检索结果-内蒙古大学图书馆

Gut microbiome moderates the association between metabolic syndrome and the cerebrospinal fluid concentration of YKL-40 in a cognitively unimpaired cohort

引用

Alzheimer's & Dementia 2023年第S15期19卷

作者： Darby Peter Margo B. Heston Gilda E. Ennis Rob Knight Rima F. Kaddurah-Daouk Sterling C Johnson Sanjay Asthana Cynthia M. Carlsson Nathaniel A. Chin Gwendlyn Kollmorgen Margherita Carboni Kaj Blennow Henrik Zetterberg Tyler K. Ulland Federico E. Rey Barbara B Bendlin Wisconsin Alzheimer’s Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA University of Wisconsin School of Medicine and Public Health Madison WI USA Neuroscience Training Program University of Wisconsin-Madison School of Medicine and Public Health Madison WI USA Correspondece Cellular and Molecular Pathology PhD Program University of Wisconsin School of Medicine and Public Health Madison WI USA University of California at San Diego San Diego CA USA Department of Medicine Duke University Durham NC USA Geriatric Research Education and Clinical Center (GRECC) William S. Middleton Memorial Veterans Hospital Madison WI USA Wisconsin Alzheimer’s Institute University of Wisconsin School of Medicine and Public Health Madison WI USA Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA Roche Diagnostics International Ltd Rotkreuz Zug Switzerland Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg Mölndal Sweden UCL Institute of Neurology London United Kingdom Department of Neurodegenerative Disease and UK Dementia Research Institute UCL Institute of Neurology Queen Square London United Kingdom Department of Bacteriology University of Wisconsin-Madison Madison WI USA

Background Type 2 diabetes (T2D) and metabolic syndrome (MetS) are associated with increased risk of dementia, as well as altered gut microbiome composition (Ott et al., 1999; Ley et al., 2006). However, the extent to which gut microbiome alterations moderate brain pathology in these conditions remains unclear. Here, we examined the extent to which MetS associates with altered cerebrospinal fluid (CSF) biomarkers of Alzheimer’s Disease (AD), glial activation, and neurodegeneration, and whether MetS interacts with gut microbiome composition to impact brain pathology. Method Cognitively unimpaired adults (n = 88, Wisconsin Registry for Alzheimer’s Prevention and Wisconsin Alzheimer’s Disease Research Center; Table 1) underwent fasting blood collection and lumbar puncture, and provided a stool sample. Twenty-six percent (n = 23) of participants met MetS criteria. Fecal microbiota composition was characterized using 16S rRNA sequencing. QIIME2 was used to denoise and classify features, followed by Phyloseq to filter rare taxa, agglomerate taxa at the phylum rank, and compute relative abundances. Analyses centered on Firmicutes:Bacteroidetes, given its previously observed alterations in T2D and MetS (Stadlbauer et al., 2015). CSF biomarkers were quantified using a robust prototype assay as part of the Roche NeuroToolKit research platform. Multiple regression models were used to determine associations between MetS and CSF biomarkers in addition to Firmicutes:Bacteroidetes, and any MetS by Firmicutes:Bacteroidetes effects on CSF biomarkers. Results are reported as significant when p < 0.05, uncorrected. Result A significant negative association between MetS and CSF YKL-40 was observed (Figs. 1a, 1b), but no significant association between MetS and Firmicutes:Bacteroidetes (Fig 1c), nor associations with other CSF biomarkers (Table 2). MetS showed a significant interaction with Firmicutes:Bacteroidetes on YKL-40 (Fig. 1d), as control participants with a higher ratio showed

关键词：

来源：评论

学校读者我要写书评

暂无评论

Relevance of Blood Cellular Indices with Inflammatory Cytokines in Patients with Pulmonary Embolism

