Coronary artery disease (CAD) is one of the top ten leading causes of death in countries worldwide. There are several methods used by physicians to diagnose CAD. One common method is the use of X-ray angiogram (XRA) i...
Recent advancements in the discovery of natural products have made significant progress in rapidly identifying known compounds from complex extracts using advanced spectroscopic technologies. Among these methods, one ...
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Controlling and guiding optical spins and pseudospins over an interface is of great importance in the emerging fields of spintronics and valleytronics, holding the promise for new degrees of freedom in the quest for e...
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Controlling and guiding optical spins and pseudospins over an interface is of great importance in the emerging fields of spintronics and valleytronics, holding the promise for new degrees of freedom in the quest for efficient information transport. Here we explore the general possibilities offered by metasurfaces to route optical momentum, spin and helicity through surface waves. We show how anisotropy and bianisotropy can be engineered to impart extreme directionality to local spin excitations. While most previous works have focused on out-of-plane spins, in-plane excitations have become particularly important for valleytronic applications relying on two-dimensional materials, and they offer specific challenges addressed here with suitably engineered nonlocality in metasurfaces.
Antenna technology is at the basis of ubiquitous wireless communication systems and sensors. Radiation is typically sustained by conduction currents flowing around resonant metallic objects that are optimized to enhan...
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Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying ...
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Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.
The exponential suppression of macroscopic quantum tunneling (MQT) in the number of elements to be reconfigured is an essential element of broken symmetry phases. Slow MQT is also a core bottleneck in quantum algorith...
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In this paper, we describe the GPU implementation of our City-LES code, which is developed at the center for Computational sciences (CCS), University of Tsukuba for detailed large eddy simulations, including surface c...
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ISBN:
(数字)9781728189468
ISBN:
(纸本)9781728189475
In this paper, we describe the GPU implementation of our City-LES code, which is developed at the center for Computational sciences (CCS), University of Tsukuba for detailed large eddy simulations, including surface conditions such as buildings, surface materials, and sunlight effect Wefocus on the 1) performance comparison between CUDA and OpenACC, and 2) how to reduce the data exchange between CPU and GPU memories. Using a number of GPU devices of NVIDIA Tesla V 100, we found that the current OpenACC compiler by PGI can achieve a comparable performance with CUDA in the main part of the LES calculation. We also apply OpenACC aggressively even for performances that are lower than that of a CPU to avoid data copying between the GPU and CPU, encapsulating all the data only on the GPU memory. In our optimized OpenACC (partially in CUDA) code, the results show that the performance of the full GPU version of code is doubled, and most of the GPU-CPU data copying is removed from the original GPU code. For the scaling performance test, a full GPU version achieves a 4. 7 x to 10x performance of the CPU version; this is done on a GPU cluster Cygnus at CCS, where each node is equipped with two Intel Xeon CPUs and four NVIDIA Tesla V100 GPUs, with strong scaling up to 32 nodes with 128 GPUs. For weak scaling, the full GPU version achieves a performance of more than 9x that of the CPU version for up to 32 nodes with 128 GPUs of parallel execution.
Budding yeast undergoes replicative aging through asymmetric cell divisions. Yeast mother cells progressively age as they generate successive daughter cells, until they ultimately die. However, their daughters are bor...
Budding yeast undergoes replicative aging through asymmetric cell divisions. Yeast mother cells progressively age as they generate successive daughter cells, until they ultimately die. However, their daughters are born rejuvenated, that is, most of them recover a full lifespan potential, with little impact of their mothers' age at their birth. In this review, we will discuss recent findings regarding the mechanisms of replicative aging and rejuvenation. Based on these insights, we will also discuss which evolutionary forces may have presided over the emergence of aging in yeast. We suggest that aging and rejuvenation represent two adaptive strategies that each bring their own benefits.
The area of the rice harvest in Banten Province in 2021 was 319,558 ha with a production of 1,63 million tons of unhusked rice or with a productivity of 5.1 tons/ha (CBS,2022). The objectives of this study were: 1) to...
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