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6th International Conference on biomedical and Health Informatics, ICBHI 2024

作者： Han, Hsieh-Ping Chow, Tong-Hsien Ho, Wen-Hsien PhD Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung807378 Taiwan Department of Sports Science R.O.C. Military Academy Kaohsiung830208 Taiwan Department of Healthcare Administration and Medical Informatics Kaohsiung Medical University Kaohsiung807378 Taiwan

ISBN: (纸本)9783031863226

Basic military training (BMT) is important and initial period for soldiers, especially the military basic throwing performance is one of the key military tactical motor skill. In recent years, machine learning (ML) techniques have been increasingly adopted to analyze extensive datasets and derive meaningful insights. To evaluate the effectiveness of fitness training strategies for military throwing, this study analyzed seven common input features: pull-ups, push-ups, squat concentric/eccentric peak power, squat maximum strength, leg tuck, and a 3 km run. Four data mining models—Random Forest, Multilayer Perceptron, AdaboostM1, and Bagging classifier—were tested to identify the most effective method for predicting performance. The Random Forest model excelled, achieving the highest accuracy, precision, recall, and F1 score, indicating its superiority in this context. These seven attributes were thus identified as key predictors of military throwing performance. However, further research is necessary to establish a definitive ranking and to fully understand the importance of each feature in refining training strategies. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Personnel training

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Understanding age-related middle ear properties and basilar membrane damage in hearing loss: A finite element analysis and retrospective cohort study

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Computers in Biology and Medicine 2025年 184卷 109376-109376页

作者： Shih, Tzu-Ching Yu, You-Cheng Wang, Tang-Chuan Department of Biomedical Imaging and Radiological Science College of Medicine China Medical University Taichung404328 Taiwan The PhD Program for Medical Engineering and Rehabilitation Science College of Biomedical Engineering China Medical University Taichung404328 Taiwan Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University Taichung404328 Taiwan Department of Otolaryngology-Head and Neck Surgery China Medical University Hsinchu Hospital Zhubei City Hsinchu302056 Taiwan

Age-related hearing loss (ARHL) is primarily attributed to inner-ear factors, yet the role of age-related middle ear characteristics remains elusive. Employing a finite element (FE) model, we conducted a comparative analysis with clinical data extracted from a retrospective cohort study involving 90 younger adults (mean age = 38.1 ± 7.7) and 111 older adults (mean age = 63.8 ± 8.4). The clinical dataset encompassed air-bone gap (ABG) measurements obtained through pure-tone audiometry (PTA) at frequencies of 0.5, 1.0, 2.0, and 4.0 kHz. FE results quantified the normalized stapes displacement value of the simulated form of air-bone gap (ABGSim) between the two age groups. The Mann-Whitney U test, with a significance threshold set at P © 2024

关键词： Bone

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Short-Chain Dense Brush Pegylation on Rigid Nanocarriers Overcomes Anti-Peg Antibody Recognition for Immune-Stealth Drug Delivery

SSRN

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SSRN 2025年

作者： Chen, Ting-Yu Chang, Chi-Yuan Wen, Ting-Chun Xu, Li Lin, Yu-Han Peng, Cheng-Liang Yeh, Yi-Qi Chen, Chueh-Hsuan Chuang, Kuo-Hsiang Wu, Si-Han Graduate Institute of Pharmacognosy Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan Department of Isotope Application National Atomic Research Institute Taoyuan Taiwan National Synchrotron Radiation Research Center Hsinchu Science Park Hsinchu30076 Taiwan Research Center for Applied Science Academia Sinica Taiwan PhD Program in Clinical Drug Development of Chinese Herbal Medicine Taipei Medical University Taipei Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