引用

Blood 2024年 144卷 2638-2638页

作者： Fakiha Siddiqui Amir Darki Bulent Kantarcioglu Debra Hoppensteadt Moorman Jawed Fareed Alfonso Tafur Manuel Monreal PhD Program in Health Sciences UCAM - Universidad Católica San Antonio de Murcia Murcia Spain Department of Pathology & Laboratory Medicine Cardiovascular Research Institute Health Science Division Loyola University Chicago Maywood IL Department of Cardiology Cardiovascular Research Institute Health Science Division Loyola University Medical Center Maywood IL Department of Pathology and Laboratory Medicine Loyola University Chicago Maywood IL Department of Pathology & Laboratory Medicine and Department of Pharmacology and Neuroscience Cardiovascular Research Institute Health Science Division Loyola University Chicago Maywood IL Department of Molecular Pharmacology and Neuroscience Department of Pathology and Laboratory Medicine Cardiovascular Research Institute Health Science Division Loyola University Chicago Maywood IL Department of Medicine Vascular Medicine Endeavor Health NorthShore University Health System. Evanston IL Chair for the Study of Thromboembolic Disease Faculty of Health Sciences. UCAM - Universidad Católica San Antonio de Murcia. Murcia Spain Hospital Universitari Germans Trias I Pujol Badalona ESP

3,800 characters. Relevance of blood cellular indices with inflammatory cytokines in patients with pulmonary embolism. Fakiha Siddiqui, Amir Darki, Bulent Kantarcioglu, Debra Hoppensteadt, Jawed Fareed, Alfonso Tafur, Manuel Monreal. Introduction Pulmonary embolism (PE) is a life-threatening condition and a leading cause of vascular disease and cardiovascular death worldwide, around 25% of the cases with PE encountered sudden death. Recently, blood cellular indices such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII, NLR*platelets) have emerged as reliable tool in assessing inflammation and immune response and can serve as a predictor of disease severity and prognosis for PE. Elevated NLR is related with an increase's inflammatory response, PLR reflects platelet activation, a prothrombotic state and adverse outcomes, while SII is linked with pronounced inflammatory state together with platelet activation. We have previously demonstrated the prognostic value of cellular indices in a large cohort of PE patients in RIETE Registry (Siddiqui, F., Tafur, A., Hussain, M., et al. The prognostic value of blood cellular indices in pulmonary embolism. American journal of hematology , 10.1002/ajh.27379. Advance online publication. https://***/10.1002/ajh.27379). This integrated study focused on the role of inflammation in patients with PE by profiling cellular indices and inflammatory cytokines and their relevance with outcome as all-cause mortality within the 30 days of diagnosis of PE. Material and Method: In the cohort of 197 PE patients, blood cellular indices and levels of biomarker of inflammation were compared to controls. Furthermore, the relevance of cellular indices and biomarkers was determined. Patients with clinically confirmed diagnosis of PE were enrolled in the Loyola PERT program, and citrated blood samples were collected. Control samples (n= 50) from 25 male and 25 female were ac

关键词：

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation

引用

Scientific reports 2018年第1期8卷 11303页

作者： A F Lima G May J Díaz-Colunga S Pedreiro A Paiva L Ferreira T Enver F J Iborra R Pires das Neves UC-Biotech CNC - Center for Neuroscience and Cell Biology University of Coimbra 3060-197 Cantanhede Portugal. Faculty of Science and Technology University Nova of Lisbon (MIT-Portugal PhD Program) 2829-516 Caparica Portugal. University College London Gower Street London WC1E 6BT UK. Centro Nacional de Biotecnología CSIC. Darwin 3 Campus de Cantoblanco 28049 Madrid Spain. Unidade de Gestão Operacional de Citometria Centro Hospitalar e Universitário de Coimbra 3000-075 Coimbra Portugal. Coimbra Institute for Clinical and Biomedical Research Faculty of MedicineUniversity of Coimbra 3004-504 Coimbra Portugal. Faculty of Medicine University of Coimbra 3004-504 Coimbra Portugal. UC-Biotech CNC - Center for Neuroscience and Cell Biology University of Coimbra 3060-197 Cantanhede Portugal. ricardo.neves@uc-biotech.pt. Institute for Interdisciplinary Research University of Coimbra 3030-789 Coimbra Portugal. ricardo.neves@uc-biotech.pt.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Correction : IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury

