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检索条件"机构=PhD Program of Aging"
257 条 记 录,以下是1-10 订阅
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In Situ Labeling of Pathogenic Tau Using Photo-Affinity Chemical Probes
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ACS CHEMICAL BIOLOGY 2025年 第3期20卷 581-591页
作者: Nie, Pengju Wu, You Robinson, John Mekala, Shekar Lee, Virginia M. Y. Li, Yue-Ming Mem Sloan Kettering Canc Ctr Chem Biol Program New York NY 10065 USA Mem Sloan Kettering Canc Ctr Triinst PhD Program Chem Biol New York NY 10065 USA Univ Penn Inst Aging Dept Pathol & Lab Med Philadelphia PA 19104 USA Univ Penn Ctr Neurodegenerat Dis Res Perelman Sch Med Philadelphia PA 19104 USA
Tau aggregation plays a crucial role in the development of Alzheimer's disease (AD). Developing specific techniques that can isolate pathogenic tau from brain tissue is important for understanding tauopathies and ...
来源: 评论
A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains
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NATURE GENETICS 2023年 第12期55卷 2104-+页
作者: Sziraki, Andras Lu, Ziyu Lee, Jasper Banyai, Gabor Anderson, Sonya Abdulraouf, Abdulraouf Metzner, Eli Liao, Andrew Banfelder, Jason Epstein, Alexander Schaefer, Chloe Xu, Zihan Zhang, Zehao Gan, Li Nelson, Peter T. Zhou, Wei Cao, Junyue Rockefeller Univ Lab Single Cell Genom & Populat Dynam New York NY 10021 USA Rockefeller Univ David Rockefeller Grad Program Biosci New York NY 10021 USA Univ Kentucky Dept Pathol Lexington KY USA Univ Kentucky Sanders Brown Ctr Aging Lexington KY 40536 USA Triinst MD PhD Program New York NY USA Triinst PhD Program Computat Biol & Med New York NY USA Rockefeller Univ High Performance Comp Resource Ctr New York NY 10021 USA Weill Cornell Med Helen & Robert Appel Alzheimers Dis Res Inst New York NY USA
Conventional methods fall short in unraveling the dynamics of rare cell types related to aging and diseases. Here we introduce EasySci, an advanced single-cell combinatorial indexing strategy for exploring age-depende... 详细信息
来源: 评论
A Multidimensional Typology of Religiosity in Three-Generation Families
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PSYCHOLOGY OF RELIGION AND SPIRITUALITY 2024年 第2期16卷 142-150页
作者: Hwang, Woosang Yoon, Joonsik Brown, Maria T. Silverstein, Merril Syracuse Univ Aging Studies Inst 310A Lyman Hall Syracuse NY 13244 USA Syracuse Univ Social Sci PhD Program Syracuse NY 13244 USA Syracuse Univ Dept Human Dev & Family Sci Syracuse NY 13244 USA Syracuse Univ Dept Sociol Syracuse NY 13244 USA
There is broad consensus that religiosity is multidimensional in nature, but little is known regarding how religiosity profiles are similar or different across grandparent, parent, and grandchild generations. In this ... 详细信息
来源: 评论
Multidimensional sleep health is associated with physical frailty in a national sample of Taiwanese community-dwelling older adults: Sex matters
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SLEEP HEALTH 2022年 第5期8卷 528-535页
作者: Chen, Tuo-Yu Lee, Soomi Buxton, Orfeu M. Taipei Med Univ Coll Publ Hlth PhD Program Global Hlth & Hlth Secur Taipei City 110 Taiwan Univ S Florida Sch Aging Studies 4202 East Fowler AveMHC 1344 Tampa FL USA Penn State Univ Dept Biobehav Hlth University Pk PA USA Taipei Med Univ Coll Publ Hlth PhD Program Global Hlth & Hlth Secur 250 Wuxing St Taipei City 110 Taiwan
Objectives: Although individual sleep characteristics are related to frailty, these characteristics do not occur separately. A multidimensional measure of sleep might provide a better estimation of frailty compared to... 详细信息
来源: 评论
The mediating role of nurses' attitude towards reporting child abuse and neglect
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JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES 2024年 78卷 106-111页
作者: Zusman, Nurit Koton, Silvia Tabak, Nili Wruble, Anna C. Kienski Woloski Henrietta Szold Sch Nursing Hadassah Jerusalem Israel Hebrew Univ Jerusalem Fac Med Jerusalem Israel Henrietta Szold Hadassah Hebrew Univ Fac Med Sch Nursing Res HUJI Jerusalem Israel Tel Aviv Univ Herczeg Inst Aging Tel Aviv Israel Sackler Fac Med Sch Hlth Profess Dept Nursing PhD Program IL-6997801 Tel Aviv Israel Tel Aviv Univ Nursing Dept Tel Aviv Israel
Purpose: Attitudes towards reporting child abuse and neglect play a significant role in determining the tendency to report abuse and neglect. In addition, Cognitive Response Theory (Shen, 2020) suggests that individua... 详细信息
来源: 评论
Rationale and design of a randomized controlled trial evaluating the effects of blueberry consumption versus placebo on brain health in older adults
