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5th International Conference on Complex, Intelligent and Software Intensive Systems, CISIS 2011

作者： Tsai, Zing Tsung-Yeh Huang, Grace Tzu-Wei Tsai, Huai-Kuang Institute of Information Science Academia Sinica Taipei 115 Taiwan Bioinformatics Program Taiwan International Graduate Program Taiwan Institute of Biomedical Informatics National Yang-Ming University Taiwan Joint CMU-Pitt PhD Program in Computational Biology University of Pittsburgh Carnegie Mellon University Pittsburgh PA United States Research Center for Information Technology Innovation Taipei 115 Taiwan Computer Science and Engineering National Taiwan Ocean University Keelung 202 Taiwan

ISBN: (纸本)9780769543734

Identifying transcription factor binding sites (TFBSs) is crucial for understanding the mechanism of transcriptional regulation. It is known that transcription factors (TFs) often cooperate to regulate genes. While traditional approaches can be used to discover binding motifs of a group of co-regulated genes, they often fail to accurately assign motifs to the corresponding TFs. Here, we consider two TFs together to infer their TFBSs and their synergistic relationship simultaneously. The basic idea is that if two TFs interact, their TFBSs, if distinct, would be conserved across species and coincided in the promoter regions of the genes they co-regulated. Applying our method to Saccharomyces cerevisiae chromatin immunoprecipitation data, we predicted 110 TF pairs with statistically significant motif assignments. A majority of these TF pairs have literature support to be synergistic, and the designated motifs to TFs match well with their known consensus. We further examined the synergism of predicted TF pairs in seven experimental conditions using ANOVA, and identified significant interactions. © 2011 IEEE.

关键词： Yeast

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Simultaneous Identification for Synergistic Transcription Factors and their Transcription Factor Binding Sites

Simultaneous Identification for Synergistic Transcription Fa...

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International Conference on Complex, Intelligent and Software Intensive Systems, CISIS

作者： Zing Tsung-Yeh Tsai Grace Tzu-Wei Huang Huai-Kuang Tsai Institute of Information Science Academia Sinica Taipei Taiwan Institute of Biomedical Informatics National Yang-Ming University Taiwan Joint CMU-Pitt PhD Program in Computational Biology University of Pittsburgh Carnegie Mellon University Pittsburgh USA Computer Science and Engineering National Taiwan Ocean University Keelung Taiwan

关键词： Bioinformatics Analysis of variance DNA Databases Gene expression Proteins Stress

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Complex photonic crystals for broadband

Complex photonic crystals for broadband

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作者： Chuang, Yi-Chen. The University of North Carolina at Charlotte.bOptical Science and Engineering (PhD).

学位级别：Ph.D.

Self-collimation is a dispersion property of many photonic crystals PCs), in which light beam can propagate free of divergence in the PCs. While self-collimation is a desired property for applications...

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Bioanalysis Young Investigator: Halil Tekin

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Bioanalysis 2011年第16期3卷 1815-1816页

作者： Halil Tekin Ali Khademhosseini Robert S Langer a Position PhD CandidatePhD Electrical Engineering and Computer Science – Bio-Electrical Engineering AreaResearch area Tissue engineering stimuli-responsive platforms and high-throughput screening systemsDepartment of Electrical Engineering & Computer Science of MIT 65 Landsdowne Street Rm. 252 Cambridge MA02139 USA. halil@mit.edu b Harvard-MIT Health Sciences & Technology Department of Medicine Harvard Medical School Brigham & Women’s Hospital Wyss Institute for Biologically Inspired Engineering 65 Landsdowne Street Rm 252 Cambridge MA02139 USA. alik@rics.bwh.harvard.edu c David H Koch Institute of Integrative Cancer Research at MIT Departments of Chemical Engineering & Biological Engineering of MIT Harvard-MIT Health Sciences & Technology 77 Massachusetts Avenue Rm 76-661 MA USA. rlanger@mit.edu

