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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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26th Annual Computational neuroscience Meeting (CNS*2017) of the Organization for Computational neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC neuroscience 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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Application of generalized linear models to investigate functional synaptic coupling and synchrony in an animal model of schizophrenia

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BMC neuroscience 2015年第1期16卷 1-2页

作者： Jennifer L Zick Rachael K Blackman Matthew V Chafee Theoden I Netoff Graduate Program in Neuroscience University of Minnesota Minneapolis MN 55455 USA Medical Scientist Training Program (MD/PhD) University of Minnesota Minneapolis MN 55455 USA Brain Sciences Center VA Medical Center Minneapolis MN 55417 USA Department of Biomedical Engineering University of Minnesota Minneapolis MN 55455 USA

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Adult neural stem cell behavior underlying constitutive and restorative neurogenesis in zebrafish

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Neurogenesis (Austin, Tex.) 2016年第1期3卷 e1148101页

作者： Joana S Barbosa Jovica Ninkovic Institute of Stem Cell Research Helmholtz Center Munich Germany PhD Program in Biomedicine and Experimental Biology (BEB) Center for Neuroscience and Cell Biology University of Coimbra Coimbra Portugal. Biomedical Center University of Munich Germany Excellence Cluster of Systems Neurology SYNERGY LMU.

Adult Neural Stem Cells (aNSCs) generate new neurons that integrate into the pre-existing networks in specific locations of the Vertebrate brain. Moreover, aNSCs contribute with new neurons to brain regeneration in some non-mammalian Vertebrates. The similarities and the differences in the cellular and molecular processes governing neurogenesis in the intact and regenerating brain are still to be assessed. Toward this end, we recently established a protocol for non-invasive imaging of aNSC behavior in their niche in vivo in the adult intact and regenerating zebrafish telencephalon. We observed different modes of aNSC division in the intact brain and a novel mode of neurogenesis by direct conversion, which contributes to stem cell depletion with age. After injury, the generation of neurons is increased both by the activation of additional aNSCs and a shift in the division mode of aNSCs, thereby contributing to the successful neuronal regeneration. The cellular behavior we observed opens new questions regarding long-term aNSC maintenance in homeostasis and in regeneration. In this commentary we discuss our data and new questions arising in the context of aNSC behavior, not only in zebrafish but also in other species, including mammals.

关键词： cell division cell fate conversion in vivo imaging neural stem cell neurogenesis regeneration

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Adjunctive pharmacotherapy for cognitive deficits in schizophrenia: meta-analytical investigation of efficacy (vol 203, pg 172, 2013)

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BRITISH JOURNAL OF PSYCHIATRY 2013年第5期203卷 392-392页

作者： Choi, K. H. Kee-Hong Choi PhD Department of Psychology Korea University Seoul South Korea Til Wykes PhD Institute of Psychiatry Kings College London UK Matthew M. Kurtz PhD Department of Psychology and Program in Neuroscience and Behavior Wesleyan University Middletown Connecticut USA

BackgroundA growing number of studies have investigated the efficacy of novel, adjunctive pharmacotherapies for treatment of cognitive deficits in schizophrenia with conflicting *** investigate the comparative efficacy of these agents on cognition and symptoms in schizophrenia, and to identify promising cognitive domains and candidate medications that can be incorporated in treatment trials combined with cognitive remediation to maximise treatment *** total of 26 double-blind, placebo-controlled studies investigating medications targeted at cholinergic, glutamatergic or serotonergic receptor classes and with participants with schizophrenia or schizoaffective disorder were *** targeted at the cholinergic receptor class produced marginal improvements in verbal learning and memory (d = 0.23, P = 0.06), and donepezil, a specific type of cholinergic agonist, produced a moderate effect (d = 0.58) on spatial learning and memory. Cholinergic and glutamatergic agents produced moderate effect-size improvements on negative symptoms (d = 0.54 and d = 0.62 respectively), and small effect-size improvements on general symptoms (d = 0.46 and d = 0.41 respectively). Serotonergic agents produced small effect-size improvements in positive symptoms (d = 0.33).ConclusionsCholinergic medications produced marginal improvement in verbal learning and memory and moderate improvements on spatial learning and memory, although there was no evidence to support the use of glutamatergic or serotonergic medications as a stand-alone treatment for improving cognitive function. Cholinergic and glutamatergic agents improved negative and general symptoms, whereas serotenergic medications improved positive symptoms.

