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Semi-automated meningioma segmentation with bounding boxes

Procedia computer science 2024年 245卷 583-590页

作者： Nur Adhianti Heryanto Mahmud Isnan Matthew Martianus Henry Bens Pardamean Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480 Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta Indonesia 11480

Segmentation is manually performed by physicians, which takes considerable time and may be subject to observers. Automating this task can increase efficiency and consistency. Existing studies on meningioma segmentation used data from limited study centers, indicating the need for research on multi-center data to assess generalizability. In this work, two semi-automated methods with bounding box priors, LiteMedSAM and BBU-Net, are evaluated on the brain tumor segmentation (BraTS) 2023 meningioma dataset collected from five study-centers. Preprocessing included exclusion of small tumors, z-score normalization, and extraction of slices that contain tumors, generating 25,602 2D axial magnetic resonance imaging (MRI) scans. A fine-tuning strategy is adopted for LiteMedSAM while BBU-Net is trained from scratch. The models are evaluated using a five-fold cross-validation, with data split at the case level. Results show that while U-Net models can achieve performance close to LiteMedSAM, the foundation model has overall better performance, with more than 90% in all evaluation scores.

关键词： Bounding boxes Meningioma Semi-automated segmentation

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LDA Topic Modeling for Bioinformatics Terms in arXiv Documents

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Procedia computer science 2024年 245卷 229-238页

作者： Andrea Stevens Karnyoto Matthew Martianus Henry Bens Pardamean Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480 Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta Indonesia 11480

A wide variety of disciplines contribute to bioinformatics research, including computer science, biology, chemistry, mathematics, and physics. This study determines the number of research articles published on arXiv classified as bioinformatics topics and the most frequently used bioinformatics terms using topic modeling, Latent Dirichlet Allocation (LDA). An algorithm based on LDA is used to discover topics hidden within large collections of documents through the use of statistical analysis. Our research examined 226453 articles on arXiv between January 2023 and January 2024. As a result, there are more than 10521 articles categorized into bioinformatics topics. Most commonly, 6352 documents are in the "Mathematical Physics" category. The second most popular category is "computer science," with 2950 documents. Accordingly, the terms 'RNA,' 'sequence,' 'tree,' and 'homology' are the three most commonly used terms in bioinformatics. The study of RNA plays a vital role in molecular biology; thus, the study of RNA is prevalent in bioinformatics. Sequential data refer to the order in which nucleotides or amino acids can be found in a DNA molecule or a protein.

关键词： arXiv bioinformatics Latent Dirichlet Allocation

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An Exploratory Computational Approach for Elucidating a Nonstructural Protein Interaction in Dengue Virus 2 9th

An Exploratory Computational Approach for Elucidating a Nons...

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9th International Conference on computer science and Computational Intelligence, ICCSCI 2024

作者： Hidayat, Alam Ahmad Nirwantono, Rudi Pardamean, Bens Mathematics Department School of Computer Science Bina Nusantara University 11480 Indonesia Biotechnology Department Faculty of Engineering Bina Nusantara University 11480 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program Bina Nusantara University Jakarta11480 Indonesia

As the dengue infection still impacts hundreds of millions of people globally, unprecedented efforts in dengue drug development have been more progressive in recent decades. Computational methods provide a fast, sustainable, and efficient screening of active compounds and newly created drug molecules, including those specifically targeting nonstructural proteins (NS) of dengue viruses. In this work, protein modeling for the NS proteins of DENV-2/16681 strain was performed using a template-based homology modeling for the NS3 protein and an Artificial Intelligence (AI)-based prediction via AlphaFold for the NS4B protein. Moreover, the protein-protein interaction between the two structures was predicted using the HADDOCK server, which employs information about active and passive residues of the interaction interface to guide the docking process. After the modeling and its respective refinement process, the predicted structures of NS3 and NS4B improved their steric clashing scoring from MolProbity assessment. The refined models were then docked, and the resulting docking pose was analyzed to extract the interacting residues based on the polar contacts within the interface of the two proteins. Our result presents a preliminary study to create a dataset related to in silico molecular interactions of the NS3-NS4B interaction of different DENV types. It is helpful for building a computational pipeline for elucidating protein-ligand problems in dengue drug screenings. © 2024 The Authors.

