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Analysis and optimization of mono parabolic leaf spring material using ANSYS

Materials Today: Proceedings 2020年 33卷 5757-5764页

作者： Pradip Kumar Chhabi Ram Matawale PhD Scholar Department of Mechanical Engineering Shri Rawatpura Sarkar University Raipur 492001 Chhattisgarh India Associate Professor Department of Mechanical Engineering Head Faculty of Engineering Shri Rawatpura Sarkar University Raipur 492001 Chhattisgarh India

This research paper describes the work carried out on a mono parabolic leaf spring of a mini loader truck (Tata Ace) with a GVW (gross vehicle weight) of 1550 kg. A leaf spring is simple form of spring, pervasively used for the suspension in automotives. In this paper analysis is done for leaf spring whose thickness varies from the centre to outer end in parabolic nature followed by mathematical equation of a parabola, hence it is named as parabolic leaf spring (PLS). The modeling and analysis of the leaf spring has done in CATIA V5 R20 and ANSYS 15. The finite element analysis of the leaf spring has been carried out by initially discretising the model and then applying the relevant boundary conditions under the static loading conditions. The results from FEA indicated that the red area close to shackle was undergoing maximum value of stress which may lead to failure of mono parabolic leaf spring. A comparison between the different materials of leaf spring has also been performed to study the influence of mechanical properties of different material of PLS, in order to find out the amount of maximum stress for different material. During the analysis of all the materials boundary condition and applied load are same.

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Development of label-free triboelectric nanosensors as screening platforms for anti-tumor drugs

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Nano Energy 2024年 125卷

作者： Cheng, Yu-Ying Ganguly, Anindita Cheng, Yi-Yun Ortiz, Christopher Llynard D. Pal, Arnab Shah, Pramod Kaswan, Kuldeep Yang, Lee-Wei Lin, Zong-Hong Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan Internet of Senses Research Center National Tsing Hua University Hsinchu30013 Taiwan Praexisio Taiwan Inc. New Taipei221425 Taiwan Institute of Bioinformatics and Structural Biology National Tsing Hua University Hsinchu300044 Taiwan Chemical Biology and Molecular Biophysics Program Taiwan International Graduate Program Institute of Biological Chemistry Academia Sinica Taipei115 Taiwan Department of Chemistry National Tsing Hua University Hsinchu300044 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu300044 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu300044 Taiwan Biomedical Artificial Intelligence PhD Program National Tsing Hua University Hsinchu300044 Taiwan Physics Division National Center for Theoretical Sciences Taipei Taiwan

This study introduces a general label-free drug screening platform with potential to support high-throughput drug screening for any protein target. Its innovation lies in quantifying the affinity of molecule-molecule interactions via voltage output variation, which achieves unprecedented selectivity and sensitivity. It combines computational analysis complemented by experimental substantiation with a solid-liquid triboelectric nanosensor. Owing to its high binding affinity, FKBP-rapamycin is used as a model system to demonstrate the platform's sensitivity. Subsequently, the research is extended to study drug interactions with an oncogenic protein ATG4B. The findings unveil the binding of S130 and Tioconazole to ATG4B, a critical cysteine protease involved in autophagy, while revealing that Dexamethasone does not bind ATG4B. This binding exerts a specific inhibitory effect on autophagic flux and triggers cancer cell apoptosis. The results support the previously verified inhibitory effects of these drugs and the effectiveness of a newly developed self-powered drug screening platform, leveraging the principles of solid-liquid contact electrification. This approach adeptly confronts enduring challenges in traditional drug development methods where biochemical assays need to be designed for each individual protein target or only time-consuming and concentration-demanding molecular interaction measurements were made available. © 2024 Elsevier Ltd

关键词： Nanosensors

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Microfluidic nanodevices for drug sensing and screening applications

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Biosensors and Bioelectronics 2023年 219卷 114783页

作者： Pal, Arnab Kaswan, Kuldeep Barman, Snigdha Roy Lin, Yu-Zih Chung, Jun-Hsuan Sharma, Manish Kumar Liu, Kuei-Lin Chen, Bo-Huan Wu, Chih-Cheng Lee, Sangmin Choi, Dongwhi Lin, Zong-Hong Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Chemistry National Tsing Hua University Hsinchu30013 Taiwan Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu30013 Taiwan Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Linkou Medical Center Taoyuan333 Taiwan Center of Quality Management National Taiwan University Hospital Hsinchu Branch Hsinchu30059 Taiwan College of Medicine National Taiwan University Taipei10051 Taiwan Institute of Cellular and System Medicine National Health Research Institute Zhunan 35053 Taiwan School of Mechanical Engineering Chung-Ang University Seoul06974 Korea Republic of Kyung Hee University Gyeonggi 17104 Korea Republic of