关键词： Cognitive Decline Schizophrenia Drug Therapy

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5th National Congress of the Italian Society of Physiotherapy

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Archives of Physiotherapy 2016年第1期6卷 1-42页

作者： Alessandro Aina Elisabetta Sarasso Marco Barbero Barbara Cagnie Elena Castelli Chad Cook Silvano Ferrari Andrea Foglia Paolo Bizzarri Donatella Giraudo Chris Littlewood Paolo Pillastrini Daniele Piscitelli Michele Romano Andrea Tettamanti Carla Vanti Stefano Vercelli Lennard Voogt Aceto Maria Spina Emanuele Silvestre Francesco Carotenuto Antonio Cerillo Ilaria Orefice Giuseppe Paone Paolo Bassi Raffaele Fiorito Serena Aina Alessandro M. Bonfanti M. Pasquetti Bortolami Arianna Pillastrini Paolo Vanti Carla D. Brioschi A. Pedretti M. Vitali G. Fraschini A. Tettamanti G. Castellini S. Gianola L. Moja S. Bonovas G. Banfi Greta Castellini Monica Gasparini Silvia Gianola Valentina Pecoraro Lorenzo Moja A. Andreano Pamela Frigerio Michela Agostini Andrea Turolla Rosa Bolotta Davide Corbetta Valeria Sirtori Paolo Gozzer Erica Guariento Linda Li G Castellini L Moja S Gianola S Bonovas Alessandro Chiarotto Caroline B. Terwee Maarten Boers Raymond W. Ostelo Lara J. Maxwell George A. Wells Peter Tugwell Ron Clijsen Cesar Fernandez-de-las-Penas Ciceri Matteo Rossetti Sara Vercelli Stefano M. Cislaghi G. Penone G. Marinelli G. Rezzan G. Melegati R. Gatti Colombo Claudio Tolosa Francesca Andrea Moriondo Stefano Doronzio Matteo Paci Marco Monticone Garzonio Fabiola Zanetta Anna Bargeri Serena Cerone Giorgia Sartorio Francesco Filippo Ghirlanda Alessandro Schneebeli Corrado Cescon G. Gioia S. Faccendini A. Aina G. Granzotto F. Gattinoni L. Coppola I. Gava M. Frassinelli Lorenzo Guidotti Marco Postiglione Bruna Lombardi Diego Leoni Michele Egloff Davide Storer Roberto Gatti Magno Tiziano Tettamanti Andrea Daniele Maremmani Giuseppe Plebani Sebastiano Cencini Federica Moresi Matteo Isnardi Alberto Gallace N. Moretti Maselli M. Testa Stefano Negrini Sabrina Donzelli Francesco Saveri Alessandra Negrini Silvana Parzini Fabio Zaina Leonardo Nesi Francesco Ferrarello Valeria Anna Maria Bianchi Luca Nannetti Giuditta Mini Mariangela Marchettini Fabio Piccolo Federica Agosta Massimo Filippi Andrea Falini Paola Adamo Federico Temporiti Rob Physiotherapist Dip. MDT private practice Milan Italy Laboratory of Movement Analysis Division of Neuroscience San Raffaele Scientific Institute and Vita-Salute San Raffaele University Milan Italy Neuroimaging Research Unit San Raffaele Scientific Institute Vita-Salute San Raffaele University Milan Italy Rehabilitation Research Laboratory Department of Business Economics Health and Social Care University of Applied Sciences and Arts of Southern Switzerland SUPSI Manno Switzerland Department of Business Health and Social Care University of Applied Sciences and Arts of Southern Switzerland (SUPSI) Manno Switzerland Department of Business Economics Health and Social Care University of Applied Sciences and Arts of Southern Switzerland SUPSI Manno Switzerland Department of Rehabilitation Sciences and Physiotherapy Ghent University Ghent Belgium San Raffaele Scientific Institute and Vita Salute University Milan Italy Division of Physical Therapy Duke University Durham NC USA Master of Manual Therapy and Musculoskeletal Rehabilitation Molecular Medicine Department of Human Anatomy University of Padova Padova Italy Master of Manual Therapy and Musculoskeletal Rehabilitation University of Padova Padova Italy Physiotherapists Orthopaedic Manual Therapists (OMT) Private practitioners Civitanova Marche Italy San Raffaele Turro Hospital Milan Italy University of Sheffield Sheffield UK Department of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy Ph.D. Candidate in Neuroscience Department of Translational Medicine and Surgery University of Milano-Bicocca Milano Italy Department of Translational medicine and Surgery Program in Physical Therapy University of Bicocca Milan Italy Rehabilitation Department S. Anna Hospital Como Italy ISICO Istituto Scientifico Italiano Colonna Vertebrale Milan Italy Laboratory of Analysis and Rehabilitation of Motor Function Neuroscience Division San Raffaele Hospital Milan Italy School of Physiotherapy