关键词： Molecular docking

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A Bioinformatics Analysis and Homology 3D Modeling of Dihydroxy-orotate-dehydrogenase of Plasmodium ovale

A Bioinformatics Analysis and Homology 3D Modeling of Dihydr...

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2023 International Conference on Informatics, Multimedia, Cyber and Information Systems, ICIMCIS 2023

作者： Nirwantono, Rudi Assidqi, Khoirunnisa Hidayat, Alam Ahmad Pebrianto Trinugroho, Joko Pardamean, Bens Bina Nusantara University Faculty of Engineering Bioinformatics and Data Science Research Center Biotechnology Department Jakarta11480 Indonesia Bina Nusantara University Faculty of Engineering Food Biotechnology Research Center Biotechnology Department Jakarta11480 Indonesia Bina Nusantara University School of Computer Science Bioinformatics and Data Science Research Center Mathematics Departement Jakarta11480 Indonesia Bina Nusantara University Bioinformatics and Data Science Research Center Jakarta11480 Indonesia Bina Nusantara University Binus Graduate Program - Computer Science Program Computer Science Department Jakarta11480 Indonesia

ISBN: (纸本)9798350307306

The infection of Plasmodium vivax is relatively less virulent than the deathliest Plasmodium falciparum. However, it still can lead to a fatal case and often induces recurring malaria due to dormant parasites in the liver. Thus, the research to study the drug to treat Plasmodium vivax is essential, where the enzyme dihydroorotate dehydrogenase (DHODH) has recently become a new drug target. However, the drug-enzyme interaction study has only recently been conducted in Plasmodium falciparum (pfDHODH) due to the lack of the 3D structure of enzyme DHODH from Plasmodium vivax that is crucial for the study. Therefore, this study aimed to perform the modelling study of Plasmodium vivax DHODH (PvDHODH) to create a 3D structure as a basis for drug-protein interaction study in upcoming studies. Sequence pvDHODH (Accession: SCO68359.1) was used in homology modelling using Modeller 10.2 with the crystal structure of DHODH from DHODH (Accession: 7KZY) as a template. Overall, the model generated from the homology modelling was considered a good model, and the 3D structure was close to the native state according to several parameters, including DOPE score, GA341 score, QMEAN4 value, 3D-1D score, ERRAT2 score, and ProSA score. Ramachandran plot also revealed that almost all amino acids were distributed in the desirable and allowed area (99.1%), and only 0.9% were in generously allowed regions. Superimposition of the model with the template also indicated that the model has an almost similar structure and amino acids positioning, including in the binding pocket and active site. Therefore, the model can be used for downstream analysis in drug-protein interaction studies. Nevertheless, some improvements can still be performed to upgrade the quality of the model by deleting unaligned residues on the C-terminal and realigning the residues at the doubting site. © 2023 IEEE.

关键词： Amino acids

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A systematic literature review of machine learning application in COVID-19 medical image classification 7

A systematic literature review of machine learning applicati...

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7th International Conference on computer science and Computational Intelligence, CSCI 2022

作者： Daniel Cenggoro, Tjeng Wawan Pardamean, Bens Computer Science Department BINUS Graduate Program - Master of Computer Science Program Bina Nusantara University Jakarta11480 Indonesia Computer Science Department School of Computer Science Bina Nusantara University Jakarta11480 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia

Detecting COVID-19 as early as possible and quickly is one way to stop the spread of COVID-19. Machine learning development can help to diagnose COVID-19 more quickly and accurately. This report aims to find out how far research has progressed and what lessons can be learned for future research in this sector. By filtering titles, abstracts, and content in the Google Scholar database, this literature review was able to find 19 related papers to answer two research questions, i.e. what medical images are commonly used for COVID-19 classification and what are the methods for COVID-19 classification. According to the findings, chest X-ray were the most commonly used data to categorize COVID-19 and transfer learning techniques were the method used in this study. Researchers also concluded that lung segmentation and use of multimodal data could improve performance. © 2022 Elsevier B.V.. All rights reserved.

