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Functional Connectome-Based Predictive Modeling in Autism

BIOLOGICAL PSYCHIATRY 2022年第8期92卷 626-642页

作者： Horien, Corey Floris, Dorothea L. Greene, Abigail S. Noble, Stephanie Rolison, Max Tejavibulya, Link O'Connor, David McPartland, James C. Scheinost, Dustin Chawarska, Katarzyna Lake, Evelyn M. R. Constable, R. Todd [a]Interdepartmental Neuroscience Program Yale School of Medicine New Haven Connecticut [b]MD-PhD Program Yale School of Medicine New Haven Connecticut [c]Department of Pediatrics Yale School of Medicine New Haven Connecticut [d]Department of Neurosurgery Yale School of Medicine New Haven Connecticut [e]Department of Radiology and Biomedical Imaging Yale School of Medicine New Haven Connecticut [f]Department of Biomedical Engineering Yale University New Haven Connecticut [g]Department of Psychology Yale University New Haven Connecticut [h]Department of Statistics and Data Science Yale University New Haven Connecticut [i]Yale Child Study Center New Haven Connecticut [j]Methods of Plasticity Research Department of Psychology University of Zürich Zurich Switzerland [k]Donders Center for Brain Cognition and Behavior Radboud University Nijmegen Nijmegen The Netherlands

Autism is a heterogeneous neurodevelopmental condition, and functional magnetic resonance imaging-based studies have helped advance our understanding of its effects on brain network activity. We review how predictive modeling, using measures of functional connectivity and symptoms, has helped reveal key insights into this condition. We discuss how different prediction frameworks can further our understanding of the brain-based features that underlie complex autism symptomatology and consider how predictive models may be used in clinical settings. Throughout, we highlight aspects of study interpretation, such as data decay and sampling biases, that require consideration within the context of this condition. We close by suggesting exciting future directions for predictive modeling in autism.

关键词： Clinical translation Development Fingerprinting Individual differences Machine learning Resting-state fMRI

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Ethnobotany and Indigenous Traditional Knowledge in Brazil: Contributions to Research in Ecopsychology

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Journal of Psychological Research 2021年第1期3卷 49-60页

作者： Maria do Carmo Pereira Santos Tito Jonas Carvalho e Silva Biologist PhD candidate at the Graduate Program in Environmental SciencesFederal University of TocantinsBrazil PhD in clinical psychology and culture(University of Brasília).German Chancellor Fellow(2019)at the Alexander von Humboldt Foundation/TU Dortmund University Germany

This paper is the result of an investigation of the flora and traditionalknowledge in the conception of Javaé indigenous people from the Txuirivillage located on Bananal Island, Brazil. The objective is to investigatethe plants used by these indigenous people, their diverse uses and tounderstand how traditional knowledge is passed on to new *** is a qualitative, descriptive and interdisciplinary survey, whose datacollection strategies included the application of semi-structured questionnairesand collection of plants for cataloguing according to AngiospermPhylogeny Group or APG III (2009). We identified 26 plant species, usedfor various purposes such as medicinal use, food, construction, craft andcultural, which were deposited in the Herbarium of the Federal Universityof Tocantins. Roots, stem and leaf are the plant parts most used bythe community. The plants mentioned were most frequently found on thebanks of the Javaés River and in the backyard of the residences. Significanttraditional knowledge of these people about the plants are transmittedto new generations, through visual, orality and experimentation. Ethnobotanicalstudies strengthen research in ecopsychology while allowingresearch into the interactions between human populations and plants.