The outbreak of pandemics (e.g., severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 in 2019), influenza A viruses (H1N1 in 2009), etc.), and worldwide spike in the aging population have created unprecedented urgency for developing new drugs to improve disease treatment. As a result, extensive efforts have been made to design novel techniques for efficient drug monitoring and screening, which form the backbone of drug development. Compared to traditional techniques, microfluidics-based platforms have emerged as promising alternatives for high-throughput drug screening due to their inherent miniaturization characteristics, low sample consumption, integration, and compatibility with diverse analytical strategies. Moreover, the microfluidic-based models utilizing human cells to produce in-vitro biomimetics of the human body pave new ways to predict more accurate drug effects in humans. This review provides a comprehensive summary of different microfluidics-based drug sensing and screening strategies and briefly discusses their advantages. Most importantly, an in-depth outlook of the commonly used detection techniques integrated with microfluidic chips for highly sensitive drug screening is provided. Then, the influence of critical parameters such as sensing materials and microfluidic platform geometries on screening performance is summarized. This review also outlines the recent applications of microfluidic approaches for screening therapeutic and illicit drugs. Moreover, the current challenges and the future perspective of this research field is elaborately highlighted, which we believe will contribute immensely towards significant achievements in all aspects of drug development. © 2022 Elsevier B.V.

关键词： Microfluidics

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Facilitating light utilization and electron transfer of TiO2 nanotube arrays for catalyzing photoelectrochemical water reduction via acid etching and copper doping

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Materials Today Chemistry 2023年 34卷

作者： Hsu, Chuan-Chih Kubendhiran, Subbiramaniyan Lai, Jhih-Hong Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Hsiao, Yu-Cheng Wu, Yung-Fu Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 03 Ouagadougou Burkina Faso Gingen Technology Co. LTD Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan

Photoelectrochemical catalytic capability mainly relies on light absorption and charge transfer efficiency. TiO2 nanotube array (TNA) having suitable band edges and one-dimensional hollow structure is regarded as one of efficient photoelectrocatalysts toward water reduction. In this study, two strategies are firstly applied to modify TNA as the photocatalyst of water reduction. Ti foils are etched by acid to produce multiple light reflections planes for improving light absorption, and Cu is doped in TNA to enhance charge transfer efficiency. The optimal Cu-doped TNA electrode on the acid-etched Ti foil presents a much smaller overpotential of 91 mV at 10 mA/cm2 compared with that of the undoped TNA (524 mV). A smaller Tafel slope of 134 mV/dec is obtained for the optimal Cu-doped TNA electrode than that of the undoped TNA (167 mV/dec). After measuring the photoelectrochemical performance for 1000 cycles, overpotential and charge-transfer resistance of modified TNA are largely reduced owing to activation. Current retention of 96.7% is achieved after continuously illuminating for 10 h. Highly improved photoelectrochemical catalytic ability of TNA modified by acid etching and Cu doping provides new pages for material modifications on substrate and active material. © 2023 Elsevier Ltd

关键词： Light absorption

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Construction of dual Z-scheme Ag3VO4–BiVO4/InVO4 photocatalysts using vanadium source from spent catalysts for contaminated water treatment and bacterial inactivation

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Chemosphere 2024年 363卷 142746页

作者： Lee, Kuen-Chan Hsu, Shih-Chieh Huang, Jen-Hsien Wang, Kuan-Syun Pang, Wei Kong Hu, Chih-Wei Jiang, Yi-Jhen Cho, Er-Chieh Weng, Huei Chu Liu, Ting-Yu Department of Science Education National Taipei University of Education No. 134 Sec. 2 Heping E. Road Da-an District Taipei City106 Taiwan PhD Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University 250 Wuxing Street Taipei City110 Taiwan Department of Chemical and Materials Engineering Tamkang University No. 151 Yingzhuan Road Tamsui District New Taipei City25137 Taiwan Department of Green Material Technology Green Technology Research Institute CPC Corporation No.2 Zuonan Rd. Nanzi District Kaohsiung City81126 Taiwan Department of Materials Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Faculty of Engineering Institute for Superconducting & Electronic Materials University of Wollongong WollongongNSW Australia National Synchrotron Radiation Research Center 101 Hsin-Ann Road Hsinchu Science Park Hsinchu30076 Taiwan School of Pharmacy College of Pharmacy Taipei Medical University 250 Wuxing Street Taipei City110 Taiwan Department of Mechanical Engineering Chung Yuan Christian University No. 200 Chungpei Road Chungli District Taoyuan City32023 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan City32003 Taiwan College of Engineering & Center for Sustainability and Energy Technologies Chang Gung University Taoyuan33302 Taiwan

