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arXiv 2023年

作者： Biswas, Abhijit Xu, Rui Alvarez, Gustavo A. Zhang, Jin Christiansen-Salameh, Joyce Puthirath, Anand B. Burns, Kory Hachtel, Jordan A. Li, Tao Iyengar, Sathvik Ajay Gray, Tia Li, Chenxi Zhang, Xiang Kannan, Harikishan Elkins, Jacob Pieshkov, Tymofii S. Vajtai, Robert Birdwell, A. Glen Neupane, Mahesh R. Garratt, Elias J. Ivanov, Tony Pate, Bradford B. Zhao, Yuji Zhu, Hanyu Tian, Zhiting Rubio, Angel Ajayan, Pulickel M. Department of Materials Science and Nanoengineering Rice University HoustonTX77005 United States Sibley School of Mechanical and Aerospace Engineering Cornell University IthacaNY14853 United States Max Planck Institute for the Structure and Dynamics of Matter Center for Free-Electron Laser Science Luruper Chaussee 149 22761 Germany Department of Materials Science & Engineering University of Virginia CharlottesvilleVA22904 United States Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak RidgeTN37831 United States Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States DEVCOM Army Research Laboratory RF Devices and Circuits AdelphiMD20783 United States Chemistry Division Naval Research Laboratory WashingtonDC20375 United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Flatiron Institute New YorkNY10010 United States

Understanding the emergent electronic structure in twisted atomically thin layers has led to the exciting field of twistronics. However, practical applications of such systems are challenging since the specific angular correlations between the layers must be precisely controlled and the layers have to be single crystalline with uniform atomic ordering. Here, we suggest an alternative, simple and scalable approach where nanocrystalline two-dimensional (2D) film on three-dimensional (3D) substrates yield twisted-interface-dependent properties. Ultrawidebandgap hexagonal boron nitride (h-BN) thin films are directly grown on high in-plane lattice mismatched wide-bandgap silicon carbide (4H-SiC) substrates to explore the twist-dependent structure-property correlations. Concurrently, nanocrystalline h-BN thin film shows strong nonlinear second-harmonic generation and ultra-low cross-plane thermal conductivity at room temperature, which are attributed to the twisted domain edges between van der Waals stacked nanocrystals with random in-plane orientations. First-principles calculations based on time-dependent density functional theory manifest strong even-order optical nonlinearity in twisted h-BN layers. Our work unveils that directly deposited 2D nanocrystalline thin film on 3D substrates could provide easily accessible twist-interfaces, therefore enabling a simple and scalable approach to utilize the 2D-twistronics integrated in 3D material devices for next-generation nanotechnology. © 2023, CC BY.

关键词： Harmonic generation

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Scalable Metagrating for Efficient Ultrasonic Focusing

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Physical Review Applied 2021年第6期16卷 064014-064014页

作者： Yan Kei Chiang Li Quan Yugui Peng Shahrokh Sepehrirahnama Sebastian Oberst Andrea Alù David A. Powell School of Engineering and Information Technology University of New South Wales Canberra ACT 2610 Australia Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 USA Photonics Initiative Advanced Science Research Center City University of New York New York New York 10031 USA Centre for Audio Acoustics and Vibration University of Technology Sydney Broadway NSW 2007 Australia Physics Program Graduate Center City University of New York New York New York 10016 USA

Acoustic metalenses have been pursued over the past decades due to their pivotal role in a wide variety of applications. Recent research efforts have demonstrated that, at ultrasonic regimes, acoustic levitation can be realized with standing waves, which are created by the interference between incoming and reflected focused waves. However, the conventional gradient-metasurface approach to focus ultrasonic waves is complex, leading to poor scalability. In this work, we propose a design principle for ultrasonic metalenses, based on metagratings—arrays of discrete scatters with coarser features than gradient metasurfaces. We achieve beam focusing by locally controlling the excitation of a single diffraction order with the use of metagratings, with geometry adiabatically varying over the lens aperture. We show that our metalens can effectively focus impinging ultrasonic waves to a focal point with a full width at half maximum of 0.364 of the wavelength. The focusing performance of the metalens is demonstrated experimentally, validating our proposed approach. This metagrating approach to focusing can be adopted for different operating frequencies by scaling the size of the structure, which has coarse features suitable for high-frequency designs, with potential applications ranging from biomedical science to nondestructive testing.