关键词： Plants Ecopsychology Javaépeople Brazil Traditional knowledge

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Expanding Our Understanding of Birth Doulas’ Emotional and Informational Support Role: A Qualitative Analysis of Interventions Delivered During COVID-19

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Women's Reproductive Health 2024年第3期11卷 509-522页

作者： Lisenbee, Jodie Webb, Jennifer B. Gil-Rivas, Virginia Quinlan, Margaret M. Dahl, Alicia A. Interdisciplinary Health Psychology PhD Program University of North Carolina at Charlotte Charlotte NC United States Department of Communication Studies University of North Carolina at Charlotte Charlotte NC United States Department of Public Health Sciences University of North Carolina at Charlotte Charlotte NC United States

Birth doulas were classified as nonessential personnel during COVID-19 and generally excluded from providing physical, in-hospital birth support. This amplified their emotional and informational support to clients, offering a unique opportunity to examine psychological mechanisms underlying birth doulas’ impact on perinatal outcomes. We conducted a methodologically rigorous qualitative case study leveraging a social action theory framework and interviewed 15 demographically diverse birth doulas. Doulas played an important role in supporting their clients’ psychological change processes (e.g., problem solving, outcome expectancies, self-efficacy, goal structures, cognitive schemas). This study contributes to our understanding of psychosocial interventions that may drive the positive effects of doula care on health outcomes, both within and beyond the pandemic context. © 2023 Society for Menstrual Cycle Research.

关键词： Birth doula childbirth COVID-19 emotional support social action theory

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Body and Fitness-related Shame Helps Explain the Association Between Internalized Weight Bias and Orthorexia Symptoms among North American Female Yoga Professionals

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Journal of the Academy of Nutrition and Dietetics 2025年

作者： Jennifer B Webb Tran Tran Lia Bauert Sophie Pringle UNC Charlotte Health Psychology PhD Program 9201 University City Blvd. Charlotte NC 28223. Electronic address: jennifer.webb@charlotte.edu. UNC Charlotte Health Psychology PhD Program 9201 University City Blvd. Charlotte NC 28223. Electronic address: ttran97@charlotte.edu. UNC Charlotte Health Psychology PhD Program 9201 University City Blvd. Charlotte NC 28223. Electronic address: lbauert@charlotte.edu. UNC Charlotte Health Psychology PhD Program 9201 University City Blvd. Charlotte NC 28223. Electronic address: springl2@charlotte.edu.

BACKGROUND:Recently, emerging population-based evidence has revealed that yoga practitioners are particularly vulnerable to engaging in disordered eating behaviors inclusive of orthorexia symptoms (OS). Although orthorexia tends to be characterized by a hypervigilance over consuming "healthy" or "clean" foods based on quality attributes, its associations with variables related to broader diet culture [e.g., internalized weight bias (IWB) and body- and fitness-related shame, guilt, and hubristic pride] remain under examined. Additionally, previous research has yet to explore the psychological correlates of OS specifically among yoga professionals, who are uniquely positioned to influence their students' and clients' orientations towards eating and embodied well-being. OBJECTIVE:This secondary analysis from the Yoga Teacher and Therapist Lifestyle and Well-Being Study (2019-2020) aimed to investigate the relationships among diet culture-related experiences, specifically IWB and body and fitness-related self-conscious emotions, role-modeling positive body image, and OS among female yoga professionals, as well as to evaluate the indirect effects of IWB via role-modeling positive body image and other diet culture-related experiences on OS. DESIGN:A cross-sectional correlational, secondary analysis was performed to address the research questions. PARTICIPANTS:The study included 406 female yoga professionals living in the US and Canada (37% racial/ethnic minority, 13% sexual minority). MAIN OUTCOME MEASURES:These included IWB, body and fitness-related self-conscious emotions, role-modeling positive body image, and OS. STATISTICAL ANALYSES PERFORMED:These included Pearson's correlations and regression models. RESULTS:Nearly 40% of participants consumed an exclusively vegetarian or vegan diet; 25% identified as engaging in "clean eating." Positive associations were observed between IWB and OS, shame, and guilt. Inverse associations were observed between IWB and role-modeling

关键词： body and fitness-related self-conscious emotions diet culture female yoga professionals internalized weight bias orthorexia role-modeling positive body image

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Outcomes of a cluster randomised control trial of Be Real’s BodyKind;A universal body image programme for adolescents in Ireland

