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Psychiatric Research and Clinical Practice 2025年第0期

作者： Guillen-Burgos, Hernan F. Gálvez-Flórez, Juan F. Moreno-López, Sergio Wong, Sabrina Kwan, Angela T. H. Ramirez-Posada, Mariana Anaya, Juan-Manuel McIntyre, Roger S. Centro de Investigaciones en Ciencias de la Vida Universidad Simón Bolívar Center for Clinical and Translational Research Barranquilla Colombia Faculty of Medicine Universidad El Bosque Center for Clinical and Translational Research Bogotá Colombia Department of Psychiatry and Mental Health Pontificia Universidad Javeriana PhD Program in Neuroscience Hospital Universitario San Ignacio Bogota Colombia Universidad El Bosque Bogotá Colombia Zerenia Clinic. Consultation - Liaison Psychiatric Unit Bogotá Colombia Faculty of Medicine Universidad de Los Andes Bogotá Colombia Mood Disorders Psychopharmacology Unit University Health Network Toronto ON Canada Department of Pharmacology and Toxicology University of Toronto Toronto ON Canada Brain and Cognition Discovery Foundation Toronto ON Canada Faculty of Medicine University of Ottawa Ottawa ON Canada Coosalud IPS Research and Innovation Center and Universidad de la Costa Barranquilla Colombia Department of Psychiatry and Pharmacology University of Toronto Toronto ON Canada

Objective: Major Depressive Disorder (MDD) is common in long COVID syndrome;however, the neurobiological mechanisms are unclear. An immune activation response has been associated with COVID-19 severity as well as in MDD. We hypothesize that high levels of pro-inflammatory cytokines during SARS-CoV-2 infection may be associated with new-onset MDD and severe outcomes such as treatment-resistant depression (TRD) and risk of suicide ideation and behavior (SI/SB). Methods: A case-control nested to a cohort study was carried out on a total of 678 COVID-19 survivors (MDD = 184 vs. non-MDD = 494). A pro-inflammatory panel of serum levels of cytokines (IL-1β, IL-4, IL-6, IL-8, IL-13, IL-17α, TNF-α) was evaluated during COVID-19 hospitalization and severe outcomes such as TRD and SI/SB were assessed in individuals with new onset of MDD after hospital discharge compared to non-MDD COVID-19 survivors. Results: High levels of pro-inflammatory cytokines during SARS-CoV-2 infection were identified in MDD participants compared to non-MDD subgroups during long COVID. These differences were sustained also for TRD and SI/SB severity outcomes. There is a mild association of high levels of pro-inflammatory cytokines and MDD, TRD, and SI/SB. Conclusion: High levels of pro-inflammatory cytokines during severe or critical COVID-19 exposure may explain long COVID associated MDD and thus severe outcomes such as TRD and SI/SB. Relevance to clinical practice: Identifying elevated pro-inflammatory cytokines during COVID-19 as a risk factor for MDD and severe outcomes underscores the need for early screening and targeted treatments in long COVID. Monitoring cytokine levels may help clinicians predict and manage TRD and SI/SB in this population, improving long-term psychiatric outcomes. © 2025 The Author(s). Psychiatric Research and Clinical Practice published by Wiley Periodicals LLC on behalf of American Psychiatric Association.

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Passive eye movements induced by electromagnetic force(EMF) in rats

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Zoological Research 2019年第3期40卷 211-218页

作者： Yue Yu Jun Huang Chun-Ming Zhang Tian-Wen Chen David S.Sandlin Shao-Xun Wang Alberto A.Arteaga Jerome Allison Yang Ou Susan Warren Paul May Hong Zhu Wu Zhou Departments of Otolaryngology and Communicative Sciences University of Mississippi Medical CenterJackson MS 39216USA Department of Otolaryngology First Affiliated HospitalShanxi Medical UniversityTaiyuan Shanxi 030001China MD/PhD Program University of Mississippi Medical CenterJackson MS 39216USA Pharmacology and Toxicology University of Mississippi Medical CenterJackson MS 39216.USA Neurobiology and Anatomical Sciences University of Mississippi Medical CenterJackson MS 39216USA Neurology University of Mississippi Medical CenterJackson MS 39216USA

