检索结果-内蒙古大学图书馆

TMET-35. UPREGULATION OF THE URIDINE SALVAGE PATHWAY IN MESENCHYMAL GLIOBLASTOMA STEM-LIKE CELLS

Neuro-Oncology 2024年第SUPPLEMENT_8期26卷 viii295–viii295页

作者： Baljinnyam, Tuvshintugs Sowers, Mark L Chang-Gu, Bruce Tang, Hui Herring, Jason L Zhang, Kangling Sowers, Lawrence C The University of Texas Medical Branch at Galveston Galveston USA Department of Pharmacology and Toxicology Galveston USA MD-PhD Combined Degree Program Galveston USA

Glioblastoma is a heterogenous tumor comprised of multiple molecular subtypes of cancer cells and cancer stem-like cells. Of particular importance are the cancer stem-like cell niche population as they are believed to be more resistant to existing therapies and re-seed the tumor following initial response to standard-of-care treatment. To better understand glioblastoma stem-like cells we completed an untargeted proteomic analysis of 35 patient derived glioblastoma stem cell lines. This revealed an increase in several important proteins involved in the uridine salvage pathway, in the mesenchymal subtype. A subset of these proteins, including ecto-5’-nucleotidase (NT5E/CD73), uridine phosphorylase (UPP1), phosphoglucomutase-2-like-1 (PGM2L1), nicotinamide phosphoribosyltransferase (NAMPT), and nicotinamide N-methyltransferase (NNMT), suggest an augmented pathway for utilization of UMP and uridine as a fuel source and to replenish NAD+. Uridine and UMP are present in human serum and are enriched in the tumor microenvironment, providing a sustainable resource to resupply the tumor. The upregulation of this pathway was validated in established cell lines and orthogonal patient-derived xenograft cell lines not included in the proteomics study. Further work is underway to selectively inhibit or exploit this pathway with small molecule inhibitors.

关键词：

来源：评论

学校读者我要写书评

暂无评论

The interaction between antidepressants and environment determines treatment outcome in a preclinical model of adolescence-onset depression

引用

Neuroscience Applied 2022年 1卷

作者： S. Poggini N. Ciano Albanese C. Barezzi C. Delli Colli I. Branchi Istituto Superiore di Sanità Center for Behavioral Sciences and Mental Health Rome Italy Sapienza University of Rome PhD program in Neurosciences Roma Italy Sapienza University of Rome PhD program in Pharmacology and Toxicology- Department of Physiology and Pharmacology “Vittorio Erspamer” Roma Italy

来源：评论

学校读者我要写书评

暂无评论

Factors determining changes in initial antiretroviral therapy

引用

Revista da Associação Médica Brasileira (English Edition) 2012年第2期58卷 222-228页

作者： Denise Girão Limaverde Lima Érico Antonio Gomes de Arruda Antonio Jorge Alves de Lima Bruna Esmeraldo Oliveira Marta Maria de França Fonteles Specialist in Hospital Pharmacy Public Health School of Ceará (ESP-CE) Pharmacist Hospital São José de Doenças Infecciosas Fortaleza CE Brazil PhD in Medical Sciences Universidade Federal do Ceará (UFC) Infectious Disease Specialist Hospital São José de Doenças Infecciosas Fortaleza CE Brazil MSc in Pathology Pharmacist Toxicology Laboratory Instituto Médico Legal Pharmacist Clinical Analysis Laboratory Dr. Perez Limardo Fortaleza CE Brazil Graduate in Pharmacy MSc Student in Pharmaceutical Sciences UFC Fortaleza CE Brazil Postdoctorate in Clinical Pharmacy Professor Specialization Program in Hospital Pharmacy ESP-CE and Postgraduate Program in Pharmaceutical Sciences UFC Fortaleza CE Brazil

Objective To investigate factors determining changes in initial antiretroviral therapy (ART) in patients attended to in an AIDS tertiary care hospital in Ceará, Brazil. Methods This descriptive and exploratory study used the analysis of request to initiate or change treatment forms in the year of 2008, and the changes in therapy were followed through the first year of treatment. Data were analyzed with SPSS and EpiInfo by using ANOVA and the exact test of the coefficient of contingency, with significance at p < 0.05. Results From 301 patients initiating ART, 22.1% (n = 68) needed a change in the first year. These patients were mostly males, aged 20 to 39 years; with only one ART changed needed in 86.8% of the cases (n = 59). Reports of two or three changes in regimen were observed. Zidovudine was the drug most often changed, followed by lopinavir/ritonavir and efavirenz. A significant association was found between changes in initial regimens and the report of adverse reactions (p < 0.001). Conclusion The main factor determining changes in the initial ART was an adverse reaction report. Most patients had one change in the initial ART over the first year of treatment. ART monitoring contributed to a better control of the specific drug therapy.

