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Author Correction: Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population reveals tumor cell-enriched and immune-rich subtypes

Nature cancer

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Nature cancer 2023年 2023 May 19页

作者： Do Young Hyeon Dowoon Nam Youngmin Han Duk Ki Kim Gibeom Kim Daeun Kim Jingi Bae Seunghoon Back Dong-Gi Mun Inamul Hasan Madar Hangyeore Lee Su-Jin Kim Hokeun Kim Sangyeop Hyun Chang Rok Kim Seon Ah Choi Yong Ryoul Kim Juhee Jeong Suwan Jeon Yeon Woong Choo Kyung Bun Lee Wooil Kwon Seunghyuk Choi Taewan Goo Taesung Park Young-Ah Suh Hongbeom Kim Ja-Lok Ku Min-Sik Kim Eunok Paek Daechan Park Keehoon Jung Sung Hee Baek Jin-Young Jang Daehee Hwang Sang-Won Lee School of Biological Sciences Seoul National University Seoul Republic of Korea. Department of Chemistry and Center for Proteogenome Research Korea University Seoul Republic of Korea. Department of Surgery and Cancer Research Institute Seoul National University College of Medicine Seoul Republic of Korea. Department of Anatomy and Cell Biology and Department of Biomedical Sciences Seoul National University College of Medicine Seoul Republic of Korea. Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Seoul Republic of Korea. Creative Research Initiatives Center for Epigenetic Code and Diseases Seoul National University Seoul Republic of Korea. Department of Biological Sciences College of Natural Sciences and Department of Molecular Science and Technology Ajou University Suwon Republic of Korea. Department of Pathology Seoul National University College of Medicine Seoul Korea. Department of Computer Science Hanyang University Seoul Republic of Korea. Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea. Department of Statistics Seoul National University Seoul Republic of Korea. Korean Cell Line Bank Laboratory of Cell Biology Cancer Research Institute Seoul National University College of Medicine Seoul Korea. Department of New Biology Daegu Gyeongbuk Institute of Science and Technology Daegu Republic of Korea. Department of Biological Sciences College of Natural Sciences and Department of Molecular Science and Technology Ajou University Suwon Republic of Korea. dpark@ajou.ac.kr. Department of Anatomy and Cell Biology and Department of Biomedical Sciences Seoul National University College of Medicine Seoul Republic of Korea. keehoon.jung@snu.ac.kr. Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center Seoul Republic of Korea. keehoon.jung@snu.ac.kr. School of Biological Sciences Seoul National University Seoul Republic of

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Convergence of Teichmüller deformations in the universal Teichmüller space

arXiv

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arXiv 2018年

作者： Miyachi, Hideki Šarić, Dragomir Division of Mathematical and Physical Sciences Graduate School of Natural Science & Technology Kanazawa University Kakuma-machi Kanazawa Ishikawa920-1192 Japan Department of Mathematics Queens College of CUNY 65-30 Kissena Blvd FlushingNY11367 United States Mathematics PhD Program CUNY Graduate Center 365 Fifth Avenue New YorkNY10016-4309 United States

Let : D → C be an integrable holomorphic function on the unit disk D and D : D → T(D) the corresponding Teichmüller disk in the universal Teichmüller space T(D). For a positive t it is known that D(t) → [µ] ∈ PMLb(D) as t → 1, where µ is a bounded measured lamination representing a point on the Thurston boundary of T(D). We extend this result by showing that D: D → T(D) extends as a continuous map from the closed disk D to the Thurston bordification. In addition, we prove that the rate of convergence of D(λ) when λ → eiθ is independent of the type of the approach to eiθ ∈ ∂D.30F60, 32G15 Copyright © 2018, The Authors. All rights reserved.

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Fundamental bounds on the operation of Fano nonlinear isolators

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Physical Review B 2018年第11期97卷 115431-115431页

作者： Dimitrios L. Sounas Andrea Alù Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 USA Photonics Initiative Advanced Science Research Center City University of New York New York 10031 USA Physics Program Graduate Center City University of New York New York 10016 USA Department of Electrical Engineering City College of The City University of New York New York 10031 USA

Nonlinear isolators have attracted significant attention for their ability to break reciprocity and provide isolation without the need of an external bias. A popular approach for the design of such devices is based on Fano resonators, which, due to their sharp frequency response, can lead to very large isolation for moderate input intensities. Here, we show that, independent of their specific implementation, these devices are subject to fundamental bounds on the transmission coefficient in the forward direction versus their quality factor, input power, and nonreciprocal intensity range. Our analysis quantifies a general tradeoff between forward transmission and these metrics, stemming directly from time-reversal symmetry, and that unitary transmission is only possible for vanishing nonreciprocity. Our results also shed light on the operation of resonant nonlinear isolators, reveal their fundamental limitations, and provide indications on how it is possible to design nonlinear isolators with optimal performance.