关键词： Acoustic measurements Acoustic metamaterials Acoustic modeling Acoustic wave phenomena Beam optics Ultrasonics Bloch-Floquet theorem Ultrasound techniques

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Cavity-mediated superthermal phonon correlations in the ultrastrong coupling regime

arXiv

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arXiv 2024年

作者： Kim, Dasom Hou, Jin Lee, Geon Agrawal, Ayush Kim, Sunghwan Zhang, Hao Bao, Di Baydin, Andrey Wu, Wenjing Tay, Fuyang Huang, Shengxi Chia, Elbert E.M. Kim, Dai-Sik Seo, Minah Mohite, Aditya D. Hagenmüller, David Kono, Junichiro Applied Physics Graduate Program Smalley–Curl Institute Rice University HoustonTX77005 United States Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States Sensor System Research Center Korea Institute of Science and Technology Seoul02792 Korea Republic of Department of Physics and Astronomy Seoul National University Seoul08826 Korea Republic of Department of Chemical and Biomolecular Engineering Rice University Houston77005 United States Ulsan44919 Korea Republic of Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore637371 Singapore Smalley–Curl Institute Rice University HoustonTX77005 United States Rice Advanced Materials Institute Rice University HoustonTX77005 United States KU–KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Université de Strasbourg CNRS Strasbourg67200 France Department of Physics and Astronomy Rice University HoustonTX77005 United States

Phonons, or vibrational quanta, are behind some of the most fundamental physical phenomena in solids, including superconductivity, Raman processes, and broken-symmetry phases. It is therefore of fundamental importance to find ways to harness phonons for controlling these phenomena and developing novel quantum technologies. However, the majority of current phonon control techniques rely on the use of intense external driving fields or strong anharmonicities, which restricts their range of applications. Here, we present a scheme for controlling the intensity fluctuations in phonon emission at room temperature based on multimode ultrastrong light–matter coupling. The multimode ultrastrong coupling regime is achieved by coupling two optical phonon modes in lead halide perovskites to an array of nanoslots, which operates as a single-mode cavity. The extremely small mode volume of the nanoslots enables unprecedented coupling strengths in a cavity phonon-polariton system. In the far-detuned, low-cavity-frequency regime, we demonstrate that the nanoslot resonator mediates an effective coupling between the phonon modes, resulting in superthermal phonon bunching in thermal equilibrium, both within the same mode and between different modes. Experimental results are in good agreement with a multimode Hopfield model. Our work paves the way for the tailoring of phonons to modify charge and energy transport in perovskite materials, with potential applications in light-collecting or emitting devices. Copyright © 2024, The Authors. All rights reserved.

关键词： Perovskite

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An artificial intelligence method for vessel detection in images of cardiac catheterization

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Informatics in Medicine Unlocked 2023年 39卷

作者： Chien, Ting-Ying Ting, Hsien-Wei Li, Hao-Wei Chang, Hsiao-Huang Department of Computer Science and Engineering Yuan Ze University 320 Taoyuan City Taiwan Graduate Program in Biomedical Informatics Yuan Ze University 320 Taoyuan City Taiwan Innovation Center for Big Data and Digital Convergence Yuan Ze University 320 Taoyuan City Taiwan Department of Neurosurgery Taipei Hospital Ministry of Health and Welfare 242 New Taipei City Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Veterans General Hospital Taipei 11217 Taiwan Department of Surgery School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan

Coronary artery disease (CAD) is one of the top ten leading causes of death in countries worldwide. There are several methods used by physicians to diagnose CAD. One common method is the use of X-ray angiogram (XRA) images. When employing a computer-aided automatic analysis method to locate blood vessels in XRA images, problems such as complex background noise, low contrast, and difficulty in separating blood vessels from the background are encountered, especially for blood vessels with a low contrast to the background noise. In this study, we used various image preprocessing methods to highlight blood vessels from complex backgrounds and different types of blood vessel, followed by the employment of four superpixel segmentation methods to partition an image into multiple segments, and finally the utilization of Weighted Voting to determine the best superpixel algorithm. A genetic algorithm was used to identify the best weights by which to determine the locations of blood vessels in images of cardiac catheterization. Our proposed method achieved an average F1-score of 73.4% in the analysis of five patients, which was better than the other superpixel algorithms tested. The results of this research will be helpful for future SYNTAX score analysis. © 2023

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Unprecedented anti-inflammatory biscembranoids with 3-hydroperoxy-3-methylcyclohex-1-ene moiety isolated from aquaculture Sarcophyton trocheliophorum

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Aquaculture Reports 2023年 33卷

