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Mechanically reprogrammable Pancharatnam-Berry metasurface for microwaves

Advanced Photonics 2022年第1期4卷 69-79页

作者： Quan Xu Xiaoqiang Su Xueqian Zhang Lijuan Dong Lifeng Liu Yunlong Shi Qiu Wang Ming Kang Andrea Alù Shuang Zhang Jiaguang Han Weili Zhang Tianjin University Center for Terahertz Waves and College of Precision Instrument and Optoelectronics EngineeringKey Laboratory of Optoelectronic Information Technology(Ministry of Education of China)TianjinChina Shanxi Datong University Institute of Solid State Physics and College of Physics and Electronic ScienceShanxi Province Key Laboratory of Microstructure Electromagnetic Functional MaterialsDatongChina Wuhan University of Technology School of Information EngineeringWuhanChina Tianjin Normal University College of Physics and Materials ScienceTianjinChina City University of New York Advanced Science Research CenterPhotonics InitiativeNew YorkUnited States City University of New York Graduate CenterPhysics ProgramNew YorkUnited States University of Hong Kong Faculty of ScienceDepartment of PhysicsHong KongChina University of Hong Kong Department of Electrical and Electronic EngineeringHong KongChina Guilin University of Electronic Technology Guangxi Key Laboratory of Optoelectronic Information ProcessingSchool of Optoelectronic EngineeringGuilinChina Oklahoma State University School of Electrical and Computer EngineeringStillwaterOklahomaUnited States

Metasurfaces have enabled the realization of several optical functionalities over an ultrathin platform,fostering the exciting field of flat *** metasurfaces are achieved by arranging a layout of static meta-atoms to imprint a desired operation on the impinging wavefront,but their functionality cannot be *** and programmability of metasurfaces are the next important step to broaden their impact,adding customized on-demand functionality in which each meta-atom can be individually *** demonstrate a mechanical metasurface platform with controllable rotation at the meta-atom level,which can implement continuous Pancharatnam–Berry phase control of circularly polarized *** the proof-of-concept experiments,we demonstrate metalensing,focused vortex beam generation,and holographic imaging in the same metasurface template,exhibiting versatility and superior *** dynamic control of electromagnetic waves using a single,low-cost metasurface paves an avenue towards practical applications,driving the field of reprogrammable intelligent metasurfaces for a variety of applications.

关键词： reprogrammable metasurfaces Pancharatnam-Berry phase mechanical metasurfaces microwaves

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Learner Action Patterns in the Problem-Solving Process Related to program Code Composition Based on Tracking System Activities

Learner Action Patterns in the Problem-Solving Process Relat...

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International Conference on Informatics and Computing (ICIC)

作者： Aulia Akhrian Syahidi Ahmad Afif Supianto Tsukasa Hirashima Yutaka Watanobe Smart City Information System Applied Undergraduate Program Politeknik Negeri Banjarmasin Banjarmasin City Indonesia Research Center for Data and Information Sciences National Research and Innovation Agency (BRIN) Bandung City Indonesia Learning Engineering Laboratory Graduate School of Advanced Science and Engineering Hiroshima University Kagamiyama Higashihiroshima Japan Department of Computer Science and Engineering Division of Information Systems University of Aizu Aizu-Wakamatsu City Fukushima Japan

ISBN: (纸本)9798350345728

Learning activities are an indicator of the learner's desire to learn during the learning process. The pattern of learner action is related to learning activities. In this case, in extracting the learning process, it is necessary to collect a lot of data through analysis of the learning process. The purpose of this study is to recommend and report the performance of an activity tracking system equipped with visual artifacts as an educational data mining approach to analyze action patterns when learners complete the arrangement of program code lines in each programming problem. In this study, data were taken from activity recordings when learners used interactive learning media for a basic programming subject called TOLSYASUPI-EduMed which had problem-solving learning models embedded in their interactions. Learning Analytics is used as a method of this research and data relationships from learner actions during the learning process using the “if-then” rule. Log data is used for recording and detecting activities carried out by learners. We confirm that the results of the study are based on the findings of the data relationship that if the lines of program code are too long (more than five lines) then almost all learners experience a bottleneck condition. The completion time of each question and the number of iterations in completing the program code lines for each question have also been recorded and have a pattern of connection between the data. The information that has been obtained is then forwarded to teachers or stakeholders as key information to make appropriate feedback to learners based on the results as a means of analyzing and evaluating the programming learning process.

