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Comparison of Histomorphometric Aspects between Oral Lichen Planus Lesions and Oral Lichenoid Lesions

Head and Neck Pathology 2025年第1期19卷 1-9页

作者： Sanches, Ana Carla Barletta Azevedo, Juliana Santos de Jesus Pimenta-Barros, Liliana Aparecida Freitas, Valéria Souza Camisasca, Danielle Resende Martins, Gabriela Botelho Postgraduate Program in Interactive Processes of Organs and Systems of the Institute of Health Sciences of the Federal University of Bahia Bahia Brazil PhD in Oral Pathology from the University of São Paulo Full Professor at the Federal University of Espírito Santo Professor of the Postgraduate Program in Dental Sciences at the Federal University of Espírito Santo Espírito Santo Vitória Brazil PhD in Oral Pathology from the Federal University of Rio Grande do Norte Adjunct Professor at the State University of Feira de Santana Professor of the Postgraduate Program in Public Health at the State University of Feira de Santana Bahia Brazil PhD in Pathology from the Fluminense Federal University Associate Professor at the Federal University of Espírito Santo Espírito Santo Brazil Professor of the Postgraduate Program in Dental Sciences at the Federal University of Espírito Santo Espírito Santo Vitória Brazil PhD in Clinical Stomatology from the Pontifical Catholic University of Rio Grande do Sul Associate Professor at the Multidisciplinary Institute of Rehabilitation and Health of the Federal University of Bahia Bahia Brazil Professor of the Postgraduate Program in Interactive Processes of Organs and Systems of the Institute of Health Sciences of the Federal University of Bahia Bahia Brazil

Introduction: Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are considered potentially malignant oral disorders, presenting with similar clinical and histopathological manifestations that make differential diagnosis difficult and reinforce the need for new techniques for their evaluation. Objective: This study aimed to compare the histomorphometric characteristics of OLP and OLL. Methodology: This retrospective cross-sectional study was based on 30 histological sections of incisional biopsies of OLP and OLL stained with hematoxylin-eosin for the analysis of morphological parameters, such as keratosis, acanthosis, inflammatory infiltrate band, eosinophilic band, degeneration of the basal layer, involvement of the epithelium-chorion interface, and degree of subepithelial inflammatory infiltrate;and morphometric parameters, such as keratin thickness, distance from the basal layer to the epithelial surface, and thickness of the inflammatory infiltrate band. Chi-square and Fisher’s exact tests were used to compare categorical variables and injury types. The t-test was used to compare morphometric variables between the two types of injury. Results: There was no significant association between the type of lesion and the clinical characteristics of the patients (p > 0.05). The degree of dysplasia, used as an inclusion criterion, was associated with lesion type (p = 0.0003). There were no significant differences between the morphometric variables evaluated for the two types of lesions (p > 0.05). Conclusion: Based on the methodology used and the sample established for this study, there were clinical and histomorphometric similarities between OLP and OLL. This justifies further discussion on whether these lesions are a spectrum of presentations of the same condition or truly distinct conditions. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.

关键词： Epithelium Inflammation Morphological and microscopic findings Oral lichen planus

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Oral toxicities associated with immunotherapy and targeted therapy in cancer treatment

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Oral Oncology Reports 2025年 13卷 100724-100724页

作者： Sueira, Michel Souza de Lima Dantas, Juliana Borges Martins, Gabriela Botelho Santana Leal, Daniela Maria de Jesus Azevedo, Juliana Santos Carrera, Manoela Nutrition Student at the State University of Bahia (UNEB) Bahia Salvador Brazil PhD in Interactive Processes of Organs and Systems Federal University of Bahia (UFBA). Professor of Dentistry at the Adventist University Center of the Northeast. Professor at the Bahiana School of Medicine and Public Health. (EBMSP) Bahia Salvador Brazil PhD in Clinical Stomatology at the Multidisciplinary Institute of Rehabilitation and Health at the Federal University of Bahia Bahia Salvador Brazil Dental Surgeon Center for Oncology Studies Bahia Salvador Brazil PhD Student in the Postgraduate Program in Interactive Processes of Organs and Systems at the Federal University of Bahia Brazil PhD in Stomatopathology at School of Dentistry Federal University of Bahia and at Departament of Life Sciences of State University of Bahia Bahia Salvador Brazil

In the context of cancer treatment, surgery, chemotherapy and radiotherapy are among the main therapies used. However, emerging therapies are gaining prominence. The use of immunotherapy and targeted therapy, even though they are based on improving the immune system's response, are associated with the prevalence of certain toxicities, some of them in the oral cavity. The aim of this review was to describe the main oral toxicities associated with immunotherapy and targeted therapy. It was observed that there is a prevalence of xerostomia, dysgeusia, lichenoid reactions, stomatitis, among others, which have a direct impact on patients' quality of life. Although these oral manifestations present a low risk of mortality, proper diagnosis and treatment is essential in order to promote clinical comfort for the patient during the therapeutic period. © 2025 The Authors

关键词： Immunotherapy Molecular targeted therapy Oral adverse events Oral toxicity

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