Understanding the mechanistic interpretability of mutation effects in a protein can help predict the clinical implications of the genetic variants. Hence, computational variant effect predictions that involve protein ...
Understanding the mechanistic interpretability of mutation effects in a protein can help predict the clinical implications of the genetic variants. Hence, computational variant effect predictions that involve protein structural features of the protein mutations might be suitable in this case. In this work, we focus on BRCT domains of BRCA1 gene that is widely studied in breast cancer studies. We retrieved 88 selected missense variants found in BRCT domains annotated in both ClinVar and gnomAD databases. To computationally characterize the pathogenic property of the mutations we used two types of features extracted from protein structures: a change in free Gibbs energy and a set of features derived from molecular dynamics simulations of each mutant. Using a dimensional reduction and Gaussian mixture model (GMM)-based clustering we demonstrate that the variants are segregated into two regions that may correspond to their pathogenic status. This method can be a potential computational pipeline for providing the preliminary mechanistic interpretation of mutation effects in terms of their thermodynamic and structural features.
This paper describes the implementation and evaluation of an RC polyphase filter (RCPF) and circuitry for measuring its frequency characteristics. The integrated circuit is fabricated on a 0.6 µm CMOS process and...
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Background and Aim: Among low viral load (DNA of hepatitis B virus (HBV) was 10 IU/mL vs 2.3 log10 IU/mL;P = 0.003), and higher proportion of prior NAs-treated history. Logistic regression analysis revealed ...
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To model the periodicity of beats, state-of-the-art beat tracking systems use 'post-processing trackers' (PPTs) that rely on several empirically determined global assumptions for tempo transition, which work w...
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We developed a terahertz time-domain spectroscopy system to generate high-resolution 2-dimensional images of paraffin-embedded murine pancreatic ductal adenocarcinoma tissues using the refractive index and absorption ...
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This research utilizes statistical path modeling to examine the relationship between the number of Venezuelans migrating to Colombia due to economic collapse and the media's coverage of specific topics. We focus o...
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As one of the largest exporters in the world, cocoa (Theobroma cacao L.) production in Indonesia provides an important contribution to the plantation sector that can, directly and indirectly, attribute to the national...
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作者：
Tu, Deng-YaoLin, Peng-ChanChou, Hsin-HungShen, Meng-RuHsieh, Sun-YuanNational Cheng Kung University
Master Degree Program on Artificial Intelligence Tainan City70101 Taiwan National Cheng Kung University
Institute of Medical Informatics Department of Oncology Department of Genomic Medicine National Cheng Kung University Hospital College of Medicine Department of Computer Science and Information Engineering Tainan City70101 Taiwan National Chi Nan University
Department of Computer Science and Information Engineering Nantou County54561 Taiwan National Cheng Kung University
Graduate Institute of Clinical Medicine Department of Obstetrics and Gynecology Department of Pharmacology National Cheng Kung University Hospital College of Medicine Tainan City70101 Taiwan National Cheng Kung University
Institute of Medical Information Institute of Manufacturing Information and Systems Center for Innovative FinTech Business Models International Center for the Scientific Development of Shrimp Aquaculture Department of Computer Science and Information Engineering Tainan City70101 Taiwan
Automatic liver tumor detection from computed tomography (CT) makes clinical examinations more accurate. However, deep learning-based detection algorithms are characterized by high sensitivity and low precision, which...
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The popularity of social media amplified the amount of text data that is used to enrich text classification research with machine learning approach. The modernization in weather information system is needed to produce...
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BACKGROUND Minimally invasive pancreatic surgery via the multi-port approach has become a primary surgical method for distal pancreatectomy(DP)due to its advantages of lower wound pain and superior cosmetic *** studie...
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BACKGROUND Minimally invasive pancreatic surgery via the multi-port approach has become a primary surgical method for distal pancreatectomy(DP)due to its advantages of lower wound pain and superior cosmetic *** studies have applied reduced-port techniques for DP in an attempt to enhance cosmetic outcomes due to the minimally invasive *** recent review studies have compared multi-port laparoscopic DP(LDP)and multi-port robotic DP(RDP);most of these studies concluded multi-port RDP is more beneficial than multi-port LDP for spleen ***,there have been no comprehensive reviews of the value of reduced-port LDP and reduced-port *** To search for and review the studies on spleen preservation and the clinical outcomes of minimally invasive DP that compared reduced-port DP surgery with multi-port DP *** The PubMed medical database was searched for articles published between 2013 and *** search terms were implemented using the following Boolean search algorithm:(“distal pancreatectomy”OR“left pancreatectomy”OR“peripheral pancreatic resection”)AND(“reduced-port”OR“single-site”OR“single-port”OR“dual-incision”OR“single-incision”)AND(“spleen-preserving”OR“spleen preservation”OR“splenic preservation”).A literature review was conducted to identify studies that compared the perioperative outcomes of reduced-port LDP and reduced-port *** Fifteen articles published in the period from 2013 to 2022 were retrieved using three groups of search *** studies were added after manually searching the related ***,10 papers were selected after removing case reports(n=3),non-English language papers(n=1),technique papers(n=1),reviews(n=1),and animal studies(n=1).The common items were defined as items reported in more than five papers,and data on these common items were extracted from all *** ten studies included a total of 337 patients(females/males:231/106)who underwent *** total,166 patients(females/male
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