关键词： Visualization Codes Media Data models Recording Data mining Problem-solving

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Association of lipid composition and unsaturated fatty acids of VLDL with atrial remodeling in metabolic syndrome

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Scientific Reports 2023年第1期13卷 1-14页

作者： Lee, Hsiang-Chun Cheng, Wei-Chung Ma, Wen-Lung Lin, Yu-Hsun Shin, Shyi-Jang Lin, Yi-Hsiung Division of Cardiology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University 100 Tzyou 1st Rd Kaohsiung 807 Taiwan Department of Internal Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Lipid Science and Aging Research Center College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Institute/Center of Medical Science and Technology National Sun Yat-Sen University Kaohsiung Taiwan Graduate Institute of Animal Vaccine Technology National Pingtung University of Science and Technology Pingtung Taiwan PhD Program for Cancer Molecular Biology and Drug Discovery China Medical University and Academia Sinica Taichung Taiwan Research Center for Cancer Biology China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences and Graduate Institution of Cancer Biology School of Medicine China Medical University Taichung Taiwan Department of Medical Research China Medical University Hospital Taichung Taiwan Department of Nursing Asia University Taichung Taiwan Grander Clinic Kaohsiung Taiwan

Subjects with metabolic syndrome (MetS) commonly have atrial remodeling, which indicates a risk for atrial fibrillation. This study determined MetS-related changes in lipid components in very-low-density lipoprotein (VLDL), which has been shown to cause atrial remodeling, the effect of statins on these changes, and the correlation between atrial remodeling and VLDL lipid compositions. Blood samples were collected from 12 non-MetS and 27 sex- and age-matched MetS subjects. Fourteen patients with MetS (MetS-off statin) discontinued statin therapy 14 days before the study, while the remaining 13 remained on it (MetS-on statin). The VLDLs were isolated and processed for mass-based lipid profiling. Lipidomic analyses were performed and associated with atrial remodeling markers measured using standard echocardiography and electrocardiography. Compared with the VLDL components of the non-MetS group, glucosyl/galactosyl ceramide, lyso-phosphatidylcholine, lyso-phosphatidylethanolamine, and triglycerides were enriched in the MetS-off statin group. Statin therapy attenuated all abnormally abundant lipid classes in MetS, except for triglycerides. In addition, lyso-phosphatidylcholine, lyso-phosphatidylethanolamine, and triglycerides were significantly correlated with atrial dilatation, and the latter two were also correlated with the PR interval. Enrichment of double bonds, which indicate unsaturated fatty acids, was also significantly correlated with atrial remodeling and P-wave duration. This study suggests that the pathological lipid payload of MetS-VLDL may contribute to atrial remodeling in patients. © 2023, The Author(s).

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ABCB1 Regulates Immune Genes in Breast Cancer

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Breast cancer (Dove Medical Press) 2023年 15卷 801-811页

作者： Han-Kun Chen Yi-Ling Chen Chih-Yang Wang Wei-Pang Chung Jung-Hua Fang Ming-Derg Lai Hui-Ping Hsu Department of Surgery Chi Mei Medical Center Tainan Taiwan. Department of Health and Nutrition Chia Nan University of Pharmacy and Science Tainan Taiwan. PhD Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Oncology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 70403 Taiwan. Center of Applied Nanomedicine National Cheng Kung University Tainan Taiwan. Laboratory Animal Center College of Medicine National Cheng Kung University Tainan Taiwan. Department of Biochemistry and Molecular Biology National Cheng Kung University Tainan Taiwan. Institute of Basic Medical Sciences College of Medicine National Cheng Kung University Tainan Taiwan. Department of Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan.

