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Heike *** Literary Sexology: Translations of Inversion, 1860–1930. Basingstoke, Hampshire: Palgrave Macmillan, 2009. 216 + xi pp. $75.00 (cloth). ISBN‐13 978‐0‐230‐22163‐5

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Journal of the History of the Behavioral sciences 2011年第2期47卷

作者： Howard H. Chiang PhD candidate Program in History of Science Princeton University Princeton NJ

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Simultaneous Identification for Synergistic Transcription Factors and their Transcription Factor Binding Sites

Simultaneous Identification for Synergistic Transcription Fa...

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International Conference on Complex, Intelligent and Software Intensive Systems, CISIS

作者： Zing Tsung-Yeh Tsai Grace Tzu-Wei Huang Huai-Kuang Tsai Institute of Information Science Academia Sinica Taipei Taiwan Institute of Biomedical Informatics National Yang-Ming University Taiwan Joint CMU-Pitt PhD Program in Computational Biology University of Pittsburgh Carnegie Mellon University Pittsburgh USA Computer Science and Engineering National Taiwan Ocean University Keelung Taiwan

Identifying transcription factor binding sites (TFBSs) is crucial for understanding the mechanism of transcriptional regulation. It is known that transcription factors (TFs) often cooperate to regulate genes. While traditional approaches can be used to discover binding motifs of a group of co-regulated genes, they often fail to accurately assign motifs to the corresponding TFs. Here, we consider two TFs together to infer their TFBSs and their synergistic relationship simultaneously. The basic idea is that if two TFs interact, their TFBSs, if distinct, would be conserved across species and coincided in the promoter regions of the genes they co-regulated. Applying our method to Saccharomyces cerevisiae chromatin immunoprecipitation data, we predicted 110 TF pairs with statistically significant motif assignments. A majority of these TF pairs have literature support to be synergistic, and the designated motifs to TFs match well with their known consensus. We further examined the synergism of predicted TF pairs in seven experimental conditions using ANOVA, and identified significant interactions.

关键词： Bioinformatics Analysis of variance DNA Databases Gene expression Proteins Stress

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Overweight and abdominal in adult population of Teresina, PI

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Revista da Associação Médica Brasileira (English Edition) 2011年第1期57卷 50-55页

作者： Lorena Guimarães Martins Holanda Maria do Carmo de Carvalho e Martins Manoel Dias de Souza Filho Cecília Maria Resende Gonçalves de Carvalho Regina Célia de Assis Lívia Maria Moura Leal Lorena Patrícia Leal Mesquita Emanuella Machado Costa M.D. from Universidade Federal do Piauí - UFPI Teresina PI Brazil PhD in Biological Sciences Professor of the Post-graduation Program on Food and Nutrition UFPI Professor of the Department of Biophysics and Professor of Faculdade NOVAFAPI Teresina PI Brazil M. Sc. in Sciences and Health Professor of UFPI – Campus Ministro Reis Veloso Parnaíba PI Brazil PhD in Nutrition Science from Universidade Estadual de Campinas Professor of the Post-Graduation Programme Food and Nutrition Department of UFPI Teresina PI Brazil PhD in Biochemistry from Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo – USP Professor of the Department of Biochemistry and Pharmacology of UFPI Teresina PI Brazil M. D. from UFPI Teresina PI Brazil

Objective To determine the prevalence of overweight and abdominal fat in the adult population in the urban area of Teresina, PI, Brazil. Methods This is a cross-sectional study with probability sampling by conglomerates. The study evaluated 464 adults, 20 to 59 years of age, living in the urban area of Teresina, PI, Brazil. Nutritional status was classified according to body mass index (BMI), and abdominal fat accumulation was estimated according to waist circumference. The significance level was set at 5% (p < 0.05). Results The prevalence of overweight and obesity according to nutritional status, based on BMI, was 30.0% and 7.7%, respectively. An increase in the proportion of overweight and obesity among men with progressively higher family income was observed. Higher rates of obesity were found among individuals 50 to 59 years of age with stable relationships and nonsmokers. An association between individual or family income and presence of abdominal fat was not observed in the population. Conclusion The prevalence of overweight in the study population follows the national trend. Proportions of overweight and obesity were higher among men and increased with age. Women and married individuals showed a greater tendency for abdominal obesity.

关键词： Overweight obesity body mass index waist-hip ratio

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Learning by collaboration in intelligent autonomous systems

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作者： Ierache, Jorge García-Martínez, Ramón De Giusti, Armando Computer Science PhD Program La Plata National University Buenos Aires University Argentina

ISBN: (纸本)3642152856

Very few learning systems applied to problem solving have focused on learning operator definitions from the interaction with a completely unknown environment. Autonomous Intelligent Systems (AIS) deal with that issue by means of architectures where learning is achieved by establishing plans, executing those plans in the environment, analyzing the results of the execution, and combining new evidence with prior evidence. This paper proposes a selective mechanism of learning allowing an AIS to learn new operators by receiving them from another AIS in a higher stage in the Learning Life Cycle (LLC) with more cycles of interaction in the environment. The proposed collaboration mechanism also considers how to deal with theory ponderation (operators ponderation) and how to include the new operators (provided for) in the set of theories of the receiver AIS. The experimental results show how using collaboration-based learning among AIS provides a better percentage of successful plans, plus an improved convergence rate, than the individual AIS alone. © 2010 IFIP.