关键词： Acquired immunodeficiency syndrome highly active antiretroviral therapy drug toxicity

来源：评论

学校读者我要写书评

暂无评论

DDDR-31. THE CHEMOTHERAPEUTIC ACTIVITY OF TEMOZOLOMIDE IS ANTAGONIZED BY ITS HYDROLYSIS PRODUCT, AIC

引用

Neuro-Oncology 2024年第SUPPLEMENT_8期26卷 viii132–viii132页

作者： Sowers, Mark L Baljinnyam, Tuvshintugs Tang, Hui Herring, Jason L Hatch, Sandra Valdes, Pablo Zhang, Kangling Sowers, Lawrence C University of Texas Medical Branch at Galveston Galveston USA MD-PhD Combined Degree Program Galveston USA Department of Pharmacology and Toxicology Galveston USA Department of Radiation Oncology Galveston USA Department of Neurosurgery Galveston USA

Temozolomide is the only FDA-approved drug that has demonstrated improved overall survival in patients with Glioblastoma. Despite the clinical impact it has had, overall survival today largely remains less than two years with current standard-of-care. Temozolomide is a prodrug that undergoes hydrolysis releasing 5-amino-4-imidazole carboxamide (AIC) before it can alkylate DNA. The DNA damage response invoked by TMZ depletes NAD+ levels. We present evidence from mass spectrometry LC-MS/MS studies that AIC released from TMZ can be aberrantly incorporated into the purine synthesis pathway, augmenting purine, and NAD+ synthesis and contributing to chemo- and radiation- resistance. The chemotherapeutic efficacy is therefore antagonized by its own hydrolysis product. TMZ analogs that do not generate AIC will likely have greater activity.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Network analysis of stress response vulnerability in a mouse model of major depressive disorder

引用

Neuroscience Applied 2024年 3卷

作者： A. Viglione C. Delli Colli F. Marsili S. Poggini T.M. Milewki K.M. Mahach V. Manzi A. Poleggi J.P. Curley I. Branchi Istituto Superiore di Sanità Center for Behavioral Sciences and Mental Health Rome Italy Sapienza University of Rome PhD program in Pharmacology and Toxicology Rome Italy University of Texas at Austin Psychology Department Austin United States Istituto Superiore di Sanità Department of Cell Biology and Neuroscience Rome Italy

来源：评论

学校读者我要写书评

暂无评论

Time moderates the interplay between 5-HTTLPR and stress on depression risk – Gene x environment interaction as dynamic process

引用

Neuroscience Applied 2022年 1卷

作者： C. Delli Colli M. Borgi S. Poggini F. Chiarotti F. Cirulli B.W.J.H. Penninx F. Benedetti B. Vai I. Branchi Sapienza University of Rome PhD program in Pharmacology and Toxicology- Department of Physiology and Pharmacology “Vittorio Erspamer” Roma Italy Istituto Superiore di Sanità Center for Behavioral Sciences and Mental Health Roma Italy Amsterdam UMC- Vrije Universiteit Department of Psychiatry Amsterdam Netherlands- The IRCCS San Raffaele Scientific Institute Psychiatry & Clinical Psychobiology- Division of Neuroscience Milano Italy

来源：评论

学校读者我要写书评

暂无评论

Chemical characterization, neuroprotective effect, and in-silico evaluation of the petroleum ether extract of three palm tree species against glutamate-induced excitotoxicity in rats

引用

Heliyon 2024年第20期10卷 e39207页

作者： Moharram, Fatma A. Hamed, Fadila M. El-Sayed, Elsayed K. Mohamed, Shimaa K. Ahmed, Asmaa A. Elgayed, Sabah H. Abdelrazek, Mohammed Lai, Kuei-Hung Mansour, Yara E. Mady, Mohamed S. Elsayed, Heba E. Department of Pharmacognosy Faculty of Pharmacy Helwan University Ein Helwan Cairo 11795 Egypt Department of Pharmacognosy Faculty of Pharmacy October 6 University 6th of October City Giza 12585 Egypt Department of Pharmacology and Toxicology Faculty of Pharmacy Helwan University Ein Helwan Cairo 11795 Egypt Department of Pharmacognosy Faculty of Pharmacy Cairo University Cairo 11562 Egypt Department of Cytology and Histology Faculty of Veterinary Medicine Cairo University Egypt Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei 11031 Taiwan PhD Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei 11031 Taiwan Pharmaceutical Organic Chemistry Department Faculty of Pharmacy Helwan University Ein Helwan Cairo 11795 Egypt

