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Signature of psychotic features on white matter in bipolar disorder and schizophrenia

neuroscience Applied 2022年 1卷

作者： B. Bravi I. Bollettini S. Poletti M. Spangaro R. Cavallaro C. Colombo R. Zanardi F. Benedetti 1IRCCS Ospedale San Raffaele Psychiatry & Clinical Psychobiology Unit- Division of Neuroscience Milano Italy 2Vita-Salute San Raffaele University Division of Neuroscience Milan Italy 3Vita-Salute San Raffaele University PhD program in Cognitive Neurosciences Milan Italy 4Vita-Salute San Raffaele University C.E.R.M.A.C. Centro di Eccellenza Risonanza Magnetica ad Alto Campo Milan Italy 5IRCCS Ospedale San Raffaele Schizophrenia Research and Clinical Unit - Department of Clinical Neurosciences Milan Italy 6IRCCS Ospedale San Raffaele Mood Disorders Unit Milano Italy

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Correction to: The Montreal Cognitive Assessment (MoCA): updated norms and psychometric insights into adaptive testing from healthy individuals in Northern Italy

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Aging clinical and experimental research 2022年第11期34卷 2923页

作者： Edoardo Nicolò Aiello Chiara Gramegna Antonella Esposito Valentina Gazzaniga Stefano Zago Teresa Difonzo Ottavia Maddaluno Ildebrando Appollonio Nadia Bolognini School of Medicine and Surgery University of Milano-Bicocca Monza Italy. e.aiello5@campus.unimib.it. PhD Program in Neuroscience University of Milano-Bicocca Monza Italy. e.aiello5@campus.unimib.it. Department of Psychology University of Milano-Bicocca Milan Italy. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico University of Milan Milan Italy. Milan Center for Neuroscience (NeuroMI) Milan Italy. Department of Psychology Sapienza University of Rome Rome Italy. School of Medicine and Surgery University of Milano-Bicocca Monza Italy. Neurology Section School of Medicine and Surgery University of Milano-Bicocca Monza Italy. Department of Psychology and NeuroMi-Milan Center for Neuroscience University of Milano Bicocca Milan Italy. Laboratory of Neuropsychology IRCCS Istituto Auxologico Italiano Milan Italy.

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Associations between gut microbial families and brain myelin in a human cohort

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Alzheimer's & Dementia 2022年第S6期18卷

作者： Kao Lee Yang Margo B. Heston Akshay Kohli Steven R Kecskemeti Antonio González Rob Knight Rima Kaddurah-Daouk Federico E. Rey Barbara B. Bendlin Neuroscience Training Program University of Wisconsin School of Medicine and Public Health Madison WI USA Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Cellular and Molecular Pathology PhD Program University of Wisconsin School of Medicine and Public Health Madison WI USA Waisman Center University of Wisconsin-Madison Madison WI USA Center for Microbiome Innovation University of California San Diego CA USA Department of Medicine Duke University Durham NC USA Department of Bacteriology University of Wisconsin Madison WI USA Department of Medicine University of Wisconsin School of Medicine and Public Health Madison WI USA

Background We previously reported brain myelin (Dean et al, 2017) and gut microbial composition alterations (Vogt et al, 2017) in Alzheimer’s disease (AD). Prior animal studies suggest that myelin is impacted by experimentally altered gut microbiota (Keogh et al, 2021), suggesting that gut microbiota may be linked to brain myelination. However, little is yet known about the human gut microbiome and myelin alterations in the context of AD. Here, we examined the gut-brain association in humans using biomarker and neuroimaging data. Method Amyloid positive (n=27) and negative (n=91) participants from the Wisconsin Alzheimer’s Disease Research Center and the Wisconsin Registry for Alzheimer’s Prevention were included based on completion of one MPnRAGE (Kecskemeti et al., 2018) scan and donation of one stool sample. Myelin was assessed using MPnRAGE-derived quantitative R1 and myelin content in 9 white matter tracts were examined as primary outcomes (Table). Intestinal microbiota composition was characterized using 16S rRNA sequencing of fecal samples. QIIME2 was used to denoise and classify features. Phyloseq was used to filter rare taxa, compute relative abundances, and agglomerate at the family taxonomic rank, resulting in 35 microbial families used as primary predictors. Multiple regression was used to test associations between each microbial family and regional myelin content. Benjamini-Hochberg false discovery rate (FDR) adjustment was applied post-regression; results were considered significant at q <.05. Result Microbial family Turicibacteraceae was positively associated with myelin indexed by R1 (Figure) in the forceps minor (b=.014, q =.037) and uncinate fasciculus (b=.011, q =.028). Across all white matter tracts, higher age was associated with lower R1. Interestingly, there was a significant Paraprevotellaceae -by-amyloid effect in the superior longitudinal fasciculus (b= -.017, p =.031) and Clostridiaceae -by-amyloid effect in the forceps major (b=.002, p =.