作者： Peng, Bo-Rong Nguyen, Ngoc Bao An Chen, Lo-Yun El-Shazly, Mohamed Hwang, Tsong-Long Su, Jui-Hsin Lai, Kuei-Hung Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei 11031 Taiwan PhD Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Department of Pharmacognosy Faculty of Pharmacy Ain-Shams University Organization of African Unity Street Cairo Abassia 11566 Egypt Research Center for Chinese Herbal Medicine College of Human Ecology Chang Gung University of Science and Technology Taoyuan 33303 Taiwan Graduate Institute of Health Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan 33303 Taiwan Department of Anaesthesiology Chang Gung Memorial Hospital Taoyuan 33305 Taiwan Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan 33302 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City 24301 Taiwan National Museum of Marine Biology & Aquarium Pingtung 94450 Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 80424 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei 11031 Taiwan

Recent advancements in the discovery of natural products have made significant progress in rapidly identifying known compounds from complex extracts using advanced spectroscopic technologies. Among these methods, one powerful approach called MS/MS molecular networking (MN) organizes chemical similarity based on MS/MS fragmentation data, serving as a valuable complement to traditional dereplication strategies. In our ongoing research focused on lead discovery from a sustainable medicinal source, an aquaculture soft coral Sarcophyton trocheliophorum, the MN profiling approach revealed the chemical diversity of biscembranoid analogs. By analyzing the MN pattern, biscembranoid derivatives with unique MS/MS fragments were prioritized for further investigation. Two novel biscembranoids, sarcotroxide A (1) and B (2), were successfully obtained through targeted isolation. These novel biscembranes contained an unprecedented 3-hydroperoxy-3-methylcyclohex-1-ene moiety compared with all biscembranoid analogs. The chemical structures of the two new biscembranoids were confirmed through spectroscopic analyses and in silico calculations. Their anti-inflammatory properties were assessed against the generation of superoxide anion (O₂^•−) and elastase release in activated human neutrophils. Sarcotroxides A (1) and B (2) exhibited anti-inflammatory activity by inhibiting O₂^•− accumulation (with 43.67% and 61.62% inhibition) and elastase release (with 38.21% and 61.62% inhibition) at 10 µM. These findings validated the potential of these biscembranoids from the cultured S. trocheliophorum as promising candidates for the future development of anti-inflammatory agents specifically designed to target neutrophils. © 2023 The Authors

关键词： Anti-inflammation Aquaculture soft coral Biscembranoid Neutrophil Sarcophyton trocheliophorum

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Routing Optical Spin and Pseudospin with Metasurfaces

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Physical Review Applied 2020年第1期14卷 014029-014029页

作者： Yarden Mazor Andrea Alù Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 USA Photonics Initiative Advanced Science Research Center City University of New York New York New York 10031 USA Physics Program Graduate Center City University of New York New York New York 10026 USA

Controlling and guiding optical spins and pseudospins over an interface is of great importance in the emerging fields of spintronics and valleytronics, holding the promise for new degrees of freedom in the quest for efficient information transport. Here we explore the general possibilities offered by metasurfaces to route optical momentum, spin and helicity through surface waves. We show how anisotropy and bianisotropy can be engineered to impart extreme directionality to local spin excitations. While most previous works have focused on out-of-plane spins, in-plane excitations have become particularly important for valleytronic applications relying on two-dimensional materials, and they offer specific challenges addressed here with suitably engineered nonlocality in metasurfaces.

关键词： Metamaterials Optical vortices Photonics Valleytronics Devices Surfaces Transition metal dichalcogenides

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Exploring disparities of teleconsultation readiness: A comparative analysis of healthcare facilities in Indonesia

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DIGITAL HEALTH 2024年 10卷

作者： Daniel Chriswinanto Adityo Nugroho Katherina Adisaputro Mitra Andini Sigilipoe Ida Ayu Triastuti Suryani Hutomo Ardhinta Bellano Septarda Aryososepti Yuwono Caraka Randi Yusuf Dedik Sulistiawan Balqis Gusbela Jason C Hsu Emily Chia-Yu Su Faculty of Medicine Universitas Kristen Duta Wacana Yogyakarta IndonesiaGraduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Faculty of Medicine Universitas Kristen Duta Wacana Yogyakarta Indonesia Faculty of Public Health Universitas Ahmad Dahlan Yogyakarta IndonesiaSchool of Public Health Taipei Medical University Taipei International PhD Program in Biotech and Healthcare Management College of Management Taipei Medical University Taipei International PhD Program in Biotech and Healthcare Management College of Management Taipei Medical University TaipeiClinical Data Center Office of Data Science Taipei Medical University TaipeiClinical Big Data Research Center Taipei Medical University Hospital TaipeiResearch Center of Health Care Industry Data Science College of Management Taipei Medical University Taipei Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University TaipeiClinical Big Data Research Center Taipei Medical University Hospital TaipeiInstitute of Biomedical Informatics College of Medicine National Yang Ming Chiao Tung University Taipei