关键词： Problem solving

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A proposal for consistency checking in dynamic software product line models using OCL

A proposal for consistency checking in dynamic software prod...

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International Conference on Software Engineering (ICSE)

作者： Fabiana G. Marinho Master and PhD Program in Computer Science Federal University of Ceará Fortaleza Ceara Brazil

Ubiquitous applications use context information to provide services and relevant information for their users. On the other hand, in Software Product Line approaches, commonality and variability of a system family should be identified and documented through variability modeling. Thus, one of the challenges to build Context-Aware Product Lines, called Dynamic Software Product Lines, is the consistent representation of context information that influences the variability model. This work proposes the use of UML profiles and OCL to formalize and represent variability and context concepts in a consistent manner.

关键词： Unified modeling language Context modeling Context Software Adaptation models Computational modeling Prototypes

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Do neighbourhood built and social environments have an influence on adult self-reported physical activity and overweight/obesity in the nation's capital?

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Canadian Journal of Diabetes 2011年第2期35卷 155-155页

作者： Prince, S.A. Kristjansson, E.A. Russell, K. Billette, J.-M. Ali, A. Sawada, M. Tremblay, M.S. Prud'homme, D. University of Ottawa Population Health PhD Program and Children's Hospital of Eastern Ontario Healthy Active Living and Obesity Research Group Ottawa Ontario Canada University of Ottawa Faculty of Social Sciences School of Psychology Ottawa Ontario Canada Ottawa Public Health Ottawa Ontario Canada Health Statistics Division Statistics Canada Ottawa Ontario Canada University of Ottawa Laboratory for Applied Geomatics and GIS Science (LAGGISS) Department of Geography Ottawa Ontario Canada Children's Hospital of Eastern Ontario Healthy Active Living and Obesity Research Group Ottawa Ontario Canada University of Ottawa Faculty of Health Sciences School of Human Kinetics Ottawa Ontario Canada

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Service Learning: Applications in Midwifery Education

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Journal of Midwifery & Women's Health 2010年第6期48卷

作者： Cindy L. Farley CNM, phd Cindy L. Farley CNM PhD is director of Greene Midwifery Care a full-scope midwifery practice located in Fairborn OH and is faculty in Philadelphia University's Master's of Science in Midwifery program.

Service learning is learning acquired through experiential education that deliberately links service to others with the goal of achieving specific academic objectives. Service learning is an educational innovation that encompasses a wide range of activities and pedagogies while maintaining a commitment to principles of service. Although midwifery is a profession rooted in service to women and their families, scant attention has been paid to the purposeful inclusion of service-learning experiences in midwifery curricula. This article describes service learning and discusses practical applications in midwifery education.

关键词： midwifery education service learning education research

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Optimized expected information gain for nonlinear dynamical systems 09

Optimized expected information gain for nonlinear dynamical ...

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26th International Conference On Machine Learning, ICML 2009

作者： Busetto, Alberto Giovanni Ong, Cheng Soon Buhmann, Joachim M. Department of Computer Science ETH Zurich Universitätstr. 6 8092 Zurich Switzerland Competence Center for Systems Physiology and Metabolic Diseases Schafmattst. 18 8093 Zurich Switzerland Life Science Zurich PhD Program on Systems Biology of Complex Diseases Switzerland

ISBN: (纸本)9781605585161

This paper addresses the problem of active model selection for nonlinear dynamical systems. We propose a novel learning approach that selects the most informative subset of time-dependent variables for the purpose of Bayesian model inference. The model selection criterion maximizes the expected Kullback-Leibler divergence between the prior and the posterior probabilities over the models. The proposed strategy generalizes the standard D-optimal design, which is obtained from a uniform prior with Gaussian noise. In addition, our approach allows us to determine an information halting criterion for model identification. We illustrate the benefits of our approach by differentiating between 18 published biochemical models of the TOR signaling pathway, a model selection problem in systems biology. By generating pivotal selection experiments, our strategy outperforms the standard A-optimal, D-optimal and E-optimal sequential design techniques.

