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Identification of factors affecting the accident rate in the construction industry

Procedia engineering 2017年 208卷 35-42页

作者： Bożena Hoła Tomasz Nowobilski Iwona Szer Jacek Szer Prof. WUST PhD Eng. Bożena Hoła MSc Eng. Tomasz Nowobilski Wroclaw University of Science and Technology Faculty of Civil Engineering Department of Construction Methods and Managements Poland Phd Eng. Iwona Szer PhD Eng. Jacek Szer Lodz University of Technology Faculty of Civil Engineering Architecture and Environmental Engineering Poland

The construction industry is one of the most accident-prone sectors of the Polish economy. There are many causes of accidents and they result from the factors that occur in the working environment. These factors, in favourable circumstances, can significantly increase the probability of a hazard becoming operational and leading to an occupational accident. The article presents the most important factors affecting the development of accidents in the construction industry, which were identified on the basis of surveys. These factors are divided into three groups due to their location in the construction work environment and its surroundings. Mutual relations between the identified factors are graphically presented in the form of the cause and effect diagram of Ishikawa. The relation between the value of construction and assembly production and the accident rate in the construction industry was calculated using the correlation coefficient.

关键词： accident factors Ishikawa diagram classification survey

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Disagreement in middle ear volume estimation between tympanometry and three-dimensional volume reconstruction in the context of tympanic membrane perforation

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Journal of Otology 2017年第2期12卷 74-79页

作者： David J.Carpenter Debara L.Tucci David M.Kaylie Dennis O.Frank-Ito Division of Head and Neck Surgery&Communication Sciences Department of SurgeryDuke University Medical CenterDurhamNCUSA Computational Biology&Bioinformatics PhD Program Duke UniversityDurhamNCUSA Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA

Introduction: Middle ear volume(MEV) is a clinically relevant parameter across middle ear diseases. MEV values between these techniques have never before been tested for agreement in ears with perforated tympanic membranes(TMs).Methods: Middle ears were identified from 36 patients ranging 18-89 years of age with TM perforations who underwent tympanometry and temporal bone computed tomography(CT) between 2005 and 2015. MEVs calculated by both tympanometry and three-dimensional volume reconstruction(3DVR) were analyzed for agreement using Bland Altman plots. The differences between tympanometric and 3DVR MEV values for each given middle ear were characterized across MEV quartiles(1= smallest; 4= largest) and across increasing states of middle ear disease using Kruskale Wallis and Wilcoxon testing with Bonferroni ***: Bland Altman plots demonstrated significant disagreement between MEV measurement techniques. Differences between tympanometric(T) and 3DVR MEV values were significantly greater with increasing average(i.e.(Tt3DVR)/2)) MEV per linear regression(p < 0.0001). Significance was demonstrated between fourth and first average MEV quartiles(p= 0.0024), fourth and second quartiles(p= 0.0024), third and first quartiles(p= 0.0048), and third and second quartiles(p= 0.048). Absolute MEV difference was not significantly different across varying states of middle ear disease(p= 0.44).Conclusion: Statistically and clinically significant disagreement was demonstrated between tympanometric and 3DVR MEV values. Studies that vary in MEV estimation techniques may be expected to demonstrate significantly different results. These preliminary results suggest that clinicians should endeavor to seek further confirmation when interpreting high tympanometric MEV values.

关键词： Middle ear volume Tympanometry Three-dimensional volume reconstruction Tympanic membrane perforation

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How can bioclimatic design foster diversification of low-energy building strategies in the next future? – design for long-term learning process in residential building

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IOP Conference Series: Earth and Environmental science 2019年第1期294卷

作者： L Barghini T Yashiro PhD candidate Graduate School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Professor Institute of Industrial Science The University of Tokyo 4-6-1 Komaba Meguro-ku Tokyo 153-8508 Japan

In recent years, Bioclimatic Design theory recognized users' adaptive behavior a central aspect to address low-energy and comfort in buildings. Users that once were considered passive receptors of comfort, now are provided with the tools to make themselves comfortable. This paper takes a step forward, recognizing that users can be passive, reactive and creative at the same time. People often adopt complex behavior, construct proper habits or create new ones, considering their own culture and values. In this scenario, Bioclimatic Design should identify new strategies to promote sustainable behavior among final users. In this sense, knowing how inhabitants learn from built environment is the first step in this direction. Designers must adopt people perspective and identify how they relate to the built environment, receive information and act pro-environmentally. Surrounded by architectures that enable learning processes, inhabitants will be able to ethically balance energy sufficiency measures as a trade-off between energy needs reduction, unpredictable events, and individual growth. Conclusions highlight that to continue differentiating energy strategies, architecture and technology should broaden user choices and allow natural development of pro-environmental attitudes based on deep ecological culture and wellbeing.

