检索结果-内蒙古大学图书馆

Universal nanocomposite coating with antifouling and redox capabilities for electrochemical affinity biosensing in complex biological fluids

引用

Nanoscale Horizons 2024年第5期9卷 843-852页

作者： Bharti, Aditya Manu Rakesh Kumar, R.K. Chuang, Cheng-Hsin Shaikh, Muhammad Omar International PhD Program for Science National Sun Yat-sen University Kaohsiung80424 Taiwan Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung80424 Taiwan Department of Chemical Engineering National Taiwan University Taipei City10617 Taiwan Institute of Biomedical Engineering and Nanomedicine National Healthcare Research Institutes Miaoli County350 Taiwan National Sun Yat-sen University Kaohsiung80424 Taiwan Sustainability Science and Management Program Tunghai University Taichung407224 Taiwan

Electrochemical affinity biosensors have the potential to facilitate the development of multiplexed point-of-care diagnostics in complex biological fluids. However, their commercial viability has been hindered by challenges such as electrode biofouling and the lack of inherent redox properties. To address this unmet need, we have developed a universal nanocomposite coating which is unique in its ability to not only allow oriented conjugation of the biorecognition element but also specific detection directly in complex biological fluids like serum and urine owing to its built-in antifouling and redox capabilities, thus improving suitability for point of care testing. This multifunctional coating comprises a 3D porous crosslinked bovine serum albumin matrix for oriented conjugation and antifouling properties with embedded graphene nanosheets modified with amino-ferrocene for enhanced conductivity and mediator-free biosensing. The coating showed minimal signal degradation despite prolonged exposure to 1% bovine serum albumin, artificial urine and untreated human serum for up to 30 days. To demonstrate its utility, we fabricated and tested proof-of-concept electrochemical immunosensors for bladder cancer protein biomarkers, specifically interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF). The practical feasibility was highlighted by the excellent sensitivity and specificity observed for IL-8 and VEGF with a limit of detection of 41 pg mL−1 and 67 pg mL−1, respectively. Consequently, this universal nanocomposite-based electrochemical biosensing platform can be extended to the point of care testing of a broad spectrum of biomarkers present in complex biological fluids, thus enabling reliable and early diagnostics. © 2024 The Royal Society of Chemistry

关键词： Biomarkers

来源：评论

学校读者我要写书评

暂无评论

Rapid Escherichia coli Cloned DNA Detection in Serum Using an Electrical Double Layer-Gated Field-Effect Transistor-Based DNA Sensor

引用

Analytical Chemistry 2023年第17期95卷 6871-6878页

作者： Paulose, Akhil K. Hou, Yueh-Ju Huang, Yu-Shan Chakkalaparambil Dileep, Navyamol Chiu, Chia-Lin Pal, Arnab Kalaimani, Vishal Mani Lin, Zong-Hong Chang, Chuang-Rung Chen, Cheng-Pin Lin, Yi-Chun Cheng, Chien-Yu Cheng, Shu-Hsing Cheng, Chao-Min Wang, Yu-Lin Institute of Nanoengineering and Microsystems National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan College of Semiconductor Research National Tsing Hua University Hsinchu30013 Taiwan Department of Life Sciences National University of Kaohsiung Kaohsiung811726 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu30013 Taiwan Department of Infectious Diseases Taoyuan General Hospital Ministry of Health and Welfare Taoyuan32748 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan

In this study, a rapid diagnosis platform was developed for the detection of Escherichia coli O157:H7. An electrical double layer (EDL)-gated field-effect transistor-based biosensor (BioFET) as a point-of-care testing device is demonstrated with its high sensitivity, portability, high selectivity, quick response, and ease of use. The specially designed ssDNA probe was immobilized on the extended gate electrode to bind the target complementary DNA segment of E. coli, resulting in a sharp drain current change within minutes. The limit of detection for target DNA is validated to a concentration of 1 fM in buffer solution and serum. Meanwhile, the results of a Kelvin probe force microscope were shown to have reduced surface potential of the DNA immobilized sensors before and after the cDNA detection, which is consistent with the decreased drain current of the BioFET. A 1.2 kb E. coli duplex DNA synthesized in plasmid was sonicated and detected in serum samples with the sensor array. Gel electrophoresis was used to confirm the efficiency of sonication by elucidating the length of DNA. Those results show that the EDL-gated BioFET system is a promising platform for rapid identification of pathogens for future clinical needs. © 2023 American Chemical Society

关键词： DNA

来源：评论

学校读者我要写书评

暂无评论

Non-Invasive Bioimpedance Spectroscopy Device Performing Periodic Measurements of Chest Hydration - Model Development

Non-Invasive Bioimpedance Spectroscopy Device Performing Per...