S1 Criteria for exercises selection in subjects with low back painAlessandro AinaS2 Recent advances in pathophysiology and treatment of myofascial trigger pointsMarco BarberoS3 Rehabilitation of scapular dyskinesiaBar... 详细信息

S1 Criteria for exercises selection in subjects with low back pain

Alessandro Aina

S2 Recent advances in pathophysiology and treatment of myofascial trigger points

Marco Barbero

S3 Rehabilitation of scapular dyskinesia

Barbara Cagnie

S4 Musculoskeletal rehabilitation in subjects affected by neurological disorders

Elena Castelli

S5 Which examination tests suggest the best candidates for manual therapy

Chad Cook

S6 Case study: the role of the measurements for the identification of targets and guidance of the treatment

Silvano Ferrari

S7 Assessment of joint mobility: state of the art

Andrea Foglia, Paolo Bizzarri

S8 Core stabilization exercises in the treatment of urinary incontinence

Donatella Giraudo

S9 Preventing surgical subacromial decompression through rotator cuff rehabilitation

Chris Littlewood

S10 Methodological aspects of Clinical Prediction Rules in the rehabilitation of Low Back Pain

Paolo Pillastrini

S11 Interpretability of outcome measures in musculoskeletal rehabilitation

Daniele Piscitelli

S12 Conservative treatment of the misalignment of the spine: state of the art and perspectives

Michele Romano

S13 Balance training in subjects with musculoskeletal disorders

Andrea Tettamanti

S14 Dosage of manual therapy: principles for clinical practice

Carla Vanti

S15 Are there speed limits in post-surgery lower limb rehabilitation?

Stefano Vercelli

S16 Classification of predominant neuropathic, nociceptive or central sensation pain

Lennard Voogt

P1 A wearable proprioceptive stabilizer (Equistasi®) for rehabilitation of balance disorders in multiple sclerosis patients: preliminary results of a randomized, double-blind, versus placebo controlled study

Aceto Maria, Spina Emanuele, Paone Paolo, Silvestre Francesco, Carotenuto Antonio, Ceri

关键词： Motor Imagery Oswestry Disability Index Manual Therapy Myofascial Pain Syndrome Clinical Prediction Rule

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Proceedings of the 14th annual conference of INEBRIA

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Addiction Science & Clinical Practice 2017年第1期12卷 1-24页