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Factors affecting fate and transport of engineered nanomaterials in terrestrial environments

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Current Opinion in Environmental science and Health 2018年 6卷 47-53页

作者： Rawat, Swati Pullagurala, Venkata L.R. Adisa, Ishaq O. Wang, Yi Peralta-Videa, Jose R. Gardea-Torresdey, Jorge L. Environmental Science and Engineering PhD Program The University of Texas at El Paso 500 West Univ. Ave. El Paso 79968 TX United States Department of Chemistry and Biochemistry The University of Texas at El Paso 500 West Univ. Ave. El Paso 79968 TX United States University of California Center for Environmental Implications of Nanotechnology (UC CEIN) The University of Texas at El Paso 500 West Univ. Ave. El Paso 79968 TX United States Centre for Nanoscale Elements Suppress Plant Disease Enhance Macronutrient Use Efficiency and Increase Crop Yield United States

The unique physico-chemical, electronic, redox, and UV-absorption properties of the engineered nano-particles (ENPs) make them suitable for many industrial applications including consumer goods. Agriculture is a major area where nanotechnologies are applied. Therefore, soil/sediment becomes an important environmental sink for ENP waste disposal. Hence, the fate and transport of ENPs in soil is of particular interest to the scientific community. This short review summarizes the recent findings of studies dealing with the related fundamental concepts. It touches upon the physico-chemical properties of soil and those of ENPs, the soil and solution chemistries, the environmental factors, and the influence of other chemical moieties as possible factors affecting the fate of ENPs in soil. © 2018 Elsevier B.V.

关键词： Colloidal chemistry Deposition Engineered nano particles Organic matter Soil chemistry Transport

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Front Cover: Bioderived Molecular Electrodes for Next-Generation Energy-Storage Materials (ChemSusChem 9/2020)

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ChemSusChem 2020年第9期13卷 2101-2101页

作者： Mikhail Miroshnikov Kiran Mahankali Dr. Naresh Kumar Thangavel Dr. Sitakanta Satapathy Dr. Leela Mohana Reddy Arava Dr. Pulickel M. Ajayan Dr. George John Department of Chemistry and Biochemistry Center for Discovery and Innovation The City College of New York 85 St. Nicholas Terrace New York NY 10031 USA The PhD Program in Chemistry The Graduate Center of the City University of New York 365 5th Ave New York NY 10016 USA Department of Mechanical Engineering Wayne State University 5050 Anthony Wayne Dr. Detroit MI 48202 USA Department of Materials Science and NanoEngineering Rice University 6100 Main Street Houston TX 77005 USA

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Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells

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Phytomedicine 2023年 116卷

作者： Jen-Chih Tseng Bi-Juan Wang Ya-Pei Wang Ying-Yu Kuo Jen-Kun Chen Tzyh-Chyuan Hour Li-Kuo Kuo Po-Jen Hsiao Chien-Chih Yeh Cheng-Li Kao Li-Jane Shih Chih-Pin Chuu Institute of Cellular and System Medicine National Health Research Institutes Miaoli County 35053 Taiwan Immunology Research Center National Health Research Institutes Miaoli County 35053 Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County 35053 Taiwan Neuroscience Research Center Kaohsiung Medical University Kaohsiung 80737 Taiwan Department of Biochemistry School of Medicine Kaohsiung Medical University Kaohsiung 80737 Taiwan Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung 80737 Taiwan Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Mackay Memorial Hospital Taipei City 104217 Taiwan Department of Nursing Mackay Medical College Taipei City Taiwan Division of Nephrology Department of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan 325 Taiwan Division of Nephrology Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei 114 Taiwan Department of Education and Medical Research Taoyuan Armed Forces General Hospital Taoyuan Taiwan Division of Colon and Rectal Surgery Department of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Division of Urology Departments of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Division of Urology Department of Surgery Taoyuan Armed Forces General Hospital Taoyuan Taiwan Graduate Institute of Medical Science National Defense Medical Center Taipei 114 Taiwan Department of Life Sciences National Central University Taoyuan 32031 Taiwan PhD Program for Aging and Graduate Institute of Basic Medical Science China Medical University Taichung City 40402 Taiwan Biotechnology Center National Chung Hsing University Taichung City 40227 Taiwan