The immunogenicity of polyethylene glycol (PEG) remains a critical challenge in nanomedicine, as pre-existing anti-PEG antibodies can compromise therapeutic efficacy through accelerated blood clearance (ABC) and life-threatening hypersensitivity. Here, we address this challenge by engineering the PEG architecture, creating short-chain dense brush PEGylation (PEG500) on rigid mesoporous silica nanoparticles (MSNs). Unlike conventional PEG2000-liposomes, MSN-PEG500 evades antibodies via three synergistic mechanisms: (1) short-chain PEG500 reduces epitope accessibility, (2) high grafting density (4.43 chains/nm2, according to TGA) forms an dense steric shield, and (3) the rigid silica surface prevents PEG burial. ELISA studies demonstrated that, at equivalent nanoparticle concentrations, MSN-PEG500 exhibits a 26-fold reduction in anti-PEG IgG (6.3) binding and a 1000-fold reduction in anti-PEG IgM (AGP3) binding compared to Lipodox (PEG2000), both of which target the PEG backbone. Furthermore, radiolabeled MSN-PEG500 achieved prolonged circulation and 25% tumor accumulation (ID/g) at 24 hours. In strongly immunized mice, doxorubicin-loaded MSN-PEG500 preserved therapeutic efficacy and 100% survival, whereas Lipodox induced fatal hypersensitivity. Mechanistic investigations revealed that complement activation drives PEG2000 immunotoxicity, and pretreatment with the C3 inhibitor compstatin effectively mitigated temperature drops from 10°C to 2°C in immunized hosts. By demonstrating that nanoscale control of polymer conformation dictates immunological fate, this work provides a clinically translatable blueprint for developing immune-evasive nanomedicines. © 2025, The Authors. All rights reserved.

关键词： Silica nanoparticles

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EFFECTS OF QUADRICEPS FEMORIS MUSCLE STRENGTHENING ON CROUCH GAIT IN CHILDREN WITH SPASTIC DIPLEGIA

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PHYSICAL THERAPY 1995年第8期75卷 658-667页

作者： DAMIANO, DL KELLY, LE VAUGHN, CL DL Damiano PhD PT is Assistant Professor of Orthopaedics University of Virginia Charlottesville VA 22903. LE Kelly PhD is Associate Professor of Education University of Virginia. CL Vaughan PhD is Professor of Orthopaedics and Biomedical Engineering University of Virginia.

Background and Purpose. Despite evidence of weakness in children with cerebral palsy, the use of strength training in this population remains controversial. Subjects. Fourteen children with spastic diplegia, ranging in age from 6 to 14 years ((X) over bar=9.1, SD= 2.5), participated in a bilateral quadriceps femoris muscle strengthening program. Methods. The children exercised three times per week for 6 weeks using ankle weights at loads of approximately 65% of each child's maximum isotonic force production. The maximal voluntary contraction of the quadriceps femoris muscles was measured before, at the mid-point of and immediately following the exercise program at 30, 60, and 90 degrees of knee flexion. Gait analyses were performed before and after the strengthening program to determine whether quadriceps femoris muscle strengthening influenced gait. Results. Children with spastic diplegia can increase quadriceps femoris muscle strength through heavy resistance exercise. Repeated-measures analysis of variance and multivariate analysis of variance procedures were used to assess changes in force and in gait variables. Improvement in the degree of crouch at initial floor contact at the freely selected speed and an increase in stride length at free and fast speeds were found, Conclusion and Discussion. These findings suggest that resistance exercise is an effective treatment strategy and as such should be considered as one component in the habilitation of children with cerebral palsy.

关键词： CEREBRAL PALSY CROUCH GAIT QUADRICEPS FEMORIS MUSCLE STRENGTHENING

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Discovering nanoparticle corona ligands for liver macrophage capture

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Nature Nanotechnology 2025年 1-12页

作者： Bussin, Bram MacDuff, Marshall G. G. Ngo, Wayne Wu, Jamie L. Y. Lin, Zachary P. Granda Farias, Adrian Stordy, Benjamin Sepahi, Zahra Ahmed, Sara Moffat, Jason Chan, Warren C. W. Department of Laboratory Medicine and Pathobiology University of Toronto TorontoON Canada Institute of Biomedical Engineering University of Toronto TorontoON Canada Terrence Donnelly Centre for Cellular and Biomolecular Research University of Toronto TorontoON Canada Gladstone Institutes San FranciscoCA United States California Institute for Quantitative Biosciences University of California Berkeley BerkeleyCA United States Innovative Genomics Institute University of California Berkeley BerkeleyCA United States Program in Genetics and Genome Biology The Hospital for Sick Children TorontoON Canada Department of Molecular Genetics University of Toronto TorontoON Canada MD/PhD Program University of Toronto TorontoON Canada School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University Singapore Singapore

