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Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells

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Phytomedicine 2023年 116卷

作者： Jen-Chih Tseng Bi-Juan Wang Ya-Pei Wang Ying-Yu Kuo Jen-Kun Chen Tzyh-Chyuan Hour Li-Kuo Kuo Po-Jen Hsiao Chien-Chih Yeh Cheng-Li Kao Li-Jane Shih Chih-Pin Chuu Institute of Cellular and System Medicine National Health Research Institutes Miaoli County 35053 Taiwan Immunology Research Center National Health Research Institutes Miaoli County 35053 Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County 35053 Taiwan Neuroscience Research Center Kaohsiung Medical University Kaohsiung 80737 Taiwan Department of Biochemistry School of Medicine Kaohsiung Medical University Kaohsiung 80737 Taiwan Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung 80737 Taiwan Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Mackay Memorial Hospital Taipei City 104217 Taiwan Department of Nursing Mackay Medical College Taipei City Taiwan Division of Nephrology Department of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan 325 Taiwan Division of Nephrology Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei 114 Taiwan Department of Education and Medical Research Taoyuan Armed Forces General Hospital Taoyuan Taiwan Division of Colon and Rectal Surgery Department of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Division of Urology Departments of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Division of Urology Department of Surgery Taoyuan Armed Forces General Hospital Taoyuan Taiwan Graduate Institute of Medical Science National Defense Medical Center Taipei 114 Taiwan Department of Life Sciences National Central University Taoyuan 32031 Taiwan PhD Program for Aging and Graduate Institute of Basic Medical Science China Medical University Taichung City 40402 Taiwan Biotechnology Center National Chung Hsing University Taichung City 40227 Taiwan

Background Epidermal growth factor receptor (EGFR) is upregulated in prostate cancer (PCa). However, suppression of EGFR did not improve the patient outcome, possibly due to the activation of PI3K/Akt signaling in PCa. Compounds able to suppress both PI3K/Akt and EGFR signaling may be effective for treating advanced PCa. Purpose We examined if caffeic acid phenethyl ester (CAPE) simultaneously suppresses the EGFR and Akt signaling, migration and tumor growth in PCa cells. Methods Wound healing assay, transwell migration assay and xenograft mice model were used to determine the effects of CAPE on migration and proliferation of PCa cells. Western blot, immunoprecipitation, and immunohistochemistry staining were performed to determine the effects of CAPE on EGFR and Akt signaling. Results CAPE treatment decreased the gene expression of HRAS, RAF1, AKT2, GSK3A , and EGF and the protein expression of phospho-EGFR (Y845, Y1069, Y1148, Y1173), phospho-FAK, Akt, and ERK1/2 in PCa cells. CAPE treatment inhibited the EGF-induced migration of PCa cells. Combined treatment of CAPE with EGFR inhibitor gefitinib showed additive inhibition on migration and proliferation of PCa cells. Injection of CAPE (15 mg/kg/3 days) for 14 days suppressed the tumor growth of prostate xenografts in nude mice as well as suppressed the levels of Ki67, phospho-EGFR Y845, MMP-9, phospho-Akt S473, phospho-Akt T308, Ras, and Raf-1 in prostate xenografts. Conclusions Our study suggested that CAPE can simultaneously suppress the EGFR and Akt signaling in PCa cells and is a potential therapeutic agent for advanced PCa.