Background Epidermal growth factor receptor (EGFR) is upregulated in prostate cancer (PCa). However, suppression of EGFR did not improve the patient outcome, possibly due to the activation of PI3K/Akt signaling in PCa. Compounds able to suppress both PI3K/Akt and EGFR signaling may be effective for treating advanced PCa. Purpose We examined if caffeic acid phenethyl ester (CAPE) simultaneously suppresses the EGFR and Akt signaling, migration and tumor growth in PCa cells. Methods Wound healing assay, transwell migration assay and xenograft mice model were used to determine the effects of CAPE on migration and proliferation of PCa cells. Western blot, immunoprecipitation, and immunohistochemistry staining were performed to determine the effects of CAPE on EGFR and Akt signaling. Results CAPE treatment decreased the gene expression of HRAS, RAF1, AKT2, GSK3A , and EGF and the protein expression of phospho-EGFR (Y845, Y1069, Y1148, Y1173), phospho-FAK, Akt, and ERK1/2 in PCa cells. CAPE treatment inhibited the EGF-induced migration of PCa cells. Combined treatment of CAPE with EGFR inhibitor gefitinib showed additive inhibition on migration and proliferation of PCa cells. Injection of CAPE (15 mg/kg/3 days) for 14 days suppressed the tumor growth of prostate xenografts in nude mice as well as suppressed the levels of Ki67, phospho-EGFR Y845, MMP-9, phospho-Akt S473, phospho-Akt T308, Ras, and Raf-1 in prostate xenografts. Conclusions Our study suggested that CAPE can simultaneously suppress the EGFR and Akt signaling in PCa cells and is a potential therapeutic agent for advanced PCa.

关键词： Prostate cancer Caffeic acid phenethyl ester Metastasis Epidermal growth factor receptor Fak Akt CAPE caffeic acid phenethyl ester CRPC castration-resistant prostate cancer EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition GAPDH glyceraldehyde-3-phosphate dehydrogenase mTOR mammalian target of rapamycin PCa prostate cancer PI3K phosphoinositide 3-kinase PSA prostate specific antigen PSMA prostate specific-membrane antigen PTEN phosphatase and tensin homolog

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Estimation of the Tourism Potential of the Municipal Divisions in Novosibirsk Region on the Basis of Classification Methods

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IOP Conference Series: Earth and Environmental science 2018年第1期204卷

作者： E O Ushakova M Ye Tsoy V Yu Shchekoldin Candidate of science (PhD) in economy science associate professor of department of real estate economy Siberian state university of geosystems and technologies Novosibirsk Russia Candidate of science (PhD) in economy science associate professor head of marketing and service department Novosibirsk state technical university Novosibirsk Russia Candidate of science (PhD) in engineering associate professor of marketing and service department Novosibirsk state technical university Novosibirsk Russia

The article presents the study of practical aspects in estimation of region tourism potential which bases on classification methods. Comparative evaluation of territory tourism potential by the example of municipalities in the Novosibirsk region was made and then most prospective and investment-attractive districts were determined.

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Hydrometeorological monitoring for hydropower reservoirs in remote areas

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IOP Conference Series: Earth and Environmental science 2019年第1期257卷

作者： H Basri LM Sidek L H C Chua A Z Abdul Razad M S Kamarulzaman PhD Candidate Civil Engineering Department College of Engineering and Sustainable Technology and Environment Group Institute of Energy Infrastructure Universiti Tenaga Nasional Malaysia Professor Civil Engineering Department College of Engineering and Sustainable Technology and Environment Group Institute of Energy Infrastructure Universiti Tenaga Nasional Malaysia Associate Professor School of Engineering Faculty of Science Engineering & Built Environment Deakin University 75 Pigdons Road Waurn Ponds 3220 VIC Australia Researcher TNB Research Sdn Bhd Malaysia Senior SCADA & Instrumentation Engineer Tenaga Nasional Berhad Malaysia