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Relevance of Blood Cellular Indices with Inflammatory Cytokines in Patients with Pulmonary Embolism

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Blood 2024年 144卷 2638-2638页

作者： Fakiha Siddiqui Amir Darki Bulent Kantarcioglu Debra Hoppensteadt Moorman Jawed Fareed Alfonso Tafur Manuel Monreal PhD Program in Health Sciences UCAM - Universidad Católica San Antonio de Murcia Murcia Spain Department of Pathology & Laboratory Medicine Cardiovascular Research Institute Health Science Division Loyola University Chicago Maywood IL Department of Cardiology Cardiovascular Research Institute Health Science Division Loyola University Medical Center Maywood IL Department of Pathology and Laboratory Medicine Loyola University Chicago Maywood IL Department of Pathology & Laboratory Medicine and Department of Pharmacology and Neuroscience Cardiovascular Research Institute Health Science Division Loyola University Chicago Maywood IL Department of Molecular Pharmacology and Neuroscience Department of Pathology and Laboratory Medicine Cardiovascular Research Institute Health Science Division Loyola University Chicago Maywood IL Department of Medicine Vascular Medicine Endeavor Health NorthShore University Health System. Evanston IL Chair for the Study of Thromboembolic Disease Faculty of Health Sciences. UCAM - Universidad Católica San Antonio de Murcia. Murcia Spain Hospital Universitari Germans Trias I Pujol Badalona ESP

3,800 characters. Relevance of blood cellular indices with inflammatory cytokines in patients with pulmonary embolism. Fakiha Siddiqui, Amir Darki, Bulent Kantarcioglu, Debra Hoppensteadt, Jawed Fareed, Alfonso Tafur, Manuel Monreal. Introduction Pulmonary embolism (PE) is a life-threatening condition and a leading cause of vascular disease and cardiovascular death worldwide, around 25% of the cases with PE encountered sudden death. Recently, blood cellular indices such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII, NLR*platelets) have emerged as reliable tool in assessing inflammation and immune response and can serve as a predictor of disease severity and prognosis for PE. Elevated NLR is related with an increase's inflammatory response, PLR reflects platelet activation, a prothrombotic state and adverse outcomes, while SII is linked with pronounced inflammatory state together with platelet activation. We have previously demonstrated the prognostic value of cellular indices in a large cohort of PE patients in RIETE Registry (Siddiqui, F., Tafur, A., Hussain, M., et al. The prognostic value of blood cellular indices in pulmonary embolism. American journal of hematology , 10.1002/ajh.27379. Advance online publication. https://***/10.1002/ajh.27379). This integrated study focused on the role of inflammation in patients with PE by profiling cellular indices and inflammatory cytokines and their relevance with outcome as all-cause mortality within the 30 days of diagnosis of PE. Material and Method: In the cohort of 197 PE patients, blood cellular indices and levels of biomarker of inflammation were compared to controls. Furthermore, the relevance of cellular indices and biomarkers was determined. Patients with clinically confirmed diagnosis of PE were enrolled in the Loyola PERT program, and citrated blood samples were collected. Control samples (n= 50) from 25 male and 25 female were ac

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Author Correction: Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation

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Nature communications 2024年第1期15卷 7618页