关键词： Prostate cancer Caffeic acid phenethyl ester Metastasis Epidermal growth factor receptor Fak Akt CAPE caffeic acid phenethyl ester CRPC castration-resistant prostate cancer EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition GAPDH glyceraldehyde-3-phosphate dehydrogenase mTOR mammalian target of rapamycin PCa prostate cancer PI3K phosphoinositide 3-kinase PSA prostate specific antigen PSMA prostate specific-membrane antigen PTEN phosphatase and tensin homolog

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Survival after First Relapse in Marginal Zone Lymphomas: Prospective Data from the International Observational NF10 Study By the Fondazione Italiana Linfomi

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Blood 2024年 144卷 1639-1639页

作者： Stefano Luminari Michele Merli Sara Rattotti Maria Elena Nizzoli Vittoria Tarantino Simone Ferrero Annalisa Talami Roberta Murru Marina Deodato Emanuele Cencini Francesca Re Carlo Visco Marcia Delamain Michele Spina Ombretta Annibali Alessandro Pulsoni Andrés José María Ferreri Caterina Stelitano Elsa Pennese Emiliano Barbieri Luca Arcaini Hematology Azienda Unità Sanitaria Locale IRCCS of Reggio Emilia Reggio Emilia Italy Hematology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy Fondazione IRCCS Policlinico San Matteo and University of Pavia Pavia Italy Hematology Unit Azienda USL- IRCCS di Reggio Emilia Reggio Emilia Italy Clinical and Experimental Medicine PhD Program University of Modena and Reggio Emilia Modena Italy Division of Hematology Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello Palermo Italy Department of Molecular Biotechnology and Health Sciences Hematology Division University of Torino Torino Italy Clinical and Experimental Medicine Doctorate School Università degli Studi di Modena e Reggio Emilia Reggio Emilia Italy Hematology and Stem Cell Transplantation Unit Ospedale Oncologico A. Businco ARNAS G. Brotzu Cagliari Italy Department of Hematology Niguarda Cancer Center ASST Grande Ospedale Metropolitano Niguarda Milano Italy Division of Hematology Azienda Ospedaliera Universitaria Senese & University of Siena Siena Italy Division of Hematology Azienda Ospedaliera Universitaria di Parma Parma Italy Hematology and Bone Marrow Transplant Unit Department of Engineering for Innovative Medicine University of Verona Verona Italy Faculdade Ciências Médicas de Minas Gerais Belo Horizonte Brazil Division of Medical Oncology IRCCS Centro Di Riferimento Oncologico Aviano Italy Division of Hematology Stem Cell Transplantation Fondazione Policlinico Universitario Campus Bio Medico Roma Italy Division of Hematology Sapienza University - Polo Pontino Department of Translational and Precision Medicine S.M. Goretti Hospital Latina Italy Unit of Lymphoid Malignancies Department of Onco-Haematology IRCCS San Raffaele Scientific Institute Milano Italy Division of Hematology Grande Ospedale Metropolitano Bianchi Melacrino Morelli Reggio Calabria Italy Centro diagnosi e terapia dei linfomi Presidio Ospedaliero Spirito Santo Pescara Italy Division of Hem

Background: Marginal Zone Lymphomas (MZL) include Splenic (SMZL), Nodal (NMZL), and Extranodal (ENMZL) pathologic subtypes and are typically associated with an indolent clinical course. Even if outcomes of most MZL cases are excellent, a significant proportion of patients relapse after first line therapy showing heterogenous behavior, with few studies describing outcomes after first relapse. In this report we investigated clinical characteristics and survival of MZL patients prospectively enrolled in the NF10 observational study who experienced a first relapse after induction systemic therapy. Methods: The NF10 Project was started in 2010 by Fondazione Italiana Linfomi (FIL) as a prospective registry specifically conceived to investigate the prognosis of Indolent Non-Follicular B-Cell Lymphomas (INFL). All pts with a histologic confirmed diagnosis of INFL were eligible for NF10 study with no exclusion criteria. In addition to conventional MZL subtypes the category of disseminated MZL (dissMZL) was defined for cases with undefined presentation. For the current study we selected only patients who experienced a first relapse after systemic therapy. Pts were followed and treated based on local institution guidelines. Primary endpoint was Progression free survival from first relapse (PFS2) which was defined as the time from the date of first relapse (Index date) from subsequent progression, re-treatment, or death due to any cause: secondary endpoint was Survival after relapse (SAR) which was calculated from the index date to death. Results: Between July 2010 and July 2018, 740 MZL cases had been registered by 65 centres in Europe and South America. Systemic therapy was administered to 435 patients (pts) at time of diagnosis and to 66 cases after initial watch& wait. Overall, 122 patients were identified who had a first relapse after systemic therapy and represented the study population. At index date 51% were older than 70 years (yrs), 47% were male, 36% 15% 29%, and 20%