Operational hydrometric network is an essential element in hydropower reservoir operation. The data collected, to be used for reservoir management and decision making require high reliability with automatic data monitoring, processing and retrieval. However, the unique characteristic of every catchment and operational requirements raises the need to balance hydrometeorological monitoring objectives and site desirability. This paper describes the overall component of the Temengor Inflow Forecasting System developed as part of a decision support module for optimised hydropower dam operation for the Temengor Hydropower Dam system in Malaysia. The equipment used and challenges faced in deployment in a densely forested catchment in the Sungei Perak basin are discussed. The siting of the hydrometeorological network was made based on World Meterological Organisation guidelines and state of the art communication technology was utilized in overcoming accessibility to our monitoring sites. The real time data on power generation, river and reservoir level, rainfall that were collected are presented in this paper.

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A simulation based framework to optimize the interior design parameters for effective Indoor Environmental Quality (IEQ) experience in affordable residential units: Cases from Mumbai, India

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IOP Conference Series: Earth and Environmental science 2019年第1期294卷

作者： A Sarkar R Bardhan PhD (pursuing) Centre for Urban Science and Engineering Indian Institute of Technology Bombay Maharashtra India 400076 Assistaint Professor Centre for Urban Science and Engineering Indian Institute of Technology Bombay Maharashtra India 400076 Associate Faculty. Interdisciplinary Programme (IDP) in Climate Studies Indian Institute of Technology Bombay Mumbai 400076 India Sustainable Design Group Building Performance Group Department of Architecture University of Cambridge Cambridge CB3 9DT UK

This study intends to optimise the interior layout of two low-income multi-rise tenement designs that would provide effective indoor environmental quality (IEQ) over the breathing zone. A variety of interior layouts were generated for both space constrained tenement units by introducing and varying interior architectural parameters and their respective design variables such as partition wall, cook-stove and furniture location. The study initiated with in-situ sensor development coupled with a stepwise simulation based framework involving sampling based parametric modelling followed by CFD simulations and multi-objective optimisation. Air velocity, temperature, and pollutant concentrations were considered as surrogate measures of IEQ. The research finally delivered two varying interior design layout with optimised design variables that would deliver indoor air quality within comfort range over the breathing zone in nat-vent conditions. Dearth of sustainable design strategies is a major dead-spot in habitat planning policies of India and needs urgent attention. This data driven research heuristics if applied through building design guidelines would help the architects, building engineers and urban planners to design and rejuvenate slum and low-income habitats by imbibing the environmental sustainability aspect in habit design policies.

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Machine learning for early prediction of circulatory failure in the intensive care unit

arXiv

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arXiv 2019年

作者： Hyland, Stephanie L. Faltys, Martin Hüser, Matthias Lyu, Xinrui Gumbsch, Thomas Esteban, Cristóbal Bock, Christian Horn, Max Moor, Michael Rieck, Bastian Zimmermann, Marc Bodenham, Dean Borgwardt, Karsten Rätsch, Gunnar Merz, Tobias M. Department of Computer Science ETH Zürich Zürich Switzerland Computational Biology Program Memorial Sloan Kettering Cancer Center New York United States Tri-Institutional PhD Program in Computational Biology and Medicine Weill Cornell Medicine New York United States Medical Informatics Group Zürich University Hospital Zürich Switzerland Department of Intensive Care Medicine University Hospital University of Bern Bern Switzerland Department of Biosystems and Engineering ETH Zürich Basel Switzerland Department of Biology ETH Zürich Zürich Switzerland Swiss Institute for Bioinformatics Lausanne Switzerland Cardiovascular Intensive Care Unit Auckland City Hospital Auckland New Zealand

Intensive care clinicians are presented with large quantities of patient information and measurements from a multitude of monitoring systems. The limited ability of humans to process such complex information hinders physicians to readily recognize and act on early signs of patient deterioration. We used machine learning to develop an early warning system for circulatory failure based on a high-resolution ICU database with 240 patient-years of data. This automatic system predicts 90.0% of circulatory failure events (prevalence 3.1%), with 81.8% identified more than two hours in advance, resulting in an area under the receiver operating characteristic curve of 94.0% and area under the precision recall curve of 63.0%. The model was externally validated in a large independent patient cohort. Copyright © 2019, The Authors. All rights reserved.

关键词： Intensive care units

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