The burden of neurological disorders is growing substantially with limited therapeutic options, urging the consideration and assessment of alternative strategies. In this regard, we aimed to elucidate the phytochemical profile of the petroleum ether extract (PEE) of three palm tree species: Aiphanes eggersii Burret, Carpoxylon macrospermum H. Wendl. & Drude, and Jubaeopsis caffra Becc. (Family Arecaceae), and to evaluate their neuroprotective effect in monosodium glutamate (MSG)-induced excitotoxicity model for the first time. We identified a total of 48, 18, and 45 compounds in A. eggersii, C. macrospermum, and J. caffra, constituting 79.41 %, 60.45 %, and 76.35 % of the total detected compounds, respectively. A. eggersii extract was rich in the methyl esters of fatty acids (65.08 %) especially methyl dodecanoate (17.72 %). C. macrospermum was exclusively prolific by the triterpene 3β-methoxy-d:c-friedo-b’:a'-neogammacer-9(11)-ene (40.36 %), while J. caffra was noticeable by hydrocarbons (30.14 %) and lupeol derivatives (19.79 %). The biochemical and histopathological analysis showed that the tested extracts significantly reduced the oxidative stress, especially at the highest tested dose (1000 mg/kg). The extracts also reduced the activity of induced nitric oxide synthetase, Ca⁺² level, and NR2B subunit expression and attenuated apoptosis and DNA damage. The docking results show that most active natural compounds bind to SOD-1 and NR2B-NMDARs, verifying the credibility of the biological findings. To sum up, the PEE of the three investigated palm tree species possessed a unique blend of lipophilic bioactive constituents that exert promising neuroprotective potential against MSG-induced excitoneurotoxicity. However, further preclinical investigation and pharmaceutical formulation are needed. © 2024 The Author(s)

关键词： Arecaceae Docking Excitotoxicity Monosodium glutamate Neuroprotective Palm trees

来源：评论

学校读者我要写书评

暂无评论

OpenMM 8: Molecular Dynamics Simulation with Machine Learning Potentials

arXiv

引用

arXiv 2023年

作者： Eastman, Peter Galvelis, Raimondas Peláez, Raúl P. Abreu, Charlles R.A. Farr, Stephen E. Gallicchio, Emilio Gorenko, Anton Henry, Michael M. Hu, Frank Huang, Jing Krämer, Andreas Michel, Julien Mitchell, Joshua A. Pande, Vijay S. Rodrigues, João P.G.L.M. Rodriguez-Guerra, Jaime Simmonett, Andrew C. Singh, Sukrit Swails, Jason Turner, Philip Wang, Yuanqing Zhang, Ivy Chodera, John D. De Fabritiis, Gianni Markland, Thomas E. Department of Chemistry Stanford University StanfordCA94305 United States Acellera Labs C Dr Trueta 183 Barcelona08005 Spain C Dr. Aiguader 88 Barcelona08003 Spain Chemical Engineering Department School of Chemistry Federal University of Rio de Janeiro Rio de Janeiro68542 Brazil Redesign Science Inc. 180 Varick St. New YorkNY10014 United States EaStCHEM School of Chemistry University of Edinburgh EH9 3FJ United Kingdom Department of Chemistry and Biochemistry Brooklyn College The City University of New York NY United States Ph.D. Program in Chemistry Ph.D. Program in Biochemistry The Graduate Center of the City University of New York New YorkNY United States Stream HPC Koningin Wilhelminaplein 1 - 40601 Amsterdam1062 HG Netherlands Computational and Systems Biology Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New YorkNY10065 United States Key Laboratory of Structural Biology of Zhejiang Province School of Life Sciences Westlake University 18 Shilongshan Road Zhejiang Hangzhou310024 China Department of Mathematics and Computer Science Freie Universität Berlin Arnimallee 12 Berlin14195 Germany The Open Force Field Initiative Open Molecular Software Foundation DavisCA95616 United States Andreessen Horowitz 2865 Sand Hill Rd Menlo ParkCA94025 United States Department of Structural Biology Stanford University StanfordCA94305 United States Charité Universitätsmedizin Berlin In silico Toxicology and Structural Bioinformatics Virchowweg 6 Berlin10117 Germany Laboratory of Computational Biology National Heart Lung and Blood Institute National Institutes of Health BethesdaMD20892 United States Entos Inc. 9310 Athena Circle La Jolla CA92037 United States College of Engineering Virginia Polytechnic Institute State University BlacksburgVA24061 United States Simons Center for Computational Physical Chemistry Center for Data Science New York University 24 Waverly Place New YorkNY10004 United States T