Accurate information on eye position in the orbit is available from visual feedback,efference copy of the oculomotor commands and proprioceptive signals from the extraocular muscles (EOM).Whereas visual feedback and oculomotor commands have been extensively studied,central processing of EOM proprioceptive signals remains to be elucidated.A challenge to the field is to develop an approach to induce passive eye movements without physically contacting the eyes.A novel method was developed to generate passive eye movements in rats.A small rare-earth magnet disk (0.7 mm diameter,0.5 mm thickness) was attached to the surface of a rat's eyeball.A metal rod (5 mm diameter) wrapped with an electromagnetic (EM) coil was placed near the magnet (8-15 mm).By passing currents to the EM coil,electromagnetic force (EMF) was generated and acted upon the magnet and induced passive eye *** EMF induced well-defined passive eye movements,whose directions were dependent on current polarity and amplitudes and peak velocities were dependent on current intensity and *** velocities of the EMF-induced eye movements were linearly related to amplitudes,exhibiting main sequence relationships similar to that of saccades in awake rats and eye movements induced by electrical microstimulation of the abducens nucleus in anesthetized *** examination showed that repetitive EMF stimulations did not appear to result in damages in the EOM *** results validated the EMF approach as a novel tool to investigate EOM proprioceptive signals and their roles in visual localization and gaze control.

关键词： Eye movement Proprioception Extraocular muscles Stretch reflex

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Time moderates the interplay between 5-HTTLPR and stress on depression risk – Gene x environment interaction as dynamic process

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Neuroscience Applied 2022年 1卷

作者： C. Delli Colli M. Borgi S. Poggini F. Chiarotti F. Cirulli B.W.J.H. Penninx F. Benedetti B. Vai I. Branchi Sapienza University of Rome PhD program in Pharmacology and Toxicology- Department of Physiology and Pharmacology “Vittorio Erspamer” Roma Italy Istituto Superiore di Sanità Center for Behavioral Sciences and Mental Health Roma Italy Amsterdam UMC- Vrije Universiteit Department of Psychiatry Amsterdam Netherlands- The IRCCS San Raffaele Scientific Institute Psychiatry & Clinical Psychobiology- Division of Neuroscience Milano Italy

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OpenMM 8: Molecular Dynamics Simulation with Machine Learning Potentials

arXiv

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arXiv 2023年

作者： Eastman, Peter Galvelis, Raimondas Peláez, Raúl P. Abreu, Charlles R.A. Farr, Stephen E. Gallicchio, Emilio Gorenko, Anton Henry, Michael M. Hu, Frank Huang, Jing Krämer, Andreas Michel, Julien Mitchell, Joshua A. Pande, Vijay S. Rodrigues, João P.G.L.M. Rodriguez-Guerra, Jaime Simmonett, Andrew C. Singh, Sukrit Swails, Jason Turner, Philip Wang, Yuanqing Zhang, Ivy Chodera, John D. De Fabritiis, Gianni Markland, Thomas E. Department of Chemistry Stanford University StanfordCA94305 United States Acellera Labs C Dr Trueta 183 Barcelona08005 Spain C Dr. Aiguader 88 Barcelona08003 Spain Chemical Engineering Department School of Chemistry Federal University of Rio de Janeiro Rio de Janeiro68542 Brazil Redesign Science Inc. 180 Varick St. New YorkNY10014 United States EaStCHEM School of Chemistry University of Edinburgh EH9 3FJ United Kingdom Department of Chemistry and Biochemistry Brooklyn College The City University of New York NY United States Ph.D. Program in Chemistry Ph.D. Program in Biochemistry The Graduate Center of the City University of New York New YorkNY United States Stream HPC Koningin Wilhelminaplein 1 - 40601 Amsterdam1062 HG Netherlands Computational and Systems Biology Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New YorkNY10065 United States Key Laboratory of Structural Biology of Zhejiang Province School of Life Sciences Westlake University 18 Shilongshan Road Zhejiang Hangzhou310024 China Department of Mathematics and Computer Science Freie Universität Berlin Arnimallee 12 Berlin14195 Germany The Open Force Field Initiative Open Molecular Software Foundation DavisCA95616 United States Andreessen Horowitz 2865 Sand Hill Rd Menlo ParkCA94025 United States Department of Structural Biology Stanford University StanfordCA94305 United States Charité Universitätsmedizin Berlin In silico Toxicology and Structural Bioinformatics Virchowweg 6 Berlin10117 Germany Laboratory of Computational Biology National Heart Lung and Blood Institute National Institutes of Health BethesdaMD20892 United States Entos Inc. 9310 Athena Circle La Jolla CA92037 United States College of Engineering Virginia Polytechnic Institute State University BlacksburgVA24061 United States Simons Center for Computational Physical Chemistry Center for Data Science New York University 24 Waverly Place New YorkNY10004 United States T

Machine learning plays an important and growing role in molecular simulation. The newest version of the OpenMM molecular dynamics toolkit introduces new features to support the use of machine learning potentials. Arbitrary PyTorch models can be added to a simulation and used to compute forces and energy. A higher-level interface allows users to easily model their molecules of interest with general purpose, pretrained potential functions. A collection of optimized CUDA kernels and custom PyTorch operations greatly improves the speed of simulations. We demonstrate these features on simulations of cyclin-dependent kinase 8 (CDK8) and the green fluorescent protein (GFP) chromophore in water. Taken together, these features make it practical to use machine learning to improve the accuracy of simulations at only a modest increase in cost. Copyright © 2023, The Authors. All rights reserved.