引用

Journal of neuroinflammation 2023年第1期20卷 287页

作者： Jonathan C Vincent Colleen N Garnett James B Watson Emma K Higgins Teresa Macheda Lydia Sanders Kelly N Roberts Ryan K Shahidehpour Eric M Blalock Ning Quan Adam D Bachstetter Department of Neuroscience University of Kentucky 741 S. Limestone St. Lexington KY 40536 USA. Spinal Cord and Brain Injury Research Center University of Kentucky Lexington KY USA. Sanders‑Brown Center on Aging University of Kentucky Lexington KY USA. MD/PhD Program University of Kentucky Lexington KY USA. Department of Cell Developmental and Integrative Biology University of Alabama at Birmingham Birmingham AL USA. Department of Pharmacology and Nutritional Sciences University of Kentucky Lexington KY USA. Department of Biomedical Science Charles E. Schmidt College of Medicine and Brain Institute Florida Atlantic University Jupiter FL USA. Department of Neuroscience University of Kentucky 741 S. Limestone St. Lexington KY 40536 USA. adam.bachstetter@uky.edu. Spinal Cord and Brain Injury Research Center University of Kentucky Lexington KY USA. adam.bachstetter@uky.edu. Sanders‑Brown Center on Aging University of Kentucky Lexington KY USA. adam.bachstetter@uky.edu.

来源：评论

学校读者我要写书评

暂无评论

P–074 Chromatin Maturity Index (CMI) in unfixed and live spermatozoa and Aniline Blue (AB) stained as an additional evaluation parameter in idiopathic male infertility

引用

Human Reproduction 2021年第SUPPLEMENT_1期36卷

作者： Notari, T Piscopo, M Bosco, L Pecoraro, S Serra, N Ricciardi, D Capra, G Montano, L Check Up - Day Surgery Polydiagnostic Centre Salerno- Italy. Check Up Research Unit Salerno Italy University of Naples “Federico II” Department of Biology Napoli Italy University of Palermo Department of Biomedicine- Neuroscience and Advanced Diagnostics Bi.N.D- Section of Biology and Genetics- Palermo- Italy IRCCS Neuromed “Malzoni Clinic” Department of Uro-Andrology- Avellino Italy University of Naples “Federico II” Department of Public Health Napoli Italy “Ricciardi” Diagnostic Centre Seminology Lab Pollena Trocchia- Napoli Italy University of Palermo Department of Sciences for Health Promotion and Mother-Child Care ‘G. D’Alessandro’ PROSAMI- Palermo Italy Local Health Authority ASL-Salerno.. Andrology Unit and Service of Lifestyle Medicine in UroAndrology- Coordination Unit of the network for Environmental and Reproductive Health EcoFoodFertility project- “Oliveto Citra Hospital”- Salerno. PhD Program

来源：评论

学校读者我要写书评

暂无评论

Gut microbe-modulated metabolites are longitudinally associated with higher neurodegeneration biomarkers in cerebrospinal fluid (CSF)

引用

Alzheimer's & Dementia 2022年第S6期18卷

作者： Margo B. Heston Cynthia M. Carlsson Corinne D. Engelman Erin M. Jonaitis Carol A. Van Hulle Yuetiva Deming Sterling C. Johnson Sanjay Asthana Gwendlyn Kollmorgen Ivonne Suridjan Norbert Wild Kaj Blennow Henrik Zetterberg Federico E. Rey Barbara B. Bendlin Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Cellular and Molecular Pathology PhD Program University of Wisconsin School of Medicine and Public Health Madison WI USA Geriatric Research Education and Clinical Center William S. Middleton Veterans Hospital Madison WI USA Wisconsin Alzheimer’s Institute University of Wisconsin School of Medicine and Public Health Madison WI USA Department of Population Health Sciences University of Wisconsin School of Medicine and Public Health Madison WI USA Roche Diagnostics International Ltd Rotkreuz Switzerland Institute of Neuroscience and Physiology Department of Psychiatry and Neurochemistry The Sahlgrenska Academy at University of Gothenburg Mölndal Sweden Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden Department of Neurodegenerative Disease and UK Dementia Research Institute UCL Institute of Neurology Queen Square London United Kingdom UCL Institute of Neurology London United Kingdom Institute of Neuroscience and Physiology The Sahlgrenska Academy at University of Gothenburg Mölndal Sweden University of Wisconsin-Madison Madison WI USA Wisconsin Alzheimer’s Institute University of Wisconsin-Madison School of Medicine and Public Health Madison WI USA

