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Predictive modelling of stem cell differentiation and apoptosis in C. elegans

9th International Conference on Information Processing in Cells and Tissues, IPCAT 2012

作者： Beyer, Antje Eberhard, Ralf Piterman, Nir Hengartner, Michael O. Hajnal, Alex Fisher, Jasmin Department of Genetics University of Cambridge Cambridge United Kingdom Institute of Molecular Life Sciences University of Zurich Zurich Switzerland PhD Program in Molecular Life Sciences Life Science Zurich Graduate School University of Zurich Zurich Switzerland Department of Computer Science University of Leicester Leicester United Kingdom Microsoft Research Cambridge United Kingdom

ISBN: (纸本)9783642287916

The nematode Caenorhabditis elegans has been established as a modeling organism in biomedical research for several decades. Its hermaphrodite germ line encompasses key developmental concepts like stem cell differentiation and apoptosis;therefore it provides a good model system for these basic concepts. Here, we have extended and refined our previous computational model, which encompasses developmental landmarks and the resulting movement of germ cells along the gonadal tube. We have used the molecular dynamics (MD) framework to model the physical movement of cells due to the force arising from cell divisions. The model simulation was calibrated with experimental time and it is in accordance with experimental observations. In addition, the model provides means for testing hypotheses regarding the behaviour of mutated germ lines and the potential mechanisms causing physiological apoptosis, which are difficult to assess experimentally. © 2012 Springer-Verlag.

关键词： Molecular dynamics

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Knowledge contribution in social media: Exploring factors influencing social taggers' acceptance towards contributing and sharing tags

Knowledge contribution in social media: Exploring factors in...

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6th International Conference on Information Systems, Management and Technology, ICISTM 2012

作者： Allam, Hesham Blustein, James Bliemel, Michael Spiteri, Louise Interdisciplinary PhD Program Dalhousie University Halifax NS Canada Faculty of Computer Science School of Information Management Dalhousie University Halifax NS Canada School of Business Administration Dalhousie University Halifax NS Canada School of Information Mangement Dalhousie University Halifax NS Canada

ISBN: (纸本)9783642291654

Based on a thorough literature review of social tagging and on technology acceptance models, we developed and empirically validated a motivational model to predict users' acceptance to add and share tagging content. Four factors successfully predicted users' intention to add and share metadata tagging content. Unlike previous studies on virtual communities, Reciprocity was found to be positively related to attitude whereas, in line with previous research, Ease of Use and Personal Productivity were confirmed to have substantial influence on users' attitude, which in turn affects the intention towards creating and sharing tagging content. Our findings are expected to shed light on developing strategies to understand and promote tagging content contribution and sharing which have the potential to increase the collective power and intelligence of the community. © 2012 Springer-Verlag.

关键词： Social networking (online)

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Bone mass and body composition in college students

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Revista da Associação Médica Brasileira (English Edition) 2012年第3期58卷 328-334页

作者： Cristina Reuter Carlos Efrain Stein Deisi Maria Vargas Undergraduate Medical Student Universidade Regional de Blumenau (FURB) Blumenau SC Brazil MSc in Computer Science Professor Department of Mathematics FURB Blumenau SC Brazil PhD in Medicine and Surgery (Pediatrics) Professor Department of Medicine FURB Blumenau SC Brazil

Objective To compare bone mineral density (BMD) and body composition (BC) of college students with different lifestyles. Methods Transversal study with 85 students of Medicine (MED) and Physical Education (PE) at the Universidade Regional de Blumenau, SC, Brazil. The anthropometric, socio-demographic, clinical, and lifestyle variables were obtained through densitometric anamnesis and densitometric variables by dual-energy X-ray (DXA). The statistical tests used were: Student's t-test, Chi-square test, and logistic regression. Results PE male students showed a higher amount of lean body mass (79.5 ± 5.9 vs. 75.1 ± 5.3; p = 0.03) and a lower amount of body fat (16.7 ± 6.1 vs. 21.6 ± 5.6; p = 0.02) and PE female students showed a higher amount of lean body mass (68.2 ± 5.5 vs. 65.3 ± 5.5; p = 0.05). The BMD of the neck of femur (NOF), total femur (TF), and total body (TB) was higher in PE students of both genders. PE students practiced more physical activities than MED students. Low bone mass (LBM) was more frequent in MED students (34.9% vs. 4.7%; p = 0.001), provided that the risk of a MED student to show LBM was nine times higher for lumbar spine (LS), five times for NOF, eight times for TF, and seven times for TB. Conclusion BC and BMD were different among the students; MED students have shown a higher risk of having LBM, and PE students practiced more physical activities.

