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CHITOSAN-COLLAGEN COMPOSITE SCAFFOLDS FOR GROWTH DIRECTION GUIDANCE OF PC12 AXONS

CHITOSAN-COLLAGEN COMPOSITE SCAFFOLDS FOR GROWTH DIRECTION G...

ASME 2024 International Design engineering Technical Conferences and Computers and Information in engineering Conference, IDETC-CIE 2024

作者： Tsai, Po-Yu Lin, Ying-Ting Wang, Gou-Jen Graduate Institute of Biomedical Engineering National Chung-Hsing University Taichung Taiwan PhD Program in Tissue Engineering and Regenerative Medicine National Chung-Hsing University Taichung Taiwan Department of Mechanical Engineering Graduate Institute of Biomedical Engineering National Chung-Hsing University Taichung Taiwan

ISBN: (纸本)9780791888421

In this study, nerve conduits of chitosan and collagen composites with biocompatibility and biodegradability were fabricated. The effects of material composition and surface morphology on the axonal growth and directionality of rat epinephric pheochromocytoma PC12 were investigated. The cells were separated by a PDMS structure to simulate nerve injury, and the growth of axons of PC12 cells was observed under the separation of large gaps. At the same time, mitochondria extracted from osteosarcoma cybrid cells (C2-GFP) were added to the culture to investigate the effect of healthy mitochondria on axon differentiation and growth. The experimental results showed that the chitosan-collagen composite film can promote the growth of PC12 axons more effectively than the pure chitosan film. Cell culture results at different groove widths also showed that smaller grooves resulted in more axon numbers and longer axon lengths. Nerve injury simulation experiments showed that the nerve repair could be almost completed after 12 days of culture. Copyright © 2024 by ASME.

关键词： Mitochondria

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Overcoming Cytosolic Delivery Barriers of Proteins Using Denatured Protein-Conjugated Mesoporous Silica Nanoparticles

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ACS Applied Materials and Interfaces 2023年第1期15卷 432-451页

作者： Dembélé, Julien Liao, Jou-Hsuan Liu, Tsang-Pai Chen, Yi-Ping Graduate Institute of Biomedical Materials & Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Laboratory of Toxicology Environment and Health Doctorate School of Health University Joseph Ki-Zerbo Ouaga03 BP 7021 Burkina Faso Department of Chemistry National Taiwan University Taipei10617 Taiwan Department of Surgery Mackay Memorial Hospital Taipei10449 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Intracellular delivery of therapeutic proteins has increased advantages over current small-molecule drugs and gene therapies, especially in therapeutic efficacies for a broad spectrum of diseases. Hence, developing the protein therapeutics approach provides a needed alternative. Here, we designed a mesoporous silica nanoparticle (MSN)-mediated protein delivery approach and demonstrated effective intracellular delivery of the denatured superoxide dismutase (SOD) protein, overcoming the delivery challenges and achieving higher enzymatic activity than native SOD-conjugated MSNs. The denatured SOD-conjugated MSN delivery strategy provides benefits of reduced size and steric hindrance, increased protein flexibility without distorting its secondary structure, exposure of the cell-penetrating peptide transactivator of transcription for enhanced efficient delivery, and a change in the corona protein composition, enabling cytosolic delivery. After delivery, SOD displayed a specific activity around threefold higher than in our previous reports. Furthermore, the in vivo biosafety and therapeutic potential for neuron therapy were evaluated, demonstrating the biocompatibility and the effective antioxidant effect in Neuro-2a cells that protected neurite outgrowth from paraquat-induced reactive oxygen species attack. This study offers an opportunity to realize the druggable possibility of cytosolic proteins using MSNs. © 2022 American Chemical Society.

关键词： Peptides

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Measurement of Blood Flow in the Carotid Artery as one of the Elements of Assessing the Ability for Pilots in the Gravitational Force Conditions–Review of Available Solutions 23rd

Measurement of Blood Flow in the Carotid Artery as one of...