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Nano oxygen particles for cell physiological condition monitoring 20

Nano oxygen particles for cell physiological condition monit...

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20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

作者： Koduri, Manohar Prasad Shao, Yu-Wei Tseng, Fan-Gang International Intercollegiate PhD Program NTHU Hsinchu Taiwan Institute of Nano Engineering and Microsystems NTHU Hsinchu Taiwan Engineering and System Science NTHU Hsinchu Taiwan

ISBN: (纸本)9780979806490

In this study we demonstrate a novel Nano-particle (NP) oxygen sensors for monitoring in vitro oxygen concentration/distribution by measuring the fluorescence intensity in HeLa cells filled alginate hydrogel sphere. The Nano Oxygen Particles (NOP) are made by conjugating oxygen sensitive fluorescence dye through the mediation of amphiphilic linkers on Polystyrene bead (PSB, 510nm in diameter) surface, as shown in figure 1.

关键词： Fluorescence

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Author Correction: Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

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Nature medicine 2024年第12期30卷 3779页

作者： Sebastian Moguilner Sandra Baez Hernan Hernandez Joaquín Migeot Agustina Legaz Raul Gonzalez-Gomez Francesca R Farina Pavel Prado Jhosmary Cuadros Enzo Tagliazucchi Florencia Altschuler Marcelo Adrián Maito María E Godoy Josephine Cruzat Pedro A Valdes-Sosa Francisco Lopera John Fredy Ochoa-Gómez Alfredis Gonzalez Hernandez Jasmin Bonilla-Santos Rodrigo A Gonzalez-Montealegre Renato Anghinah Luís E d'Almeida Manfrinati Sol Fittipaldi Vicente Medel Daniela Olivares Görsev G Yener Javier Escudero Claudio Babiloni Robert Whelan Bahar Güntekin Harun Yırıkoğulları Hernando Santamaria-Garcia Alberto Fernández Lucas David Huepe Gaetano Di Caterina Marcio Soto-Añari Agustina Birba Agustin Sainz-Ballesteros Carlos Coronel-Oliveros Amanuel Yigezu Eduar Herrera Daniel Abasolo Kerry Kilborn Nicolás Rubido Ruaridh A Clark Ruben Herzog Deniz Yerlikaya Kun Hu Mario A Parra Pablo Reyes Adolfo M García Diana L Matallana José Alberto Avila-Funes Andrea Slachevsky María I Behrens Nilton Custodio Juan F Cardona Pablo Barttfeld Ignacio L Brusco Martín A Bruno Ana L Sosa Ortiz Stefanie D Pina-Escudero Leonel T Takada Elisa Resende Katherine L Possin Maira Okada de Oliveira Alejandro Lopez-Valdes Brian Lawlor Ian H Robertson Kenneth S Kosik Claudia Duran-Aniotz Victor Valcour Jennifer S Yokoyama Bruce Miller Agustin Ibanez Latin American Brain Health Institute Universidad Adolfo Ibañez Santiago de Chile Chile. Cognitive Neuroscience Center Universidad de San Andrés Buenos Aires Argentina. Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston MA USA. Universidad de los Andes Bogota Colombia. Global Brain Health Institute (GBHI) University of California San Francisco CA USA. Global Brain Health Institute (GBHI) Trinity College Dublin Dublin Ireland. The University of California Santa Barbara (UCSB) Santa Barbara CA USA. Escuela de Fonoaudiología Universidad San Sebastián Santiago de Chile Chile. Grupo de Bioingeniería Decanato de Investigación Universidad Nacional Experimental del Táchira San Cristóbal Venezuela. Advanced Center for Electrical and Electronic Engineering Universidad Técnica Federico Santa María Valparaíso Chile. University of Buenos Aires Buenos Aires Argentina. The Clinical Hospital of Chengdu Brain Sciences Institute University of Electronic Sciences and Technology of China Chengdu China. Technology of China Chengdu China. Cuban Neuroscience Center La Habana Cuba. Grupo de Neurociencias de Antioquia (GNA) University of Antioquia Medellín Colombia. Department of Psychology Master Program of Clinical Neuropsychology Universidad Surcolombiana Neiva Neiva Colombia. Department of Psychology Universidad Cooperativa de Colombia Arauca Colombia. Neurocognition and Psychophysiology Laboratory Universidad Surcolombiana Neiva Colombia. Reference Center of Behavioural Disturbances and Dementia School of Medicine University of Sao Paulo Sao Paulo Brazil. Traumatic Brain Injury Cognitive Rehabilitation Out-Patient Center University of Sao Paulo Sao Paulo Brazil. Center for Social and Cognitive Neuroscience School of Psychology Universidad Adolfo Ibáñez Santiago Chile. Neuropsychology and Clinical Neuroscience Laboratory (LANNEC) Physiopathology Program-Institute of Biomedical Sciences (ICBM) Neuroscience and East Neuroscience Dep