作者： Aisha S. Holloway Sarah Landale Laura Cariola Jennifer Ferguson Dorothy Newbury-Birch Amy Flynn John R. Knight Lon Sherritt Sion K. Harris Amy J. O’Donnell Eileen Kaner Barbara Hanratty Denise Howel Elaine McColl Ruth McGovern Stephanie Scott Elaine Stamp Ellen Lynch Amy M. Loree Steve Martino Amy C. Justice Kimberly A. Yonkers Kate Gilstead-Hayden Steven J. Ondersma Joy Scheidell Angeline Adam Jennifer McNeely Robert P. Schwartz Li-Tzy Wu Geetha Subramaniam Gaurav Sharma Anne H. Berman Karoline Kolaas Elisabeth Petersén Erik Hedman Kristina Sinadinovic Anna Thurang Sven Andréasson Ingvar Rosendahl Mikael Gajecki Preben Bendtsen Catharina Linderoth Ulrika Müssener Fredrik Spak Ida Gremyr Ann M. Mitchell Brayden N. Kameg Deborah Finnell Christine L. Savage Khadejah F. Mahmoud Benjamin C. Riordan Tamlin S. Conner Jayde A. M. Flett Damian Scarf Bonnie McRee Janice Vendetti Karen Steinberg Gallucci Kate Robaina Brendan J. Clark Kathryne D. Reed Rachel M. Hodapp Ivor Douglas Ellen L. Burnham Jacqueline Jones Laura Aagaard Paul F. Cook Brett R. Harris Jiang Yu Margaret Wolff Meighan Rogers Carolina Barbosa Brendan J. Wedehase Laura J. Dunlap Shannon G. Mitchell Kristi A. Dusek Jan Gryczynski Arethusa S. Kirk Marla T. Oros Colleen Hosler Kevin E. O’Grady Barry S. Brown Colin Angus Sidney Sherborne Duncan Gillespie Petra Meier Alan Brennan Divane de Vargas Janaina Soares Donna Castelblanco Ian Wittman Ryan P. McCormack Mirelis Gonzalez Kelly M. Doran Donna Shelley John Rotrosen Lillian Gelberg E. Jennifer Edelman Christopher J. Cutter Lynn E. Fiellin Patrick G. O’Connor David A. Fiellin Nathan B. Hansen Stephen A. Maisto Yanhong Deng James Dziura Roger Bedimo Cynthia Gibert Vincent C. Marconi David Rimland Maria C. Rodriguez-Barradas Michael S. Simberkoff Kendall J. Bryant Emma L. Giles Grant J. McGeechan Simon Coulton Nadine Hendrie Paolo Deluca Colin Drummond Sadie Boniface Amy Ramsey Harry Sumnall Luke Vale Viviana Alabani Amanda Atkinson Grant Stanley Jo Frankham Eilish Gilvarry Nicola Howe Justine Clephane David Gar Nursing Studies School of Health in Social Science The University of Edinburgh Edinburgh UK Health and Social Care Institute School of Health and Social Care Teesside University Middlesbrough Tees Valley UK School of Health and Social Care Teesside University Middlesbrough Tees Valley UK Alcohol and Public Health Team School of Health and Social Care Middlesbrough Teesside UK Department of Pediatrics Harvard Medical School Boston MA USA Center for Adolescent Substance Abuse Research Boston Children’s Hospital Boston MA USA Institute of Health and Society Newcastle University Baddiley-Clark Building Richardson Road Newcastle Upon Tyne Northumberland UK VA Connecticut Healthcare System Veterans Aging Cohort Study West Haven CT USA Department of Psychiatry Yale University School of Medicine New Haven CT USA Department of Psychiatry Yale School of Medicine VA Connecticut Healthcare New Haven CT USA Department of Psychiatry Yale School of Medicine VA Connecticut Healthcare System West Haven CT USA Yale University School of Medicine New Haven CT USA Merrill-Palmer Skillman Institute and Department of Psychiatry and Behavioral Neurosciences Wayne State University Detroit MI USA Department of Psychiatry and Behavioral Neurosciences Merrill-Palmer Skillman Institute Detroit MI USA Department of Psychiatry and Behavioral Neurosciences and Merrill-Palmer Skillman Institute Wayne State University Detroit MI USA Department of Population Health NYU School of Medicine New York NY USA Friends Research Institute Inc Baltimore MD USA Department of Psychiatry and Behavioral Sciences Department of Medicine and Duke Clinical Research Institute Duke University Medical Center Durham NC USA Center for the Clinical Trials Network National Institute on Drug Abuse National Institutes of Health Bethesda MD USA The EMMES Corporation Rockville MD USA Department of Clinical Neuroscience Center for Psychiatry Research Karolinska Institutet Stockholm Sweden

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Multidisciplinary intensive rehabilitation treatment improves sleep quality in Parkinson's disease

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Journal of clinical movement disorders 2015年第1期2卷 11页