Machine learning plays an important and growing role in molecular simulation. The newest version of the OpenMM molecular dynamics toolkit introduces new features to support the use of machine learning potentials. Arbitrary PyTorch models can be added to a simulation and used to compute forces and energy. A higher-level interface allows users to easily model their molecules of interest with general purpose, pretrained potential functions. A collection of optimized CUDA kernels and custom PyTorch operations greatly improves the speed of simulations. We demonstrate these features on simulations of cyclin-dependent kinase 8 (CDK8) and the green fluorescent protein (GFP) chromophore in water. Taken together, these features make it practical to use machine learning to improve the accuracy of simulations at only a modest increase in cost. Copyright © 2023, The Authors. All rights reserved.

关键词： Machine learning

来源：评论

学校读者我要写书评

暂无评论

The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase

引用

Journal of Biomedical Science 2023年第1期30卷 68-68页

作者： Yang, Yi-Chieh Lin, Yung-Wei Lee, Wei-Jiunn Lai, Feng-Ru Ho, Kuo-Hao Chu, Chih-Ying Hua, Kuo-Tai Chen, Ji-Qing Tung, Min-Che Hsiao, Michael Wen, Yu-Ching Chien, Ming-Hsien Department of Medical Research Tungs’ Taichung MetroHarbor Hospital Taichung Taiwan Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 250 Wu Hsing Street Taipei 11031 Taiwan International Master/PhD Program in Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Urology Wan Fang Hospital Taipei Medical University 111 Section 3 Hsing Long Road Taipei 11696 Taiwan Department of Urology School of Medicine College of Medicine and TMU Research Center of Urology and Kidney (TMU-RCUK) Taipei Medical University Taipei Taiwan Department of Medical Education and Research Wan Fang Hospital Taipei Medical University Taipei Taiwan Graduate Institute of Toxicology College of Medicine National Taiwan University Taipei Taiwan Department of Cancer Biology Geisel School of Medicine at Dartmouth Lebanon NH United States Department of Surgery Tungs’ Taichung Metro Harbor Hospital Taichung Taiwan Genomics Research Center Academia Sinica Taipei Taiwan TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei Taiwan Pulmonary Research Center Wan Fang Hospital Taipei Medical University Taipei Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei Taiwan

Background: KH-type splicing regulatory protein (KHSRP, also called KSRP), a versatile RNA-binding protein, plays a critical role in various physiological and pathological conditions through modulating gene expressions at multiple levels. However, the role of KSRP in clear cell renal cell carcinoma (ccRCC) remains poorly understood. Methods: KSRP expression was detected by a ccRCC tissue microarray and evaluated by an in silico analysis. Cell loss-of-function and gain-of-function, colony-formation, anoikis, and transwell assays, and an orthotopic bioluminescent xenograft model were conducted to determine the functional role of KRSP in ccRCC progression. Micro (mi)RNA and complementary (c)DNA microarrays were used to identify downstream targets of KSRP. Western blotting, quantitative real-time polymerase chain reaction, and promoter- and 3-untranslated region (3'UTR)-luciferase reporter assays were employed to validate the underlying mechanisms of KSRP which aggravate progression of ccRCC. Results: Our results showed that dysregulated high levels of KSRP were correlated with advanced clinical stages, larger tumor sizes, recurrence, and poor prognoses of ccRCC. Neural precursor cell-expressed developmentally downregulated 4 like (NEDD4L) was identified as a novel target of KSRP, which can reverse the protumorigenic and prometastatic characteristics as well as epithelial-mesenchymal transition (EMT) promotion by KSRP in vitro and in vivo. Molecular studies revealed that KSRP can decrease NEDD4L messenger (m)RNA stability via inducing mir-629-5p upregulation and directly targeting the AU-rich elements (AREs) of the 3’UTR. Moreover, KSRP was shown to transcriptionally suppress NEDD4L via inducing the transcriptional repressor, Wilm's tumor 1 (WT1). In the clinic, ccRCC samples revealed a positive correlation between KSRP and mesenchymal-related genes, and patients expressing high KSRP and low NEDD4L had the worst prognoses. Conclusion: The current findings unveil novel m

关键词： ccRCC EMT KSRP NEDD4L Progression

来源：评论

学校读者我要写书评

暂无评论

Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

引用

The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：