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Body Image 2025年 54卷 101905页

作者： Ciara Mahon Denise Hamburger Zali Yager Jennifer B. Webb Georgia Brown Amanda Fitzgerald School of Psychology University College Dublin Ireland Be Real USA NFP USA The Embrace Collective Australia Department of Psychological Science Health Psychology PhD Program University of North Carolina at Charlotte Charlotte USA

Body image has a key impact on adolescent mental health. Yet there are few evidence-based interventions for older adolescents (aged 14 + years). This study evaluated the effectiveness of Be Real’s BodyKind, a strengths-focused, gender-inclusive programme, culturally adapted for older adolescents in Ireland, which combines empirically-supported principles of cognitive dissonance, self-compassion, compassion for others, and social activism to support positive body image. Twenty-three second-level schools in Ireland participated in a pragmatic cluster randomised controlled trial. Overall, 1099 students (612 girls, 460 boys, 27 gender minority students) in Transition (4th) Year aged 15–16 years ( M =15.4, SD =.5) were randomly assigned to receive the 4-session intervention delivered by teachers ( n  = 630) or waitlist control ( n  = 469). Outcomes were assessed at baseline, post-intervention and 2-month follow-up. Significant improvements in the main outcome of body appreciation ( p  = .03, d =.17) were observed at post-intervention. Girls demonstrated higher levels of body appreciation at post-intervention, and self-compassion at follow-up, but not boys. No significant changes in body satisfaction, psychological wellbeing, body ideal internalisation, compassion for others or social activism were observed. Findings indicate that girls may experience brief gains in body appreciation, but refining the programme and optimising implementation may be warranted to enhance programme impact, particularly in boys.

关键词： Body image School-based Adolescent Compassion-based Intervention

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A novel PNPLA2 mutation causing total loss of RNA and protein expression in two NLSDM siblings with early onset but slowly progressive severe myopathy

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Genes & Diseases 2021年第1期8卷 73-78页

作者： Daniela Tavian Lorenzo Maggi Marina Mora Lucia Morandi Cinzia Bragato Sara Missaglia Laboratory of Cellular Biochemistry and Molecular Biology CRIBENSUniversita`Cattolica del Sacro Cuorepz Buonarroti 30Milan20145Italy Department of Psychology Universita`Cattolica del Sacro CuoreLargo Gemelli 1Milan20123Italy Neuromuscular Diseases and Neuroimmunology Unit Fondazione IRCCS Istituto Neurologico“Carlo Besta”MilanItaly PhD program in Neuroscience University of Milano-BicoccaVia Cadore 48Monza20900Italy

Neutral lipid storage disease with myopathy(NLSDM)is a rare autosomal recessive disorder,due to an enzymatic error of lipid *** present always with skeletal muscle myopathy and variable cardiac and hepatic *** is caused by mutations in the PNPLA2 gene,which encodes the adipose triglyceride lipase(ATGL).Here we report the molecular characterization and clinical findings of two NLSDM siblings carrying the novel c.187t1G>C homozygous PNPLA2 mutation,localized in the splice site of intron *** analyses revealed that neither aberrant PNPLA2 mRNA isoforms,nor ATGL mutated protein were detectable in patient’s ***,both patients presented early onset muscle weakness,in particular of proximal upper limb *** almost 15 years,muscle damage affected also distal upper *** is a NLSDM family,displaying a severe PNPLA2 mutation in two siblings with clinical presentation characterized by an early onset,but a slowly evolution of severe myopathy.

关键词： Cardiomyopathy Lipid metabolism Neutral lipid storage disease with myopathy PNPLA2 Splicing mutation Triglyceride lipase

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A mechanistically interpretable model of the retinal neural code for natural scenes with multiscale adaptive dynamics 55

A mechanistically interpretable model of the retinal neural ...