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52P Liquid biopsy monitoring in BRAF V600E mutated NSCLC patients treated with dabrafenib plus trametinib: A prospective, explorative, multicentric study, LiBRA study (GOIRC-03-2020)

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ESMO Open 2024年 9卷 102631-102631页

作者： Leonetti, A. Minari, R. Pluchino, M. Passiglia, F. Bianchi, A. Sartore Cortinovis, D.L. Toschi, L. Gelsomino, F. Frega, S. Metro, G. Pilotto, S. Galetta, D. Camerini, A. Bertolini, A. Baldini, E. Mazzoni, F. Bria, E. Trudu, L. Del Conte, A. Tiseo, M. Medical Oncology Unit University Hospital of Parma Parma Italy Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC) Parma Italy Medical Oncology Unit University Hospital of Parma Parma Italy Department of Oncology University of Turin San Luigi Hospital Orbassano Italy SC Ricerca Clinica e Innovazione ASST Grande Ospedale Metropolitano Niguarda Milan Italy Dipartimento Oncologia Medica SC Oncologia medica Fondazione IRCCS San Gerardo dei Tintori Monza Italy Università degli Studi Milano-Bicocca Milan Italy Medical Oncology IRCCS Humanitas Research Hospital Rozzano Italy Medical Oncology IRCCS Azienda Ospedaliero-Universitaria di Bologna Bologna Italy Division of Medical Oncology 2 Veneto Institute of Oncology IOV-IRCCS Padua Italy Medical Oncology S. Maria Della Misericordia Hospital Perugia Italy Section of Oncology Department of Engineering for Innovative Medicine University of Verona Verona Italy Medical Thoracic Oncology Unit IRCCS Istituto Tumori "Giovanni Paolo II" Bari Italy UOC Oncologia Medica USL Toscana Nord Ovest Ospedale Versilia Lido Di Camaiore Italy Oncologia Medica ASST della Valtellina e Alto Lario Ospedale di Sondrio Sondrio Italy Dip.to Oncologico ATNO UOC Oncologia Medica Ospedale San Luca Lucca Italy SODc Oncologia Clinica Azienda Ospedaliero Universitaria Careggi Florence Italy UOSD Oncologia Toraco-Polmonare Comprehensive Cancer Center Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Medical Oncology Department of Traslational Medicine and Surgery Università Cattolica del Sacro Cuore Rome Italy PhD Program Clinical & Experimental Medicine University of Modena & Reggio Emilia Modena Italy Centro di Riferimento Oncologico di Aviano (CRO) IRCCS S.O.C. Oncologia Medica e dei Tumori Immunocorrelati Aviano Italy Medical Oncology Unit University Hospital of Parma Parma Italy Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC) Parma Italy Department of Medicine and Surgery University of Parma Parma

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Current findings on terrestrial plants – Engineered nanomaterial interactions: Are plants capable of phytoremediating nanomaterials from soil?