Background Gut bacterial metabolites in circulation and postmortem brain tissue differ in abundance between cognitively unimpaired (CU) and Alzheimer’s disease (AD) individuals. Furthermore, in mice chronic injection of bacterial components exacerbates AD pathology. In CSF, we found the microbially-produced trimethylamine-N-oxide was linked to AD and neurodegeneration biomarkers. However, the broader extent to which microbe-modulated metabolites relate to AD and neurodegeneration is unknown. We tested the hypothesis that in CSF of non-demented adults, elevated metabolites would longitudinally associate with higher biomarkers. Method CSF was collected biannually in the Wisconsin Alzheimer’s Disease Research Center and Wisconsin Registry for Alzheimer’s Prevention studies. Biomarkers of pTau 181 , Aβ 42 , tTau, axonal (NfL) and synaptic (neurogranin, α-synuclein) degeneration were quantified using Elecsys assays (NeuroToolKit robust prototype, Roche Diagnostics). Metabolite relative abundances were quantified via untargeted metabolomics analysis (ultrahigh performance liquid chromatography-tandem mass spectrometry, Metabolon). A priori literature and database review identified 76 detected microbe-modulated metabolites. 200 CU participants with two or more analyzed CSF samples were included in statistical analysis (Table 1). For each metabolite-biomarker pair, multilevel linear growth modeling tested person-level mean metabolite effects on biomarker slope and intercept, and time-varying metabolite effects on biomarker intercept (Figure 1). Covariates included age, sex, and APOE risk score; Benjamini-Hochberg corrections adjusted for Type I error inflation. Result Seven metabolites were positively associated with biomarker slope or intercept (Table 2). Mean gluconate, glycerate, and oxalate levels were correlated with increased tTau slope, and N-acetylaspartate, N-acetylglutamate and cholesterol were correlated with higher a-synuclein or neurogranin intercepts. Phenol s

关键词：

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation

引用

Nature communications 2024年第1期15卷 7618页

作者： Fan Li Jazlyn Gallego Natasha N Tirko Jenna Greaser Derek Bashe Rudra Patel Eric Shaker Grace E Van Valkenburg Alanoud S Alsubhi Steven Wellman Vanshika Singh Camila Garcia Padilla Kyle W Gheres John I Broussard Roger Bagwell Maureen Mulvihill Takashi D Y Kozai Department of Bioengineering University of Pittsburgh Pittsburgh PA USA. Center for Neural Basis of Cognition Pittsburgh PA USA. Computational Modeling and Simulation PhD Program University of Pittsburgh Pittsburgh PA USA. Department of Biochemistry and Molecular Biology Pennsylvania State University University Park PA USA. Actuated Medical Bellefonte PA USA. Washington University in St. Louis St. Louis MO USA. Department of Neuroscience University of Pittsburgh Pittsburgh PA USA. Columbia University New York NY USA. Department of Bioengineering University of Pittsburgh Pittsburgh PA USA. TK.Kozai@pitt.edu. Center for Neural Basis of Cognition Pittsburgh PA USA. TK.Kozai@pitt.edu. Center for Neuroscience University of Pittsburgh Pittsburgh PA USA. TK.Kozai@pitt.edu. McGowan Institute of Regenerative Medicine University of Pittsburgh Pittsburgh PA USA. TK.Kozai@pitt.edu. NeuroTech Center University of Pittsburgh Brain Institute Pittsburgh PA USA. TK.Kozai@pitt.edu.