Supervisor’s supporting commentsI am very pleased to nominate Halil Tekin for theBioanalysisYoung Investigator award. Halil has proven himself to be an excellent researcher, a very bright laboratory member and a strong leader since joining my laboratory. He has excelled at all of the skills required of a phd candidate at MIT with his research focusing primarily on future advances in drug development, drug discovery and medicine with high-throughput drug toxicity screening. His efforts have focused on developing novel biomimetic tissue constructs by microengineering methods to further advance the applications of implantable tissues and drug toxicity screening devices. Halil has demonstrated an unprecedented ability not only to learn new material quickly, but more importantly to synthesize new information and ask the important questions needed to move science forward. I am constantly impressed with Halil’s ability, drive and determination in learning, and contributing to the research conducted in my laboratory. Halil’s unique combination of a strong electrical engineering background and his current knowledge and experience in tissue engineering has enabled him to look at fundamental challanges in a novel and insightful way, which resulted in very interesting *** is an exceptional phd student conducting outstanding research in tissue engineering which can bring novel applications in human health care. Halil published a paper in a top journal in the field of microtechnology,Lab on a Chip, describing a new way of making cell aggregates and then retrieving them from the microwells in a controllable manner for further experimentation and analysis. He also published a paper inLangmuir, introducing a novel method to fabricate conformally coated thermo-responsive microgrooves to form stripe tissues and harvest them in a temperature-dependent manner. These responsive microstructures can be scalable into high-throughput systems and potentially be useful in tissue

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Nursing students administering medication: appreciating and seeking appropriate supervision

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JOURNAL OF ADVANCED NURSING 2010年第3期66卷 532-541页

作者： Reid-Searl, Kerry Moxham, Lorna Walker, Sandra Happell, Brenda Kerry Reid-Searl MClin Ed PhD RN Senior Lecturer Department of Health Innovation Faculty of Science Engineering and Health and Institute for Health and Social Science Research CQUniversity Australia Queensland Australia Lorna Moxham MHN PhD RN Associate Professor and Dean Research and Research Training Institute for Health and Social Science Research CQUniversity Australia Queensland Australia Sandra Walker PhD RN RM Senior Lecturer Faculty of Science Engineering and Health and Institute for Health and Social Science Research CQUniversity Australia Queensland Australia Brenda Happell PhD RN RPN Professor of Contemporary Nursing Department of Health Innovation Faculty of Science Engineering and Health and Deputy Director Institute for Health and Social Science Research CQUniversity Australia Queensland Australia *Correspondence: B. Happell: e-mail: b.happell@cqu.edu.au

P>Aim. This paper is a report of a study of undergraduate nursing students' experience of administering medication in the clinical setting. Background. Safe administration of medication is an important component of skilled nursing practice, and nursing students require personal and supportive supervision from Registered Nurses to enhance learning and promote safety. A review of the literature revealed a lack of research addressing students' experiences in administering medication. Methods. A grounded theory methodology was used. In-depth semi-structured interviews were conducted with a convenience sample of 27 undergraduate nursing students in Queensland Australia in 2005. Findings. Supervision emerged as the central category in this study. Participants acknowledged the need for and importance of supervision according to the following sub-themes: a university requirement;scope of practice;and safety, the five rights. They also described behaviours they adopted to seek supervision, including negotiating, chasing, waiting and avoiding. Conclusion. Universities and healthcare settings need to collaborate more closely to ensure that adequate supervision is provided to ensure safe practices.

关键词： clinical education grounded theory medication administration nursing students supervision

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Three level diode clamped inverter for DTC-SVM of induction motor

Three level diode clamped inverter for DTC-SVM of induction ...