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Proceedings of the 23rd Polish Conference on Biocybernetics and biomedical engineering, PCBEE 2023

作者： Sobotnicka, Ewelina Mocha, Jan Sobotnicki, Aleksander Galecka, Jerzy Gacek, Adam Lukasiewicz Research Network Krakow Institute of Technology The Centre for Biomedical Engineering Zakopianska Str. 73 Krakow30-418 Poland PhD School Silesian University of Technology Gliwice Poland

ISBN: (纸本)9783031384295

Continuous monitoring of cardiac function is highly desirable for long-term assessment of cardiovascular health, detection of acute cardiac dysfunction. Information from volume flow rate may be important in a variety of different clinical circumstances, such as stroke, arteriovenous malformation, cardiac failure. The main aim of the work was review of non-invasive measurements of carotid blood flow methods and devices. There are various types of methods and devices for monitoring blood flow in the carotid artery, however, so far no mobile recorder of the appropriate quality of registration has been developed. The most promising solutions are wireless wearable patches that, when applied to the skin of the neck, will not be a burden during measurements. This is important when measurements are to be made, during extreme activities, such as in pilots. As a result of the conducted research, there is a presumption that carotid blood flow measurements methods has great potential to be a useful tool in the diagnosis of the pilot's predisposition, at the same time performing a warning function, the so-called alerters, before the imminent overload loss of consciousness. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Blood

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Optimized photonic integrated circuit components for optical coherence tomography at 1060 nm

Optimized photonic integrated circuit components for optical...

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2024 Conference on Lasers and Electro-Optics, CLEO 2024

作者： Hao, Senyue Adkins, Aaron J. Zhang, Yitian Zhou, Chao Department of Electrical & Systems Engineering Washington University Saint Louis United States Imaging Science PhD Program Washington University Saint Louis United States Department of Biomedical Engineering Washington University Saint Louis United States

To implement optical coherence tomography on photonic chips, we developed optimized and experimentally validated silicon nitride-based components for photonic integrated circuits in order to achieve high sensitivity a... 详细信息

ISBN: (纸本)9781957171395

关键词： Photonic integrated circuits

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Optimized photonic integrated circuit components for optical coherence tomography at 1060 nm

Optimized photonic integrated circuit components for optical...

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CLEO: Applications and Technology in CLEO 2024, CLEO: A and T 2024 - Part of Conference on Lasers and Electro-Optics

关键词： Photonic integrated circuits

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Heterojunction and co-catalyst engineering of bismuth vanadate by nickel molybdenum oxide and carbon quantum dot decorations for photoelectrochemical water splitting

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International Journal of Hydrogen Energy 2024年 51卷 1099-1108页

作者： Kuo, Tsung-Rong Chiou, Yu-Tai Huang, Hsiao-Wen Kongvarhodom, Chutima Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Lin, Lu-Yin Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Improving the charge diffusion length and water oxidation kinetics of bismuth vanadate (BiVO4) is essential to achieve better photoelectrochemical catalytic ability for water oxidation. Establishing heterojunctions and incorporating co-catalysts with BiVO4 create facile charge transfer paths and generate more water oxidation reactions. In this work, nickel molybdenum oxide (NM) and carbon quantum dot (CQD) are firstly deposited on BiVO4 by hydrothermal and soaking processes to design an efficient co-catalyst/photocatalyst system for water oxidation. The depositing amount of CQD is optimized to balance contributions of CQD and NM as the hole sink and the light-to-electron generator, respectively. The highest photocurrent densities of 2.2 and 3.9 mA/cm2 are achieved for BiVO4/NM/CQD in the electrolyte without and with hole scavenger, respectively. The BiVO4 electrode only shows a photocurrent density of 1.2 mA/cm2 in the electrolyte without hole scavenger. The best photoelectrochemical catalytic ability of BiVO4/NM/CQD is approached by the reduced charge-transfer resistance and charge recombination as well as the enhancement on carrier densities. The excellent long-term stability with the photocurrent retention of 90% under illumination for 24 h is also obtained for BiVO4/NM/CQD. This study opens a blueprint on designing efficient catalysts for water oxidation by incorporating heterojunction and co-catalyst materials simultaneously. © 2023 Hydrogen Energy Publications LLC