关键词： COVID-19

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A review: Data pre-processing techniques used for diabetes prediction

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Procedia computer science 2024年 245卷 667-676页

作者： Mahmud Isnan Gregorius Natanael Elwirehardja Bens Pardamean Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta 11480 Indonesia Computer Science Department School of Computer Science Bina Nusantara University Jakarta 11480 Indonesia Cmputer Science Department BINUS Graduate Program – Master of Computer Science Program Bina Nusantara University Jakarta 11480 Indonesia

When processing datasets in diabetes classification, common problems included a large number of missing values, outliers, and dataset imbalance. To deal with those issues, this study analyzed 18 studies on diabetes classification with machine learning algorithms over the past 5 years. This revealed the important role of data pre-processing in creating effective classification models, as it was found that by using different data pre-processing techniques, the same model can provide different performance. The study identified K-Nearest Neighbor (KNN) and support vector machine (SVM) as superior methods for filling in missing values, achieving an accuracy of 98.49% and 94.89%, respectively. These approaches outperformed traditional methods such as median or mean replacement. However, the challenge of imbalanced data sets remains in all studies reviewed. The common evaluation metrics used to evaluate the created models in previous studies included accuracy, precision, specificity, sensitivity/recall, and F1 Score. Overall, this review showed that the role of data pre-processing is no less important than algorithm selection to improve the performance of machine learning models in diabetes classification.

关键词： Diabetes Classification Data Pre-Processing Machine Learning Imbalanced Dataset

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Determining Variables Associated with Annual Oil Palm Yield: An Explainable Gradient Boosting Approach 8

Determining Variables Associated with Annual Oil Palm Yield:...

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8th International Conference on computer science and Computational Intelligence, ICCSCI 2023

作者： Elwirehardja, Gregorius Natanael Suparyanto, Teddy Miftakhurrokhmat Pardamean, Bens Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department School of Computer Science Bina Nusantara University Jakarta11480 Indonesia Faculty of Agricultural Technology Institute of Agriculture STIPER Yogyakarta55282 Indonesia Faculty of Industrial Technology Universitas Islam Indonesia Yogyakarta55584 Indonesia Computer Science Department BINUS Graduate Program - Master of Computer Science Program Bina Nusantara University Jakarta11480 Indonesia

With the growing demands for Precision Agriculture (PA) in Indonesia, researchers have evaluated the utilization of Machine Learning for predicting oil palm yields and determining variables affecting them. Previous studies showed that meteorological variables, including rainfalls and wind speed, are associated with oil palm yields. In this research, the Extreme Gradient Boosting (XGBoost) model and the Shapley Additive exPlanations (SHAP) were deployed for analyzing the importance of 15 agrometeorological variables in predicting oil palm yield. The best model attained 1.911 RMSE and 0.855 RRʹ. By analyzing the weights and gains of the XGBoost model along with the SHAP values, it was found that the yield in the previous year, the age and number of plants, the area of peat lands, and meteorological parameters such as rainfall rates and the number of rainy days in the previous three years were considered important. The previous year's yield in particular possesses the greatest weight and gain values according to the model, and the highest SHAP value among all input variables. However, the meteorological data used in this research are only limited to rainfall rates and the number of rainy days. In the future, more diverse variables can be analyzed. © 2023 The Authors. Published by Elsevier B.V.

关键词： Machine Learning Oil Palm Yield SHAP XAI XGBoost

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Multivariate Time-Series Deep Learning for Joint Prediction of Temperature and Relative Humidity in a Closed Space 8

Multivariate Time-Series Deep Learning for Joint Prediction ...