Vanadate-based photocatalysts have recently attracted substantial attention owing to their outstanding photocatalytic activity for degrading organic pollutants and generating energy via photocatalytic processes. However, the relatively high price of vanadium has hindered the development of vanadate-based photocatalysts for various applications. Spent catalysts obtained from oil refineries typically contain a significant quantity of vanadium, making them valuable for recovery and utilization as precursors for the production of high-value-added photocatalysts. In this study, we transformed the V present in spent catalysts produced by the petrochemical industry into ternary vanadate-based photocatalysts [BiVO4/InVO4/Ag3VO4 (BVO/IVO/AVO, respectively)] designed for water remediation. The ternary composites revealed an enhanced photocatalytic capability, which was 1.42 and 5.1 times higher than those of the binary BVO/IVO and pristine AVO due to the facilitated charge separation. The ternary photocatalysts not only effectively treated wastewater containing various organic dyes, such as methylene blue (MB), rhodamine 6G (R6G), and brilliant green (BG), but also exhibited remarkable photocatalytic performance in the degradation of antibiotics, reduction of Cr(VI), and bacterial inactivation. This paper proposes a feasible route for recycling industrial waste as a source of vanadium to produce highly efficient vanadate-based photocatalysts. © 2024 Elsevier Ltd

关键词： Water pollution

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Biased Kernel Density Estimators for Chance Constrained Optimal Control Problems

Biased Kernel Density Estimators for Chance Constrained Opti...

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American Control Conference

作者： Rachel E. Keil Alexander Miller Mrinal Kumar Anil V. Rao Ph. D. Candidate in the Department of Mechanical and Aerospace Engineering University of Florida Gainesville FL Associate Professor in the Department of Mechanical and Aerospace Engineering The Ohio State University Columbus OH Professor Erich Farber Faculty Fellow and University Term Professor in the Department of Mechanical and Aerospace Engineering University of Florida Gainesville FL

ISBN: (数字)9781538682661

ISBN: (纸本)9781538682678

A method is developed for transforming chance constrained optimization problems to a form numerically solvable. The transformation is accomplished by reformulating the chance constraints as nonlinear constraints using a method that combines the previously developed Split-Bernstein approximation and kernel density estimator (KDE) methods. The Split-Bernstein approximation in a particular form is a biased kernel density estimator. The bias of this kernel leads to a nonlinear approximation that does not violate the bounds of the original chance constraint. The method of applying biased KDEs to reformulate chance constraints as nonlinear constraints transforms the chance constrained optimization problem to a deterministic optimization problems that retains key properties of the chance constrained optimization problem and can be solved numerically. This method can be applied to chance constrained optimal control problems. As a result, the Split-Bernstein and Gaussian kernels are applied to a chance constrained optimal control problem and the results are compared.

关键词： Kernel Optimal control Probability density function Optimization Random variables Bandwidth Transforms

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Thermoplastic Starch Films Reinforced with Electrospun PLLA Fibers and Oxidized Sucrose

SSRN

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SSRN 2025年

作者： Jakubska, Justyna Janik, Weronika Jakubski, Lukasz Polak, Martyna Stachewicz, Urszula Furgol, Simona Sabura, Ewa Gębura, Katarzyna Golombek, Klaudiusz Dudek, Gabriela Department of Physical Chemistry and Technology of Polymers Faculty of Chemistry Silesian University of Technology Strzody 9 Gliwice44-100 Poland Department of Physical Chemistry and Technology of Polymers PhD School Silesian University of Technology Akademicka 2A Gliwice44-100 Poland AGH University of Science and Technology of Krakow Faculty of Metals Engineering and Industrial Computer Science Al. A. Mickiewicza 30 Kraków30-059 Poland Lukasiewicz Research Network Institute of Heavy Organic Synthesis Blachownia Energetyków 9 Kędzierzyn-Koźle47-225 Poland Materials Research Laboratory Faculty of Mechanical Engineering Silesian University of Technology Konarskiego 18A Gliwice44-100 Poland

The increasing demand for eco-friendly packaging materials has driven extensive research into biodegradable alternatives. This paper focuses on enhancing starch-based films' mechanical and water barrier properties by incorporating electrospun PLLA fibers, with oxidized sucrose introduced as novel crosslinking agent. Varying oxidized sucrose concentrations (3–15 wt%) were examined for their impact on the films structure and performance. Results demonstrate that oxidized sucrose functionates as both an effective crosslinker and compatibilizer, improving integration between the starch matrix and PLLA fibers. This dual functionality contributes to a more cohesive and durable film structure, providing significant enhancements over non-crosslinked films. The formulation with 9 wt% oxidized sucrose exhibited a tensile strength of 1.8 MPa and an elongation at break of 40%, surpassing traditional alternatives. Additionally, water barrier properties reached the expected standards, positioning this film as highly promising for practical applications. These findings highlight the potential of oxidized sucrose to advance biodegradable packaging solutions. © 2025, The Authors. All rights reserved.

