The time needed to apply a hierarchical clustering algorithm is most often dominated by the number of computations of a pairwise dissimilarity measure. Such a constraint, for larger data sets, puts at a disadvantage t...
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Recent studies of genotype-phenotype (GP) maps have reported universally enhanced phenotypic robustness to genotype mutations, a feature essential to evolution. Virtually all of these studies make a simplifying assump...
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This paper focuses on how populations by the use of technology, more specifically an app, can comprehend the enactment of ordinances (local laws) in an urban area along with their public reactions expressed as tweets....
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This paper presents iCommunity, an application that will be aimed at finding a universal method for inclusive societies in decision-making processes for cultural heritage management. iCommunity is being designed as a ...
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Alzheimer's is a neurodegenerative disease that quietly steals human memory. This study analyzed hippocampal volume in Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI), and Normal Cognition (NC) using...
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ISBN:
(数字)9798350386844
ISBN:
(纸本)9798350386851
Alzheimer's is a neurodegenerative disease that quietly steals human memory. This study analyzed hippocampal volume in Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI), and Normal Cognition (NC) using MRI image slices from the ADNI database and YOLOv8 instance segmentation. We used 300 images to segment the left and right hippocampal. This study focused on volume calculation from five MRI image slices. The results showed 0.98 (AD), 0.92 (MCI), and 0.90 (NC) and revealed significant volumetric differences showed in the NC class (P = 0.045). This suggests early neuroanatomical changes can occur without cognitive symptoms, highlighting the potential of deep learning in the early detection of neurodegenerative diseases.
Targeted proteolysis is a hallmark of *** is especially important in long-lived cells that can be found in higher eukaryotes,like *** task is mainly fulfilled by the ubiquitin–proteasome ***,proteolysis by the 26S pr...
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Targeted proteolysis is a hallmark of *** is especially important in long-lived cells that can be found in higher eukaryotes,like *** task is mainly fulfilled by the ubiquitin–proteasome ***,proteolysis by the 26S proteasome is vital to development,immunity,and cell *** the yeast and animal proteasomes are well characterized,there is only limited information on the plant *** determined the first plant 26S proteasome structure from Spinacia oleracea by single-particle electron cryogenic microscopy at an overall resolution of 3.3 A°.We found an almost identical overall architecture of the spinach proteasome compared with the known structures from mammals and ***,we noticed a structural difference in the proteolytic active b1 ***,we uncovered an unseen compression state by characterizing the proteasome’s conformational *** suspect that this new conformation of the 20S core protease,in correlation with a partial opening of the unoccupied gate,may contribute to peptide release after *** data provide a structural basis for the plant proteasome,which is crucial for further studies.
Let Γ be a finite graph and let A(Γ) be the corresponding right-angled Artin group. We characterize the Hamiltonicity of Γ via the structure of the cohomology algebra of A(Γ). In doing so, we define and develop a ...
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Consumer protection in banking is a particularly relevant issue, especially in light of the increasing complexity of banking transactions and the related legal reference cases. For this reason, the adoption of pre-con...
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ISBN:
(数字)9798350378009
ISBN:
(纸本)9798350378016
Consumer protection in banking is a particularly relevant issue, especially in light of the increasing complexity of banking transactions and the related legal reference cases. For this reason, the adoption of pre-contractual disclosures and contractual texts as complete as possible has been mandated to enable the consumer to be fully aware of the characteristics of the contractual relationship. This has led to the creation of contracts that are particularly detailed and full of content, with graphics designed to reduce the size of the relevant documents but inadequate to allow an understanding of these documents. It is therefore necessary to change the paradigm in the drafting of contractual texts and pre-contractual disclosures through the adoption of legal design methodologies. In particular, added value could be provided by adopting AI and metrology techniques for measuring the level of clarity of contractual texts and subsequently creating a more user-friendly version of these.
Interpretability for machine learning models in medical imaging (MLMI) is an important direction of research. However, there is a general sense of murkiness in what interpretability means. Why does the need for interp...
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Gene expression profiling technologies have been used in various applications such as cancer biology. The development of gene expression profiling has expanded the scope of target discovery in transcriptomic studies, ...
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