Background:Resistance to standard chemotherapy is a critical problem for breast cancer patients. The ATP-binding cassette (ABC) superfamily transporters actively pump out drugs and play an important role in chemoresistance. ABCB1 (ABC subfamily B, member 1, also named as multidrug resistance protein 1, MDR1) and suppressive myeloid-derived suppressor cells (MDSCs) potentially involve in chemoresistance of breast cancer. The relationship between ABCB1 and immune genes in breast cancer has not been widely studied. Methods:Microarray and RNA sequencing data were obtained from The Cancer Genome Atlas Breast Invasive Carcinoma in Genomic Data Commons Data Portal and Gene Expression Omnibus database. A patient-derived xenograft (PDX) model of HER2 breast cancer was established to investigate the association between and immune genes in breast cancer. Results:Expression of increased in doxorubicin-selected MCF-7/ADR cells. High expression of mRNA is correlated with lymph-node metastasis and worse overall survival in patients with breast cancer. is positively correlated with , and . In the HER2 stage IIA breast cancer PDX model, both doxorubicin and paclitaxel suppressed growth of P2 tumors. IL6, CSF1, CSF3, and PTGS2 expression were suppressed by paclitaxel but not doxorubicin. Intrasplenic MDSCs, including CD11bLy6G and CD11bLy6C cells, were more abundant than intratumor MDSCs in PDX-carrying nude mice. Clinically, the patient developed cancer recurrence after adjuvant chemotherapy with doxorubicin-based regimen and was well controlled after paclitaxel-trastuzumab combined therapy. Conclusion:ABCB1 was a poor predictor of HER2 LN breast cancer. Regulation of immune genes by ABCB1 contributed to cancer recurrence and treatment effect. The PDX model was suitable for investigation the expression of target genes and expansion of immune cells.

关键词： ABC transporters ABCB1 breast cancer myeloid-derived suppressor cells patient-derived xenograft

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Compressibility-Near-Zero Acoustic Radiation

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Physical Review Applied 2021年第2期15卷 024022-024022页

作者： Curtis Rasmussen Andrea Alù Department of Mechanical Engineering The University of Texas at Austin Austin Texas 78712 USA Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 USA Photonics Initiative CUNY Advanced Science Research Center New York New York 10031 USA Physics Program Graduate Center City University of New York New York New York 10026 USA

A hallmark of near-zero-index materials is the uniform phase profile that the waves experience as they propagate with staticlike properties in these media. This feature is exploited in electromagnetics for several applications, including for the realization of compact highly directive antennas illuminated by a single source. Here, we discuss the promise of near-zero metamaterials for acoustic radiation, based on the cutoff of a higher-order mode in a waveguide with small holes. We show that the near-zero nature of this phenomenon ensures unusual robustness to disorder, which is analyzed using a statistical description of the radiation patterns for randomly generated location of the holes. The radiation pattern can be made more directive by simply increasing the overall radiating aperture, without having to worry about the specific location of individual holes and their relative distance. The proposed zero-compressibility material offers a promising alternative to traditional acoustic directive sources due to its design simplicity, inherent robustness, and compact profile.

关键词： Acoustic metamaterials Acoustic wave phenomena Disordered systems Acoustic techniques Cavity resonators Green's function methods

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Determining clinically relevant features in cytometry data using persistent homology

arXiv

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arXiv 2022年

作者： Mukherjee, Soham Wethington, Darren Dey, Tamal K. Das, Jayajit Computer Science Department Purdue University West LafayetteIN United States Biomedical Science Graduate Program Wexner College of Medicine The Ohio State University ColumbusOH United States Biophysics Program The Ohio State University ColumbusOH United States Battelle Center for Mathematical Medicine Abigail Wexner Research Institute Nationwide Children’s Hospital ColumbusOH United States Departments of Pediatrics Biomedical Informatics Pelotonia Institute of Immuno-Oncology Wexner College of Medicine The Ohio State University ColumbusOH United States