引用

International Conference on Mixed Design of Integrated Circuits and Systems (MIXDES)

作者： Mirella Urzeniczok Andrzej Michnik Kamil Pilarski Ilona Karpiel Łukasiewicz Research Network - Krakow Institute of Technology The Centre for Biomedical Engineering Zabrze Poland Silesian University of Technology PhD School Gliwice Poland

Bioimpedance measurement of body tissues is a non-invasive method that makes it possible to obtain a lot of information about the health of a patient with cardiac problems. A particular body part is measured by injecting a constant current signal to the object and studying the frequency response of the electrical impedance of biological tissues, which depends on the tissue composition and frequency of the applied alternating current signal. The CardioBIS device was created as part of the internal project CardioBIS - Multiparameter cardiac telemonitoring system. The CardioBIS device is a non-invasive mobile device for performing periodic measurements of chest hydration by using bioimpedance spectroscopy in the range of 5 kHz to 250 kHz, impedance cardiography and electrocardiography, with electrodes attached to the patient's body. The analog input circuits of the device ensure the registration of bioimpedance leads using eight electrodes in the form of four pairs connected in parallel. Preliminary tests have been conducted to compare bioimpedance measurements of the human body with a resistor value approximately corresponding to the human impedance at low frequencies. The observed signal waveforms confirm the adopted electronic model. The device requires further work and development.

关键词：

来源：评论

学校读者我要写书评

暂无评论

A Foldable Hybrid Supercapacitor with High Energy Density Driven by Cu-BDC@fMWCNT// Cashew De-Oiled Shell Derived Activated Carbon

引用

Advanced Sustainable Systems 2025年

作者： Prasath, Jeeva Sengottaiyan, Chinnasamy Arivanandhan, Mukannan Govindasamy, Mani Jayavel, Ramasamy Centre for Nanoscience and Technology Anna University Chennai600025 India International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Toyota Technological Institute Tempaku Aichi Nagoya468-8511 Japan Centre for Energy Storage Technologies Anna University Chennai600025 India Research Centre for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Crystal Growth Centre Anna University Chennai600025 India

The development of lightweight and foldable energy storage systems is pivotal for advancing next-generation automotive technologies. A high-performance foldable pouch cell supercapacitor is fabricated using Cu-BDC@fMWCNT as the positive electrode, cashew de-oiled shell-derived activated carbon as the negative electrode and a PVA-KOH/Super-P gel electrolyte. The device demonstrates an outstanding specific capacity of 163 C g−1 at 1 A g−1, achieving a remarkable energy density of 36.22 W h kg−1 and a peak power density of 4000 W kg−1. Rigorous mechanical evaluations, including 90° and 360° folding tests, confirm excellent foldability and mechanical stability with negligible performance degradation. The superior electrochemical performance arises from the synergistic charge storage mechanisms of the hybrid electrodes, enhancing ion transport and redox activity. The foldable supercapacitor combines exceptional energy storage capabilities with robust mechanical endurance, setting a new benchmark for advanced, high-performance energy storage devices tailored to the stringent demands for automotive applications. © 2025 Wiley-VCH GmbH.

关键词： Capacitor storage

来源：评论

学校读者我要写书评

暂无评论

Study and realization of a tele-medical platform dedicated to the objective assessment and to the follow-up of dysphonia chronic laryngeal origin by spectro-temporal analysis of acoustic vocal signal

Study and realization of a tele-medical platform dedicated t...

引用

International Conference on Computer Medical Applications (ICCMA)

作者： S. Abdelouahed S. Aounallah M. Benabdellah Department of Electrical engineering Laboratory of Biomedical Phd Tlemcen university Tlemcen Algeria Specialist in Oto-Rhino-Laryngology (ORL) University Hospital of Tlemcen Tlemcen university Tlemcen Algeria Department of Electrical engineering Laboratory of Biomedical Engineering Tlemcen university Tlemcen Algeria

In this paper we develop a system dedicated to the objective characterization of dysphonia chronic laryngeal origin. The purpose of this system is threefold: diagnosis, treatment and monitoring of patient. He includes a chain tele medical made up of: (1) Hardware with a microphone and a sound card of terminal computer. (2) a software with vocal Audacity environment for the recording of the acoustic signal, Wamp environment for the establishment of data base on line and Visual BASIC environment for the transfer of the data under protocol TCP/IP making profitable architecture customer server supported by the component Winsock of VB in relation to the operating system Windows. For that we design an experimental protocol which consists of the recording and the archiving of the acoustic vocal signal by means of the software environment Audacity which makes it possible to deliver a temporal signal under format WAVE. Our contribution consisted of the implementation, under the Visual Basic environment, of an algorithm that allows performing the analysis of a spectro-temporal acoustic voiced speech signal in this case the vowel “a” sustained for three seconds. We applied this algorithm on six healthy subjects and six pathological subjects of whose four with cancer of the larynx, one with chronic laryngitis and one presenting an inflammatory polyp of the vocal cords. The results obtained show a variability of spectro-temporal characteristics between healthy and pathological subjects and prone pathological between them according to the nature of the lesion in particular with regard to spectral content evaluated by DFT-RD and the fundamental frequency F0 averaged over several frames of the voiced signal.