关键词： Machine learning

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The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase

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Journal of Biomedical Science 2023年第1期30卷 68-68页

作者： Yang, Yi-Chieh Lin, Yung-Wei Lee, Wei-Jiunn Lai, Feng-Ru Ho, Kuo-Hao Chu, Chih-Ying Hua, Kuo-Tai Chen, Ji-Qing Tung, Min-Che Hsiao, Michael Wen, Yu-Ching Chien, Ming-Hsien Department of Medical Research Tungs’ Taichung MetroHarbor Hospital Taichung Taiwan Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 250 Wu Hsing Street Taipei 11031 Taiwan International Master/PhD Program in Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Urology Wan Fang Hospital Taipei Medical University 111 Section 3 Hsing Long Road Taipei 11696 Taiwan Department of Urology School of Medicine College of Medicine and TMU Research Center of Urology and Kidney (TMU-RCUK) Taipei Medical University Taipei Taiwan Department of Medical Education and Research Wan Fang Hospital Taipei Medical University Taipei Taiwan Graduate Institute of Toxicology College of Medicine National Taiwan University Taipei Taiwan Department of Cancer Biology Geisel School of Medicine at Dartmouth Lebanon NH United States Department of Surgery Tungs’ Taichung Metro Harbor Hospital Taichung Taiwan Genomics Research Center Academia Sinica Taipei Taiwan TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei Taiwan Pulmonary Research Center Wan Fang Hospital Taipei Medical University Taipei Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei Taiwan

Background: KH-type splicing regulatory protein (KHSRP, also called KSRP), a versatile RNA-binding protein, plays a critical role in various physiological and pathological conditions through modulating gene expressions at multiple levels. However, the role of KSRP in clear cell renal cell carcinoma (ccRCC) remains poorly understood. Methods: KSRP expression was detected by a ccRCC tissue microarray and evaluated by an in silico analysis. Cell loss-of-function and gain-of-function, colony-formation, anoikis, and transwell assays, and an orthotopic bioluminescent xenograft model were conducted to determine the functional role of KRSP in ccRCC progression. Micro (mi)RNA and complementary (c)DNA microarrays were used to identify downstream targets of KSRP. Western blotting, quantitative real-time polymerase chain reaction, and promoter- and 3-untranslated region (3'UTR)-luciferase reporter assays were employed to validate the underlying mechanisms of KSRP which aggravate progression of ccRCC. Results: Our results showed that dysregulated high levels of KSRP were correlated with advanced clinical stages, larger tumor sizes, recurrence, and poor prognoses of ccRCC. Neural precursor cell-expressed developmentally downregulated 4 like (NEDD4L) was identified as a novel target of KSRP, which can reverse the protumorigenic and prometastatic characteristics as well as epithelial-mesenchymal transition (EMT) promotion by KSRP in vitro and in vivo. Molecular studies revealed that KSRP can decrease NEDD4L messenger (m)RNA stability via inducing mir-629-5p upregulation and directly targeting the AU-rich elements (AREs) of the 3’UTR. Moreover, KSRP was shown to transcriptionally suppress NEDD4L via inducing the transcriptional repressor, Wilm's tumor 1 (WT1). In the clinic, ccRCC samples revealed a positive correlation between KSRP and mesenchymal-related genes, and patients expressing high KSRP and low NEDD4L had the worst prognoses. Conclusion: The current findings unveil novel m

关键词： ccRCC EMT KSRP NEDD4L Progression

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Facilitating Interdisciplinary Graduate Education: Barriers, Solutions, and Needed Innovations

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Change: The Magazine of Higher Learning 2018年第5期50卷 53-59页

作者： Meredith Welch-Devine Alana Shaw Julie Coffield Nik Heynen Meredith Welch-Devine is the Director of Interdisciplinary and Innovative Initiatives for the University of Georgia Graduate School. In addition to helping develop and administer interdisciplinary programs for the university she has a research interest in interdisciplinary team science and interdisciplinary training.http://***/0000-0001-8519-4585 Alana Shaw received her PhD from the University of Georgia in 2016 and is now the Environmental Coordinator for the Village of Wainwright. Shaw was a student in the interdisciplinary Integrative Conservation program. Julie Coffield recently returned to the faculty after serving as Associate Dean of the Graduate School. She also formerly directed the Interdisciplinary Toxicology Program at UGA. Nik Heynen is the immediate past director of the interdisciplinary Integrative Conservation program.