作者： Fan Li Jazlyn Gallego Natasha N Tirko Jenna Greaser Derek Bashe Rudra Patel Eric Shaker Grace E Van Valkenburg Alanoud S Alsubhi Steven Wellman Vanshika Singh Camila Garcia Padilla Kyle W Gheres John I Broussard Roger Bagwell Maureen Mulvihill Takashi D Y Kozai Department of Bioengineering University of Pittsburgh Pittsburgh PA USA. Center for Neural Basis of Cognition Pittsburgh PA USA. Computational Modeling and Simulation PhD Program University of Pittsburgh Pittsburgh PA USA. Department of Biochemistry and Molecular Biology Pennsylvania State University University Park PA USA. Actuated Medical Bellefonte PA USA. Washington University in St. Louis St. Louis MO USA. Department of Neuroscience University of Pittsburgh Pittsburgh PA USA. Columbia University New York NY USA. Department of Bioengineering University of Pittsburgh Pittsburgh PA USA. TK.Kozai@pitt.edu. Center for Neural Basis of Cognition Pittsburgh PA USA. TK.Kozai@pitt.edu. Center for Neuroscience University of Pittsburgh Pittsburgh PA USA. TK.Kozai@pitt.edu. McGowan Institute of Regenerative Medicine University of Pittsburgh Pittsburgh PA USA. TK.Kozai@pitt.edu. NeuroTech Center University of Pittsburgh Brain Institute Pittsburgh PA USA. TK.Kozai@pitt.edu.

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Tract Integrity Predicts Neurological Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy

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Pediatrics & Neonatology 2025年

作者： Pei-Ling Tsai Yu-Chun Lo Yi-Shan Tsai Yea-Shwu Hwang Ting-Chun Lin Yao-Wen Liang Chen-En Huang Fu-Chun Hsu Yi-Fang Tu You-Yin Chen Institute of Allied Health Sciences College of Medicine National Cheng Kung University Tainan Taiwan PhD Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Medical Imaging National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan Department of Occupational Therapy College of Medicine National Cheng Kung University Tainan Taiwan Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei Taiwan College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Department of Pediatrics National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan Medical Device Innovation and Translation Center National Yang Ming Chiao Tung University Taipei Taiwan

Objective Early prognostication in infants with neonatal hypoxic-ischemic encephalopathy (HIE) is crucial for follow-up management. Alternations of microstructural integrity of neural fiber tracts in large-scale neural networks might predict neurological outcomes. Methods All consecutively-admitted patients with neonatal HIE from 2016 to 2020 were enrolled. Diffusion tensor imaging (DTI) tractography was performed at 4–7 days of age. Neurodevelopmental outcomes at 24 months of age were assessed with Bayley Scales of Infant Development, 3rd edition. Results A total of 62 HIE infants were enrolled, and 53 of these underwent DTI. Fractional anisotropy (FA) and mean diffusivity (MD) were measured to indicate the microstructural integrity of tracts, including the arcuate fasciculus, uncinate fasciculus, inferior fronto-occipital fasciculus, corticospinal tract (CST), and optic radiations (OR). Lower FA values of target tracts were associated with lower developmental scores at 24 months of age, particularly in the CST and OR (all P ≤ 0.003). The prognostic accuracy of FA values in CST surpassed that in the region of thalamus/basal ganglia (area under curves 0.839, 95% CI: 0.728–0.950 vs. 0.755, 95% CI: 0.583–0.928). Furthermore, the correlation between FA values in target tracts and developmental scores was most significant in infants with HIE stage III and this was not affected by therapeutic hypothermia. Conclusion Tract integrity in the CST and OR detected by DTI provides valuable insights for early prognostication in infants with HIE, regardless of therapeutic hypothermia.

关键词： neonatal hypoxic-ischemic encephalopathy diffusion tensor imaging tractography corticospinal tract optic radiations neurodevelopmental outcome

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Gut microbiome moderates the association between metabolic syndrome and the cerebrospinal fluid concentration of YKL-40 in a cognitively unimpaired cohort

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Alzheimer's & Dementia 2023年第S15期19卷