关键词： Layout Speech Cancer Educational institutions Larynx Pathology Acoustics

来源：评论

学校读者我要写书评

暂无评论

Space Division Multiplexing Optical Coherence Tomography for Wide-field Angiographic Imaging of the Human Retina

Space Division Multiplexing Optical Coherence Tomography for...

引用

2024 Frontiers in Optics, FiO 2024

作者： Adkins, Aaron J. Hao, Senyue Ren, Chao Song, Andrew Zhou, Chao Department of Biomedical Engineering Washington University in St. Louis St. LouisMO United States Imaging Science PhD Program Washington University in St. Louis St. LouisMO United States Department of Electrical and Systems Engineering Washington University in St. Louis St. LouisMO United States

We have constructed a parallelized 4-channel multi-beam optical coherence tomography system capable of achieving high speed and wide field of view angiographic imaging of the retina. © Optica Publishing Group 202... 详细信息

关键词： Optical coherence tomography

来源：评论

学校读者我要写书评

暂无评论

Facile synthesis of copper cobalt sulfide and nickel hydroxide tube-like composites as battery-type active material of energy storage devices

引用

Journal of Energy Storage 2023年 65卷

作者： Kuo, Tsung-Rong Fitriannisa, Istikhori Chung, Ren-Jei Lin, Kuan-Hsien Yougbaré, Sibidou Lin, Lu-Yin Wu, Yung-Fu International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan BP 218 11 Nanoro Burkina Faso Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan

Bimetallic sulfide has attracted much attentions as efficient electroactive materials of battery supercapacitor hybrid (BSH), because of numerous redox states, high conductivity and good energy efficiency. Developing composites having excellent chemical and electrochemical properties is necessary to enhance the energy storage features of bimetallic sulfides. In this study, CuCo2S4 and Ni(OH)2 composites (CuCo2S4@Ni(OH)2) are designed on Ni foam via the facial hydrothermal process and chemical bath deposition as the electroactive material of BSH at first time. Effects of Ni(OH)2 amounts on CuCo2S4 on electrochemical and physical properties of CuCo2S4@Ni(OH)2 are investigated. The physical mixed CuCo2S4 and Ni(OH)2 composite is also fabricated to verify synergistic effects of CuCo2S4@Ni(OH)2. A higher specific capacitance (CF) of 1583.9 F/g along with the capacity of 220.0 mAh/g are got for optimal CuCo2S4@Ni(OH)2 electrode, respectively comparing to 831.7 and 1063.3 F/g of CuCoS4 and Ni(OH)2 electrodes. A BSH is fabricated by the CuCo2S4@Ni(OH)2 electrode and the activated carbon electrode. The potential window of 1.6 V and maximum energy density of 32.1 Wh/kg at 1.1 kW/kg are achieved. The CF retention of 78% and Coulombic efficiency higher than 97% in 8000 charge/discharge cycles are also obtained for this BSH. © 2023

关键词： Sulfur compounds

来源：评论

学校读者我要写书评

暂无评论

Automatic Platform for Upper Extremity Musculoskeletal Disorder Risks Estimation from Repetitive Actions -Preliminary results.

Automatic Platform for Upper Extremity Musculoskeletal Disor...

引用

2023 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2023

作者： Aqueveque, Pablo Gutierrez, Manuel Pena, Guisella Germany, Enrique Gomez, Britam Retamal, Gustavo Ortega-Bastidas, Paulina Universidad de Concepción Faculty of Engineering Electrical Engineering Department Concepción Chile Universidad de Concepción Faculty of Biological Sciences Ergonomics Department Concepción Chile Universidad de Santiago de Chile Biomedical Engineering Faculty of Engineering Santiago Chile Universidad de Concepción Faculty of Medicine Kinesiology Department Concepción Chile Universidad Rey Juan Carlos Health Sciences PhD Programme Madrid Spain