Cytometry experiments yield high-dimensional point cloud data that is difficult to interpret manually. Boolean gating techniques coupled with comparisons of relative abundances of cellular subsets is the current standard for cytometry data analysis. However, this approach is unable to capture more subtle topological features hidden in data, especially if those features are further masked by data transforms or significant batch effects or donor-to-donor variations in clinical data. We present that persistent homology, a mathematical structure that summarizes the topological features, can distinguish different sources of data, such as from groups of healthy donors or patients, effectively. Analysis of publicly available cytometry data describing non-naïve CD8+ T cells in COVID-19 patients and healthy controls shows that systematic structural differences exist between single cell protein expressions in COVID-19 patients and healthy controls. We identify proteins of interest by a decision-tree based classifier, sample points randomly and compute persistence diagrams from these sampled points. The resulting persistence diagrams identify regions in cytometry datasets of varying density and identify protruded structures such as ‘elbows’. We compute Wasserstein distances between these persistence diagrams for random pairs of healthy controls and COVID-19 patients and find that systematic structural differences exist between COVID-19 patients and healthy controls in the expression data for T-bet, Eomes, and Ki-67. Further analysis shows that expression of T-bet and Eomes are significantly downregulated in COVID-19 patient non-naïve CD8+ T cells compared to healthy controls. This counter-intuitive finding may indicate that canonical effector CD8+ T cells are less prevalent in COVID-19 patients than healthy controls. This method is applicable to any cytometry dataset for discovering novel insights through topological data analysis which may be difficult to ascertain otherwise

关键词： T-cells

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Overexpression of tyrosine phosphorylated proteins in reproductive tissues of polycystic ovary syndrome rats induced by letrozole

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Asian pacific Journal of Reproduction 2020年第6期9卷 275-282页

作者： Sudtida Bunsueb Supatcharee Arun Arada Chaiyamoon Alexander Tsang-Hsien Wu Sitthichai Iamsaard Department of Anatomy Faculty of MedicineKhon Kaen UniversityKhon Kaen40002Thailand Research Institute for Human High Performance and Health Promotion Khon Kaen University40002Khon KaenThailand The PhD Program for Translational Medicine College of Medical Science and TechnologyTaipei Medical University and Academia SinicaTaipei Graduate Institute of Medical Sciences National Defense Medical CenterTaipei

Objective:To identify the alteration of tyrosine phosphorylated protein expression in rats with polycystic ovary syndrome(PCOS).Methods:Sixteen female Sprague-Dawley rats were divided into the control and letrozole-induced PCOS *** oestrus cycle of rats was performed by vaginal *** hormones and morphology of the ovary,oviduct,and uterus were *** and intensity of androgen receptor and tyrosine phosphorylated proteins of reproductive organs were investigated by Western ***:Various polycysts and increased androgen receptor expression were present in the ovary of the PCOS *** levels of follicle-stimulating hormone and testosteone were significantly higher in the PCOS group while progesterone and estradiol levels were significantly decreased as compared with the control group(P<0.05).Only the size of uterus in the PCOS group was significantly smaller than the control ***,the density of collagen fibers observed in PCOS uterus was greater than the control ***,tyrosine phosphorylated proteins were significantly overexpressed in ovary(52,42,and 28 kDa),oviduct(72,56,42,and 28 kDa),and uterus(53 and 42 kDa)of the PCOS group compared to the control ***:Presence of tyrosine phosphorylated proteins in the ovary,oviduct and uterus suggests that overexpression of tyrosine phosphorylated proteins may be involved in potential mechanism of female infertility especially in PCOS.