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55th Asilomar Conference on Signals, Systems and Computers, ACSSC 2021

作者： Ding, Xuehao Lee, Dongsoo Grant, Satchel Stein, Heike McIntosh, Lane Maheswaranathan, Niru Baccus, Stephen Stanford University Department of Applied Physics Stanford United States Stanford University Neurosciences PhD Program Stanford United States Stanford University Department of Psychology Stanford United States University of Barcelona August Pi i Sunyer Biomedical Research Institute Barcelona Spain Stanford University Neurobiology Department Stanford United States

ISBN: (纸本)9781665458283

The visual system processes stimuli over a wide range of spatiotemporal scales, with individual neurons receiving input from tens of thousands of neurons whose dynamics range from milliseconds to tens of seconds. This poses a challenge to create models that both accurately capture visual computations and are mechanistically interpretable. Here we present a model of salamander retinal ganglion cell spiking responses recorded with a multielectrode array that captures natural scene responses and slow adaptive dynamics. The model consists of a three-layer convolutional neural network (CNN) modified to include local recurrent synaptic dynamics taken from a linear-nonlinear-kinetic (LNK) model [1]. We presented alternating natural scenes and uniform field white noise stimuli designed to engage slow contrast adaptation. To overcome difficulties fitting slow and fast dynamics together, we first optimized all fast spatiotemporal parameters, then separately optimized recurrent slow synaptic parameters. The resulting full model reproduces a wide range of retinal computations and is mechanistically interpretable, having internal units that correspond to retinal interneurons with biophysically modeled synapses. This model allows us to study the contribution of model units to any retinal computation, and examine how long-term adaptation changes the retinal neural code for natural scenes through selective adaptation of retinal pathways. © 2021 IEEE.

关键词： Dynamics

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No Best Prize, But a Better Way: Exploring the Primary Prevention Application of Rewards in School-Wide Positive Behavior Support (SWPBS) programs

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Bulletin of Educational psychology 2024年第1期56卷 25-44页

作者： Yu, Yi-Jen Karen Huang, Shih-Tseng Tina Shyi, Gary Chon-Wen Gong, Shu-Ping PhD Program in Cognitive Sciences National Chung Cheng University Taiwan Department of Psychology National Chung Cheng University Taiwan Department of Foreign Languages National Chiayi University Taiwan

A variety of behavioral measures have been adopted and demonstrated to affect students’ academic performance and learning behaviors in educational settings. Among them, verbal praise has been deemed as the dominant and effective type of reinforcement in the literature, whereas tangible rewards have been regarded as the controversial type compared to verbal praise. After reviewing the evidence of tangible rewards for their positive behavioral impact, we propose the alternative of combined deployment of the two most widely used forms of reward and argue how the combined use might yield even greater synergetic outcomes. Specifically, we suggest four guidelines to follow and set up the tangible reward as the external goal for students to achieve and the verbal praise as the connector between the external goal, their inner motivation, and effort. These not only provide a goal to strive for and enhance inner confidence, but also empower students to feel that their future is determined by themselves. Several possible advantages could arise from such deployment of combined rewards. Not only the combined rewards might take less time to produce their joint effects, but better support proper behaviors. In addition to providing another model to get praise, the combined rewards could offer greater feasibility in dealing with children’s serious problems in educational settings. These suggestions may provide frontline teachers with strategies to promote more effective primary prevention of students’ positive behaviors. © 2024, National Taiwan Normal University. All rights reserved.

关键词： primary preventi tangible rewards the effect of combination verbal praise for effort

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Barriers and Facilitators to Peer-Supported Implementation of Mental Health Mobile Applications with Veterans in Primary Care

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Journal of Technology in Behavioral Science 2022年第1期7卷 1-12页

作者： Montena, Alexandra L. Possemato, Kyle Kuhn, Eric Carlson, Eve B. McGovern, Mark Smith, Jennifer Blonigen, Daniel Clinical Psychology PhD Program Palo Alto University Palo Alto CA United States VA Center for Integrated Health Syracuse VA Medical Center Syracuse NY United States National Center for PTSD Dissemination and Training Division VA Palo Alto Health Care System Palo Alto CA United States Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine Stanford CA United States Center for Innovation to Implementation VA Palo Alto Health Care System Menlo Park CA United States Department of Medicine Stanford University School of Medicine Stanford CA United States