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Current Opinion in Environmental Science and Health 2018年 6卷 9-15页

作者： Cota-Ruiz, Keni Delgado-Rios, Marcos Martínez-Martínez, Alejandro Núñez-Gastelum, José Alberto Peralta-Videa, Jose Ramon Gardea-Torresdey, Jorge Luis Department of Chemistry The University of Texas at El Paso 500 West University Avenue El Paso 79968 TX United States Departamento de Ciencias Químico Biológicas Instituto de Ciencias Químico Biológicas Universidad Autónoma de Ciudad Juárez Anillo Envolvente del PRONAF y Estocolmo S/n Ciudad Juárez Chihuahua 32310 Mexico El Colegio de Chihuahua Calle Partido Díaz 4723 Esquina con Anillo Envolvente del PRONAF Ciudad Juárez Chihuahua 32310 Mexico Environmental Science and Engineering PhD Program Department of Chemistry The University of Texas at El Paso 500 West University Avenue El Paso 79968 TX United States UC Center for Environmental Implications of Nanotechnology (UC CEIN) The University of Texas at El Paso 500 West University Avenue El Paso 79968 TX United States

Engineered Nanomaterials (ENMs) are revolutionizing our daily lives, industry, and agriculture. Along with their novel applications, major concerns have emerged due to the potential toxicity to biological systems. Since soils are considered the main destination for ENMs, research focused on their interaction with plants is gaining more attention, especially at the physiological and biochemical levels. This review addresses the capacity of some plants to accumulate ENMs or released ions, highlighting the beneficial and detrimental effects and the potential use of some plants to remediate ENM-contaminated environments. Although the uptake process depends on multiple factors, the literature suggests that concentrations <50 mg/kg are beneficial, while higher doses negatively impact physiological and biochemical parameters. However, the current data does not allow the formulation of mechanistic model effects. Finally, this review remarks on the pivotal role played by plants as a sustainable alternative to face the environmental buildup of ENMs and to guarantee food security. © 2018 Elsevier B.V.

关键词： Biotransformation ENM-plant interactions Food security Phytoremediation Risk assessment

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Author Correction: Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein

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Nature communications 2024年第1期15卷 6413页

