This paper addresses the interesting problem of processing and analyzing data in geographic information systems (GIS) to achieve a clear perspective on urban sprawl. The term "urban sprawl" refers to overgro...
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Fluorescent proteins (FPs) have recently emerged as a serious contender for realizing ultra-low threshold room temperature exciton-polariton condensation and lasing. Our contribution investigates the thermalization of...
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We characterize k–colorability of a simplicial graph via the intrinsic algebraic structure of the associated right-angled Artin group. As a consequence, we show that a certain problem about the existence of homomorph...
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Search engine privacy has not been an option for web exploration in the past. Search history returns to users as personalized merchandise promotion from search engine companies. Here we demonstrate a privacy-guarantee...
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The purpose of this article is to give a characterization of families of expander graphs via right-angled Artin groups. We prove that a sequence of simplicial graphs {Γi}i∈ forms a family of expander graphs if and o...
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Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by the selective loss of spinal motor neurons (MNs) and concomitant muscle weakness. Mutation of is known to cause SMA, and restoring SMN pro...
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Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by the selective loss of spinal motor neurons (MNs) and concomitant muscle weakness. Mutation of is known to cause SMA, and restoring SMN protein levels via antisense oligonucleotide treatment is effective for ameliorating symptoms. However, this approach is hindered by exorbitant costs, invasive procedures, and poor treatment responses of some patients. Here, we seek to circumvent these hurdles by identifying reliable biomarkers that could predict treatment efficacy. We uncovered that MiR34 exhibits consistent downregulation during SMA progression in both human and rodent contexts. Importantly, family-knockout mice display axon swelling and reduced neuromuscular junction (NMJ) endplates, recapitulating SMA pathology. Introducing MiR34a via scAAV9 improved the motor ability of SMNΔ7 mice, possibly by restoring NMJ endplate size. Finally, we observed a consistent decreasing trend in MiR34 family expression in the cerebrospinal fluid (CSF) of type I SMA patients during the loading phase of nusinersen treatment. Baseline CSF MiR34 levels before nusinersen injection proved predictive of patient motor skills 1 year later. Thus, we propose that MiR34 may serve as a biomarker of SMA since it is associated with the pathology and can help evaluate the therapeutic effects of nusinersen.
Clustering high-dimensional data, such as images or biological measurements, is a long-standing problem and has been studied extensively. Recently, Deep Clustering gained popularity due to the non-linearity of neural ...
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Machine learning plays an important and growing role in molecular simulation. The newest version of the OpenMM molecular dynamics toolkit introduces new features to support the use of machine learning potentials. Arbi...
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In this paper we will offer a new symmetric-key cryptographic scheme which is based on the existence of exponentially distorted subgroups in arithmetic groups. Aside from this, we will also provide new examples of dis...
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