关键词： Electromagnetism Metamaterials Nonlinear optics

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Nonlinear Isolators and Circulators Based on Networks of Coupled Resonators 12

Nonlinear Isolators and Circulators Based on Networks of Cou...

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12th International Congress on Artificial Materials for Novel Wave Phenomena, METAMATERIALS 2018

作者： Sounas, D.L. Soric, J. Draguanno, G. Alu, A. University of Texas at Austin Department of Electrical and Computer Engineering AustinTX78712 United States Raytheon AndoverMA United States Johns Hopkins University Applied Physics Laboratory LaurelMD United States Photonics Initiative Advanced Science Research Center City University of New York New YorkNY10031 United States Physics Program Graduate Center City University of New York New YorkNY10016 United States Department of Electrical Engineering City College of New York New YorkNY10031 United States

ISBN: (纸本)9781538647028

We present our recent results in the area of nonlinear nonreciprocal devices, including isolators and circulators. We show that the nonlinear isolators based on single Fano resonators are subject to a fundamental trade-off between transmission and isolation intensity range or bandwidth, stemming from time reversal symmetry. We also show how we can overcome this limitation by using multiple nonlinear resonators. Finally, we show that networks with many nonlinear resonators can also be used to realize more advanced devices, such as circulators. © 2018 IEEE.

关键词： Resonators

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Towards Universal Chemosensory Testing: Needs, Barriers and Opportunities

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Chemical senses 2025年第50期volume卷 bjaf015页

作者： Steven D Munger Kai Zhao Linda A Barlow Duncan Boak Katie Boateng Susan E Coldwell Pamela Dalton Richard L Doty Jennifer E Douglas Valerie Duffy F Abron Franklin John E Hayes Howard J Hoffman Patrice Hubert Paule V Joseph Jeb M Justice Joshua M Levy Julie A Mennella Marianna Obrist M Yanina Pepino Jayant M Pinto Edmund A Pribitkin Christopher T Simons Mark W Albers Valentina Parma Department of Otolaryngology - Head and Neck Surgery University of Virginia Charlottesville VA 22908 USA. Center for Smell and Taste Disorders University of Virginia Charlottesville VA 22908 USA. Department of Otolaryngology-Head & Neck Surgery the Ohio State University 915 Olentangy River Road Columbus OH 43212 USA. Department of Cell and Developmental Biology University of Colorado Anschutz Medical Campus Aurora CO 80045 USA. Rocky Mountain Taste and Smell Center University of Colorado Anschutz Medical Campus Aurora CO 80045 USA. Cell Biology Stem Cells and Development Graduate Program University of Colorado Anschutz Medical Campus Aurora CO 80045 USA. Fifth Sense Unit 2 Franklins House Wesley Lane Bicester OX26 6JU UK. The Smell and Taste Association of North America Philadelphia PA USA. Oral Health Sciences School of Dentistry University of Washington Room B-509 Health Sciences Building Box 357475 Seattle WA 98195-7475 USA. Monell Chemical Senses Center 3500 Market Street Philadelphia PA USA. Department of Otorhinolaryngology - Head & Neck Surgery University of Pennsylvania Philadelphia PA 19104 USA. Department of Allied Health Sciences University of Connecticut Storrs CT 06269 USA. Philadelphia Department of Public Health City of Philadelphia PA USA. Department of Preventive Medicine and Community Health Morehouse School of Medicine Atlanta GA USA. Sensory Evaluation Center The Pennsylvania State University University Park Centre County PA 16802 USA. Department of Food Science Pennsylvania State University PA16803 USA. Epidemiology and Statistics Program National Institute on Deafness and Other Communication Disorders National Institutes of Health Bethesda MD 20892 USA. National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institutes of Health Bethesda MD 20892 USA. National Institute on Deafness and Other Communication Disorders (NIDCD) National Institutes of Health Bethesda MD 20892 USA. National Smell and Ta