关键词： Heterojunctions

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Efficiently catalyzing photo-oxidation of water by surface engineering of bismuth vanadate with nickel molybdenum oxide coverages

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International Journal of Hydrogen Energy 2024年 51卷 613-622页

作者： Kuo, Tsung-Rong Huang, Hsiao-Wen Kongvarhodom, Chutima Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou 03 Burkina Faso Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Bismuth vanadate with suitable band edges is one of the efficient photocatalysts for water oxidation. Establishing heterojunction can improve electron diffusion lengths and photocatalytic ability of BiVO4. In this work, nickel molybdenum oxide (Ni–Mo–O) and BiVO4 heterojunction is established by the hydrothermal process with different nickel to molybdenum precursor ratios. The Ni–Mo–O/BiVO4 electrode is applied as photoanodes for water oxidation. The growth mechanism of Ni–Mo–O on BiVO4 surface is proposed. The Ni–Mo–O deposition amount is optimized regarding to light absorbance and charger transportation. The largest photocurrent density of 1.72 mA/cm2 at 1.23 VRHE is obtained for the optimal NiMoO4/BiVO4 electrode (NM12) in the electrolyte without hole scavenger, while the pure BiVO4 electrode only shows a photocurrent density of 0.90 mA/cm2. The NM12 electrode even presented an impressive photocurrent density of 5.39 mA/cm2 at 1.23 VRHE in the electrolyte with the hole scavenger, owing to the abundant active sites and higher light absorbance as well as the favorable synergistic effects from its suitable Ni to Mo ratio. The NM12 electrode also shows excellent long-term stability with the photocurrent retention of 83% after illumination for 6500 s. This work opens a blueprint for establishing a novel heterojunction with the adjustable metal ratio and coverage on BiVO4. © 2023 Hydrogen Energy Publications LLC

关键词： Heterojunctions

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Enhanced light-driven photoelectrochemical catalysis of water splitting by TiO2 nanotubes grown on acid-etched titanium foils

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International Journal of Hydrogen Energy 2024年第PartA期51卷 1483-1493页

作者： Hsiao, Yu-Cheng Lai, Jhih-Hong Fan, Yu-Min Chen, Hung-Ming Yougbaré, Sibidou Saukani, Muhammad Chen, Chih-Yu Wu, Yung-Fu Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei City23561 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan

Titanium dioxide with suitable band edges is one of promising photocatalysts for water splitting. Nanotubes with one-dimensional structure can induce efficient charge transfers and hollow centers can provide large surface area for surface reactions. Modifying Ti foils for anodization can enhance light utilization of TiO2 nanotube photoelectrodes. In this work, it is firstly to fabricate TiO2 nanotube photoelectrodes on acid-etched Ti foils by anodization (MNT) for photoelectrochemical catalyzing water splitting. Different acid-etching durations are applied on Ti foils to induce various rugged surfaces. The resulting photoelectrodes present largely enhanced light utilization than that fabricated by the pristine Ti foil. The anodization duration is also optimized to find suitable lengths of MNT. The smallest overpotential of 524.7 mV at 10 mA/cm2 and Tafel slope of 167 mV/dec are obtained for the optimal MNT photoelectrode. The TiO2 nanotubes grown on the pristine Ti foil shows the overpotential of 679.3 mV at 10 mA/cm2 and Tafel slope of 285 mV/dec. This result opens a blueprint for raising the photocatalytic ability by simply modifying the surface property of the conductive substrate. Other modifications may be applicable to enhance the roughness of Ti foils for growing more efficient MNT array as photocatalysis of water splitting. © 2023 Hydrogen Energy Publications LLC