关键词： Osteoporosis students lifestyle densitometry photon absorptiometry bone density

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Automatic Brain MR Images Diagnosis Based on Edge Fractal Dimension and Spectral Energy Signature

Automatic Brain MR Images Diagnosis Based on Edge Fractal Di...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： Salim Lahmiri Mounir Boukadoum PhD candidate in the same department department of computer science at the University of Quebec at Montreal. C.P. 8888 Succ. C.-V. Montreal (Quebec) H3C 3P8 Canada

ISBN: (纸本)9781424441198

A new automatic system to detect pathologies in human brain magnetic resonance (MR) images is presented. The goal is to classify normal versus abnormal images affected by Alzheimer, Glioma, Herpes, Metastatic, and Multiple Sclerosis. The extracted features are the fractal dimension of edges in the Hilbert domain, and the skewness and kurtosis of their spectral energy distribution. The proposed system (FDSE) outperforms the popular discrete wavelet transform (DWT) and principal component analysis (PCA).

关键词： Automatic Brain Images Diagnosis Based Fractal Dimension

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A narrative game as an educational entertainment resource to teach words to children with learning deficits: A feasibility study

A narrative game as an educational entertainment resource to...

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10th International Conference on Entertainment Computing, ICEC 2011

作者： Silva, Marcos Alexandre Rose De Lima, Débora Corrêa Anacleto, Junia Coutinho De Souza, Deisy Das Graças Martinez, Claudia Maria Simões Phd Program on Computer Science Federal University of São Carlos Brazil Phd Program on Special Education Federal University of São Carlos Brazil Department of Computer Science Federal University of São Carlos Brazil Department of Psycologist Federal University of São Carlos Brazil Department of Occupational Therapy Federal University of São Carlos Brazil

ISBN: (纸本)9783642244995

We describe the use of an entertainment computer narrative game to teach words to a child in a special education process. In order to observe the potential of this kind of game, we chosen a child who has difficult to learn some words using a basic computer tool at writing learning special education environment. The results showed that narrative games and its entertainment resources can be a good way to allow child reads and writes words considering different sentences and contexts, as well as, resources of the game can be a useful strategy to engage child on the storytelling. © 2011 Springer-Verlag.

关键词： computer games

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Q&A

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Design Management Review 2014年第3期25卷

作者： John Maeda Steven Heller Tim Hoover Has been a design partner at Kleiner Perkins Caufield & Byers since January 2014 helping entrepreneurs and portfolio companies to build design into their company cultures. He served as the president of Rhode Island School of Design for six years through 2013 and also served as an associate director of research at the MIT Media Lab. Maeda has been a practicing designer since 1990 and his work is in the permanent collections of the Museum of Modern Art San Francisco Museum of Modern Art and the Cartier Foundation. He serves on the boards of several corporations including Sonos and Wieden + Kennedy and is chair of eBay's Design Advisory Board. His four published books include The Laws of Simplicity and Redesigning Leadership. Maeda is the recipient of a variety of international awards for his creative work including induction into the Art Director's Club Hall of Fame. In 2001 he received the White House National Design Award in 2002 he received the Mainichi Design Prize in Japan and in 2005 he was awarded the Raymond Loewy Foundation Prize in Germany. Maeda earned a BS and an MS from MIT in computer science and electrical engineering. He received a PhD in design science from the University of Tsukuba Institute of Art and Design in Japan as well as an MBA from Arizona State University. Co‐chair and co‐founder of the MFA Designer as Author and Entrepreneur program at the School of Visual Arts in New York. He was the art director of The New York Times Book Review and now writes the VISUALS column for the NYTBR. He also writes “The Daily Heller” at *** a weekly online design column for Atlantic magazine. He is author co‐author and editor of more than 165 books on the history and practice of graphic design illustration and satiric art. His forthcoming books include 100 Classic Graphic Design Magazines (Laurence King Publishers) and Raw Data: The Process Behind Information Graphics (Thames + Hudson). Heller was the 2011 recipient of the Smithsonian National Design Award for Design Mind. He has also writ