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Radio-transparent dipole antenna based on a metasurface cloak

arXiv

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arXiv 2021年

作者： Soric, Jason Ra'di, Younes Farfan, Diego Alù, Andrea Department of Electrical and Computer Engineering University of Texas at Austin AustinTX78712 United States Photonics Initiative Advanced Science Research Center City University of New York NY10031 United States Physics Program Graduate Center City University of New York NY10016 United States Department of Electrical Engineering City College of the City University of New York NY10031 United States

Antenna technology is at the basis of ubiquitous wireless communication systems and sensors. Radiation is typically sustained by conduction currents flowing around resonant metallic objects that are optimized to enhance efficiency and bandwidth. However, resonant conductors are prone to large scattering of impinging waves, leading to challenges in crowded antenna environments due to blockage and distortion. Metasurface cloaks have been explored in the quest of addressing this challenge by reducing antenna scattering, but with limited performance in terms of bandwidth, footprint and overall scattering reduction. Here we introduce a different route towards radio-transparent antennas, in which the cloak itself acts as the radiating element, drastically reducing the overall footprint while enhancing scattering suppression and bandwidth, without sacrificing other relevant radiation metrics compared to conventional antennas. This technique offers a new application of cloaking technology, with promising features for crowded wireless communication platforms and noninvasive sensing. © 2021, CC BY-NC-ND.

关键词： Bandwidth

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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries (vol 55, pg 89, 2023)

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NATURE GENETICS 2023年第3期55卷 519-520页

作者： Fernandez-Rozadilla, Ceres Timofeeva, Maria Chen, Zhishan Law, Philip Thomas, Minta Schmit, Stephanie Diez-Obrero, Virginia Hsu, Li Fernandez-Tajes, Juan Palles, Claire Sherwood, Kitty Briggs, Sarah Svinti, Victoria Donnelly, Kevin Farrington, Susan Blackmur, James Vaughan-Shaw, Peter Shu, Xiao-ou Long, Jirong Cai, Qiuyin Guo, Xingyi Lu, Yingchang Broderick, Peter Studd, James Huyghe, Jeroen Harrison, Tabitha Conti, David Dampier, Christopher Devall, Mathew Schumacher, Fredrick Melas, Marilena Rennert, Gad Obon-Santacana, Mireia Martin-Sanchez, Vicente Moratalla-Navarro, Ferran Oh, Jae Hwan Kim, Jeongseon Jee, Sun Ha Jung, Keum Ji Kweon, Sun-Seog Shin, Min-Ho Shin, Aesun Ahn, Yoon-Ok Kim, Dong-Hyun Oze, Isao Wen, Wanqing Matsuo, Keitaro Matsuda, Koichi Tanikawa, Chizu Ren, Zefang Gao, Yu-Tang Jia, Wei-Hua Hopper, John Jenkins, Mark Win, Aung Ko Pai, Rish Figueiredo, Jane Haile, Robert Gallinger, Steven Woods, Michael Newcomb, Polly Duggan, David Cheadle, Jeremy Kaplan, Richard Maughan, Timothy Kerr, Rachel Kerr, David Kirac, Iva Bohm, Jan Mecklin, Lukka-Pekka Jousilahti, Pekka Knekt, Paul Aaltonen, Lauri Rissanen, Harri Pukkala, Eero Eriksson, Johan Cajuso, Tatiana Hanninen, Ulrika Kondelin, Johanna Palin, Kimmo Tanskanen, Tomas Renkonen-Sinisalo, Laura Zanke, Brent Mannisto, Satu Albanes, Demetrius Weinstein, Stephanie Ruiz-Narvaez, Edward Palmer, Julie Buchanan, Daniel Platz, Elizabeth Visvanathan, Kala Ulrich, Cornelia Siegel, Erin Brezina, Stefanie Gsur, Andrea Campbell, Peter Chang-Claude, Jenny Hoffmeister, Michael Brenner, Hermann Slattery, Martha Potter, John Tsilidis, Konstantinos Schulze, Matthias Gunter, Marc Murphy, Neil Castells, Antoni Castellvi-Bel, Sergi Moreira, Leticia Arndt, Volker Shcherbina, Anna Stern, Mariana Pardamean, Bens Bishop, Timothy Giles, Graham Southey, Melissa Idos, Gregory McDonnell, Kevin Abu-Ful, Zomoroda Greenson, Joel Shulman, Katerina Lejbkowicz, Flavio Offit, Kenneth Su, Yu-Ru Steinfelder, Robert Keku, Temitope van Guelpen, Bethany Hudson, Thomas Hampel, Heather Pearlman, Edinburgh Cancer Research Centre Institute of Genomics and Cancer University of Edinburgh Edinburgh UK Genomic Medicine Group Instituto de Investigacion Sanitaria de Santiago Santiago de Compostela Spain Colon Cancer Genetics Group Medical Research Council Human Genetics Unit Institute of Genetics and Cancer University of Edinburgh Edinburgh UK Danish Institute for Advanced Study Department of Public Health University of Southern Denmark Odense Denmark Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University Medical Center Nashville TN USA Division of Genetics and Epidemiology Institute of Cancer Research London UK Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle WA USA Genomic Medicine Institute Cleveland Clinic Cleveland OH USA Population and Cancer Prevention Program Case Comprehensive Cancer Center Cleveland OH USA Colorectal Cancer Group ONCOBELL Program Bellvitge Biomedical Research Institute Barcelona Spain Oncology Data Analytics Program Catalan Institute of Oncology Barcelona Spain Consortium for Biomedical Research in Epidemiology and Public Health Madrid Madrid Spain Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain Department of Biostatistics School of Public Health University of Washington Seattle WA USA Institute of Cancer and Genomic Sciences College of Medical and Dental Sciences University of Birmingham Birmingham UK Department of Public Health Richard Doll Building University of Oxford Oxford UK Department of Biomedical Informatics Vanderbilt University School of Medicine Nashville TN USA Department of Preventive Medicine USC Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California Los Angeles CA USA Center for Public Health Genomics Department of Public Health Sciences University of Virginia Charlottesville VA USA Department of Populat

Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.

关键词： Colorectal cancer Epigenomics Genome-wide association studies Transcriptomics

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Exponential acceleration of macroscopic quantum tunneling in a Floquet Ising model

arXiv

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arXiv 2023年

作者： Grattan, George Barton, Brandon A. Feeney, Sean Mossi, Gianni Patnaik, Pratik Sagal, Jacob C. Carr, Lincoln D. Oganesyan, Vadim Kapit, Eliot Quantum Engineering Program Colorado School of Mines 1523 Illinois St CO Golden80401 United States Department of Computer Science Colorado School of Mines 1500 Illinois St CO Golden80401 United States Department of Applied Mathematics and Statistics Colorado School of Mines 1500 Illinois St CO Golden80401 United States Department of Physics Colorado School of Mines 1523 Illinois St CO Golden80401 United States KBR Inc. 601 Jefferson St. HoustonTX77002 United States NASA Ames Research Center Moffett FieldCA94035 United States Department of Physics and Astronomy College of Staten Island CUNY Staten IslandNY10314 United States Physics program and Initiative for the Theoretical Sciences The Graduate Center CUNY New YorkNY10016 United States Center for Computational Quantum Physics Flatiron Institute 162 5th Avenue New YorkNY10010 United States

The exponential suppression of macroscopic quantum tunneling (MQT) in the number of elements to be reconfigured is an essential element of broken symmetry phases. Slow MQT is also a core bottleneck in quantum algorithms, such as traversing an energy landscape in optimization, and adiabatic state preparation more generally. In this work, we demonstrate the possibility to accelerate MQT through Floquet engineering with the application of a uniform, high frequency transverse drive field. Using the ferromagnetic phase of the transverse field Ising model in one and two dimensions as a prototypical example, we identify three qualitatively distinct regimes as a function of drive strength: (i) for weak drive, the system exhibits exponentially slow MQT alongside robust magnetic order, as expected;(ii) at intermediate drive strength, we find polynomial decay of rates alongside vanishing magnetic order consistent with critical or paramagnetic state;(iii) at very strong drive strengths both the tunnelling rate and time-averaged magnetic order remain finite with increasing system size. We support these claims with extensive full wavefunction and matrix-product state numerical simulations, and theoretical analysis. An experimental test of these results presents a technologically important and novel scientific question accessible on NISQ-era quantum computers. © 2023, CC BY.

关键词： Ising model

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