关键词： Titanium dioxide

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Clinical Biomarkers to Evaluate Next Generation Inhaled Tobacco Products’ Effect in the Oral Cavity: a Narrative Review

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Current Oral Health Reports 2024年第1期11卷 30-39页

作者： Sarles, S. Emma Hensel, Edward C. Rahman, Irfan Robinson, Risa J. Biomedical and Chemical Engineering PhD Program Rochester Institute of Technology Rochester NY United States Department of Mechanical Engineering Respiratory Technologies Lab Rochester Institute of Technology Rochester NY United States Department of Environmental Medicine Rahman Lab University of Rochester Medical Center Rochester NY United States

Purpose of Review: Biomarkers in the oral cavity of users of next generation tobacco products, such as electronic cigarettes (EC), provide data about effects on oral and systemic health and help predict long-term health effects, such as cardiovascular, respiratory, and periodontal disease. Despite oral cavity health provides, translation of findings to regulatory outcomes around EC is lacking. A review of the current state of the art in use of clinical biomarkers of the oral cavity was conducted. This identified inconsistencies and gaps in tobacco regulatory science to address how to improve clinical studies for screening tobacco products and studying disease. Recent Findings: The review identified that saliva and buccal biopsies provide dependable biomarkers of oral and systemic health when several parameters of health are standardized and considered. Inflammatory cytokines in oral tissue and biofluids of EC users are conflicting due to differences in sample collection and analysis techniques. Salivary C-reactive protein levels provide information about systemic inflammation and risk of cardiovascular disease, but analysis of this biomarker in the oral cavity does not appear in the current literature. The oral microbiome plays a significant role in human health and may be a useful tool to study systemic effects of tobacco products non-invasively, yet inconsistencies in reporting metrics make studies difficult to compare or translate into tangible outcomes. Effects of tobacco product use on hard dental tissue are not widely investigated despite correlations observed between e-cigarette use and broken teeth. Summary: This review provides a comprehensive update on clinical biomarkers in systemic and oral diseases associated with emerging nicotine products. © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

关键词： Biomarkers Electronic cigarette Oral health Tobacco regulatory science Vaping

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Systematic designs of single metal compounds synthesized using ammonia fluoride-based complex as structure directing agents for energy storage

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Journal of Colloid and Interface Science 2023年第PartA期652卷 294-304页

作者： Kuo, Tsung-Rong Zher Yu, You Wu, Chung-Hsien Lee, Pin-Yan Kongvarhodom, Chutima Chen, Hung-Ming Husain, Sadang Yougbaré, Sibidou Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou 03 Burkina Faso

Tailoring morphology and composition of metal organic frameworks (MOF) can improve energy storage by establishing high surface area, large porosity and multiple redox states. Structure directing agents (SDA) is functional of designing surface properties of electroactive materials. Ammonium fluoride has functional abilities for designing MOF derivatives with excellent energy storage abilities. Systematic design of MOF derivatives using ammonia fluoride-based complex as SDA can essentially create efficient electroactive materials. Metal species can also play significant roles on redox reactions, which are the main energy storage mechanism for battery-type electrodes. In this work, 2-methylimidazole, two novel SDAs of NH4BF4 and NH4HF2, and six metal species of Al, Mn, Co, Ni, Cu and Zn are coupled to synthesize MOF derivatives for energy storage. Metal species-dependent compositions including hydroxides, oxides, and hydroxide nitrates are observed. The nickel-based derivative (Ni-HBF) shows the highest specific capacitance (CF) of 698.0F/g at 20 mV/s, due to multiple redox states and advanced flower-like surface properties. The diffusion and capacitive-control contributions of MOF derivatives are also analyzed. The battery supercapacitor hybrid with Ni-HBF electrode shows a maximum energy density of 27.9 Wh/kg at 325 W/kg. The CF retention of 170.9% and Coulombic efficiency of 93.2% are achieved after 10,000 cycles. © 2023 Elsevier Inc.

关键词： Supercapacitor

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