Mental health disorders are highly prevalent among veterans in primary care, yet most of these patients do not receive adequate treatment due to provider time constraints, patient travel costs, and stigma associated with mental health care. Mobile health (mHealth) can overcome these impediments to care access;however, poor patient engagement with mHealth limits its routine implementation. Peer specialists may increase patient engagement with mHealth by offering supportive accountability and support through shared experiences. This study sought to identify barriers and facilitators of peer-supported mHealth implementation with veteran primary care patients. Qualitative interviews, guided by the Consolidated Framework of Implementation Research ([CFIR] Damschroder et al., 2009), were conducted with 28 key informants (17 peer specialists and 11 primary care providers) from 14 sites participating in a Department of Veterans Affairs national evaluation of peers in primary care. Thematic analysis was used to identify CFIR determinants to peer-supported mHealth implementation. CFIR barrier domains included Inner Setting (e.g., lack of implementation infrastructure, limited peer training on mHealth, and ineffective promotion of mHealth) and Characteristics of Individuals (e.g., lack of knowledge of the peer role and limited tech literacy). CFIR facilitator domains comprised Intervention Characteristics (e.g., strong support for peers in this role), Characteristics of Individuals (e.g., role alignment with a holistic care approach), and Outer Setting (e.g., emphasizing app benefits, the importance of app demonstrations, and follow-up encounters). The findings inform the development of a strategy for implementing peer-supported mental health mobile apps with veterans in primary care. © 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature.

关键词： Mental health Mobile health Peer specialists Primary care Veteran health administration

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Harmonized cognitive performance in an older adult cohort of Vietnamese American immigrants: The VIP study

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Alzheimer's and Dementia 2025年第5期21卷 e70097页

作者： Gavett, Brandon E. Tomaszewski Farias, Sarah Tiet, Quyen Q. Park, Van T. Harvey, Danielle Vuong, Quyen Hinton, Ladson Kanaya, Alka M. Whitmer, Rachel A. Mai, Lauren Meyer, Oanh L. Department of Neurology University of California Davis School of Medicine Sacramento CA United States Clinical Psychology PhD Program California School of Professional Psychology at Alliant International University Emeryville CA United States National Center for PTSD Dissemination and Training Division VA Palo Alto Health Care System Menlo Park CA United States Department of Medicine University of California San Francisco San Francisco CA United States International Children Assistance Network (ICAN) Milpitas CA United States Zuckerberg San Francisco General Hospital and Trauma Center San Francisco CA United States

INTRODUCTION: Vietnamese Americans represent an understudied population with unique risk factors relevant to cognitive aging. The current study sought to model global cognition in the Vietnamese Insights into Cognitive Aging program (VIP) study and harmonize ability estimates with the National Alzheimer's Coordinating Center (NACC) Uniform Data Set. METHODS: Cognitive data from VIP (N = 548) and NACC (N = 15,923) were analyzed using item response theory. Seven common items were assessed for differential item functioning (DIF);items without salient DIF were used to harmonize the cognitive composite score across the two cohorts. RESULTS: Although five of the seven common items showed evidence of DIF, the magnitude of this DIF was negligible, affecting the factor score estimates of only 12 (2.19%) VIP participants by more than one standard error. DISCUSSION: Global cognitive functioning can be estimated in Vietnamese American immigrants with minimal bias and psychometrically matched to one of the largest studies of cognitive aging and dementia worldwide. Highlights: This is the first known study to model cognition in older Vietnamese Americans. Global cognition was harmonized with minimal bias across two diverse cohorts. Differential item functioning was found in five of seven items, but the impact was not salient. Results create new opportunities to study health disparities in an underrepresented group. © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

关键词： aging cognition cultural diversity item response theory neuropsychological tests

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