作者： Darby Peter Margo B. Heston Gilda E. Ennis Rob Knight Rima F. Kaddurah-Daouk Sterling C Johnson Sanjay Asthana Cynthia M. Carlsson Nathaniel A. Chin Gwendlyn Kollmorgen Margherita Carboni Kaj Blennow Henrik Zetterberg Tyler K. Ulland Federico E. Rey Barbara B Bendlin Wisconsin Alzheimer’s Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA University of Wisconsin School of Medicine and Public Health Madison WI USA Neuroscience Training Program University of Wisconsin-Madison School of Medicine and Public Health Madison WI USA Correspondece Cellular and Molecular Pathology PhD Program University of Wisconsin School of Medicine and Public Health Madison WI USA University of California at San Diego San Diego CA USA Department of Medicine Duke University Durham NC USA Geriatric Research Education and Clinical Center (GRECC) William S. Middleton Memorial Veterans Hospital Madison WI USA Wisconsin Alzheimer’s Institute University of Wisconsin School of Medicine and Public Health Madison WI USA Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA Roche Diagnostics International Ltd Rotkreuz Zug Switzerland Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden UCL Institute of Neurology London United Kingdom Department of Neurodegenerative Disease and UK Dementia Research Institute UCL Institute of Neurology Queen Square London United Kingdom Department of Bacteriology University of Wisconsin-Madison Madison WI USA

Background Type 2 diabetes (T2D) and metabolic syndrome (MetS) are associated with increased risk of dementia, as well as altered gut microbiome composition (Ott et al., 1999; Ley et al., 2006). However, the extent to which gut microbiome alterations moderate brain pathology in these conditions remains unclear. Here, we examined the extent to which MetS associates with altered cerebrospinal fluid (CSF) biomarkers of Alzheimer’s Disease (AD), glial activation, and neurodegeneration, and whether MetS interacts with gut microbiome composition to impact brain pathology. Method Cognitively unimpaired adults (n = 88, Wisconsin Registry for Alzheimer’s Prevention and Wisconsin Alzheimer’s Disease Research Center; Table 1) underwent fasting blood collection and lumbar puncture, and provided a stool sample. Twenty-six percent (n = 23) of participants met MetS criteria. Fecal microbiota composition was characterized using 16S rRNA sequencing. QIIME2 was used to denoise and classify features, followed by Phyloseq to filter rare taxa, agglomerate taxa at the phylum rank, and compute relative abundances. Analyses centered on Firmicutes:Bacteroidetes, given its previously observed alterations in T2D and MetS (Stadlbauer et al., 2015). CSF biomarkers were quantified using a robust prototype assay as part of the Roche NeuroToolKit research platform. Multiple regression models were used to determine associations between MetS and CSF biomarkers in addition to Firmicutes:Bacteroidetes, and any MetS by Firmicutes:Bacteroidetes effects on CSF biomarkers. Results are reported as significant when p < 0.05, uncorrected. Result A significant negative association between MetS and CSF YKL-40 was observed (Figs. 1a, 1b), but no significant association between MetS and Firmicutes:Bacteroidetes (Fig 1c), nor associations with other CSF biomarkers (Table 2). MetS showed a significant interaction with Firmicutes:Bacteroidetes on YKL-40 (Fig. 1d), as control participants with a higher ratio showed

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Sensory experience remodels genome architecture in neural circuit to drive motor learning (vol 569, pg 708, 2019)

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NATURE 2019年第7760期570卷 E33-E33页

作者： Yamada, Tomoko Yang, Yue Valnegri, Pamela Juric, Ivan Abnousi, Armen Markwalter, Kelly H. Guthrie, Arden N. Godec, Abigail Oldenborg, Anna Hu, Ming Holy, Timothy E. Bonni, Azad Department of Neuroscience Washington University School of Medicine St. Louis USA Faculty of Medicine University of Tsukuba Tsukuba Japan Department of Neurobiology Northwestern University Evanston USA Department of Quantitative Health Sciences Lerner Research Institute Cleveland Clinic Foundation Cleveland USA MD-PhD Program Washington University School of Medicine St. Louis USA

In this Letter, '≥' should be '≤' in the sentence: "Intra-chromosomal reads were further split into short-range reads (≥1 kb) and long-range reads (>1 kb)". This error has been correcte...

In this Letter, '≥' should be '≤' in the sentence: "Intra-chromosomal reads were further split into short-range reads (≥1 kb) and long-range reads (>1 kb)". This error has been corrected *** amendment to this paper has been published and can be accessed via a link at the top of the paper.