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关键词： INTERDISCIPLINARY education GRADUATE education HUMAN resources departments STUDENTS TRAINING

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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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TIPdb-3D: The three-dimensional structure database of phytochemicals from Taiwan indigenous plants

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Database 2014年第2014期2014卷 bau055页

作者： Tung, Chun-Wei Lin, Ying-Chi Chang, Hsun-Shuo Wang, Chia-Chi Chen, Ih-Sheng Jheng, Jhao-Liang Li, Jih-Heng School of Pharmacy Kaohsiung Medical University Kaohsiung 80708 Taiwan PhD Program in Toxicology Kaohsiung Medical University Kaohsiung 80708 Taiwan National Environmental Health Research Center National Health Research Institutes Miaoli County 35053 Taiwan

The rich indigenous and endemic plants in Taiwan serve as a resourceful bank for biologically active phytochemicals. Based on our TIPdb database curating bioactive phytochemicals from Taiwan indigenous plants, this study presents a three-dimensional (3D) chemical structure database named TIPdb-3D to support the discovery of novel pharmacologically active compounds. The Merck Molecular Force Field (MMFF94) was used to generate 3D structures of phytochemicals in TIPdb. The 3D structures could facilitate the analysis of 3D quantitative structure-activity relationship, the exploration of chemical space and the identification of potential pharmacologically active compounds using protein-ligand docking. © The Author(s) 2014.

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Factors determining changes in initial antiretroviral therapy

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Revista da Associação Médica Brasileira (English Edition) 2012年第2期58卷 222-228页

作者： Denise Girão Limaverde Lima Érico Antonio Gomes de Arruda Antonio Jorge Alves de Lima Bruna Esmeraldo Oliveira Marta Maria de França Fonteles Specialist in Hospital Pharmacy Public Health School of Ceará (ESP-CE) Pharmacist Hospital São José de Doenças Infecciosas Fortaleza CE Brazil PhD in Medical Sciences Universidade Federal do Ceará (UFC) Infectious Disease Specialist Hospital São José de Doenças Infecciosas Fortaleza CE Brazil MSc in Pathology Pharmacist Toxicology Laboratory Instituto Médico Legal Pharmacist Clinical Analysis Laboratory Dr. Perez Limardo Fortaleza CE Brazil Graduate in Pharmacy MSc Student in Pharmaceutical Sciences UFC Fortaleza CE Brazil Postdoctorate in Clinical Pharmacy Professor Specialization Program in Hospital Pharmacy ESP-CE and Postgraduate Program in Pharmaceutical Sciences UFC Fortaleza CE Brazil

Objective To investigate factors determining changes in initial antiretroviral therapy (ART) in patients attended to in an AIDS tertiary care hospital in Ceará, Brazil. Methods This descriptive and exploratory study used the analysis of request to initiate or change treatment forms in the year of 2008, and the changes in therapy were followed through the first year of treatment. Data were analyzed with SPSS and EpiInfo by using ANOVA and the exact test of the coefficient of contingency, with significance at p < 0.05. Results From 301 patients initiating ART, 22.1% (n = 68) needed a change in the first year. These patients were mostly males, aged 20 to 39 years; with only one ART changed needed in 86.8% of the cases (n = 59). Reports of two or three changes in regimen were observed. Zidovudine was the drug most often changed, followed by lopinavir/ritonavir and efavirenz. A significant association was found between changes in initial regimens and the report of adverse reactions (p < 0.001). Conclusion The main factor determining changes in the initial ART was an adverse reaction report. Most patients had one change in the initial ART over the first year of treatment. ART monitoring contributed to a better control of the specific drug therapy.

关键词： Acquired immunodeficiency syndrome highly active antiretroviral therapy drug toxicity

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Principles and Methods in toxicology

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International Journal of toxicology 2001年第5期20卷 333 - 335页

作者： Udayan M. Apte Kartik Shankar Vishal S. Vaidya Pallavi B. Limaye Sharmilee Sawant Doctoral Students Training program in Toxicology Harihara M. Mehendale PhD Professor and DeGree Chair in Toxicology Department of Toxicology College of Pharmacy The University of Louisiana at Monroe Monroe Louisiana USA

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