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International Conference on Power Electronic Drives and Energy Systems for Industrial Growth

作者： Jagan Mohana Rao Malla Siva Ganesh Malla HOD of AE and IE Gandhi Institute of Engineering and Technology Gunupur Orissa India PhD scholar Department of Electrical science Indian Institute of Technology Bhubaneswar Bhubaneswar Orissa India

Direct Torque Control is a control technique used in AC drive systems to obtain high performance torque control. The conventional DTC drive contains a pair of hysteresis comparators, a flux and torque estimator and a voltage vector selection table. The torque and flux are controlled simultaneously by applying suitable voltage vectors, and by limiting these quantities within their hysteresis bands, decoupled control of torque and flux can be achieved. However, as with other hysteresis-bases systems, DTC drives utilizing hysteresis comparators suffer from high torque ripple and variable switching frequency. The most common solution to this problem is to use the space vector with multilevel inverter depends on the reference torque and flux. The reference voltage vector is then realized using a voltage vector modulator. Several variations of DTC-SVM with three level inverter have been proposed and discussed in the literature. The work of this project is to study, evaluate and compare the various techniques of the DTC-SVM with three level inverter applied to the induction machines through simulations. The simulations were carried out using MATLAB/ SIMULINK simulation package. Evaluation was made based on the drive performance, which includes dynamic torque and flux responses, feasibility and the complexity of the systems. It is better technology in electric vehicles.

关键词： Inverters Torque Stators Induction motors Simulation Torque control Modulation

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High-speed implementation of Hamming neural network

High-speed implementation of Hamming neural network

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Seminar on Neural Network Applications in Electrical engineering

作者： Vladimir B. Kovačević Ana M. Gavrovska Milorad P. Paskaš Institute Mihajlo Pupin University of Belgrade Belgrade Serbia PhD stipendiary of the Ministry of Science and Technological Development Republic of Serbia is with the School of Electrical Engineering University of Belgrade Belgrade Serbia Innovation Center of the School of Electrical Engineering University of Belgrade Belgrade Serbia

Advancements in digital electronics and signal processing algorithms for various purposes generated the possibility and need for designing artificial neural networks in hardware. The selected platform, FPGA, enables fulfillment of their demands and provides comfortable work and test environment. This paper presents development cycle and specifics for implementation of high speed Hamming artificial neural network.

关键词： Artificial neural networks Field programmable gate arrays Prototypes Hardware Generators Hamming distance Computer architecture

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Numerical simulation of continuous casting process of bloom by fifite point method

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TMS 2009 Annual Meeting and Exhibition

作者： Jenabali-Jahromi, Seyed Ahmad Alizadeh, Mostafa Nasihatkon, Sayyed Behrouz Professor Department of materials science and engineering Shiraz University Shiraz Iran PhD student Department of materials science and engineering Shiraz University Shiraz Iran M.S. student Department of computer engineering Shiraz University Shiraz Iran

ISBN: (纸本)9780873397353

In this paper a meshless method called Finite Point Method (FPM) is developed to simulate the solidification process of continuously cast bloom steel in both primary and secondary cooling region. The method is based on the use of a weighted least-square interpolation procedure. A transverse slice of bloom as it moves with casting speed is considered as computational domain. The two dimensional heat transfer equation together with temperature dependent thermophysical properties is solved in the computational domain. The present work is verified in the mold region by the comparison of the surface temperature simulated by FPM and finite volume method (FVM) and also comparison of solidified shell thickness simulated by FPM and measured on a breakout bloom. For secondary cooling region the validation is done by comparison of the surface temperature simulated by FPM, FVM and thermovision measurements.