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CONTEMPORARY CLINICAL TRIALS 2025年 154卷 107926-107926页
作者: Uttke, Zachary Gabriel, Olivia Smith, Ceilidh Guardino, Eric T. Mukamal, Kenneth Djousse, Luc Greater Boston Med Student Aging Res Boston MA USA Brown Univ MD PhD Program Providence RI USA Univ Texas Hlth San Antonio STX MSTP San Antonio TX USA Brigham & Womens Hosp Boston MA USA Beth Israel Deaconess Med Ctr Boston MA USA Harvard Med Sch Boston MA USA Harvard TH Chan Sch Publ Hlth Boston MA USA
Background: Age-related cognitive decline results in significant clinical and public health costs. Cognitive decline predisposes individuals to dementia and leads to difficulties with activities of daily living and in... 详细信息
来源: 评论
Excitatory-inhibitory synaptic imbalance induced by acute intra-hippocampus injections of amyloid-β oligomers
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2025年 742卷 151133页
作者: Arriagada, Jorge Merceron, Daymara Ardiles, Alvaro Munoz, Pablo Paula-Lima, Andrea Univ Chile PhD Program Biomed Sci Santiago Chile Univ Valparaiso Ctr Translat Res Neuropharmacol CITNE Valparaiso Chile Univ Valparaiso Fac Med Med Sch Dept Pathol & Physiol Valparaiso Chile Univ Valparaiso Interuniv Ctr Hlth Aging CIES Valparaiso Chile Univ Chile Inst Res Dent Sci Fac Dent Santiago Chile Univ Chile Biomed Neurosci Inst BNI Fac Med Santiago Chile Univ Chile Fac Med Dept Neurosci Santiago Chile
Alzheimer's disease (AD) is characterized by the accumulation of soluble amyloid-beta oligomers (A beta Os) in the brain, which disrupt synaptic function and promote cognitive decline. Here, we investigated the ef... 详细信息
来源: 评论
Religiosity and Mental Health Among Young-Adults in Generation X from Emerging to Established Adulthood
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JOURNAL OF ADULT DEVELOPMENT 2023年 第1期30卷 108-117页
作者: Hwang, Woosang Cheng, Kent Jason Kim, Jeung Hyun Brown, Maria T. Vasilenko, Sara A. Silverstein, Merril Syracuse Univ Aging Studies Inst 307B Lyman Hall Syracuse NY 13244 USA Syracuse Univ Social Sci PhD Program Syracuse NY USA Syracuse Univ Dept Sociol Syracuse NY USA Syracuse Univ Sch Social Work Syracuse NY USA Syracuse Univ Dept Human Dev & Family Sci Syracuse NY USA
This investigation examined how religiosity in the period of life ranging from emerging to established adulthood is associated with mental health. To address this issue, we examined the relationship between multiple d... 详细信息
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Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT
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Cancer Gene Therapy 2024年 第6期31卷 807-815页
作者: Kuo, Ying-Yu Huo, Chieh Li, Chia-Yang Chuu, Chih-Pin Institute of Cellular and System Medicine National Health Research Institutes Miaoli County Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Medical Research Kaohsiung Medical University Kaohsiung Taiwan PhD Program for Aging and Graduate Institute of Basic Medical Science China Medical University Taichung City Taiwan Biotechnology Center National Chung Hsing University Taichung City Taiwan Department of Life Sciences National Central University Taoyuan City Taiwan
Androgen receptor (AR) splice variant 7 (AR-V7) is capable to enter nucleus and activate downstream signaling without ligand. AR-V7 assists the tumor growth, cancer metastasis, cancer stemness, and the evolvement of t... 详细信息
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Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine
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JOURNAL OF NEUROCHEMISTRY 2023年 第3期165卷 318-333页
作者: Gioia, Roberta Seri, Tommaso Diamanti, Tamara Fimmano, Stefania Vitale, Marina Ahlenius, Henrik Kokaia, Zaal Tirone, Felice Micheli, Laura Biagioni, Stefano Lupo, Giuseppe Rinaldi, Arianna De Jaco, Antonella Cacci, Emanuele Sapienza Univ Rome Dept Biol & Biotechnol Charles Darwin Rome Italy Sapienza Univ Rome PhD Program Behav Neurosci Rome Italy Lund Univ Fac Med Dept Clin Sci Lund Neurol Stem Cells Aging & Neur Lund Sweden Lund Stem Cell Ctr Lund Sweden Lund Univ Hosp Lund Stem Cell Ctr Dept Clin Sci Lund Sweden CNR Inst Biochem & Cell Biol Rome Italy Sapienza Univ Rome Ctr Res Neurobiol D Bovet Rome Italy
Neuron generation persists throughout life in the hippocampus but is altered in animal models of neurological and neuropsychiatric diseases, suggesting that disease-associated decline in cognitive and emotional hippoc...
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