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8th International Conference on computer science and Computational Intelligence, ICCSCI 2023

作者： Gunawan, Fergianto E. Budiman, Arief S. Pardamean, Bens Juana, Endang Romeli, Sugiarto Cenggoro, Tjeng W. Purwandari, Kartika Hidayat, Alam A. Redi, Anak A.N.P. Asrol, Muhammad Industrial Engineering Department BINUS Graduate Program - Master of Industrial Engineering Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program - Master of Computer Science Program Bina Nusantara University Jakarta11480 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Electrical Engineering Department Faculty of Industrial Technology Universitas Trisakti Jakarta11440 Indonesia PT Impack Pratama Industri Jakarta14350 Indonesia Computer Science Department School of Computer Science Bina Nusantara University Jakarta11480 Indonesia Mathematics Department School of Computer Science Bina Nusantara University Jakarta11480 Indonesia

An accurate predictive model of temperature and humidity plays a vital role in many industrial processes that utilize a closed space such as in agriculture and building management. With the exceptional performance of deep learning on time-series data, developing a predictive temperature and humidity model with deep learning is propitious. In this study, we demonstrated that deep learning models with multivariate time-series data produce remarkable performance for temperature and relative humidity prediction in a closed space. In detail, all deep learning models that we developed in this study achieve almost perfect performance with an R value over 0.99. © 2023 The Authors. Published by Elsevier B.V.

关键词： closed space deep learning humity prediction indoor temperature prediction

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Cloud-Based Mixed Reality System in Machinery Vocational School: ICT Blueprint

Cloud-Based Mixed Reality System in Machinery Vocational Sch...

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2022 International Conference on science and Technology, ICOSTECH 2022

作者： Suryodiningrat, Satrio Pradono Gaol, Ford L. Supangkat, Suhono Harso Ranti, Benny Bina Nusantara University Binus Graduate Program Doctor of Computer Science Computer Science Department Jakarta Indonesia Bina Nusantara University Faculty of Computing and Media Computer Science Department Jakarta Indonesia Bina Nusantara University Jakarta Doctor of Computer Science Graduate Program Jakarta Indonesia Smart City and Community Innovation Center Bandung Institute of Technology Bandung Indonesia

ISBN: (纸本)9781665479851

Education is always the most important part of our lives. To make education make a significant impact on today's learners, teaching and learning must evolve to match with today's learner's profile. Any education including vocational education has an important role in economic development and one of the ways to maximize the contribution of vocational educations is strengthening the link and match with the world of work [1]. As the technology also keeps evolving and it is getting more and more advanced, one technology that has significant traction lately is the mixed reality system and is often used for education purposes. Most big ICT companies like Microsoft, and HTC are racing to develop mixed reality systems to help the teaching and learning process to be more effective and efficient. Where everything is cloud-based, having a cloud-based mixed reality system is just makes sense but will have a great challenge and considered as a big ICT project. One of the ways to make the ICT project successful is to make a blueprint before it is started. The objective of this paper is how to develop an ICT Blueprint for implementing a cloud-based mixed reality system for machinery vocational schools to make the project have a higher success rate. © 2022 IEEE.

关键词： Blueprints

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Placement Refinement Strategies for Security Closure

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IEEE Transactions on computer-Aided Design of Integrated Circuits and Systems 2025年

作者： Danigno, Marcelo Fogaca, Mateus Schvittz, Rafael Butzen, Paulo Microelectronic Graduate Program Porto Alegre Brazil Cadence Design Systems Inc United States Computer Science Center Rio Grande Brazil

The security closure of integrated circuits (ICs) is an emerging area of research within the very large scale integration (VLSI) community. Malicious third parties, referred to as "attackers", can employ various techniques to leak, alter, or manipulate the logic of a circuit. When targeting a completed layout, their primary goal is often the insertion of hardware trojans. In this work, we present algorithms that strengthen placement solutions against hardware trojan attacks. While state-of-the-art methods rely on exhaustive placement algorithms, we propose a clustering-based placement approach that reduces the number of moved cells by up to 17%. Additionally, we introduce a cell movement heuristic aimed at preventing increases in wirelength. Our methods reduce vulnerable placement sites by up to 78% while maintaining minimal impact on design performance. Compared to other approaches, our solution decreases the amount of moved cells to an average of 8%, mitigating the impact on wirelength to an average of 0.5%. © 1982-2012 IEEE.

关键词： Electronic design automation

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