Millions of people in the United States experience a reduced or distorted ability to smell or taste. Chemosensory disorders such as anosmia (the inability to smell), parosmia (distorted smell), or dysgeusia (altered taste) have major impacts on health and quality of life including difficulty sensing dangers such as fire or spoilage, a diminished palatability of food and drink that can negatively influence diet and nutrition, feelings of social isolation, and an increased incidence of frailty, anxiety, and depression. Smell or taste dysfunction can also be symptoms of other health issues, including sinonasal disease, cancer, or neurodegenerative disease. Aging adults are disproportionately affected. However, smell and taste function are not regularly assessed as a part of routine healthcare despite their prevalence and impact. This is a lost opportunity, as early detection of a chemosensory disorder would enable patients to obtain needed validation, education and support for their health challenge, could direct both patient and provider to treatment options, and may suggest underlying health issues that should be addressed. To better understand the current barriers to including chemosensory testing as a regular component of health care and to identify opportunities to overcome those barriers, the conference "Towards Universal Chemosensory Testing" was convened on November 5-7, 2023, in Philadelphia, PA. This conference brought together scientists, clinicians, patients, and other experts to discuss these issues and identify collective ways to overcome barriers to testing. This white paper - which is focused primarily on the US healthcare system - is the result of those discussions.

关键词： anosmia clinical dysgeusia hyposmia smell taste

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Brain-like object recognition with high-performing shallow recurrent ANNs

arXiv

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arXiv 2019年

作者： Kubilius, Jonas Schrimpf, Martin Kar, Kohitij Rajalingham, Rishi Hong, Ha Majaj, Najib J. Issa, Elias B. Bashivan, Pouya Prescott-Roy, Jonathan Schmidt, Kailyn Nayebi, Aran Bear, Daniel Yamins, Daniel L.K. DiCarlo, James J. McGovern Institute for Brain Research MIT CambridgeMA02139 United States Brain and Cognition KU Leuven Leuven Belgium Department of Brain and Cognitive Sciences MIT CambridgeMA02139 United States Center for Brains Minds and Machines MIT CambridgeMA02139 Bay Labs Inc. San FranciscoCA94102 United States Center for Neural Science New York University New YorkNY10003 United States Department of Neuroscience Zuckerman Mind Brain Behavior Institute Columbia University New YorkNY10027 United States Neurosciences PhD Program Stanford University StanfordCA94305 United States Department of Psychology Stanford University StanfordCA94305 United States Department of Computer Science Stanford University StanfordCA94305 United States

Deep convolutional artificial neural networks (ANNs) are the leading class of candidate models of the mechanisms of visual processing in the primate ventral stream. While initially inspired by brain anatomy, over the past years, these ANNs have evolved from a simple eight-layer architecture in AlexNet to extremely deep and branching architectures, demonstrating increasingly better object categorization performance, yet bringing into question how brain-like they still are. In particular, typical deep models from the machine learning community are often hard to map onto the brain's anatomy due to their vast number of layers and missing biologically-important connections, such as recurrence. Here we demonstrate that better anatomical alignment to the brain and high performance on machine learning as well as neuroscience measures do not have to be in contradiction. We developed CORnet-S, a shallow ANN with four anatomically mapped areas and recurrent connectivity, guided by Brain-Score, a new large-scale composite of neural and behavioral benchmarks for quantifying the functional fidelity of models of the primate ventral visual stream. Despite being significantly shallower than most models, CORnet-S is the top model on Brain-Score and outperforms similarly compact models on ImageNet. Moreover, our extensive analyses of CORnet-S circuitry variants reveal that recurrence is the main predictive factor of both Brain-Score and ImageNet top-1 performance. Finally, we report that the temporal evolution of the CORnet-S "IT" neural population resembles the actual monkey IT population dynamics. Taken together, these results establish CORnet-S, a compact, recurrent ANN, as the current best model of the primate ventral visual stream. Copyright © 2019, The Authors. All rights reserved.

关键词： Object recognition

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STRING-AVERAGING ALGORITHMS FOR CONVEX FEASIBILITY WITH INFINITELY MANY SETS

arXiv

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arXiv 2018年

作者： Kong, T. Yung Pajoohesh, Homeira Herman, Gabor T. Computer Science Department Queens College City University of New York FlushingNY11367 United States Mathematics Department Medgar Evers College City University of New York BrooklynNY11225 United States Computer Science Ph.D. Program The Graduate Center City University of New York New YorkNY10016 United States

Algorithms for convex feasibility find or approximate a point in the intersection of given closed convex sets. Typically there are only finitely many convex sets, but the case of infinitely many convex sets also has some applications. In this context, a string is a finite sequence of points each of which is obtained from the previous point by considering one of the convex sets. In a string-averaging algorithm, an iterative step from a first point to a second point computes a number of strings, all starting with the first point, and then calculates a (weighted) average of those strings’ end-points: This average is that iterative step’s second point, which is used as the first point for the next iterative step. For string-averaging algorithms based on strings in which each point either is the projection of the previous point on one of the convex sets or is equal to the previous point, we present theorems that provide answers to the following question: "How can the iterative steps be specified so that the string-averaging algorithm generates a convergent sequence whose limit lies in the intersection of the sets of a given convex feasibility problem?" This paper focuses on the case where the given collection of convex sets is infinite, whereas prior work on the same question that we are aware of has assumed the collection of convex sets is finite (or has been applicable only to a small subset of the algorithms we consider). The string-averaging algorithms that are shown to generate a convergent sequence whose limit lies in the intersection are also shown to be perturbation resilient, so they can be superiorized to generate sequences that also converge to a point of the intersection but in a manner that is superior with respect to some application-dependent criterion.46N10 46N40 47H09 47H10 47J25 47N10 65F10 65J99 65K10 90C25 90C30 Copyright © 2018, The Authors. All rights reserved.