关键词： Nonlinear dynamical systems

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REVIEW ARTICLE: Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury

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Journal of Pineal Research 2010年第3期49卷

作者： Yonggeun Hong K. J. Palaksha Kanghui Park Sookyoung Park Hyun-Dong Kim Russel J. Reiter Kyu-Tae Chang Cardiovascular & Metabolic Disease Center Department of Rehabilitation Science in Interdisciplinary PhD Program College of Biomedical Science & Engineering Inje University Gimhae National Primate Research Center (NPRC) Korea Research Institute of Bioscience and Biotechnology (KRIBB) Ochang Department of PM & R. (Physical Medicine and Rehabilitation) College of Medicine Inje University Busan Korea Department of Cellular & Structural Biology The UT Health Science Center San Antonio TX USA

Abstract: Spinal cord injury (SCI) is damage to the spinal cord caused by the trauma or disease that results in compromised or loss of body function. Subsequent to SCI in humans, many individuals have residual motor and sensory deficits that impair functional performance and quality of life. The available treatments for SCI are rehabilitation therapy, activity-based therapies, and pharmacological treatment using antioxidants and their agonists. Among pharmacological treatments, the most efficient and commonly used antioxidant for experimental SCI treatment is melatonin, an indolamine secreted by pineal gland at night. Melatonin’s receptor-independent free radical scavenging action and its broad-spectrum antioxidant activity makes it an ideal antioxidant to protect tissue from oxidative stress-induced secondary damage after SCI. Owing to the limitations of an activity-based therapy and antioxidant treatment singly on the functional recovery and oxidative stress-induced secondary damages after SCI, a melatonin plus exercise treatment may be a more effective therapy for SCI. As suggested herein, supplementation with melatonin in conjunction with exercise not only would improve the functional recovery by enhancing the beneficial effects of exercise but would reduce the secondary tissue damage simultaneously. Finally, melatonin may protect against exercise-induced fatigue and impairments. In this review, based on the documented evidence regarding the beneficial effects of melatonin, activity-based therapy and the combination of both on functional recovery, as well as reduction of secondary damage caused by oxidative stress after SCI, we suggest the melatonin combined with exercise would be a novel neurorehabilitative strategy for the faster recovery after SCI.

关键词： animal model exercise melatonin rehabilitation secondary/oxidative damage spinal cord injury

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知证卫生决策工具之五--使用证据拟订解决问题的方案

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中国循证医学杂志 2010年第3期10卷 269-275页

作者： John N Lavis Michael G Wilson Andrew D Oxman Jeremy Grimshaw Simon Lewin Atle Fretheim 李玲蒋兰慧王莉李幼平 Centre for Health Economics and Policy Analysis Department of Clinical Epidemiology and Biostatistics and Department of Political Science McMaster University 1200 Main St. West HSC-2D3 Hamilton ON Canada L8N 3Z5 Health Research Methodology PhD Program and Department of Clinical Epidemiology and Biostatistics 1200 Main St. West HSC-2D1 Area Hamilton ON Canada L8N 3Z5 Norwegian Knowledge Centre for the Health Services P.O. Box 7004 St. Olavs plass N 0130 Oslo Norway Clinical Epidemiology Program Ottawa Health Research Institute Administration Building Room 2-017 1053 Carling Ave. Ottawa ON Canada K1Y 4E9 Health Systems Research Unit Medical Research Council of South Africa Section for International Health Institute of General Practice and Community Medicine Faculty of Medicine University of Oslo Norway

决策者及其决策支持者可能会面临以下三种情况中的一种或多种,均需要他们评估拟订方案的成本和效果。这三种情况如下:①当做出决策后,决策者及其决策支持者需考虑如何使该方案的获益最大化、危害最小化、资金使用最优化。如果方案可能... 详细信息

决策者及其决策支持者可能会面临以下三种情况中的一种或多种,均需要他们评估拟订方案的成本和效果。这三种情况如下:①当做出决策后,决策者及其决策支持者需考虑如何使该方案的获益最大化、危害最小化、资金使用最优化。如果方案可能需要的成本及产生的效果都存在很大不确定性时,还需制定监测和评估计划;②决策过程中,决策者及其决策支持者需要对提交上来的方案进行评估;③决策尚未做出前,决策者及其决策支持者需开展确定方案、分析方案不同的成本和效果、寻找实施方案的最佳时机。上述情况下,研究证据,特别是有关利弊评估及成本分析方面的证据可帮助决策者及其决策支持者了解方案的可行性。本文将列出以下6个问题供那些为解决最优问题和评估项目成本和效果而需要理清政策和项目方案的人参考:①是否已有一套解决问题的合理方案?②哪些获益对受方案影响者重要;每种方案将会产生哪些获益?③哪些方案会严重影响受方案影响者;各种方案将产生哪些危害?④每种方案的当地成本是多少;是否有各种方案成本效果研究的当地证据?⑤执行任何一项"拿来方案"时应做出哪些相应的调整,其是否会改变方案的获益、危害和成本?⑥哪些利益相关者的哪些意见和经验可能影响方案的可接受性以及方案获益、危害和成本?

关键词：证据卫生决策成本分析工具利益相关者资金使用项目成本成本效果

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