ISBN: (纸本)9781665493840

Work-related musculoskeletal disorders is a major problem for worker's health when dealing with repetitive tasks. The Occupational Repetitive Actions Index (OCRA) is one of the most widely used methods for determining upper extremity risk from repetitive actions. Traditional risk assessment consists in observing and recording the entire workday or part of it. This observational assessment depends on the evaluator's expertise, which lead to inter-evaluator variability in the results even for the same job. This paper presents preliminary results of a platform that combines motion capture data with a digitalized OCRA Index method to classify risks under repetitive tasks conditions. Repetitive action tasks were performed in a controlled laboratory environment on ten healthy subjects, where optical and inertial sensors were used to capture movement. Body segment positions, displacements and joint angles were fed into the platform comparing their processing time and reliability. Although results indicate that optical systems have a better performance than inertial sensors for posture evaluation, the last has better practical applicability since optical markers occlusion in the working setup induced measurement errors. In addition, inertial systems are more likely to be used on in real working scenarios due to their ease of use and portability. Finally, inertial sensors combined with the digitized OCRA index method platform effectively reduces 67% of the needed evaluation time compared to traditional observational methods. © 2023 IEEE.

关键词： Risk assessment

来源：评论

学校读者我要写书评

暂无评论

Optimized Silicon Nitride-Based Passive Components for 850 nm OCT on Photonic Chips

Optimized Silicon Nitride-Based Passive Components for 850 n...

引用

2024 Laser Science, LS 2024

作者： Meng, Jiawei Hao, Senyue Adkins, Aaron J. Zhou, Weiyan Zhou, Chao Department of Biomedical Engineering Washington University in St. Louis St. LouisMO63130 United States Department of Electrical & Systems Engineering Washington University in St. Louis St. LouisMO63130 United States Imaging Science PhD Program Washington University in St. Louis St. LouisMO63130 United States

For optical coherence tomography (OCT) on photonic chips, we designed and validated optimized silicon nitride-based passive components for photonic integrated circuits. Centered at 850 nm, these components offer high ... 详细信息

关键词： Silicon nitride

来源：评论

学校读者我要写书评

暂无评论

Long-term performance of air quality networks: implications in health and environmental management

引用

International Journal of Environmental Science and Technology 2025年

作者： Galán-Madruga, D. de Lourdes Berríos Cintrón, M. Broomandi, P. Oleniacz, R. Cáceres, J.O. Ctra. Majadahonda a Pozuelo Madrid28222 Spain Department of Health Sciences Inter American University of Puerto Rico Barranquitas Campus Bo. Helechal Street 156 Barranquitas Puerto Rico Department of Civil and Environmental Engineering School of Engineering and Digital Sciences Nazarbayev University Kabanbay Batyr Ave. 53 Astana010000 Kazakhstan Department of Electrical and Computer Engineering School of Engineering and Digital Sciences Nazarbayev University Kabanbay Batyr Ave. 53 Astana010000 Kazakhstan Department of Environmental Management and Protection Faculty of Geo-Data Science Geodesy and Environmental Engineering AGH University of Krakow 30 Mickiewicza Av Kraków30-059 Poland Laser Chemistry Research Group Department of Analytical Chemistry Faculty of Chemistry Complutense University of Madrid Plaza de Ciencias 1 Madrid28040 Spain ISCIII-UNED PhD Programme in Biomedical Sciences and Public Health Majadahonda Madrid Spain

Potential changes in the air pollutant spatial gradient may modify the performance of air quality networks, affecting function fulfillment. This study aims to elucidate, for the first time, whether the air quality networks’ design may be sustained over time. For that, temporal-spatial indicators were assessed in the long term. Particulate matter data (2005–2022) monitored by two target air quality networks (interior southwest European region) were regarded as a case study. The approach was applied to 2005–2022 particulate matter data. Broadly, the implementation of current European legislation (from 2008) has translated into a noticeable decrease in pollution levels. Polluting disparities were observed within the same fixed station category (urban, suburban, and rural). Diverse fixed monitoring stations showed different long-term pollution sceneries, evidencing varied exposure contexts. Distinct spatial patterns (quali- and quantitatively) were observed at global and local levels. Although the annual average PM2.5/PM10 ratio remains stable, suggesting common emission sources, the legislative limit exceedances are not sustained over the study due to fluctuating environmental conditions. Meteorological variables, particularly temperature, consistently impact particulate matter. Variable long-time environmental pollution situations may affect the performance of air quality networks. Based on a solid body of evidence, this work reveals needing to assess the long-time performance of air quality networks to secure the adequate fulfillment of their functions, given that non-redundant stations can become redundant ones and vice versa, thereby serving as a helpful methodology to complement current European air quality directives due to the lack of harmonized methodologies to achieve such an objective. © The Author(s) 2025.

关键词： Air quality

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：