John Maeda is a past president of Rhode Island School of Design and an internationally known designer. He's now involved in helping entrepreneurs build design into their company cultures. Writer and educator Steven Heller pairs up with Tim Hoover, head of product and design at Canary, to talk about designer CEOs, start‐ups, and cutting out the middleman.

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Computational Models of First Language Acquisition Special Issue of Research on Language and Computation

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Research on Language and Computation 2011年第2期8卷 101-106页

作者： Alexander Clark William Gregory Sakas Department of Computer Science Royal Holloway University of London London UK Department of Computer Science Hunter College PhD Programs in Linguistics and Computer Science The Graduate Center The City University of New York (CUNY) New York USA

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The use of distributed databases in e-learning systems

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Procedia - Social and Behavioral sciences 2011年 15卷 2673-2677页

作者： Iacob Nicoleta Magdalena Phd student Doctoral School University of Pitesti Department of Computer Science Str. Targu din Vale nr.1 Arges and Postcode 110040 Romania

E-learning: The modern technologies in education and research aims to build a society based on knowledge. In this paper we will describe the advantages of e-learning education and the importance of data allocation in the process of designing a distributed database system. In addition, we are going to analyze the available strategies for optimizing the query execution in a distributed environment, in order to obtain the smallest system response time. The purpose of this paper is to present the advantages offered by the use of distributed databases in the education field by universities with geographically distributed locations.

关键词： e-learning architecture design allocation query optimization strategies

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Information security in E-learning Platforms

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Procedia - Social and Behavioral sciences 2011年 15卷 2689-2693页

作者： Defta Costinela Luminita Phd student Doctoral School University of Pitesti Department of Computer Science Str. Targu din Vale nr.1 Arges and Postcode 110040 Romania

Security is an important issue in the actual educational context where e-learning increases in popularity and more and more people are taking online courses. There are many important elements that must be taken into account: authentication, access control, data integrity, content protection, etc. Information security can be obtained using methods such as cryptography and network protocols. In this paper we will highlight some key security issues that must be taken into consideration in developing and using an e-learning platform. We will also examine some security aspects of one of the most popular open-source e-learning systems: Moodle.

关键词： e-learning security education attacks Moodle

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Graph-based approach for gene markers and applications in next-generation sequencing data analysis 11

Graph-based approach for gene markers and applications in ne...

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2011 ACM Conference on Bioinformatics, Computational Biology and Biomedicine, ACM-BCB 2011

作者： Johnson, Daniel Wang, Kun Cramer, Carole L. Huang, Xiuzhen Molecular Bioscience PhD Program Arkansas State University Jonesboro AR United States Department of Computer Science Arkansas State University P.O. Box 9 Jonesboro AR United States Arkansas Bioscience Institute Dept. of Biology Arkansas State University Jonesboro AR United States

ISBN: (纸本)9781450307963

With the tremendous large data sets from next-generation sequencing technology, there is the big challenging task of how to transform the large amount of sequencing data to information meaningful for biologists and life scientists. The initial step is to align these data sets to the known reference genomes, which is essential for further data analysis. However next-generation sequencing read alignment is very time consuming. To address this challenge, we developed a general framework to build genome-wide unique gene markers. This framework includes a novel graph theoretical model for extracting robust gene markers and effective methods for evaluating the sets of gene markers. The genome-wide unique gene markers will help accelerating the next-generation sequencing read alignment process. We use the E. Coli genome as a model genome to illustrate our approach and demonstrate its significance in time saving for read alignment. Further testing on using the sets of gene markers for read coverage analysis is being conducted. Copyright © 2011 ACM.

关键词： Genes

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