关键词： Iterative methods

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Broadband Cyclic-Symmetric Magnet-less Circulatorsand Theoretical Bounds on their Bandwidth

arXiv

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arXiv 2018年

作者： Kord, Ahmed Sounas, Dimitrios L. Xiao, Zhicheng Alù, Andrea Department of Electrical and Computer Engineering University of Texas at Austin AustinTX78712 United States Advanced Science Research Center Physics Program Graduate Center Photonics Initiative Department of Electrical Engineering City College of New York City University of New York New York NY10031 United States

In this paper, we explore theoretically and experimentally broadband spatiotemporally modulated (STM) magnet-less circulators realized by combining three-port non-reciprocal junctions with three identical bandpass filters. We develop a rigorous theory for the proposed circuit, which allows to optimize its design and to derive a global bound on the maximum possible bandwidth (BW). We verify our theory with simulations and measurements of a printed circuit board (PCB) prototype based on a differential wye junction and second-order Chebyshev bandpass filters, resulting in a measured fractional BW of 13.9% at a center frequency of 1 GHz. Copyright © 2018, The Authors. All rights reserved.

关键词： Bandwidth

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Commuting planar polynomial vector fields for conservative Newton systems

arXiv

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arXiv 2018年

作者： Nagloo, Joel Ovchinnikov, Alexey Thompson, Peter Cuny Bronx Community College Department of Mathematics and Computer Science 2155 University Avenue BronxNY10453 United States Cuny Queens College Department of Mathematics 65-30 Kissena Blvd QueensNY11367 United States Cuny Graduate Center PH.D. Programs in Mathematics and Computer Science 365 Fifth Avenue New YorkNY10016 United States Cuny Graduate Center PH.D. Program in Mathematics 365 Fifth Avenue New YorkNY10016 United States

We study the problem of characterizing polynomial vector fields that commute with a given polynomial vector field on a plane. It is a classical result that one can write down solution formulas for an ODE that corresponds to a planar vector field that possesses a linearly independent commuting vector field. This problemis also central to the question of linearizability of vector fields. Let f ϵ K[x], where K is a field of characteristic zero, and d the derivation that corresponds to the differential equation x = f (x) in a standard way. Let also H be the Hamiltonian polynomial for d, that is H = 1 2 y2-R f (x)dx. It is known that the set of all polynomial derivations that commute with d forms a K[H]-module Md . In this paper, we show that, for every such d, the module Md is of rank 1 if and only if deg f ≥ 2. For example, the classical elliptic equation x = 6x2+a, where a ϵ ℂ, falls into this category.37J30, 13N10, 70H07 Copyright © 2018, The Authors. All rights reserved.

关键词： Hamiltonians

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Active Microwave Cloaking Using Parity-Time-Symmetric Satellites

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Physical Review Applied 2018年第5期10卷 054040-054040页

作者： Ahmed Kord Dimitrios L. Sounas Andrea Alù Department of Electrical and Computer Engineering the University of Texas at Austin Austin Texas 78712 USA Photonics Initiative Advanced Science Research Center City University of New York New York New York 10031 USA Physics Program Graduate Center City University of New York New York New York 10026 USA Department of Electrical Engineering City College of New York New York New York 10031 USA

In this paper, we present and study the dynamics of an active microwave cloaking technique that alleviates the trade-offs between loss, bandwidth, and size inherent in passive approaches. The presented cloak consists of a finite number of satellite antennas loaded with parity-time-symmetric lumped admittances, which, without external control, can track in real time the amplitude, frequency, and phase variations of the impinging signals and generate the required current distributions at the antennas to totally suppress the scattered waves, including reflections and shadows. We analytically derive the optimal density and frequency dispersion of the antenna satellites surrounding the object in order to achieve substantial reduction in the scattering crosssection over a wide bandwidth. We also investigate the conditions necessary to maintain the cloak stability and study its transient response for excitation with pulsed signals.

关键词： Cloaking Metamaterials Optical cloaking PT-symmetry Microwave techniques

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