Liver macrophages capture circulating nanoparticles and reduce their delivery to target organs. Serum proteins adsorb to the nanoparticle surface after administration. However, the adsorbed serum proteins and their cognate cell receptors for removing nanoparticles from the bloodstream have not been linked. Here we use a multi-omics strategy to identify the adsorbed serum proteins binding to specific liver macrophage receptors. We discovered six absorbed serum proteins that bind to two liver macrophage receptors. Nanoparticle physicochemical properties can affect the degree of the six serum proteins adsorbing to the surface, the probability of binding to cell receptors and whether the liver removes the nanoparticle from circulation. Identifying the six adsorbed proteins allowed us to engineer decoy nanoparticles that prime the liver to take up fewer therapeutic nanoparticles, enabling more nanoparticles for targeting extrahepatic tissues. Elucidating the molecular interactions governing the nanoparticle journey in vivo will enable us to control nanoparticle delivery to diseased tissues. © The Author(s), under exclusive licence to Springer Nature Limited 2025.

关键词： Nanoparticles

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IMPEDIMETRIC MEASUREMENT OF 3D ANGIOGENIC PROCESS 25

IMPEDIMETRIC MEASUREMENT OF 3D ANGIOGENIC PROCESS

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25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021

作者： Huang, Chun-Hao Lei, Kin Fong PhD Program in Biomedical Engineering College of Engineering Chang Gung University Taiwan Graduate Institute of Biomedical Engineering Chang Gung University Taiwan Department of Radiation Oncology Chang Gung Memorial Hospital Taiwan

ISBN: (纸本)9781733419031

In this research, a microfluidic biochip for impedance measurement was developed to explore the angiogenesis ability affected by VEGF in a 3D microenvironment. The process of angiogenesis and invasion of human umbilical vein endothelial cells (HUVEC) is studied by using microfluidic technology and bio colloids (Matrigel) to construct a 3D biological barrier. During angiogenesis affected by different concentrations of vascular endothelial growth factor (VEGF), the impedance changes and time points were recorded to analyze the angiogenesis ability. The results showed that the impedance measurement can quantify the angiogenesis ability in the microfluidic biochip in real-time. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Microfluidics

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Multimodal identification of the mouse brain using simultaneous Ca²⁺ imaging and fMRI

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Communications Biology 2025年第1期8卷 1-14页

作者： Mandino, Francesca Horien, Corey Shen, Xilin Desrosiers-Grégoire, Gabriel Luo, Wendy Markicevic, Marija Constable, R. Todd Papademetris, Xenophon Chakravarty, Mallar M. Betzel, Richard F. Lake, Evelyn M. R. Department of Radiology and Biomedical Imaging Yale University School of Medicine New Haven CT United States Interdepartmental Neuroscience Program Yale University School of Medicine New Haven CT United States MD/PhD program Yale University School of Medicine New Haven CT United States Computational Brain Anatomy Laboratory Douglas Mental Health University Institute Montreal QC Canada Integrated Program in Neuroscience McGill University Montreal QC Canada Department of Biomedical Engineering Yale University School of Medicine New Haven CT United States Department of Neurosurgery Yale University School of Medicine New Haven CT United States Deparment of Biomedical Informatics and Data Science Yale University New Haven CT United States Department of Psychological and Brain Sciences Indiana University Bloomington IN United States Wu Tsai Institute Yale University New Haven CT United States

Individual differences in neuroimaging are of interest to clinical and cognitive neuroscientists based on their potential for guiding the personalized treatment of various heterogeneous neurological conditions and diseases. Despite many advantages, the prevailing modality in this field—blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI)—suffers from low spatiotemporal resolution and specificity as well as a propensity for noise and spurious signal corruption. To better understand individual differences in BOLD-fMRI data, we can use animal models where fMRI, alongside complementary but more invasive contrasts, can be accessed. Here, we apply simultaneous wide-field fluorescence calcium imaging and BOLD-fMRI in mice to interrogate individual differences using a connectome-based identification framework adopted from the human fMRI literature. This approach yields high spatiotemporal resolution cell-type specific signals (here, from glia, excitatory, as well as inhibitory interneurons) from the whole cortex. We found mouse multimodal connectome-based identification to be successful and explored various features of these data. © The Author(s) 2025.

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Application of Reminiscence Treatment on Older People With Dementia: A Case Study in Pingtung, Taiwan (vol 17, pg 112, 2009)

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JOURNAL OF NURSING RESEARCH 2009年第3期17卷 231-231页

作者： Huang, S. L. Li, C. M. Yang, C. Y. Chen, J. J. PhD Assistant Professor Department of Social Work Chaoyang University of Technology *MD Director Department of Rehabilitation Pingtung Hospital Department of Health Executive Yuan **BS Researcher Department of Social Work Meiho Institute of Technology ***PhD Professor Institute of Biomedical Engineering National Cheng Kung University.