来源：评论

学校读者我要写书评

暂无评论

OS02.6.A Lacosamide in monotherapy in brain tumour-related epilepsy (BTRE): results from an Italian multicentre retrospective study

引用

Neuro-Oncology 2022年第SUPPLEMENT_2期24卷 ii11-ii11页

作者： Bruno, F Mo, F Meletti, S Belcastro, V Quadri, S Napolitano, M Bello, L Dainese, F Scarpelli, M Florindo, I Mascia, A Pauletto, G Pellerino, A Giovannini, G Polosa, M Sessa, M Conti Nibali, M Di Gennaro, G Gigli, G Cavallieri, F Pisanello, A Rudà, R University and City of Health and Science Turin Italy Turin Italy Division of Neurology Modena University Hospital Modena Italy Modena Italy Center for Neuroscience and Neurotechnology Department of Biomedical Metabolic and Neural Sciences University of Modena and Reggio Emilia Italy Modena and Reggio Emilia Italy Division of Neurology Maggiore Hospital Lodi Italy Lodi Italy Division of Neurology ASST Papa Giovanni XXIII of Bergamo Italy Bergamo Italy Division of Neurology and Stroke Unit Hospital A. Cardarelli Napoli Italy Naples Italy Division of Neurosurgical Oncology Department of Oncology and Hemato-oncology Università degli Studi di Milano Italy Milan Italy Epilepsy Centre Division of Neurology Hospital of Venezia Italy Venice Italy Division of Neurology Department of Neuroscience AOUI Verona Verona Italy Verona Italy Division of Neurology Hospital of Parma Italy Parma Italy IRCCS Neuromed Pozzilli Italy Pozzilli Italy Neurology Unit Department of Neuroscience “S. Maria della Misericordia” University Hospital Udine Italy Udine Italy Clinical and Experimental Medicine PhD Program University of Modena and Reggio Emilia Modena Italy Modena and Reggio Emilia Italy Division of Neurosurgery ASST Lariana Como Italy Como Italy Department of Medicine (DAME) University of Udine Udine Italy Udine Italy Clinical Neurology Unit “S. Maria della Misericordia” University Hospital Udine Italy Udine Italy Neurology Unit Neuromotor & Rehabilitation Department Azienda USL-IRCCS di Reggio Emilia Reggio Emilia Italy Reggio Emilia Italy Dept. of Neurology Castelfranco and Treviso Hospitals Italy Treviso Italy

来源：评论

学校读者我要写书评

暂无评论

Multidisciplinary intensive rehabilitation treatment improves sleep quality in Parkinson's disease

引用

Journal of clinical movement disorders 2015年第1期2卷 11页

作者： Giuseppe Frazzitta Roberto Maestri Davide Ferrazzoli Giulio Riboldazzi Rossana Bera Cecilia Fontanesi Roger P Rossi Gianni Pezzoli Maria F Ghilardi Department of Parkinson Disease Rehabilitation Moriggia-Pelascini Hospital Gravedona ed Uniti Fondazione Europea Ricerca Biomedica FERB "S.Isidoro" Hospital Trescore Balneario Italy Department of Parkinson Rehabilitation Ospedale Moriggia Pelascini Via Pelascini 3 Gravedona ed Uniti Como 22015 Italy. Department of Biomedical Engineering Scientific Institute of Montescano S. Maugeri Foundation IRCCS Montescano Italy. Department of Parkinson Disease Rehabilitation Moriggia-Pelascini Hospital Gravedona ed Uniti Fondazione Europea Ricerca Biomedica FERB "S.Isidoro" Hospital Trescore Balneario Italy. Center for Parkinson's Disease Macchi Foundation Varese and Department of Rehabilitation "Le Terrazze" Hospital Cunardo Italy. Department of Physiol. Pharmacol. & Neuroscience CUNY Medical School Harris Hall 08 CCNY 160 Convent Ave New York NY 10031 USA The Graduate Center Biology - Neuroscience PhD Program CUNY New York NY USA. Department of Physical Medicine & Rehabilitation JFK Johnson Rehabilitation Institute Edison NJ USA NYU Movement Disorder Center New York University New York NY USA. Parkinson Institute Istituti Clinici di Perfezionamento Milano Italy. Department of Physical Medicine & Rehabilitation JFK Johnson Rehabilitation Institute Edison NJ USA.