关键词： Tensile strength

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Compressed air energy storage systems (CAES) and assessment of expansion cooling as an ancillary process

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Science Talks 2024年 10卷

作者： Abdul Hai Alami Ahmad Yasin Siren Khuri Ayman Mudallal Mohamad Ayoub Adnan Alashkar Rashid AlRashid Shamma Abdalla Sustainable and Renewable Energy Engineering Department University of Sharjah Sharjah P.O. Box 27272 United Arab Emirates Materials Science and Engineering PhD Program American University of Sharjah Sharjah P.O. Box 26666 United Arab Emirates Mechanical Engineering Department American University of Sharjah Sharjah 26666 United Arab Emirates

This work introduces compressed air energy storage (CAES) systems and their role in mitigating the lag between energy supply and demand. The concept of energy storage relies on storing energy during periods of low demand to supply it during periods of high demand, where CAES stands as a scalable solution with the ability to house ancillary systems in order to harvest useful effects such as expansion cooling. CAES on its own compares well with electrochemical batteries, while bearing a simpler system design and less stringent operational requirements; however, with the integration of thermal management the role of CAES can be extended to produce chilled water that can be used for cooling applications. Not only does expansion cooling broaden the utilization of CAES, it has also enhanced the energetic efficiency of the system by 4%. Future work within the scope of CAES includes the integration of heat pipes and latent heat energy storage, and experimenting with different working gases.

关键词： Compressed air energy storage (CAES) mechanical energy storage Expansion cooling Thermal management

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Progress in experimental assessments of buoyancy work energy storage

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Science Talks 2024年 10卷

作者： Abdul Hai Alami Mohamad Ayoub Adnan Alashkar Shamma Abdalla Ahmad Yasin Ayman Mdallal Sustainable and Renewable Energy Engineering Department University of Sharjah Sharjah P.O. Box 27272 United Arab Emirates Materials Science and Engineering PhD Program American University of Sharjah Sharjah P.O. Box 26666 United Arab Emirates Mechanical Engineering Department American University of Sharjah Sharjah 26666 United Arab Emirates

This work reiterates the potential of buoyancy work energy storage (BWES) systems which has been presented in previously published experimental-based literature. The concept of buoyancy work can be grasped when studying the operation of mobility devices such as hot air balloons or boats, where buoyancy plays a key role in keeping them afloat. Conventional experimental BWES systems that were studied in previous literature consist of a water tank, a submergible buoy, a motor/generator carrying out the charging/discharging processes, respectively, and a data acquisition interface. It is interesting to see the progression of this technology at lab scale, where initial designs included the use of a barrel as the water tank, and Styrofoam cut-outs as buoys. One design utilized a ring with multiple Styrofoam buoys attached to it, and it was later enhanced by adding helical engravings to the buoys' surface to affect its interaction with water positively during descension and ascension. The latest study added to this timeline of ongoing development investigates the effect of different buoy materials, surface coatings, buoy infill gasses, and load.

关键词： Buoyancy work energy storage mechanical energy storage Offshore wind turbines Battery alternatives

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Stability study and flight simulation of a blended-wing-body UAV

Stability study and flight simulation of a blended-wing-body...

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9th EASN International Conference on Innovation in Aviation and Space, EASN 2019

作者： Dimopoulos, Thomas Panagiotou, Pericles Yakinthos, Kyros Mechanical Engineer PhD Candidate Laboratory of Fluid Mechanics and Turbomachinery Aristotle University of Thessaloniki Thessaloniki54124 Greece Dr. Mechanical Engineer Aristotle University of Thessaloniki Thessaloniki54124 Greece Department of Mechanical Engineering of Aristotle University of Thessaloniki Laboratory of Fluid Mechanics and Turbomachinery Thessaloniki54124 Greece

This article is a product of the design process of a Blended-Wing- Body Unmanned Aerial Vehicle (BWB UAV). The BWB geometry blends the wing and the fuselage so that the fuselage also contributes in lift generation. This geometry reduces the lift to drag ratio significantly, however it also compromises the aircraft's stability and controllability, since there is no horizontal and vertical tail. As these features are absent from the BWB layout, the need to incorporate their functions in the new geometry arises so that they cover stability demands sufficiently, according to aircraft of similar size, use and speed. Additionally, the method used for stability studies of conventional aircraft must also be adapted. This article covers the adaptation of the method to the new BWB geometry, its results in comparison to those of conventional aircraft and the use of the results for a computational simulation of the aircraft' flight. © The Authors, published by EDP Sciences, 2019.

关键词： Antennas

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