Reminiscence therapy has been utilized for many years in the treatment of dementia in older people. Purposes of the research included examining different methods of promoting interactivity, social participation, cognitive function improvement in those with dementia, and the effectiveness in reducing symptoms of depression following group treatment. This study used pretest and posttest electroencephalography (EEG) measurements to test reminiscence therapy efficacy on participants. This research organized a social group work with 12 elderly clients with dementia (mild to moderate stage) selected from among 90 residents of an older persons care facility in Pingtung. Eleven agreed to join the study, and 10 completed successfully all treatment sessions. Eight sessions of reminiscence cooking lessons were conducted. The effectiveness of interventions was evaluated by comparing presession and postsession EEG, mental health status, depression scale, and feeling of participation scale scores. Significant differences in values, particularly for EEG, were found between the two sets of scores. The average value of participants' fast waves rose from 43.88 to 55.12, whereas average slow-wave values fell from 56.12 to 44.13. After analysis using the Wilcoxon matched paired signed rank test, significant differences were noted. Findings and suggestions include the following: (a) The rise in Mini-Mental State Examination and reduction in depression scale scores, although noted, were not significant, and (b) the self-achievement, emotional stability, family atmosphere, and physical needs of participants were met. The authors recommend that reminiscence group work be promoted in the home for older persons and that childhood cooking sessions twice each week may be the ideal format for reminiscence group work.

关键词： feeling of participation reminiscence treatment social group work

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EEF/MEG BRAIN MAPPING OF HUMAN PAIN

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神经解剖学杂志 2001年第B07期17卷 56-64页

作者： Andrew CN CHEN Human Brain Mapping and Cortical Imaging Laboratory The International Doctoral School in Biomedical Science and Engineering SMI Aalborg University Denmark MD PhD

Introduction The study of pain has progressed steadily after the publication of the seminal volume 'The Management of Pain' by the late Prof. John J. Bonica nearly 50 years ago (Bonica, 1953). Since this past decade of 1990s, we have been witnessing an explosion of new research within the basic science of nociception and pain in the human brain. This new landmark of brain mapping and neuroirnaging in the study of the human brain

关键词：人体疼痛脑电地形图 EEF/MEG

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Overcoming Cytosolic Delivery Barriers of Proteins Using Denatured Protein-Conjugated Mesoporous Silica Nanoparticles

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ACS Applied Materials and Interfaces 2023年第1期15卷 432-451页

作者： Dembélé, Julien Liao, Jou-Hsuan Liu, Tsang-Pai Chen, Yi-Ping Graduate Institute of Biomedical Materials & Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Laboratory of Toxicology Environment and Health Doctorate School of Health University Joseph Ki-Zerbo Ouaga03 BP 7021 Burkina Faso Department of Chemistry National Taiwan University Taipei10617 Taiwan Department of Surgery Mackay Memorial Hospital Taipei10449 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Intracellular delivery of therapeutic proteins has increased advantages over current small-molecule drugs and gene therapies, especially in therapeutic efficacies for a broad spectrum of diseases. Hence, developing the protein therapeutics approach provides a needed alternative. Here, we designed a mesoporous silica nanoparticle (MSN)-mediated protein delivery approach and demonstrated effective intracellular delivery of the denatured superoxide dismutase (SOD) protein, overcoming the delivery challenges and achieving higher enzymatic activity than native SOD-conjugated MSNs. The denatured SOD-conjugated MSN delivery strategy provides benefits of reduced size and steric hindrance, increased protein flexibility without distorting its secondary structure, exposure of the cell-penetrating peptide transactivator of transcription for enhanced efficient delivery, and a change in the corona protein composition, enabling cytosolic delivery. After delivery, SOD displayed a specific activity around threefold higher than in our previous reports. Furthermore, the in vivo biosafety and therapeutic potential for neuron therapy were evaluated, demonstrating the biocompatibility and the effective antioxidant effect in Neuro-2a cells that protected neurite outgrowth from paraquat-induced reactive oxygen species attack. This study offers an opportunity to realize the druggable possibility of cytosolic proteins using MSNs. © 2022 American Chemical Society.

关键词： Peptides

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