作者：
RESNER, MEKLOMPARENS, SHLYNCH, JPMr. Michael E. Resner:received an Engineering Degree from Texas A&M University in 1966 and has done graduate work in management at American University. He is Director
Machinery Arrangements/Control Systems and Industrial Facilities Division (SEA 525) at the Naval Sea Systems Command. His previous positions have included Program Manager Solar Total Energy Program at the Department of Energy and Branch Chief Machinery Control Systems Branch at the Naval Ship Engineering Center. Mr. Stephen H. Klomparens:is a Naval Architect at Designers & Planners
Inc. and is engaged in development of computer aids for ship design. He received his B.S.E. degree in Naval Architecture and Marine Engineering from the University of Michigan in 1973 and his M.S. degree in Computer Science from the Johns Hopkins University. Mr. Kolmparens began his professional career at Hydronautics Inc. in 1974 where he was involved in the use of marine laboratory facilities for test and development of conventional and advanced marine craft. Since 1977 he has been involved with naval and commercial ship design and with development of computer-aided ship design tools. Mr. John P. Lynch:is a Principal Marine Engineer with Hydronautics
Inc. He was previously employed in the auxiliary machinery and computer-aided design divisions of the David W. Taylor Naval Ship R&D Center the machinery design division of the New York Naval Shipyard and the machinery arrangement code of the Bureau of Ships. His active naval service was as a ship superintendent in the production department of the Long Beach Naval Shipyard. Mr. Lynch received his B. S. degree in Marine Engineering from the New York State Maritime College and his M.S. degree in Mechanical Engineering from Columbia University. He is a licensed Professional Engineer in the State of New York and a member of ASNE.
The machinery arrangement design process has remained relatively unchanged over the years. Recently, external demands have been placed on both the product and the producers that call for changes to this process. This ...
The machinery arrangement design process has remained relatively unchanged over the years. Recently, external demands have been placed on both the product and the producers that call for changes to this process. This paper cites these external demands and traces the evolution of the process changes from the rule-of-thumb machinery box sizing routines up to the current automated procedures. The machinery arrangement design practice is presented, and existing analytic and graphics aids are discussed. The user requirements for improved design aids are presented, with implementation guidelines and hardware/software alternatives.
This paper presents an integrated approach to computer-Aided Ship Design for U.S. Navy preliminary and contract design. An integrated Hull Design System (HDS), currently under development by the Hull Group of the Nava...
This paper presents an integrated approach to computer-Aided Ship Design for U.S. Navy preliminary and contract design. An integrated Hull Design System (HDS), currently under development by the Hull Group of the Naval Sea Systems Command (NAVSEA 32). is the vehicle for the discussion. This paper is directed toward practicing ship design professionals and the managers of the ship design process. Primary emphasis of this paper, and of the development effort currently under way, is on aiding ship design professionals in their work. Focus is on integration and management control of the extremely complex set of processes which make up naval ship design. The terminology of the Ship Designer and Design Manager is used. The reader needs no familiarity with the technologies of computerscience.
作者：
OLSON, STEPHEN R.USNThe Author received his BS degree in Naval Science upon graduation from the U.S. Naval Academy in 1967 and his MS degree in Operations Research from the U. S. Naval Postgraduate School
Monterey Calij. in 1975. He is a qualified Suflace Warfare Oflcer and has sewed as the Electronics Maintenance Ofleer and CIC Oflcer in the USS Shelton (DO-790) and as Operations Officer in the USS John R. Craig (DD-885). He was a member of the Precommissioning Crew and Chief Engineer in the USS Flint (AE-32) from commissioning through her maiden deployment to the Western Pacific. While attending Postgraduate School he spent jbur months with the CVN Program Manager's Office (PMS-392) and the Patrol Frigate Pmgram Manager's Office (PMS-399). His graduate thesis was entitled “A Computer Model to Assess Financing Provisions of Naval FPIF Shipbuilding Contracts.” The seakeeping analysis reported hereaper was undertaken while the Author was assigned as a Systems Analyst at the Center jbr Naval Analyses. Currently he is assigned as a Special Project OfJicer jbr the Naval Personnel Program Support Activity. LCdr. Olson's military decorations include the Navy Commendation Medal and the Navy Achievement Medal with 2 Stars in lieu of second award.
作者：
PLATO, ARTIS I.GAMBREL, WILLIAM DAVIDArtis I. Plato:is Head of the Design Work Study/ Shipboard Manning/Human Factors Engineering Section
Systems Engineering and Analysis Branch Naval Ship Engineering Center (NAVSEC). He graduated from the City College of New York in 1956 receiving his Bachelor of Mechanical Engineering degree. Following this he started work at the New York Naval Shipyard in the Internal Combustion Engine and Cargo Elevator Section. During 1957 and 1958 he was called up for active duty with the U.S. Army Corps of Engineers and served in Europe with a Construction Engineer Battalion. After release from active duty he returned to the shipyard where he remained until 1961 when he transferred to the Naval Supply Research and Development Facility Bayonne New Jersey. Initially he was in charge of an Engineering Support Test Group and the drafting services for the whole Facility. Later he became a Project Engineer in the Food Services Facilities Branch with duties that included planning and designing new afloat and ashore messing facilities for the Navy. In 1966 he transferred to NAVSEC as a Project Engineer in the Design Work Study Section and in this capacity worked on selected projects and manning problems for new construction and also developed a computer program (Manpower Determination Model) that makes accurate crew predictions for feasibility studies. In 1969 he became Head of the Section. He has been active in the U.S. Army Reserve since his release from active duty and his duties have included command of an Engineer Company various Staff positions and his present assignment as Operations Officer for a Civil Affairs Group. He has completed the U. S. A rmy Corps of Engineers Career Course and the Civil Affairs Career Course and is presently enrolled in the U.S. Army Command and General Staff College non-resident course. Additionally he completed graduate studies at American University Washington D.C in 1972 receiving his MSTM degree in Technology of Management and is a member of ASE ASME CAA U. S. Naval Instit
The purpose of this paper is to discuss a system analysis technique called “Design Work Study”, that is used by the U.S. Navy for the development of improved ship control systems. The Design Work Study approach is o...
Castration-resistant prostate cancer (CRPC) presents significant challenges in clinical management due to its resistance to conventional androgen receptor (AR)-targeting therapies. The advent of proteolysis targeting ...
Castration-resistant prostate cancer (CRPC) presents significant challenges in clinical management due to its resistance to conventional androgen receptor (AR)-targeting therapies. The advent of proteolysis targeting chimeras (PROTACs) has revolutionized cancer therapy by enabling the targeted degradation of key molecular players implicated in CRPC progression. In this review we discuss the developments of PROTACs for CRPC treatment, focusing on AR and other CRPC-associated regulators. We provide an overview of the strategic trends in AR PROTAC development from the aspect of targeting site selection and preclinical antitumor evaluation, as well as updates on AR degraders in clinical applications. Additionally, we briefly address the current status of selective AR degrader development. Furthermore, we review new developments in PROTACs as potential CRPC treatment paradigms, highlighting those targeting chromatin modulators BRD4, EZH2, and SWI/SNF; transcription regulator SMAD3; and kinases CDK9 and PIM1. Given the molecular targets shared between CRPC and neuroendocrine prostate cancer (NEPC), we also discuss the potential of PROTACs in addressing NEPC.
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