi-Chen Hsieh Li-Nien Chien Department of Neurosurgery Taipei Medical University Hospital Taipei Medical University Taipei Taiwan. Department of Surgery School of Medicine Taipei Medical University Taipei Taiwan. Health Data Analytics and Statistics Center Office of Data Science Taipei Medical University Taipei Taiwan. Julius L. Chambers Biomedical/Biotechnology Institute and Department of Biological & Biomedical Sciences North Carolina Central University Durham NC USA. Department of Neurology Taipei Medical University Hospital Taipei Taipei Medical University Taipei Taiwan. Department of Neurology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Neurosurgery Shuang Ho Hospital Taipei Medical University Taipei Taiwan. The PhD Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University 250 Wu-Hsing Street Taipei Taiwan. ychsieh@tmu.edu.tw. Institute of Health and Welfare Policy College of Medicine National Yang Ming Chiao Tung University No.155 Sec. 2 Linong St. Beitou District Taipei Taiwan. linien.chien@nycu.edu.tw. Graduate Institute of Data Science College of Management Taipei Medical University Taipei Taiwan. linien.chien@nycu.edu.tw.

PURPOSE:Pediatric hydrocephalus is the most common cause of surgically treatable neurological disease in children. Controversies exist whether endoscopic third ventriculostomy (ETV) or cerebrospinal fluid (CSF) shunt placement is the most appropriate treatment for pediatric hydrocephalus. This study aimed to compare the risk of re-operation and death between the two procedures. METHODS:We performed a retrospective population-based cohort study and included patients younger than 20-years-old who underwent CSF shunt or ETV for hydrocephalus from the Taiwan National Health Insurance Research Database. RESULTS:A total of 3,555 pediatric patients from 2004 to 2017 were selected, including 2,340 (65.8%) patients that received CSF shunt placement and 1215 (34.2%) patients that underwent ETV. The incidence of all-cause death was 3.31 per 100 person-year for CSF shunt group and 2.52 per 100 person-year for ETV group, with an adjusted hazard ratio (HR) of 0.79 (95% confidence interval [CI] = 0.66-0.94, p = 0.009). The cumulative incidence competing risk for reoperation was 31.2% for the CSF shunt group and 26.4% for the ETV group, with an adjusted subdistribution HR of 0.82 (95% CI = 0.70-0.96, p = 0.015). Subgroup analysis showed that ETV was beneficial for hydrocephalus coexisting with brain or spinal tumor, central nervous system infection, and intracranial hemorrhage. CONCLUSION:Our data indicates ETV is a better operative procedure for pediatric hydrocephalus when advanced surgical techniques and instruments are available.

关键词： Cerebrospinal shunt Pediatric hydrocephalus Reoperation Third ventriculostomy

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Authors’ Response to Peer Reviews of “The Role of Animal-Assisted Therapy in Enhancing Patients’ Well-Being: Systematic Study of the Qualitative and Quantitative Evidence”

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JMIRx Med 2024年 5卷

作者： Ramendra Pati Pandey Himanshu Gunjan Riya Mukherjee Chung-Ming Chang School of Health Sciences & Technology University of Petroleum and Energy Studies Dehradun Uttarakhand India Graduate Institute of Biomedical Sciences Chang Gung University Taoyuan Taiwan Master & PhD Program in Biotechnology Industry Chang Gung University Taoyuan Taiwan Department of Medical Biotechnology and Laboratory Science Chang Gung University Taoyuan Taiwan

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The Role of Animal-Assisted Therapy in Enhancing Patients' Well-Being: Systematic Study of the Qualitative and Quantitative Evidence

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JMIRx med 2024年 5卷 e51787页

作者： Ramendra Pati Pandey Riya Mukherjee Chung-Ming Chang School of Health Sciences & Technology University of Petroleum and Energy Studies Dehradun Uttarakhand India. Graduate Institute of Biomedical Sciences Chang Gung University Taoyuan Taiwan. Master & PhD Program in Biotechnology Industry Chang Gung University Taoyuan Taiwan. Department of Medical Biotechnology and Laboratory Science Chang Gung University Taoyuan Taiwan.

Background:Animal-assisted therapy, also known as pet therapy, is a therapeutic intervention that involves animals to enhance the well-being of individuals across various populations and settings. Objective:This systematic study aims to assess the outcomes of animal-assisted therapy interventions and explore the associated policies. Methods:A total of 16 papers published between 2015 and 2023 were selected for analysis. These papers were chosen based on their relevance to the research topic of animal-assisted therapy and their availability in scholarly databases. Thematic synthesis and meta-analysis were used to synthesize the qualitative and quantitative data extracted from the selected papers. Results:The analysis included 16 studies that met the inclusion criteria and were deemed to be of moderate or higher quality. Among these studies, 4 demonstrated positive results for therapeutic mediation and one for supportive mediation in psychiatric disorders. Additionally, all studies showed positive outcomes for depression and neurological disorders. Regarding stress and anxiety, 3 studies indicated supportive mediation, while 2 studies showed activating mediation. Conclusions:The overall assessment of animal-assisted therapy shows promise as an effective intervention in promoting well-being among diverse populations. Further research and the establishment of standardized outcome assessment measures and comprehensive policies are essential for advancing the field and maximizing the benefits of animal-assisted therapy.

关键词： animal-assisted therapy outcome assessment pet therapy policies systematic study

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