作者： Giuseppe Frazzitta Roberto Maestri Davide Ferrazzoli Giulio Riboldazzi Rossana Bera Cecilia Fontanesi Roger P Rossi Gianni Pezzoli Maria F Ghilardi Department of Parkinson Disease Rehabilitation Moriggia-Pelascini Hospital Gravedona ed Uniti Fondazione Europea Ricerca Biomedica FERB "S.Isidoro" Hospital Trescore Balneario Italy Department of Parkinson Rehabilitation Ospedale Moriggia Pelascini Via Pelascini 3 Gravedona ed Uniti Como 22015 Italy. Department of Biomedical Engineering Scientific Institute of Montescano S. Maugeri Foundation IRCCS Montescano Italy. Department of Parkinson Disease Rehabilitation Moriggia-Pelascini Hospital Gravedona ed Uniti Fondazione Europea Ricerca Biomedica FERB "S.Isidoro" Hospital Trescore Balneario Italy. Center for Parkinson's Disease Macchi Foundation Varese and Department of Rehabilitation "Le Terrazze" Hospital Cunardo Italy. Department of Physiol. Pharmacol. & Neuroscience CUNY Medical School Harris Hall 08 CCNY 160 Convent Ave New York NY 10031 USA The Graduate Center Biology - Neuroscience PhD Program CUNY New York NY USA. Department of Physical Medicine & Rehabilitation JFK Johnson Rehabilitation Institute Edison NJ USA NYU Movement Disorder Center New York University New York NY USA. Parkinson Institute Istituti Clinici di Perfezionamento Milano Italy. Department of Physical Medicine & Rehabilitation JFK Johnson Rehabilitation Institute Edison NJ USA.

BACKGROUND:Sleep disturbances are among the most common non-motor symptoms of Parkinson's disease (PD), greatly interfering with daily activities and diminishing life quality. Pharmacological treatments have not been satisfactory because of side effects and interactions with anti-parkinsonian drugs. While studies have shown that regular exercise improves sleep quality in normal aging, there is no definitive evidence in PD. METHODS:In a retrospective study, we determined whether an intense physical and multidisciplinary exercise program improves sleep quality in a large group of patients with PD. We analyzed the scores of PD Sleep Scale (PDSS), which was administered twice, 28 days apart, to two groups of patients with PD of comparable age, gender, disease duration and pharmacological treatment. The control group (49 patients) did not receive rehabilitation, The treated group (89 patients) underwent a 28-day multidisciplinary intensive rehabilitation program (three one-hour daily sessions comprising cardiovascular warm-up, relaxation, muscle-stretching, balance and gait training, occupational therapy to improve daily living activities). RESULTS:At enrolment, control and treated groups had similar UPDRS and PDSS scores. At re-test, 28 days later, UPDRS and total PDSS scores improved in the treated (p < 0.0001) but not in the control group. In particular, the treated group showed significant improvement in PDSS scores for sleep quality, motor symptoms and daytime somnolence. The control group did not show improvement for any item. CONCLUSIONS:These results suggest that multidisciplinary intensive rehabilitation treatment may have a positive impact on many aspects of sleep in PD.

关键词： PDSS Plasticity Rehabilitation Sleep quality

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Research highlights

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Lab on a Chip 2013年第10期13卷 1842-1845页

作者： João Ribas Mark W. Tibbitt Mehmet R. Dokmeci Ali Khademhosseini Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge Massachusetts 02139 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA PhD Program in Experimental Biology and Biomedicine CNC-Center for Neuroscience and Cell Biology and Institute for Interdisciplinary Research (IIIUC) University of Coimbra 3004-517 Coimbra Portugal Biocant–Center of Innovation and Biotechnology 3060-197 Cantanhede Portugal Department of Chemical and Biological Engineering University of Colorado Boulder Colorado 80303 USA Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts 02115 USA World Premier International–Advanced Institute for Materials Research (WPI-AIMR) Tohoku University Sendai 980-8577 Japan

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Research highlights

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Lab on a Chip 2013年第4期13卷 599-601页

作者： Francesco Piraino João Ribas Mehmet R. Dokmeci Ali Khademhosseini Bioengineering Department Politecnico di Milano Piazza Leonardo da Vinci 32 20133 Milano Italy Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge Massachusetts 02139 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Biocant-Center of Innovation and Biotechnology 3060-197 Cantanhede Portugal PhD Program in Experimental Biology and Biomedicine CNC-Centre for Neuroscience and Cell Biology 3004-517 Coimbra Portugal Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts 02115 USA World Premier International – Advanced Institute for Materials Research (WPI-AIMR) Tohoku University Sendai 980-8577 Japan

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