作者： Xiaobo Mao Hao Gu Donghoon Kim Yasuyoshi Kimura Ning Wang Enquan Xu Ramhari Kumbhar Xiaotian Ming Haibo Wang Chan Chen Shengnan Zhang Chunyu Jia Yuqing Liu Hetao Bian Senthilkumar S Karuppagounder Fatih Akkentli Qi Chen Longgang Jia Heehong Hwang Su Hyun Lee Xiyu Ke Michael Chang Amanda Li Jun Yang Cyrus Rastegar Manjari Sriparna Preston Ge Saurav Brahmachari Sangjune Kim Shu Zhang Yasushi Shimoda Martina Saar Haiqing Liu Sin Ho Kweon Mingyao Ying Creg J Workman Dario A A Vignali Ulrike C Muller Cong Liu Han Seok Ko Valina L Dawson Ted M Dawson Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. xmao4@jhmi.edu. Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. xmao4@jhmi.edu. Adrienne Helis Malvin Medical Research Foundation New Orleans LA 70130-2685 USA. xmao4@jhmi.edu. Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Neurology Nanjing Brain Hospital Nanjing Jiangsu 210029 PR China. Medical College Yangzhou University Yangzhou Jiangsu 225001 PR China. Department of Pharmacology College of Medicine Dong-A University 32 Daesin Gongwwon-ro Seo-gu Busan 49201 Republic of Korea. Adrienne Helis Malvin Medical Research Foundation New Orleans LA 70130-2685 USA. Department of Anesthesiology West China Hospital Sichuan University. The Research Units of West China (2018RU012)-Chinese Academy of Medical Sciences West China Hospital Sichuan University Chengdu Sichuan 610041 PR China. Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 26 Qiuyue Road Shanghai 201210 China. University of the Chinese Academy of Sciences 19 A Yuquan Road Shijingshan District Beijing 100049 China. Institute for NanoBioTechnology Johns Hopkins University Baltimore MD 21218 USA. Department of Materials Science and Engineering Whiting School of Engineering Johns Hopkins University Baltimore MD 21218 USA. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA 02139 USA. Picower Institute for Learning and Memory Cambridge MA 02139 USA. Harvard-MIT MD/PhD Program Harvard Medical School Boston MA 02115 USA. Department of Biological Science and Biotechnology Chungbuk Nati

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Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia

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Cell stem cell 2025年

作者： Maria Sirenko Soobeom Lee Zhengxi Sun Ronan Chaligne Sanam Loghavi Georgios Asimomitis Charlotte K Brierley Elsa Bernard Sheng F Cai Robert M Myers Bettina Nadorp Junya Sango Morgan Lallo Max F Levine Dylan Domenico Juan E Arango Ossa Juan S Medina-Martinez Kamal Menghrajani Audrey Lasry Alice S Mims Helee Desai Andrea Laganson Chris Famulare Minal Patel Gerard Lozanski Kelly L Bolton Aaron D Viny Mikhail Roshal Ross L Levine Eirini P Papapetrou Eytan M Stein Dan A Landau Ann-Kathrin Eisfeld Iannis Aifantis Elli Papaemmanuil Department of Pathology New York University Grossman School of Medicine New York NY USA Laura and Isaac Perlmutter Cancer Center New York University Grossman School of Medicine New York NY USA Louis V. Gerstner Jr. Graduate School of Biomedical Sciences Memorial Sloan Kettering Cancer Center New York NY USA Computational Oncology Service Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA. Department of Biology New York University New York NY USA. Laura and Isaac Perlmutter Cancer Center New York University Grossman School of Medicine New York NY USA. Program for Computational and Systems Biology Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York NY 10065 USA. Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA. Computational Oncology Service Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Biomedical Systems Laboratory Department of Mechanical Engineering National Technical University of Athens Athens Greece. Medical Research Council Weatherall Institute of Molecular Medicine University of Oxford Oxford UK NIHR Biomedical Research Centre University of Oxford Oxford UK. Leukemia Service Department of Medicine Center for Hematologic Malignancies Memorial Sloan Kettering Cancer Center New York NY USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY USA. Tri-Institutional MD-PhD Program Weill Cornell Medicine Rockefeller University Memorial Sloan Kettering Cancer Center New York NY USA. Division of Precision Medicine Department of Medicine New York University School of Medicine New York NY USA. Department of Oncological Sciences Tisch Cancer Institute Center for Advancement of Blood Cancer Therapies Icahn School of Medicine at Mount Sinai New York NY USA. Vilcek Institute of Graduate Biomedical Sciences NYU Grossman School of Medicine N