关键词： Continuous casting

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Investigation of transient cavitating flow in viscoelastic pipes

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IOP Conference Series: Earth and Environmental science 2010年第1期12卷

作者： A Keramat A S Tijsseling A Ahmadi PhD student Department of Civil Engineering Shahrood University of Technology Iran Department of Mathematics and Computer Science Eindhoven University of Technology PO Box 513 5600 MB Eindhoven The Netherlands Department of Civil Engineering Shahrood University of Technology Iran Post Code: *** University Boulevard Shahrood Iran presently Department of Mathematics and Computer Science Eindhoven University of Technology The Netherlands

A study on water hammer in viscoelastic pipes when the fluid pressure drops to liquid vapour pressure is performed. Two important concepts including column separation and the effects of retarded strains in the pipe wall on the fluid response have been investigated separately in recent works, but there is some curiosity as to how the results for pressure and discharge are when column separation occurs in a viscoelastic pipe. For pipes made of plastic such as polyethylene (PE) and polyvinyl chloride (PVC), viscoelasticity is a crucial mechanical property which changes the hydraulic and structural transient responses. Based on previous developments in the analysis of water hammer, a model which is capable of analysing column separation in viscoelastic pipes is presented and used for solving the selected case studies. For the column-separation modelling the Discrete Vapour Cavity Model (DVCM) is utilised and the viscoelasticity property of the pipe wall is modelled by Kelvin-Voigt elements. The effects of viscoelasticity play an important role in the column separation phenomenon because it changes the water hammer fundamental frequency and so affects the time of opening or collapse of the cavities. Verification of the implemented computer code is performed for the effects of viscoelasticity and column separation – separately and simultaneously – using experimental results from the literature. In the provided examples the focus is placed on the simultaneous effect of viscoelasticity and column separation on the hydraulic transient response. The final conclusions drawn are that if rectangular grids are utilised the DVCM gives acceptable predictions of the phenomenon and that the pipe wall material's retarded behaviour strongly dampens the pressure spikes caused by column separation.

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REVIEW ARTICLE: Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury

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Journal of Pineal Research 2010年第3期49卷

作者： Yonggeun Hong K. J. Palaksha Kanghui Park Sookyoung Park Hyun-Dong Kim Russel J. Reiter Kyu-Tae Chang Cardiovascular & Metabolic Disease Center Department of Rehabilitation Science in Interdisciplinary PhD Program College of Biomedical Science & Engineering Inje University Gimhae National Primate Research Center (NPRC) Korea Research Institute of Bioscience and Biotechnology (KRIBB) Ochang Department of PM & R. (Physical Medicine and Rehabilitation) College of Medicine Inje University Busan Korea Department of Cellular & Structural Biology The UT Health Science Center San Antonio TX USA

Abstract: Spinal cord injury (SCI) is damage to the spinal cord caused by the trauma or disease that results in compromised or loss of body function. Subsequent to SCI in humans, many individuals have residual motor and sensory deficits that impair functional performance and quality of life. The available treatments for SCI are rehabilitation therapy, activity-based therapies, and pharmacological treatment using antioxidants and their agonists. Among pharmacological treatments, the most efficient and commonly used antioxidant for experimental SCI treatment is melatonin, an indolamine secreted by pineal gland at night. Melatonin’s receptor-independent free radical scavenging action and its broad-spectrum antioxidant activity makes it an ideal antioxidant to protect tissue from oxidative stress-induced secondary damage after SCI. Owing to the limitations of an activity-based therapy and antioxidant treatment singly on the functional recovery and oxidative stress-induced secondary damages after SCI, a melatonin plus exercise treatment may be a more effective therapy for SCI. As suggested herein, supplementation with melatonin in conjunction with exercise not only would improve the functional recovery by enhancing the beneficial effects of exercise but would reduce the secondary tissue damage simultaneously. Finally, melatonin may protect against exercise-induced fatigue and impairments. In this review, based on the documented evidence regarding the beneficial effects of melatonin, activity-based therapy and the combination of both on functional recovery, as well as reduction of secondary damage caused by oxidative stress after SCI, we suggest the melatonin combined with exercise would be a novel neurorehabilitative strategy for the faster recovery after SCI.

关键词： animal model exercise melatonin rehabilitation secondary/oxidative damage spinal cord injury

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