BACKGROUND:Sleep disturbances are among the most common non-motor symptoms of Parkinson's disease (PD), greatly interfering with daily activities and diminishing life quality. Pharmacological treatments have not been satisfactory because of side effects and interactions with anti-parkinsonian drugs. While studies have shown that regular exercise improves sleep quality in normal aging, there is no definitive evidence in PD. METHODS:In a retrospective study, we determined whether an intense physical and multidisciplinary exercise program improves sleep quality in a large group of patients with PD. We analyzed the scores of PD Sleep Scale (PDSS), which was administered twice, 28 days apart, to two groups of patients with PD of comparable age, gender, disease duration and pharmacological treatment. The control group (49 patients) did not receive rehabilitation, The treated group (89 patients) underwent a 28-day multidisciplinary intensive rehabilitation program (three one-hour daily sessions comprising cardiovascular warm-up, relaxation, muscle-stretching, balance and gait training, occupational therapy to improve daily living activities). RESULTS:At enrolment, control and treated groups had similar UPDRS and PDSS scores. At re-test, 28 days later, UPDRS and total PDSS scores improved in the treated (p < 0.0001) but not in the control group. In particular, the treated group showed significant improvement in PDSS scores for sleep quality, motor symptoms and daytime somnolence. The control group did not show improvement for any item. CONCLUSIONS:These results suggest that multidisciplinary intensive rehabilitation treatment may have a positive impact on many aspects of sleep in PD.

关键词： PDSS Plasticity Rehabilitation Sleep quality

来源：评论

学校读者我要写书评

暂无评论

腺苷受体是调节大脑内侧前额叶皮质星形胶质细胞大麻素1型(CB1)受体对突触可塑性作用的开关

引用

神经损伤与功能重建 2024年第4期19卷 250页

作者： Joana Gon?alves-Ribeiro Oksana K Savchak Sara Costa-Pinto Joana I Gomes Rafael Rivas-Santisteban Alejandro Lillo Javier Sánchez Romero Ana M Sebasti?o Marta Navarrete Gemma Navarro Rafael Franco Sandra H Vaz Instituto de Farmacologia e Neurociencias Faculdade de MedicinaUniversidade de Lisboa Instituto de Medicina Molecular Joao Lobo Antunes Faculdade de MedicinaUniversidade de Lisboa Department of Biochemistry and Physiology School of Pharmacy and Food ScienceUniversitat de Barcelona CiberNed Network Center for Neurodegenerative DiseasesNational Spanish Health Institute Carlos Ⅲ Instituto Cajal CSIC PhD Program in Neuroscience Universidad Autonoma de Madrid-Instituto Cajal Institut de Neurociencies Universitat de Barcelona Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFaculty of Biology School of Chemistry Universitat de Barcelona

内侧前额叶皮质（mPFC）参与诸如工作记忆等认知功能。星形胶质细胞大麻素1型受体（CB1R）诱导细胞质内钙离子(Ca2+)浓度变化,对神经元功能产生影响。mPFC的星形胶质细胞也表达腺苷A1和A2A受体(A1R,A2AR),但目前尚不清楚这些细胞中的CB1... 详细信息

内侧前额叶皮质（mPFC）参与诸如工作记忆等认知功能。星形胶质细胞大麻素1型受体（CB1R）诱导细胞质内钙离子(Ca2+)浓度变化,对神经元功能产生影响。mPFC的星形胶质细胞也表达腺苷A1和A2A受体(A1R,A2AR),但目前尚不清楚这些细胞中的CB1R与腺苷受体之间的交流。我们在这里展示,通过CB1R-A2AR或CB1R-A1R异源二聚体,星形胶质细胞Ca2+信号传递发生了进一步的调节,最终影响mPFC突触可塑性。当A1R和A2AR被激活时,CB1R介导的Ca2+瞬变出现增加或减少,揭示了腺苷受体可能是星形胶质细胞CB1R的调节器。CB1R的激活导致mPFC的长时程增强（LTP）增强,受A1R控制,但不受A2AR控制。值得注意的是,在IP3R2KO小鼠中,由于没有显示出星形胶质细胞Ca2+水平升高,CB1R的激活减少了LTP,这种效果不受A1R或A2AR的调节。本研究表明,CB1R在mPFC LTP上具有稳态作用,受到A1R的控制,可能是由于这些受体在星形胶质细胞中的交流,最终改变了CB1R Ca2+信号传递。

关键词： CB1受体腺苷受体星形胶质细胞内侧前额叶皮质突触可塑性

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：