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The role of astrocytes in attention-deficit hyperactivity disorder: An update

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Psychiatry research 2025年 350卷 116558页

作者： Louisa Charlotte Dury Cristine Marie Yde Ohki Klaus-Peter Lesch Susanne Walitza Edna Grünblatt Department of Child and Adolescent Psychiatry and Psychotherapy Translational Molecular Psychiatry Psychiatric University Hospital Zurich University of Zurich Wagistrasse 12 8952 Schlieren Switzerland Biomedicine PhD Program University of Zurich Winterthurerstrasse 11 8057 Zurich Switzerland. Department of Child and Adolescent Psychiatry and Psychotherapy Translational Molecular Psychiatry Psychiatric University Hospital Zurich University of Zurich Wagistrasse 12 8952 Schlieren Switzerland. Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy Center of Mental Health University of Würzburg Würzburg Germany Division of Molecular Psychiatry Center of Mental Health University of Würzburg Würzburg Germany. Neuroscience Center Zurich University of Zurich and the ETH Zurich Winterthurerstrasse 11 8057 Zurich Switzerland Zurich Center for Integrative Human Physiology University of Zurich Winterthurerstrasse 11 8057 Zurich Switzerland. Zurich Center for Integrative Human Physiology University of Zurich Winterthurerstrasse 11 8057 Zurich Switzerland. Electronic address: edna.gruenblatt@kjpd.uzh.ch.

Attention-deficit hyperactivity disorder (ADHD), the most prevalent neurodevelopmental disorder, is characterized by inattention, hyperactivity, and impulsivity, manifesting in distinct symptoms and varying degrees of severity among patients. While the cellular processes underlying the neurobiology of ADHD are still being explored, in vitro studies suggest the involvement of certain cellular pathways in its clinical manifestations. Neurodevelopmental disorders such as ADHD are caused by malfunctions in numerous cells in the central nervous system (CNS) throughout development; nevertheless, most of the research focuses on neuronal dysfunction. In the last decade, it has become evident that glia and astrocytes play a crucial role in neurodevelopmental processes, which, if deficient, may result in neurodevelopmental disorders. Besides contributing to homeostatic maintenance of the blood-brain barrier (BBB) and other glial cell types, astrocytes provide neurons with structural, trophic, and metabolic support, which is indispensable for their proper functionality. Emerging evidence implicates that astrocytes are involved in processes associated with the etiopathology of ADHD, including oxidative stress, aberrant synaptic formation, neuroinflammation, and excitatory/inhibitory imbalance. This review will summarize the current knowledge addressing astrocyte dysfunction in ADHD, the remaining caveats in clinical data, and the possibilities for drug therapy. Findings substantiated by in vivo, in vitro, and genetic data will be provided, along with the impact of methylphenidate on astrocyte condition.

关键词： Astrocytes Attention-deficit hyperactivity disorder Neurodevelopmental disorder Pathogenesis

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Correction : IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury

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Journal of neuroinflammation 2023年第1期20卷 287页

作者： Jonathan C Vincent Colleen N Garnett James B Watson Emma K Higgins Teresa Macheda Lydia Sanders Kelly N Roberts Ryan K Shahidehpour Eric M Blalock Ning Quan Adam D Bachstetter Department of Neuroscience University of Kentucky 741 S. Limestone St. Lexington KY 40536 USA. Spinal Cord and Brain Injury Research Center University of Kentucky Lexington KY USA. Sanders‑Brown Center on Aging University of Kentucky Lexington KY USA. MD/PhD Program University of Kentucky Lexington KY USA. Department of Cell Developmental and Integrative Biology University of Alabama at Birmingham Birmingham AL USA. Department of Pharmacology and Nutritional Sciences University of Kentucky Lexington KY USA. Department of Biomedical Science Charles E. Schmidt College of Medicine and Brain Institute Florida Atlantic University Jupiter FL USA. Department of Neuroscience University of Kentucky 741 S. Limestone St. Lexington KY 40536 USA. adam.bachstetter@uky.edu. Spinal Cord and Brain Injury Research Center University of Kentucky Lexington KY USA. adam.bachstetter@uky.edu. Sanders‑Brown Center on Aging University of Kentucky Lexington KY USA. adam.bachstetter@uky.edu.

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