Isocitrate dehydrogenase 1/2 (IDH) mutations are early initiating events in acute myeloid leukemia (AML). The complex clonal architecture and cellular heterogeneity in IDH-mutant AML underlies the heterogeneous clinical presentation and outcomes. Integrating single-cell genotyping and transcriptomics, we demonstrate a stem-like and inflammatory phenotype of IDH-mutant AML and identify clone-specific programs associated with NPM1, NRAS, and SRSF2 co-mutations. Furthermore, these clones had distinct responses to treatment with combination IDH inhibitors and chemotherapy, including elimination, reconstitution of myeloid differentiation, or retention within progenitor populations. At relapse after IDH inhibitor monotherapy, we identify upregulated stemness, inflammation, mitochondrial metabolism, and anti-apoptotic factors, as well as downregulated major histocompatibility complex (MHC) class II antigen presentation. At the pre-leukemic stage, we observe upregulation of IDH2-associated pathways, including inflammation. We deliver a detailed phenotyping of IDH-mutant AML and a framework for dissecting contributions of recurrently mutated genes in AML at diagnosis and following therapy, with implications for precision medicine.

关键词： IDH inhibitors IDH1/2 mutations acute myeloid leukemia cellular hierarchy clonal architecture clonal evolution relapse single-cell transcriptomics targeted therapy treatment resistance

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Spatial-Temporal pattern analysis and prediction of air quality in Taiwan

Spatial-Temporal pattern analysis and prediction of air qual...

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IEEE International Conference on Ubi-Media Computing

作者： Ping-Wei Soh Kai-Hsiang Chen Jen-Wei Huang Hone-Jay Chu Institute of Computer and Communication Engineering National Cheng Kung University Tainan Taiwan PhD Program for Multimedia Systems and Intelligent Computing National Cheng Kung University and Academia Sinica Tainan Taiwan Department of Electrical Engineering National Cheng Kung University Tainan Taiwan Department of Geomatics National Cheng Kung University Tainan Taiwan

This study explores the spatial-temporal patterns of particulate matter (PM) in Taiwan. Probability map of PM and daily patterns are discussed in this study. Data mining provides more detailed spatial-temporal information for PM variations and trends. The proposed model will show that data mining provides a relatively high goodness of fit and sufficient space-time explanatory power, particularly air pollution frequency and affect areas. In the proposed model, a method using Dynamic Time Warping is proposed to analyse temporal similarity between stations. The proposed model can eliminate global effect on a single station through the performance of multiple stations. The proposed model will further be used for prediction of PM2.5. The prediction results will discuss the spatial-temporal relations between stations. This study will investigate the distribution of PM and its cyclicality.

关键词： Predictive models Time series analysis Atmospheric modeling Air pollution Conferences Data mining

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Intra-operative ultrasound-based augmented reality guidance for laparoscopic surgery

Intra-operative ultrasound-based augmented reality guidance ...

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作者： Singla, Rohit Edgcumbe, Philip Pratt, Philip Nguan, Christopher Rohling, Robert Department of Electrical and Computer Engineering University of British Columbia VancouverV6T1Z4 Canada MD/PhD Program University of British Columbia VancouverV6T1Z4 Canada Department of Surgery and Cancer Imperial College London SW72BX United Kingdom Department of Urological Sciences University of British Columbia VancouverV6T1Z4 Canada Department of Mechanical Engineering University of British Columbia VancouverV6T1Z4 Canada

In laparoscopic surgery, the surgeon must operate with a limited field of view and reduced depth perception. This makes spatial understanding of critical structures difficult, such as an endophytic tumour in a partial nephrectomy. Such tumours yield a high complication rate of 47%, and excising them increases the risk of cutting into the kidney's collecting system. To overcome these challenges, an augmented reality guidance system is proposed. Using intra-operative ultrasound, a single navigation aid, and surgical instrument tracking, four augmentations of guidance information are provided during tumour excision. Qualitative and quantitative system benefits are measured in simulated robot-assisted partial nephrectomies. Robot-to-camera calibration achieved a total registration error of 1.0 ± 0.4 mm while the total system error is 2.5 ± 0.5 mm. The system significantly reduced healthy tissue excised from an average (±standard deviation) of 30.6 ± 5.5 to 17.5 ± 2.4 cm3 (p

关键词： Tumors

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