关键词： Polycystic ovary syndrome Overexpression Tyrosine phosphorylated proteins Ovary Oviduct Uterus

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Financial transaction database design for jamu small-medium enterprises

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AIP Conference Proceedings 2023年第1期2594卷

作者： R. Rahutomo A. Permatasari Y. Lie B. Pardamean Information Systems Department School of Information Systems Bina Nusantara University Jakarta Indonesia 11480 Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480 Computer Science Department BINUS Graduate Program Master of Computer Science Bina Nusantara University Jakarta Indonesia 11480

As jamu small-medium enterprises (SMEs) concentrate on establishing online sales and computerized systems, Point of Sales (PoS) becomes a strategic solution to maintain financial ...

As jamu small-medium enterprises (SMEs) concentrate on establishing online sales and computerized systems, Point of Sales (PoS) becomes a strategic solution to maintain financial stability with its capabilities in recording electronic transactions accurately. As the initial step in technology empowerment for jamu SMEs, the research proposes a concept in facilitating jamu SMEs to adapt in online business. A combination of Connolly and Begg's database design principles and McCarthy's Marketing Mix 4P generates a conceptual design of PoS database targeted specifically for jamu SMEs. The database design manages online purchasing transactions for jamu products by involving not only jamu SMEs and consumers but also a system administrator who manages data verification and extraction.

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Questionnaire design for analyzing important risk factors of cervical cancer

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AIP Conference Proceedings 2023年第1期2594卷

作者： K. Purwandari D. Sudigyo A. S. Perbangsa A. Irwan B. Pardamean Bioinformatics & Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480 Information Systems Department School of Information Systems Bina Nusantara University Jakarta Indonesia 11480 Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta Indonesia 11480

Cervical cancer is Indonesia's second leading cause of death, following only breast cancer. According to the World Health Organization (WHO), non-communicable disorders will be blamed for 70% of all deaths and illnesses in 2020, while other disease types will account for 60%. Cervical cancer can be detected earlier, lowering the chance of death. This study aims to validate and check the pap smear test results obtained from the previously conducted pap smear screening program. The pap smear questionnaire developed would help in the compilation of a patient's habit history that has undergone a pap smear test during his life based on the factors associated with the occurrence of cervical cancer. Specific details, social-demographic features, diet, genital hygiene activities, reproductive background and behaviors, and health care and cancer prevention behavior are also included in the questionnaire template. The consequence of this design is the completeness of evidence on the theory of anomalies dependent on the findings of pap smear sampling.

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Intrinsic Parameter Fluctuation and Process Variation Effect of Vertically Stacked Silicon Nanosheet Complementary Field-Effect Transistors

Intrinsic Parameter Fluctuation and Process Variation Effect...

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IEEE International Symposium on Quality Electronic Design

作者： Sekhar Reddy Kola Yiming Li Min-Hui Chuang Parallel and Scientific Computing Laboratory Hsinchu Taiwan Electrical Engineering and Computer Science International Graduate Program Hsinchu Taiwan Institute of Communications Engineering Hsinchu Taiwan Institute of Biomedical Engineering Hsinchu Taiwan Institute of Pioneer Semiconductor Innovation Hsinchu Taiwan Institute of Artificial Intelligence Innovation Hsinchu Taiwan Department of Electronics and Electrical Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan Center for mmWave Smart Radar System and Technologies National Yang Ming Chiao Tung University Hsinchu Taiwan

We study the variability of vertically stacked gate-all-around silicon nanosheet (GAA Si NS) complementary field-effect transistors (CFETs). The process variation effect (PVE), the work function fluctuation (WKF), and the random dopant fluctuation (RDF) of CFETs are statistically estimated using an experimentally validated device simulation technique. Among five factors of PVE, the channel thickness (T Nch /T Pch ), the channel width (W ch ), and the gate length (L G ) are significant. Owing to superior GAA channel control and increased effective gate area, both WKF and RDF are suppressed. Notably, the PVE on both N-/P-FETs of GAA Si CFET induce the largest off-state current fluctuations of 80% and 278%, respectively, because the device characteristic is very sensitive to the layer thickness and width of channel.

关键词： Fluctuations Gallium arsenide Logic gates Electric variables Silicon Resource description framework Semiconductor process modeling

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